Chlorpyrifos oxon (BioDeep_00000177416)
human metabolite blood metabolite
代谢物信息卡片
O,O-Diethyl O-3,5,6-trichloro-2-pyridyl phosphate
化学式: C9H11Cl3NO4P (332.94912660000006)
中文名称: 氯吡硫磷一氧
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOP(=O)(OCC)OC1=C(Cl)C=C(Cl)C(Cl)=N1
InChI: InChI=1S/C9H11Cl3NO4P/c1-3-15-18(14,16-4-2)17-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yixi Zhang, Baojun Yang, Zhiming Yang, Lu Kai, Zewen Liu. Alternative Splicing and Expression Reduction of P450 Genes Mediating the Oxidation of Chlorpyrifos Revealed a Novel Resistance Mechanism in Nilaparvata lugens.
Journal of agricultural and food chemistry.
2023 Mar; 71(9):4036-4042. doi:
10.1021/acs.jafc.2c08957. [PMID: 36848634] - Stacey Herriage, Guangping Chen, Carey Pope. Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2022 Feb; 78(?):105268. doi:
10.1016/j.tiv.2021.105268. [PMID: 34756920] - Jordi Blanco, Laia Guardia-Escote, Miquel Mulero, Pia Basaure, Judit Biosca-Brull, Maria Cabré, Maria Teresa Colomina, José L Domingo, Domènec J Sánchez. Obesogenic effects of chlorpyrifos and its metabolites during the differentiation of 3T3-L1 preadipocytes.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Mar; 137(?):111171. doi:
10.1016/j.fct.2020.111171. [PMID: 32017950] - Supta Das, Kimberly J Hageman, Madeleine Taylor, Sue Michelsen-Heath, Ian Stewart. Fate of the organophosphate insecticide, chlorpyrifos, in leaves, soil, and air following application.
Chemosphere.
2020 Mar; 243(?):125194. doi:
10.1016/j.chemosphere.2019.125194. [PMID: 31739250] - George F Antonious, Eric T Turley, Mutari Abubakari, John C Snyder. Dissipation, half-lives, and mass spectrometric identification of chlorpyrifos and its two metabolites on field-grown collard and kale.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2017 Apr; 52(4):251-255. doi:
10.1080/03601234.2016.1270683. [PMID: 28080209] - Alicia J Dafferner, Sofya Lushchekina, Patrick Masson, Gaoping Xiao, Lawrence M Schopfer, Oksana Lockridge. Characterization of butyrylcholinesterase in bovine serum.
Chemico-biological interactions.
2017 Mar; 266(?):17-27. doi:
10.1016/j.cbi.2017.02.004. [PMID: 28189703] - Natàlia Garcia-Reyero, Lynn Escalon, Eva Prats, Melissa Faria, Amadeu M V M Soares, Demetrio Raldúa. Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes.
Bulletin of environmental contamination and toxicology.
2016 Jun; 96(6):707-13. doi:
10.1007/s00128-016-1798-3. [PMID: 27086301] - Alper Coban, Russell L Carr, Howard W Chambers, Kenneth O Willeford, Janice E Chambers. Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase.
Toxicology letters.
2016 Apr; 248(?):39-45. doi:
10.1016/j.toxlet.2016.03.002. [PMID: 26965078] - Hirotaka Sato, Yuki Ito, Jun Ueyama, Yuya Kano, Tomoya Arakawa, Masahiro Gotoh, Takaaki Kondo, Yuka Sugiura, Isao Saito, Eiji Shibata, Michihiro Kamijima. Effects of Paraoxonase 1 gene polymorphisms on organophosphate insecticide metabolism in Japanese pest control workers.
Journal of occupational health.
2016; 58(1):56-65. doi:
10.1539/joh.15-0175-oa. [PMID: 26549836] - Tawit Suriyo, Phum Tachachartvanich, Daranee Visitnonthachai, Piyajit Watcharasit, Jutamaad Satayavivad. Chlorpyrifos promotes colorectal adenocarcinoma H508 cell growth through the activation of EGFR/ERK1/2 signaling pathway but not cholinergic pathway.
