Cicletanine (BioDeep_00000177483)
human metabolite blood metabolite
代谢物信息卡片
1,3-dihydro-6-Methyl-7-hydroxy-3-(4-chlorophenyl)furo(3,4-D)pyridine
化学式: C14H12ClNO2 (261.0556522)
中文名称: 西氯他宁
谱图信息:
最多检出来源 Homo sapiens(blood) 33.33%
分子结构信息
SMILES: CC1=C(O)C2=C(C=N1)C(OC2)C1=CC=C(Cl)C=C1
InChI: InChI=1S/C14H12ClNO2/c1-8-13(17)12-7-18-14(11(12)6-16-8)9-2-4-10(15)5-3-9/h2-6,14,17H,7H2,1H3
描述信息
C - Cardiovascular system > C03 - Diuretics > C03B - Low-ceiling diuretics, excl. thiazides
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic
D045283 - Natriuretic Agents > D004232 - Diuretics
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:135078
- PubChem: 54910
- HMDB: HMDB0250233
- DrugBank: DB12766
- ChEMBL: CHEMBL191886
- Wikipedia: Cicletanine
- CAS: 89943-82-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Vijaya M Musini, Pouria Rezapour, James M Wright, Ken Bassett, Ciprian D Jauca. Blood pressure-lowering efficacy of loop diuretics for primary hypertension.
The Cochrane database of systematic reviews.
2015 May; ?(5):CD003825. doi:
10.1002/14651858.cd003825.pub4. [PMID: 26000442] - Vijaya M Musini, Pouria Rezapour, James M Wright, Ken Bassett, Ciprian D Jauca. Blood pressure lowering efficacy of loop diuretics for primary hypertension.
The Cochrane database of systematic reviews.
2012 Aug; ?(8):CD003825. doi:
10.1002/14651858.cd003825.pub3. [PMID: 22895937] - Adam Whaley-Connell, James R Sowers. The kaliuretic impact of cicletanine compared to hydrochlorothiazide.
Journal of hypertension.
2012 Apr; 30(4):691-2. doi:
10.1097/hjh.0b013e3283517439. [PMID: 22418907] - Frank Wagner, Marie-Pierre Malice, Erol Wiegert, Helen E McGrath, John Gildea, Shabri Mitta, Kristien Van Dyck, Inge De Lepeleire, Amy O Johnson-Levonas, Christine McCrary Sisk, Rose Fernandez, Danielle M Greenwalt, Chan Beals, Robert M Carey, Irene Nunes. A comparison of the natriuretic and kaliuretic effects of cicletanine and hydrochlorothiazide in prehypertensive and hypertensive humans.
Journal of hypertension.
2012 Apr; 30(4):819-27. doi:
10.1097/hjh.0b013e32835022a8. [PMID: 22278145] - Vijaya M Musini, James M Wright, Ken Bassett, Ciprian D Jauca. Blood pressure lowering efficacy of loop diuretics for primary hypertension.
The Cochrane database of systematic reviews.
2009 Oct; ?(4):CD003825. doi:
10.1002/14651858.cd003825.pub2. [PMID: 19821314] - M J Duran, S Sennoune, C Arnaud, S Garcia, M T Droy-Lefaix, J M Maixent. Protective effect of cicletanine on renal function in diabetic spontaneously hypertensive rats.
Cellular and molecular biology (Noisy-le-Grand, France).
2004 Nov; 50(7):869-74. doi:
NULL. [PMID: 15672472] - Olga V Fedorova, Mark I Talan, Natalia I Agalakova, Marie-Therese Droy-Lefaix, Edward G Lakatta, Alexei Y Bagrov. Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension.
Hypertension (Dallas, Tex. : 1979).
2003 Mar; 41(3):505-11. doi:
10.1161/01.hyp.0000053446.43894.9f. [PMID: 12623951] - A J Reyes. Diuretics in the therapy of hypertension.
Journal of human hypertension.
2002 Mar; 16 Suppl 1(?):S78-83. doi:
10.1038/sj.jhh.1001349. [PMID: 11986901] - Z Szilvássy, T Csont, T Páli, M T Droy-Lefaix, P Ferdinandy. Nitric oxide, peroxynitrite and cGMP in atherosclerosis-induced hypertension in rabbits: beneficial effects of cicletanine.
Journal of vascular research.
