Chroman-2-ol (BioDeep_00000177461)
human metabolite blood metabolite
代谢物信息卡片
化学式: C9H10O2 (150.0681)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2=CC=CC=C2OC1O
InChI: InChI=1S/C9H10O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-4,9-10H,5-6H2
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jawahar Lal, Nidhi Sharma. Simultaneous quantification of centchroman and its 7-demethylated metabolite in rat dried blood spot samples using LC-MS/MS.
Biomedical chromatography : BMC.
2012 Sep; 26(9):1089-95. doi:
10.1002/bmc.1752
. [PMID: 22102520] - Toru Egashira, Shinsuke Yuasa, Tomoyuki Suzuki, Yoshiyasu Aizawa, Hiroyuki Yamakawa, Tomohiro Matsuhashi, Yohei Ohno, Shugo Tohyama, Shinichiro Okata, Tomohisa Seki, Yusuke Kuroda, Kojiro Yae, Hisayuki Hashimoto, Tomofumi Tanaka, Fumiyuki Hattori, Toshiaki Sato, Shunichiro Miyoshi, Seiji Takatsuki, Mitsushige Murata, Junko Kurokawa, Tetsushi Furukawa, Naomasa Makita, Takeshi Aiba, Wataru Shimizu, Minoru Horie, Kaichiro Kamiya, Itsuo Kodama, Satoshi Ogawa, Keiichi Fukuda. Disease characterization using LQTS-specific induced pluripotent stem cells.
Cardiovascular research.
2012 Sep; 95(4):419-29. doi:
10.1093/cvr/cvs206
. [PMID: 22739119] - Katerina Krumova, Sayuri Friedland, Gonzalo Cosa. How lipid unsaturation, peroxyl radical partitioning, and chromanol lipophilic tail affect the antioxidant activity of α-tocopherol: direct visualization via high-throughput fluorescence studies conducted with fluorogenic α-tocopherol analogues.
Journal of the American Chemical Society.
2012 Jun; 134(24):10102-13. doi:
10.1021/ja301680m
. [PMID: 22568598] - Tomohiko Taniguchi, Mai Uesugi, Toru Arai, Takashi Yoshinaga, Norimasa Miyamoto, Kohei Sawada. Chronic probucol treatment decreases the slow component of the delayed-rectifier potassium current in CHO cells transfected with KCNQ1 and KCNE1: a novel mechanism of QT prolongation.
Journal of cardiovascular pharmacology.
2012 Apr; 59(4):377-86. doi:
10.1097/fjc.0b013e318245e0c5
. [PMID: 22189896] - Maike J Ohlow, Matthias Granold, Mathias Schreckenberger, Bernd Moosmann. Is the chromanol head group of vitamin E nature's final truth on chain-breaking antioxidants?.
FEBS letters.
2012 Mar; 586(6):711-6. doi:
10.1016/j.febslet.2012.01.022
. [PMID: 22281199] - Syed Fairus, Rosnah M Nor, Hwee M Cheng, Kalyana Sundram. Alpha-tocotrienol is the most abundant tocotrienol isomer circulated in plasma and lipoproteins after postprandial tocotrienol-rich vitamin E supplementation.
Nutrition journal.
2012 Jan; 11(?):5. doi:
10.1186/1475-2891-11-5
. [PMID: 22252050] - Shawn N Watson, Mark A Nelson, Willem C Wildering. Redox agents modulate neuronal activity and reproduce physiological aspects of neuronal aging.
Neurobiology of aging.
2012 Jan; 33(1):149-61. doi:
10.1016/j.neurobiolaging.2010.01.017
. [PMID: 20153084] - András Szarka, Bálint Tomasskovics, Gábor Bánhegyi. The ascorbate-glutathione-α-tocopherol triad in abiotic stress response.
International journal of molecular sciences.
2012; 13(4):4458-4483. doi:
10.3390/ijms13044458
. [PMID: 22605990] - Maria S Dwiyanti, Tetsuya Yamada, Masako Sato, Jun Abe, Keisuke Kitamura. Genetic variation of γ-tocopherol methyltransferase gene contributes to elevated α-tocopherol content in soybean seeds.