Toxicology.
2015 Dec; 338(?):117-29. doi:
10.1016/j.tox.2015.10.009. [PMID: 26514924] - Shuwen Wu, Kairan Zuo, Zhaokui Kang, Yihua Yang, John G Oakeshott, Yidong Wu. A point mutation in the acetylcholinesterase-1 gene is associated with chlorpyrifos resistance in the plant bug Apolygus lucorum.
Insect biochemistry and molecular biology.
2015 Oct; 65(?):75-82. doi:
10.1016/j.ibmb.2015.09.005. [PMID: 26363297] - Matthew K Ross, Abdolsamad Borazjani, Lee C Mangum, Ran Wang, J Allen Crow. Effects of toxicologically relevant xenobiotics and the lipid-derived electrophile 4-hydroxynonenal on macrophage cholesterol efflux: silencing carboxylesterase 1 has paradoxical effects on cholesterol uptake and efflux.
Chemical research in toxicology.
2014 Oct; 27(10):1743-56. doi:
10.1021/tx500221a. [PMID: 25250848] - R Hunter Coombes, Edward C Meek, Mary Beth Dail, Howard W Chambers, Janice E Chambers. Human paraoxonase 1 hydrolysis of nanomolar chlorpyrifos-oxon concentrations is unaffected by phenotype or Q192R genotype.
Toxicology letters.
2014 Oct; 230(1):57-61. doi:
10.1016/j.toxlet.2014.07.029. [PMID: 25093614] - Toby B Cole, Wan-Fen Li, Aila L Co, Ariel M Hay, James W MacDonald, Theo K Bammler, Federico M Farin, Lucio G Costa, Clement E Furlong. Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues.
Toxicological sciences : an official journal of the Society of Toxicology.
2014 Oct; 141(2):409-22. doi:
10.1093/toxsci/kfu144. [PMID: 25070982] - Jordan Ned Smith, Paul M Hinderliter, Charles Timchalk, Michael J Bartels, Torka S Poet. A human life-stage physiologically based pharmacokinetic and pharmacodynamic model for chlorpyrifos: development and validation.
Regulatory toxicology and pharmacology : RTP.
2014 Aug; 69(3):580-97. doi:
10.1016/j.yrtph.2013.10.005. [PMID: 24200834] - Füsun Okçu Pelit, Çiğdem Yengin. Application of solidified floating organic drop microextraction method for biomonitoring of chlorpyrifos and its oxon metabolite in urine samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Feb; 949-950(?):109-14. doi:
10.1016/j.jchromb.2014.01.004. [PMID: 24487040] - Bin Li, Peter Eyer, Michael Eddleston, Wei Jiang, Lawrence M Schopfer, Oksana Lockridge. Protein tyrosine adduct in humans self-poisoned by chlorpyrifos.
Toxicology and applied pharmacology.
2013 Jun; 269(3):215-25. doi:
10.1016/j.taap.2013.03.021. [PMID: 23566956] - Wei Jiang, Ellen G Duysen, Oksana Lockridge. Mice treated with a nontoxic dose of chlorpyrifos oxon have diethoxyphosphotyrosine labeled proteins in blood up to 4 days post exposure, detected by mass spectrometry.
Toxicology.
2012 May; 295(1-3):15-22. doi:
10.1016/j.tox.2012.03.001. [PMID: 22406659] - Toby B Cole, Jenna C Fisher, Thomas M Burbacher, Lucio G Costa, Clement E Furlong. Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon.
Neurotoxicology and teratology.
2012 May; 34(3):311-22. doi:
10.1016/j.ntt.2012.02.003. [PMID: 22425525] - Jibran Y Khokhar, Rachel F Tyndale. Rat brain CYP2B-enzymatic activation of chlorpyrifos to the oxon mediates cholinergic neurotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Apr; 126(2):325-35. doi:
10.1093/toxsci/kfs029. [PMID: 22287024] - Ellen G Duysen, John R Cashman, Lawrence M Schopfer, Florian Nachon, Patrick Masson, Oksana Lockridge. Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran.
