Cyclic-hpmpc (BioDeep_00000177457)
human metabolite blood metabolite
代谢物信息卡片
化学式: C8H12N3O5P (261.0515)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(OCP(=O)(O1)O)CN2C=CC(=NC2=O)N
InChI: InChI=1S/C8H12N3O5P/c9-7-1-2-11(8(12)10-7)3-6-4-16-17(13,14)5-15-6/h1-2,6H,3-5H2,(H,13,14)(H2,9,10,12)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Natacha Coen, Sophie Duraffour, Lieve Naesens, Marcela Krecmerová, Joost Van den Oord, Robert Snoeck, Graciela Andrei. Evaluation of novel acyclic nucleoside phosphonates against human and animal gammaherpesviruses revealed an altered metabolism of cyclic prodrugs upon Epstein-Barr virus reactivation in P3HR-1 cells.
Journal of virology.
2013 Nov; 87(22):12422-32. doi:
10.1128/jvi.02231-13. [PMID: 24027315] - Larryn W Peterson, Monica Sala-Rabanal, Ivan S Krylov, Michaela Serpi, Boris A Kashemirov, Charles E McKenna. Serine side chain-linked peptidomimetic conjugates of cyclic HPMPC and HPMPA: synthesis and interaction with hPEPT1.
Molecular pharmaceutics.
2010 Dec; 7(6):2349-61. doi:
10.1021/mp100186b. [PMID: 20929265] - N Bourne, F J Bravo, D I Bernstein. Cyclic HPMPC is safe and effective against systemic guinea pig cytomegalovirus infection in immune compromised animals.
Antiviral research.
2000 Aug; 47(2):103-9. doi:
10.1016/s0166-3542(00)00100-5. [PMID: 10996398] - K C Cundy, P Barditch-Crovo, B G Petty, A Ruby, M Redpath, H S Jaffe, P S Lietman. Clinical pharmacokinetics of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine in human immunodeficiency virus-infected patients.
Antimicrobial agents and chemotherapy.
1999 Feb; 43(2):271-7. doi:
10.1128/aac.43.2.271. [PMID: 9925517] - K C Cundy, A M Bidgood, G Lynch, J P Shaw, L Griffin, W A Lee. Pharmacokinetics, bioavailability, metabolism, and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats.
Drug metabolism and disposition: the biological fate of chemicals.
1996 Jul; 24(7):745-52. doi:
NULL. [PMID: 8818571] - K C Cundy, G Lynch, J P Shaw, M J Hitchcock, W A Lee. Distribution and metabolism of intravitreal cidofovir and cyclic HPMPC in rabbits.
Current eye research.
1996 May; 15(5):569-76. doi:
10.3109/02713689609000768. [PMID: 8670758] - N Bischofberger, M J Hitchcock, M S Chen, D B Barkhimer, K C Cundy, K M Kent, S A Lacy, W A Lee, Z H Li, D B Mendel. 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo.
Antimicrobial agents and chemotherapy.
1994 Oct; 38(10):2387-91. doi:
10.1128/aac.38.10.2387. [PMID: 7840575]