2001 Jan; 38(1):39-46. doi:
10.1159/000051028. [PMID: 11173993] - M Kohzuki, X M Wu, M Kamimoto, K Yoshida, M Nagasaka, M Kanazawa, M Yasujima, T Saito, T Sato. Renal-protective effect of nondepressor dose of cicletanine in diabetic rats with hypertension.
American journal of hypertension.
2000 Mar; 13(3):298-306. doi:
10.1016/s0895-7061(99)00189-2. [PMID: 10777035] - A Y Bagrov, R I Dmitrieva, N A Dorofeeva, O V Fedorova, D A Lopatin, E G Lakatta, M T Droy-Lefaix. Cicletanine reverses vasoconstriction induced by the endogenous sodium pump ligand, marinobufagenin, via a protein kinase C dependent mechanism.
Journal of hypertension.
2000 Feb; 18(2):209-15. doi:
10.1097/00004872-200018020-00012. [PMID: 10694190] - A Monroy, C Plata, G Gamba, M T Droy-Lefaix, R P Garay. [Lack of effect of cicletanine and its sulfoconjugated metabolite on the thiazide receptor expressed in Xenopus oocytes].
Archives des maladies du coeur et des vaisseaux.
1999 Aug; 92(8):1001-4. doi:
NULL. [PMID: 10486654] - H Nakamoto, H Suzuki, A Ohishi, H Katsumata, H Sakaguchi, T Saruta. Effects of cicletanine on the progression of renal failure in 5/6 nephrectomized hypertensive rats.
Clinical and experimental pharmacology & physiology.
1999 Mar; 26(3):236-41. doi:
10.1046/j.1440-1681.1999.03021.x. [PMID: 10081620] - J M Valdivielso, A I Morales, F Pérez-Barriocanal, J M López-Novoa. Effect of cicletanine on renal cGMP production.
Canadian journal of physiology and pharmacology.
1998 Dec; 76(12):1151-5. doi:
10.1139/cjpp-76-12-1151. [PMID: 10326838] - F Vargas, M Alvarez-Guerra, M T Droy-Lefaix, R P Garay. Inhibition by (-)-cicletanine of the vascular reactivity to angiotensin II and vasopressin in isolated rat vessels.
American journal of hypertension.
1998 May; 11(5):579-84. doi:
10.1016/s0895-7061(97)00407-x. [PMID: 9633794] - T Yasu, M Imanishi. Effects of cicletanine on prostaglandin I2 and E2 levels in patients with essential hypertension.
American journal of hypertension.
1997 Jul; 10(7 Pt 1):750-5. doi:
10.1016/s0895-7061(97)00055-1. [PMID: 9234829] - Y Uehara, N Hirawa, Y Kawabata, Y Akie, A Ichikawa, N Funahashi, A Goto, M Omata. Lipid metabolism and renal protection by chronic cicletanine treatment in Dahl salt-sensitive rats with salt-induced hypertension.
Blood pressure.
1997 May; 6(3):180-7. doi:
10.3109/08037059709061935. [PMID: 9181257] - N Hirawa, Y Uehara, Y Kawabata, Y Akie, A Ichikawa, N Funahashi, A Goto, M Omata. Restoration of endothelial cell function by chronic cicletanine treatment in Dahl salt-sensitive rats with salt-induced hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension.
1996 Dec; 19(4):263-70. doi:
10.1291/hypres.19.263. [PMID: 8986457] - G R Mashori, A R Tariq, M M Shahimi, H Suhaimi. The effects of Cicletanine, a new antihypertensive agent on insulin release in rat isolated pancreas by the perfusion technique.
Singapore medical journal.
1996 Jun; 37(3):278-81. doi:
NULL. [PMID: 8942229] - M C Bayés, M J Barbanoj, J Vallès, J Torrent, R Obach, F Jané. A drug interaction study between cicletanine and tolbutamide in healthy volunteers.
European journal of clinical pharmacology.
1996; 50(5):381-4. doi:
10.1007/s002280050127. [PMID: 8839660] - T Yasu, M Imanishi, G Kimura, T Tsuji, H Matsuoka, M Kuramochi, T Omae. Short-term increase in prostaglandin I2 synthesis caused by cicletanine in patients with essential hypertension.
American journal of hypertension.
1995 Sep; 8(9):944-8. doi:
10.1016/0895-7061(95)00159-m. [PMID: 8541011] - R Vistelle, D Lamiable, E Morin, T Trenque, M Kaltenbach. Urinary excretion of cicletanine in the rat. Stereochemical aspects.