Chemico-biological interactions.
2012 Feb; 195(3):189-98. doi:
10.1016/j.cbi.2011.12.006. [PMID: 22209767] - Toby B Cole, Richard P Beyer, Theo K Bammler, Sarah S Park, Federico M Farin, Lucio G Costa, Clement E Furlong. Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression.
Toxicological sciences : an official journal of the Society of Toxicology.
2011 Sep; 123(1):155-69. doi:
10.1093/toxsci/kfr157. [PMID: 21673326] - Ellen G Duysen, Oksana Lockridge. Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons.
Toxicology and applied pharmacology.
2011 Sep; 255(2):214-20. doi:
10.1016/j.taap.2011.06.021. [PMID: 21767560] - Jordan Ned Smith, Charles Timchalk, Michael J Bartels, Torka S Poet. In vitro age-dependent enzymatic metabolism of chlorpyrifos and chlorpyrifos-oxon in human hepatic microsomes and chlorpyrifos-oxon in plasma.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Aug; 39(8):1353-62. doi:
10.1124/dmd.111.038745. [PMID: 21521795] - Fayssal M Farahat, Corie A Ellison, Matthew R Bonner, Barbara P McGarrigle, Alice L Crane, Richard A Fenske, Michael R Lasarev, Diane S Rohlman, W Kent Anger, Pamela J Lein, James R Olson. Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers.
Environmental health perspectives.
2011 Jun; 119(6):801-6. doi:
10.1289/ehp.1002873. [PMID: 21224175] - Limin Wang, Donglai Lu, Jun Wang, Dan Du, Zhexiang Zou, Hua Wang, Jordan N Smith, Charles Timchalk, Fengquan Liu, Yuehe Lin. A novel immunochromatographic electrochemical biosensor for highly sensitive and selective detection of trichloropyridinol, a biomarker of exposure to chlorpyrifos.
Biosensors & bioelectronics.
2011 Feb; 26(6):2835-40. doi:
10.1016/j.bios.2010.11.008. [PMID: 21195597] - Miguel A Sogorb, Eugenio Vilanova. Serum albumins and detoxication of anti-cholinesterase agents.
Chemico-biological interactions.
2010 Sep; 187(1-3):325-9. doi:
10.1016/j.cbi.2010.03.001. [PMID: 20211614] - Bin Li, Ivan Ricordel, Lawrence M Schopfer, Frédéric Baud, Bruno Mégarbane, Patrick Masson, Oksana Lockridge. Dichlorvos, chlorpyrifos oxon and Aldicarb adducts of butyrylcholinesterase, detected by mass spectrometry in human plasma following deliberate overdose.
Journal of applied toxicology : JAT.
2010 Aug; 30(6):559-65. doi:
10.1002/jat.1526. [PMID: 20809544] - Florian Eyer, Darren M Roberts, Nicholas A Buckley, Michael Eddleston, Horst Thiermann, Franz Worek, Peter Eyer. Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF).
Biochemical pharmacology.
2009 Sep; 78(5):531-7. doi:
10.1016/j.bcp.2009.05.004. [PMID: 19433070] - Karen Huen, Rebecca Richter, Clement Furlong, Brenda Eskenazi, Nina Holland. Validation of PON1 enzyme activity assays for longitudinal studies.
Clinica chimica acta; international journal of clinical chemistry.
2009 Apr; 402(1-2):67-74. doi:
10.1016/j.cca.2008.12.019. [PMID: 19146843] - Rebecca J Richter, Gail P Jarvik, Clement E Furlong. Paraoxonase 1 (PON1) status and substrate hydrolysis.
Toxicology and applied pharmacology.
2009 Feb; 235(1):1-9. doi:
10.1016/j.taap.2008.11.001. [PMID: 19071155] - Renate Heilmair, Florian Eyer, Peter Eyer. Enzyme-based assay for quantification of chlorpyrifos oxon in human plasma.
Toxicology letters.