BMC plant biology.
2011 Nov; 11(?):152. doi:
10.1186/1471-2229-11-152
. [PMID: 22053941] - Ingrid Elisia, David D Kitts. Quantification of hexanal as an index of lipid oxidation in human milk and association with antioxidant components.
Journal of clinical biochemistry and nutrition.
2011 Nov; 49(3):147-52. doi:
10.3164/jcbn.10-142
. [PMID: 22128211] - A M Neal, H C Taylor, I D Millar, J D Kibble, S J White, L Robson. Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K+ conductance in the proximal tubule.
The Journal of physiology.
2011 Jul; 589(Pt 14):3595-609. doi:
10.1113/jphysiol.2011.209155
. [PMID: 21576273] - Meixia Gao, Anju Singh, Kristin Macri, Curt Reynolds, Vandana Singhal, Shyam Biswal, Ernst W Spannhake. Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system.
Respiratory research.
2011 Jul; 12(?):92. doi:
10.1186/1465-9921-12-92
. [PMID: 21752292] - Juliana Almeida, Leandro Quadrana, Ramón Asís, Nathalia Setta, Fabiana de Godoy, Luisa Bermúdez, Santiago N Otaiza, Junia V Corrêa da Silva, Alisdair R Fernie, Fernando Carrari, Magdalena Rossi. Genetic dissection of vitamin E biosynthesis in tomato.
Journal of experimental botany.
2011 Jul; 62(11):3781-98. doi:
10.1093/jxb/err055
. [PMID: 21527625] - Anna M Wobus, Peter Löser. Present state and future perspectives of using pluripotent stem cells in toxicology research.
Archives of toxicology.
2011 Feb; 85(2):79-117. doi:
10.1007/s00204-010-0641-6
. [PMID: 21225242] - Noriko Yamaguchi, Yoshihiro Mezaki, Mitsutaka Miura, Katsuyuki Imai, Mayako Morii, Tatsuzo Hebiguchi, Kiwamu Yoshikawa. Antiproliferative and proapoptotic effects of tocopherol and tocol on activated hepatic stellate cells.
Journal of nutritional science and vitaminology.
2011; 57(5):317-25. doi:
10.3177/jnsv.57.317
. [PMID: 22293208] - Rodrigo Alzamora, Fiona O'Mahony, Wing-Hung Ko, Tiffany Wai-Nga Yip, Derek Carter, Mustapha Irnaten, Brian Joseph Harvey. Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels.
Frontiers in physiology.
2011; 2(?):33. doi:
10.3389/fphys.2011.00033
. [PMID: 21747769] - Henning Fröhlich, Krishna M Boini, Guiscard Seebohm, Nathalie Strutz-Seebohm, Oana N Ureche, Michael Föller, Melanie Eichenmüller, Ekaterina Shumilina, Ganesh Pathare, Anurag Kumar Singh, Ursula Seidler, Karl E Pfeifer, Florian Lang. Hypothyroidism of gene-targeted mice lacking Kcnq1.
Pflugers Archiv : European journal of physiology.
2011 Jan; 461(1):45-52. doi:
10.1007/s00424-010-0890-5
. [PMID: 20978783] - Cimen Karasu. Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment.
The open cardiovascular medicine journal.
2010 Nov; 4(?):240-56. doi:
10.2174/1874192401004010240
. [PMID: 21270942] - Teshager Bitew, Christopher E Sveen, Belinda Heyne, Vanina Zaremberg. Vitamin E prevents lipid raft modifications induced by an anti-cancer lysophospholipid and abolishes a Yap1-mediated stress response in yeast.
The Journal of biological chemistry.