Drug metabolism and disposition: the biological fate of chemicals.
1995 Sep; 23(9):988-92. doi:
NULL. [PMID: 8565790] - J Greven, A Rahn, E Brändle. Effects of cicletanine on kidney function. 2. Role of renal prostaglandins and kinins, and of muscarinic receptors.
The Journal of pharmacology and experimental therapeutics.
1995 Jun; 273(3):1197-202. doi:
NULL. [PMID: 7791091] - J Greven. Effects of cicletanine on kidney function. 1. Clearance and micropuncture studies in anesthetized rats.
The Journal of pharmacology and experimental therapeutics.
1995 Jun; 273(3):1190-6. doi:
NULL. [PMID: 7791090] - R P Garay, C Rosati, K Fanous, M Allard, E Morin, D Lamiable, R Vistelle. Evidence for (+)-cicletanine sulfate as an active natriuretic metabolite of cicletanine in the rat.
European journal of pharmacology.
1995 Feb; 274(1-3):175-80. doi:
10.1016/0014-2999(94)00731-l. [PMID: 7768271] - B Moulin, J P Fillastre, M Godin, A Coquerel, E Decoopman. Renal hemodynamics and sodium excretion after acute and chronic administration of cicletanine in normotensive and hypertensive subjects.
Journal of cardiovascular pharmacology.
1995 Feb; 25(2):292-9. doi:
10.1097/00005344-199502000-00015. [PMID: 7752655] - K Ando, A Ono, Y Sato, S Asano, T Fujita. Involvement of the sympathetic nervous system in antihypertensive effect of cicletanine in salt-loaded young spontaneously hypertensive rats.
American journal of hypertension.
1994 Jun; 7(6):550-4. doi:
10.1093/ajh/7.6.550. [PMID: 7917154] - K Fanous, C Nazaret, N Senn, E Decoopman-Morin, M Allard, R P Garay. Opposite effects of cell growth factors and cicletanine sulfate on the sodium-independent [Cl-/HCO3-] exchange in cultured vascular smooth muscle.
American journal of hypertension.
1993 Aug; 6(8):674-9. doi:
10.1093/ajh/6.8.674. [PMID: 8217030] - Y Uehara, Y Kawabata, N Hirawa, S Takada, T Nagata, A Numabe, J Iwai, T Sugimoto. Possible radical scavenging properties of cicletanine and renal protection in Dahl salt sensitive rats.
American journal of hypertension.
1993 Jun; 6(6 Pt 1):463-72. doi:
10.1093/ajh/6.6.463. [PMID: 8343228] - K Ando, A Ono, Y Sato, T Fujita. Involvement of prostaglandins and renal haemodynamics in salt-sensitivity of young spontaneously hypertensive rats.
Journal of hypertension.
1993 Apr; 11(4):373-7. doi:
10.1097/00004872-199304000-00007. [PMID: 8390504] - R D Bukoski, J Bo, H Xue, K Bian. Antiproliferative and endothelium-dependent vasodilator properties of 1,3-dihydro-3-p-chlorophenyl-7-hydroxy-6-methyl-furo-(3,4c) pyridine hydrochloride (cicletanine).
The Journal of pharmacology and experimental therapeutics.
1993 Apr; 265(1):30-5. doi:
NULL. [PMID: 8474013] - K Tsunoda, K Abe, K Omata, T Hagino, N Minami, M Munakata, K Yoshida, H Sakuma, S Misawa, S Arima. Effects of cicletanine on the urinary excretion of prostanoids and kallikrein, and on renal function in man.
Cardiovascular drugs and therapy.
1993 Apr; 7(2):253-6. doi:
10.1007/bf00878515. [PMID: 8357779] - M A Boim, R Bregman, V Melhado, C Versolato, L A Moura, C T Bergamaschi, N Schor. Effect of cicletanine on the progression of chronic renal failure in rats.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
1993; 26(1):99-108. doi:
NULL. [PMID: 8220274] - J Pruñonosa, R Obach, A Diez-Cascón, L Gouesclou. Comparison of high-performance liquid chromatography and high-performance capillary electrophoresis for the determination of cicletanine in plasma.
Journal of chromatography.
