Cimicoxib (BioDeep_00000177503)

   

human metabolite blood metabolite


代谢物信息卡片


4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]benzene-1-sulfonamide

化学式: C16H13ClFN3O3S (381.03501500000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C(C=C1)C2=C(N=CN2C3=CC=C(C=C3)S(=O)(=O)N)Cl)F
InChI: InChI=1S/C16H13ClFN3O3S/c1-24-14-7-2-10(8-13(14)18)15-16(17)20-9-21(15)11-3-5-12(6-4-11)25(19,22)23/h2-9H,1H3,(H2,19,22,23)

描述信息

C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor

同义名列表

3 个代谢物同义名

4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]benzene-1-sulfonamide; Cimicoxib; UR-8880



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • M Schneider, F Dron, E Cuinet, F Woehrlé. Comparative pharmacokinetic profile of cimicoxib in dogs and cats after IV administration. Veterinary journal (London, England : 1997). 2021 Apr; 270(?):105625. doi: 10.1016/j.tvjl.2021.105625. [PMID: 33641805]
  • A Di Salvo, M Giorgi, H K Lee, C Vercelli, F Rueca, M Trabalza Marinucci, G Della Rocca. Plasma profile of cimicoxib in sheep after oral administration at two different rates. Polish journal of veterinary sciences. 2017 Sep; 20(3):535-538. doi: 10.1515/pjvs-2017-0065. [PMID: 29166275]
  • M Schneider, A Kuchta, F Dron, F Woehrlé. Disposition of cimicoxib in plasma and milk of whelping bitches and in their puppies. BMC veterinary research. 2015 Jul; 11(?):178. doi: 10.1186/s12917-015-0496-4. [PMID: 26228538]
  • T W Kim, G Della Rocca, A Di Salvo, R Ryschanova, M Sgorbini, M Giorgi. Evaluation of pharmacokinetic and pharmacodynamic properties of cimicoxib in fasted and fed horses. New Zealand veterinary journal. 2015 Mar; 63(2):92-7. doi: 10.1080/00480169.2014.950355. [PMID: 25075617]
  • T W Kim, B Lebkowska-Wieruszewska, H Owen, H I Yun, C J Kowalski, M Giorgi. Pharmacokinetic profiles of the novel COX-2 selective inhibitor cimicoxib in dogs. Veterinary journal (London, England : 1997). 2014 Apr; 200(1):77-81. doi: 10.1016/j.tvjl.2013.12.020. [PMID: 24461644]
  • Elisabeth C Jeunesse, Marc Schneider, Frederique Woehrle, Mathieu Faucher, Herve P Lefebvre, Pierre-Louis Toutain. Pharmacokinetic/pharmacodynamic modeling for the determination of a cimicoxib dosing regimen in the dog. BMC veterinary research. 2013 Dec; 9(?):250. doi: 10.1186/1746-6148-9-250. [PMID: 24330630]
  • Mario Giorgi, Tae-Won Kim, Alessandro Saba, Mohammad-Reza Rouini, Hyoin Yun, Raushan Ryschanova, Helen Owen. Detection and quantification of cimicoxib, a novel COX-2 inhibitor, in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology. Journal of pharmaceutical and biomedical analysis. 2013 Sep; 83(?):28-33. doi: 10.1016/j.jpba.2013.04.024. [PMID: 23685411]
  • Włodzimierz Matysiak, Barbara Jodłowska-Jedrych. Does administration of non-steroidal anti-inflammatory drug determine morphological changes in adrenal cortex: ultrastructural studies. Protoplasma. 2010 Oct; 246(1-4):109-18. doi: 10.1007/s00709-010-0194-9. [PMID: 20721677]
  • Mariko Tanaka, Yoshihiko Fujisaki, Kazunori Kawamura, Kiichi Ishiwata, Qinggeletu, Fumihiko Yamamoto, Takahiro Mukai, Minoru Maeda. Radiosynthesis and evaluation of 11C-labeled diaryl-substituted imidazole and indole derivatives for mapping cyclooxygenase-2. Biological & pharmaceutical bulletin. 2006 Oct; 29(10):2087-94. doi: 10.1248/bpb.29.2087. [PMID: 17015956]
  • Carmen Almansa, Javier Bartrolí, Jordi Belloc, Fernando L Cavalcanti, Rosa Ferrando, Luis A Gómez, Isabel Ramis, Elena Carceller, Manuel Merlos, Julián García-Rafanell. New water-soluble sulfonylphosphoramidic acid derivatives of the COX-2 selective inhibitor cimicoxib. A novel approach to sulfonamide prodrugs. Journal of medicinal chemistry. 2004 Oct; 47(22):5579-82. doi: 10.1021/jm040844j. [PMID: 15481993]