2010 Aug; 285(33):25731-42. doi:
10.1074/jbc.m110.122200
. [PMID: 20538604] - Won Sun Park, Youn Kyoung Son, Eun A Ko, Seong Woo Choi, Nari Kim, Tae-Hoon Choi, Hyun Joo Youn, Su-Hyun Jo, Da Hye Hong, Jin Han. A Carbohydrate Fraction, AIP1, from Artemisia Iwayomogi Reduces the Action Potential Duration by Activation of Rapidly Activating Delayed Rectifier K Channels in Rabbit Ventricular Myocytes.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.
2010 Jun; 14(3):119-25. doi:
10.4196/kjpp.2010.14.3.119
. [PMID: 20631882] - Christophe Duranton, Isabelle Rubera, Sebastien L'hoste, Marc Cougnon, Philippe Poujeol, Jacques Barhanin, Michel Tauc. KCNQ1 K+ channels are involved in lipopolysaccharide-induced apoptosis of distal kidney cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2010; 25(4-5):367-78. doi:
10.1159/000303041
. [PMID: 20332617] - Tsuyoshi Goto, Nobuyuki Takahashi, Shizuka Hirai, Teruo Kawada. Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism.
PPAR research.
2010; 2010(?):483958. doi:
10.1155/2010/483958
. [PMID: 20613991] - Shan-Shan Qin, Zhi-Wu Yu, Yang-Xin Yu. Structural and kinetic properties of alpha-tocopherol in phospholipid bilayers, a molecular dynamics simulation study.
The journal of physical chemistry. B.
2009 Dec; 113(52):16537-46. doi:
10.1021/jp9074306
. [PMID: 19928873] - Wen-Chi Huang, Zhi-Chyang Kang, Yi-Jen Li, Huey-Mei Shaw. Effects of Oxidized Frying Oil on Proteins Related to alpha-Tocopherol Metabolism in Rat Liver.
Journal of clinical biochemistry and nutrition.
2009 Jul; 45(1):20-8. doi:
10.3164/jcbn08-250
. [PMID: 19590703] - Sergey Missan, Jiansong Qi, Julie Crack, Terence F McDonald, Paul Linsdell. Regulation of wild-type and mutant KCNQ1/KCNE1 channels by tyrosine kinase.
Pflugers Archiv : European journal of physiology.
2009 Jul; 458(3):471-80. doi:
10.1007/s00424-008-0634-y
. [PMID: 19139916] - Anna Goraca, Katarzyna Asłanowicz-Antkowiak. Prophylaxis with alpha-lipoic acid against lipopolysaccharide-induced brain injury in rats.
Archivum immunologiae et therapiae experimentalis.
2009 Mar; 57(2):141-6. doi:
10.1007/s00005-009-0015-z
. [PMID: 19333732] - Yi-Jen Li, Sheng-Ching Luo, Yi-Jing Lee, Fu-Jung Lin, Chi-Cheng Cheng, Yung-Shung Wein, Yueh-Hsiung Kuo, Ching-jang Huang. Isolation and identification of alpha-CEHC sulfate in rat urine and an improved method for the determination of conjugated alpha-CEHC.
Journal of agricultural and food chemistry.
2008 Dec; 56(23):11105-13. doi:
10.1021/jf802459d
. [PMID: 18991451] - Jolanta Gruszka, Anna Pawlak, Jerzy Kruk. Tocochromanols, plastoquinol, and other biological prenyllipids as singlet oxygen quenchers-determination of singlet oxygen quenching rate constants and oxidation products.
Free radical biology & medicine.
2008 Sep; 45(6):920-8. doi:
10.1016/j.freeradbiomed.2008.06.025
. [PMID: 18634868] - DaZheng Wu, Zhibi Hu. Rutaecarpine induces chloride secretion across rat isolated distal colon.
The Journal of pharmacology and experimental therapeutics.
2008 Apr; 325(1):256-66. doi:
10.1124/jpet.107.131961
. [PMID: 18187619] - Hong-Bo Shao, Li-Ye Chu, Zhao-Hua Lu, Cong-Min Kang. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells.
International journal of biological sciences.