1992 Oct; 581(2):219-26. doi:
10.1016/0378-4347(92)80275-u. [PMID: 1452612] - C Emond, G Bompart, J Rakotoarivony, J L Bascands, C Pecher, A Adam, T Tarrade, P Berthet, J P Girolami. Protective effect of cicletanine on hypertension-induced decreases in the renal kallikrein-kinin and prostaglandin systems in stroke-prone spontaneously hypertensive rats.
Journal of cardiovascular pharmacology.
1992 Oct; 20(4):601-8. doi:
10.1097/00005344-199210000-00014. [PMID: 1280717] - J Pruñonosa, C Peraire, J Torrent, R Obach. Pharmacokinetic study of cicletanine in healthy volunteers.
International journal of clinical pharmacology, therapy, and toxicology.
1992 Aug; 30(8):265-70. doi:
NULL. [PMID: 1526688] - F Terzi, H Beaufils, D Laouari, M Burtin, C Kleinknecht. Renal effect of anti-hypertensive drugs depends on sodium diet in the excision remnant kidney model.
Kidney international.
1992 Aug; 42(2):354-63. doi:
10.1038/ki.1992.296. [PMID: 1405318] - H Jin, R H Yang, S Oparil. Cicletanine blunts the pulmonary pressor response to acute hypoxia in rats.
The American journal of the medical sciences.
1992 Jul; 304(1):14-9. doi:
10.1097/00000441-199207000-00005. [PMID: 1642247] - R P Garay, C Rosati, C Nazaret, A Esanu, T Tarrade, P Braquet. Cicletanine sulfate: inhibition of anion transport systems and natriuretic activity.
Naunyn-Schmiedeberg's archives of pharmacology.
1992 Jul; 346(1):114-9. doi:
10.1007/bf00167580. [PMID: 1328892] - E O Mikkelsen, S H Poulsen, N C Nyborg, N Korsgaard, J Sehested. Difference between aortic and renal vascular reactivity in cyclosporin A treated rats and the effect of cicletanine.
Naunyn-Schmiedeberg's archives of pharmacology.
1992 Mar; 345(3):356-61. doi:
10.1007/bf00168698. [PMID: 1620237] - J Pruñonosa, R Obach, A Diez-Cascón, L Gouesclou. Determination of cicletanine enantiomers in plasma by high-performance capillary electrophoresis.
Journal of chromatography.
1992 Feb; 574(1):127-33. doi:
10.1016/0378-4347(92)80106-z. [PMID: 1629275] - S M Antoniewicz, J A Cook, R R Brown. Determination of cicletanine in human plasma by high-performance liquid chromatography using automated column switching.
Journal of chromatography.
1992 Jan; 573(1):93-8. doi:
10.1016/0378-4347(92)80479-a. [PMID: 1564111] - M Szczepańska-Konkel, M Redlak, S Angielski. Glibenclamid-sensitive K+ channels are responsible for angiotensin II hypersensitive contraction and atrial natriuretic factor refractoriness of glomeruli in low-sodium rats.
Biochemical and biophysical research communications.
1991 Dec; 181(2):871-6. doi:
10.1016/0006-291x(91)91271-d. [PMID: 1836728] - Y Uehara, A Numabe, N Hirawa, Y Kawabata, J Iwai, H Ono, H Matsuoka, Y Takabatake, S Yagi, T Sugimoto. Antihypertensive effects of cicletanine and renal protection in Dahl salt-sensitive rats.
Journal of hypertension.
1991 Aug; 9(8):719-28. doi:
10.1097/00004872-199108000-00005. [PMID: 1655882] - Y Uehara, A Numabe, Y Kawabata, T Nagata, J Iwai, H Matsuoka, S Yagi, Y Takabatake, T Sugimoto. Evidence for medial-mass regression in the vascular wall of Dahl hypertensive rats by cicletanine treatment.
Journal of cardiovascular pharmacology.
1991 Jul; 18(1):158-66. doi:
10.1097/00005344-199107000-00021. [PMID: 1719285] - H K Jin, R H Yang, P Esunge, Y F Chen, J Durand, S Oparil. Antihypertensive effect of cicletanine is exaggerated in NaCl-sensitive hypertension.
The American journal of the medical sciences.
1991 Jun; 301(6):383-9. doi:
10.1097/00000441-199106000-00005. [PMID: 1645501] - C Peraire, J Torrent, J Pruñonosa, O Azcona, M Nomen, R Obach. Multiple dose pharmacokinetic study of cicletanine in healthy volunteers.