2007 Dec; 4(1):8-14. doi:
10.7150/ijbs.4.8
. [PMID: 18167531] - Lars M Voll, Ali-Reza Abbasi. Are there Specific In Vivo Roles for alpha- and gamma-Tocopherol in Plants?.
Plant signaling & behavior.
2007 Nov; 2(6):486-8. doi:
10.4161/psb.2.6.4499
. [PMID: 19704593] - Fiona O'Mahony, Rodrigo Alzamora, Vicki Betts, Franck LaPaix, Derek Carter, Mustapha Irnaten, Brian J Harvey. Female gender-specific inhibition of KCNQ1 channels and chloride secretion by 17beta-estradiol in rat distal colonic crypts.
The Journal of biological chemistry.
2007 Aug; 282(34):24563-73. doi:
10.1074/jbc.m611682200
. [PMID: 17556370] - J K Kim, H Y Yoo, S J Kim, Y-S Hwang, J Han, J A Kim, C S Kim, H S Cho. Effects of sevoflurane on the cAMP-induced short-circuit current in mouse tracheal epithelium and recombinant Cl- (CFTR) and K+ (KCNQ1) channels.
British journal of anaesthesia.
2007 Aug; 99(2):245-51. doi:
10.1093/bja/aem123
. [PMID: 17567648] - Timothy J Sontag, Robert S Parker. Influence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega-hydroxylase.
Journal of lipid research.
2007 May; 48(5):1090-8. doi:
10.1194/jlr.m600514-jlr200
. [PMID: 17284776] - Wakako Tsuzuki, Ritsuko Yunoki, Hiroyuki Yoshimura. Intestinal epithelial cells absorb gamma-tocotrienol faster than alpha-tocopherol.
Lipids.
2007 Mar; 42(2):163-70. doi:
10.1007/s11745-007-3021-0
. [PMID: 17393222] - Peter Dörmann. Functional diversity of tocochromanols in plants.
Planta.
2007 Jan; 225(2):269-76. doi:
10.1007/s00425-006-0438-2
. [PMID: 17115182] - Wen-Zhi Lan, Penny Y T Wang, Ceredwyn E Hill. Modulation of hepatocellular swelling-activated K+ currents by phosphoinositide pathway-dependent protein kinase C.
American journal of physiology. Cell physiology.
2006 Jul; 291(1):C93-103. doi:
10.1152/ajpcell.00602.2005
. [PMID: 16452155] - Phillip Nava, Matt Cecchini, Sara Chirico, Heather Gordon, Samantha Morley, Danny Manor, Jeffrey Atkinson. Preparation of fluorescent tocopherols for use in protein binding and localization with the alpha-tocopherol transfer protein.
Bioorganic & medicinal chemistry.
2006 Jun; 14(11):3721-36. doi:
10.1016/j.bmc.2006.01.053
. [PMID: 16481173] - Wolfgang Gregor, Katrin Staniek, Hans Nohl, Lars Gille. Distribution of tocopheryl quinone in mitochondrial membranes and interference with ubiquinone-mediated electron transfer.
Biochemical pharmacology.
2006 May; 71(11):1589-601. doi:
10.1016/j.bcp.2006.02.012
. [PMID: 16569397] - Ming-Qing Dong, Chu-Pak Lau, Zhan Gao, Gea-Ny Tseng, Gui-Rong Li. Characterization of recombinant human cardiac KCNQ1/KCNE1 channels (I (Ks)) stably expressed in HEK 293 cells.
The Journal of membrane biology.
2006 Apr; 210(3):183-92. doi:
10.1007/s00232-006-0006-5
. [PMID: 16909339] - Fang Wang, Tinghua Wang, Jianhua Lai, Ming Li, Chenggang Zou. Vitamin E inhibits hemolysis induced by hemin as a membrane stabilizer.
Biochemical pharmacology.
2006 Mar; 71(6):799-805. doi:
10.1016/j.bcp.2005.12.002
. [PMID: 16405920] - Katrin Staniek, Thomas Rosenau, Wolfgang Gregor, Hans Nohl, Lars Gille. The protection of bioenergetic functions in mitochondria by new synthetic chromanols.
Biochemical pharmacology.
2005 Nov; 70(9):1361-70. doi:
10.1016/j.bcp.2005.07.030
. [PMID: 16150421] - W-Z Lan, H Abbas, A-M Lemay, M M Briggs, C E Hill. Electrophysiological and molecular identification of hepatocellular volume-activated K+ channels.
Biochimica et biophysica acta.
2005 Mar; 1668(2):223-33. doi:
10.1016/j.bbamem.2004.12.010
. [PMID: 15737333] - Robert S Parker, Timothy J Sontag, Joy E Swanson, Charles C McCormick. Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism.
Annals of the New York Academy of Sciences.
2004 Dec; 1031(?):13-21. doi:
10.1196/annals.1331.002
. [PMID: 15753130] - Noriko Saegusa, Toshiaki Sato, Takehiko Ogura, Issei Komuro, Haruaki Nakaya. Inhibitory effects of AMP 579, a novel cardioprotective adenosine A1/A2A receptor agonist, on native IKr and cloned HERG current.
Naunyn-Schmiedeberg's archives of pharmacology.
2004 Dec; 370(6):492-9. doi:
10.1007/s00210-004-0999-1
. [PMID: 15558241] - Francesco Galli, Marta Piroddi, Anna Lannone, Silvia Pagliarani, Aldo Tomasi, Ardesio Floridi. A comparison between the antioxidant and peroxynitrite-scavenging functions of the vitamin E metabolites alpha- and gamma-carboxyethyl-6-hydroxychromans.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
2004 Sep; 74(5):362-73. doi:
10.1024/0300-9831.74.5.362
. [PMID: 15628675] - Gabriela Gramlich, Jiayun Zhang, Werner M Nau. Diffusion of alpha-tocopherol in membrane models: probing the kinetics of vitamin E antioxidant action by fluorescence in real time.
Journal of the American Chemical Society.
2004 May; 126(17):5482-92. doi:
10.1021/ja039845b
. [PMID: 15113220] - Sharon E Campbell, William L Stone, Sarah G Whaley, Min Qui, Koyamangalath Krishnan. Gamma (gamma) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines.
BMC cancer.
2003 Oct; 3(?):25. doi:
10.1186/1471-2407-3-25
. [PMID: 14521714] - Scott E Sattler, Edgar B Cahoon, Sean J Coughlan, Dean DellaPenna. Characterization of tocopherol cyclases from higher plants and cyanobacteria. Evolutionary implications for tocopherol synthesis and function.
Plant physiology.
2003 Aug; 132(4):2184-95. doi:
10.1104/pp.103.024257
. [PMID: 12913173] - Eva Collakova, Dean DellaPenna. Homogentisate phytyltransferase activity is limiting for tocopherol biosynthesis in Arabidopsis.
Plant physiology.
2003 Feb; 131(2):632-42. doi:
10.1104/pp.015222
. [PMID: 12586887] - Klaus Turnheim, Herbert Plass, Wolfgang Wyskovsky. Basolateral potassium channels of rabbit colon epithelium: role in sodium absorption and chloride secretion.
Biochimica et biophysica acta.
2002 Feb; 1560(1-2):51-66. doi:
10.1016/s0005-2736(01)00456-4
. [PMID: 11958775] - A V Kuperman, A S Kalgutkar, A Marfat, R J Chambers, T E Liston. Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue.
Drug metabolism and disposition: the biological fate of chemicals.
2001 Nov; 29(11):1403-9. doi:
NULL
. [PMID: 11602515] - T V Pham, E A Sosunov, R Z Gainullin, P Danilo, M R Rosen. Impact of sex and gonadal steroids on prolongation of ventricular repolarization and arrhythmias induced by I(K)-blocking drugs.
Circulation.
2001 May; 103(17):2207-12. doi:
10.1161/01.cir.103.17.2207
. [PMID: 11331264]