European journal of drug metabolism and pharmacokinetics.
1991; Spec No 3(?):173-7. doi:
NULL. [PMID: 1820874] - C Damase-Michel, J P Girolami, J L Bascands, M A Tran, J P Moatti, C Pecher, P Berthet, T Tarrade, J L Montastruc. Effects of cicletanine on vasoactive systems in conscious sinoaortic-denervated dogs.
Fundamental & clinical pharmacology.
1991; 5(8):719-32. doi:
10.1111/j.1472-8206.1991.tb00760.x. [PMID: 1783361] - I Berlin, G Deray, G Maistre, F Masson, C Barthelemy, J C Legrand, C Jacobs. Cicletanine does not affect plasma atrial natriuretic peptide concentration in healthy subjects.
European journal of clinical pharmacology.
1990; 39(6):593-4. doi:
10.1007/bf00316103. [PMID: 1965645] - D R Singer, N D Markandu, A L Sugden, G A MacGregor. A comparison of the acute effects of cicletanine and bendrofluazide on urinary electrolytes and plasma potassium in essential hypertension.
European journal of clinical pharmacology.
1990; 39(3):227-32. doi:
10.1007/bf00315101. [PMID: 2257857] - M Sato, K Abe, M Yasujima, K Omata, S Fang, K Tsunoda, K Kudo, K Takeuchi, T Hagino, M Kanazawa. Inhibitory effect of cicletanine on vascular smooth muscle cell proliferation.
Archives des maladies du coeur et des vaisseaux.
1989 Nov; 82 Spec No 4(?):63-6. doi:
NULL. [PMID: 2514671] - M T Droy-Lefaix, M M Ruchoux, P Berthet, F Bakri, D Bosquet, G Narcisse, G Guillemain. [Effectiveness of cicletanine on lesions in spontaneously hypertensive rats. Curative study--dose-effect relationship].
Archives des maladies du coeur et des vaisseaux.
1989 Nov; 82 Spec No 4(?):163-8. doi:
NULL. [PMID: 2514659] - M M Ruchoux, F Huguet, M T Droy, J Guillemain, G Chauveau, Y Lhuintre. [Effects of cicletanine on kidney lesions associated with age. Light and electron microscopy studies].
Archives des maladies du coeur et des vaisseaux.
1989 Nov; 82 Spec No 4(?):181-5. doi:
NULL. [PMID: 2514662] - M M Ruchoux, F Bakri, D Bosquet, M T Droy, J Guillemain, Y Lhuintre. [Comparison of the effects of cicletanine and captopril on kidney and heart lesions in spontaneously hypertensive rats (SHR-SP)].
Archives des maladies du coeur et des vaisseaux.
1989 Nov; 82 Spec No 4(?):169-74. doi:
NULL. [PMID: 2514660] - C Deby, G Deby-Dupont, M T Droy-Lefaix, D Bosquet, P Berthet, F Bakri. [Effects of treatment with cicletanine on kidney PGE2 and PGI1 in spontaneously hypertensive rats].
Archives des maladies du coeur et des vaisseaux.
1989 Nov; 82 Spec No 4(?):37-40. doi:
NULL. [PMID: 2514666] - A Hornych, J Boisson, J C Gaschard. [Reduction of kidney prostaglandin synthesis in patients with essential hypertension. Stimulating effect of cicletanine].
Archives des maladies du coeur et des vaisseaux.
1989 Nov; 82 Spec No 4(?):85-90. doi:
NULL. [PMID: 2514674] - C Damase-Michel, M A Tran, P Berthet, T Tarrade, J L Montastruc. [Cicletanine and the sympathetic nervous system. A study of awake sino-aortic denervated hypertensive dogs].
Archives des maladies du coeur et des vaisseaux.
1989 Nov; 82 Spec No 4(?):55-8. doi:
NULL. [PMID: 2514670] - J Rouffy, F Djian, I Aubert. [Effects of cicletanine on plasma lipid metabolism. Mid-term open trial in hypertensive patients with normal blood lipids and hyperlipidemia].
Archives des maladies du coeur et des vaisseaux.
1989 Nov; 82 Spec No 4(?):131-4. doi:
NULL. [PMID: 2514652] - S Witchitz, S Gryner. [Evaluation of rhythm tolerance of cicletanine using continuous electrocardiographic recording].
Archives des maladies du coeur et des vaisseaux.
1989 Nov; 82 Spec No 4(?):145-9. doi:
NULL. [PMID: 2514655] - P Hudson, T K Holland, A P McCraw, J Duffen, A K Sim. Evaluation of the effect of cicletanine on genetic atherosclerosis in the rabbit.
Archives des maladies du coeur et des vaisseaux.
1989 Nov; 82 Spec No 4(?):71-7. doi:
NULL. [PMID: 2514673] - P Passa. [Cicletanine tolerance in hypertensive patients with metabolic disorders].
Archives des maladies du coeur et des vaisseaux.
1989 Nov; 82 Spec No 4(?):135-8. doi:
". [PMID: 2514653] - M M Ruchoux, F Huguet, M T Droy-Lefaix, A Gelot, P Ruchoux, A Autret. The effect of cicletanine on cerebrovascular injury in stroke-prone spontaneously hypertensive rats.
American journal of hypertension.
1989 Sep; 2(9):683-9. doi:
10.1093/ajh/2.9.683. [PMID: 2803675] - M M Ruchoux, M T Droy-Lefaix, F Bakri, P Berthet, D Bosquet, Y Lhuintre. [Protective action of cicletanine on the vascular walls in stroke-prone spontaneously hypertensive rats].
Archives des maladies du coeur et des vaisseaux.
1989 Jul; 82(7):1163-8. doi:
NULL. [PMID: 2510643] - P Guinot, J Jewitt-Harris, T Tarrade. Determination of the optimal dose of the antihypertensive drug cicletanine hydrochloride in man.
Arzneimittel-Forschung.
1989 Jan; 39(1):86-9. doi:
NULL. [PMID: 2655611] - C Deby, R H Bourgain, R Andries, P Braquet. Modulation of prostacyclin synthetase by cicletanine and drugs which affect ion transport.
Pharmacological research communications.
1988 Sep; 20 Suppl 3(?):101-8. doi:
10.1016/s0031-6989(88)80109-7. [PMID: 3147465] - C Deby, G Deby-Dupont, P Braquet, R Bourgain, J Pincemail, D Bosquet. [Increase of the prostacyclin/thromboxane A2 ratio in the plasma of rabbits treated with cicletanine, a new antihypertensive agent].
Archives des maladies du coeur et des vaisseaux.
1988 Jun; 81 Spec No(?):97-9. doi:
NULL. [PMID: 3142438] - N Ferry, J Geoffroy, N Pozet, G Cuisinaud, D Benzoni, P Y Zech, J Sassard. Influence of renal insufficiency on the pharmacokinetics of cicletanine and its effects on the urinary excretion of electrolytes and prostanoids.
British journal of clinical pharmacology.
1988 Mar; 25(3):359-66. doi:
10.1111/j.1365-2125.1988.tb03314.x. [PMID: 3358898] - R Zini, D Morin, P Jouenne, J P Tillement. Cicletanine binding to human plasma proteins and erythrocytes, a particular HSA-drug interaction.
Life sciences.
1988; 43(25):2103-15. doi:
10.1016/0024-3205(88)90360-8. [PMID: 3210902] - E Malherbe, M Le Hegarat, F Clostre, P Braquet. Comparison of cicletanine with other antihypertensive drugs in SHR-SP models.
Drugs under experimental and clinical research.
1988; 14(2-3):83-8. doi:
NULL. [PMID: 2970955] - P Jungers. Pharmacokinetics of cicletanine in patients with impaired renal function.
Drugs under experimental and clinical research.
1988; 14(2-3):189-94. doi:
NULL. [PMID: 3416723] - C Deby, R H Bourgain, G Deby-Dupont, J Pincemail, R P Garay, P Braquet. Modulation of in vivo generation of prostanoids by drugs affecting membrane ion transport.
Drugs under experimental and clinical research.
1988; 14(2-3):123-34. doi:
NULL. [PMID: 3138095] - G Fredj. Clinical pharmacokinetics of cicletanine hydrochloride.
Drugs under experimental and clinical research.
1988; 14(2-3):181-8. doi:
NULL. [PMID: 3416722] - H Bippi, P Guinot. Study of the effects of cicletanine on the renin-angiotensin-aldosterone system.
Drugs under experimental and clinical research.
1988; 14(2-3):215-20. doi:
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