2008 Sep; 181(1):19-24. doi:
10.1016/j.toxlet.2008.06.868. [PMID: 18655824] - Shi-Jian Ding, John Carr, James E Carlson, Larry Tong, Weihua Xue, Yifeng Li, Lawrence M Schopfer, Bin Li, Florian Nachon, Oluwatoyin Asojo, Charles M Thompson, Steven H Hinrichs, Patrick Masson, Oksana Lockridge. Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin.
Chemical research in toxicology.
2008 Sep; 21(9):1787-94. doi:
10.1021/tx800144z. [PMID: 18707141] - Ayman Samir Farid, Yoichiro Horii. Gastrointestinal nematode infection increases organophosphate toxicity in rats.
Toxicology letters.
2008 Jul; 180(1):33-7. doi:
10.1016/j.toxlet.2008.05.016. [PMID: 18577432] - Mabruka H Tarhoni, Timothy Lister, David E Ray, Wayne G Carter. Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2008 Jun; 13(4):343-63. doi:
10.1080/13547500801973563. [PMID: 18484351] - J Allen Crow, Abdolsamad Borazjani, Philip M Potter, Matthew K Ross. Hydrolysis of pyrethroids by human and rat tissues: examination of intestinal, liver and serum carboxylesterases.
Toxicology and applied pharmacology.
2007 May; 221(1):1-12. doi:
10.1016/j.taap.2007.03.002. [PMID: 17442360] - Maria Francesca Cometa, Franca Maria Buratti, Stefano Fortuna, Paola Lorenzini, Maria Teresa Volpe, Laura Parisi, Emanuela Testai, Annarita Meneguz. Cholinesterase inhibition and alterations of hepatic metabolism by oral acute and repeated chlorpyrifos administration to mice.
Toxicology.
2007 May; 234(1-2):90-102. doi:
10.1016/j.tox.2007.02.008. [PMID: 17382447] - Ellen G Duysen, Bin Li, Sultan Darvesh, Oksana Lockridge. Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.
Toxicology.
2007 Apr; 233(1-3):60-9. doi:
10.1016/j.tox.2006.11.069. [PMID: 17194517] - Bin Li, Lawrence M Schopfer, Steven H Hinrichs, Patrick Masson, Oksana Lockridge. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411.
Analytical biochemistry.
2007 Feb; 361(2):263-72. doi:
10.1016/j.ab.2006.11.018. [PMID: 17188226] - Daniel K Nomura, Kathleen A Durkin, Kyle P Chiang, Gary B Quistad, Benjamin F Cravatt, John E Casida. Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions.
Chemical research in toxicology.
2006 Sep; 19(9):1142-50. doi:
10.1021/tx060117m. [PMID: 16978018] - Gary B Quistad, Shannon N Liang, Karl J Fisher, Daniel K Nomura, John E Casida. Each lipase has a unique sensitivity profile for organophosphorus inhibitors.
Toxicological sciences : an official journal of the Society of Toxicology.
2006 May; 91(1):166-72. doi:
10.1093/toxsci/kfj124. [PMID: 16449251] - C Timchalk, T S Poet, A A Kousba. Age-dependent pharmacokinetic and pharmacodynamic response in preweanling rats following oral exposure to the organophosphorus insecticide chlorpyrifos.
Toxicology.
2006 Mar; 220(1):13-25. doi:
10.1016/j.tox.2005.11.011. [PMID: 16343727] - J B Salles, V L F Cunha Bastos, M V Silva Filho, O L T Machado, C M C Salles, S Giovanni de Simone, J Cunha Bastos. A novel butyrylcholinesterase from serum of Leporinus macrocephalus, a Neotropical fish.
Biochimie.
2006 Jan; 88(1):59-68. doi:
10.1016/j.biochi.2005.06.017. [PMID: 16085351] - R Kacham, S Karanth, P Baireddy, J Liu, C Pope. Interactive toxicity of chlorpyrifos and parathion in neonatal rats: role of esterases in exposure sequence-dependent toxicity.
Toxicology and applied pharmacology.
2006 Jan; 210(1-2):142-9. doi:
10.1016/j.taap.2005.09.014. [PMID: 16260018] - Toby B Cole, Betsy J Walter, Diana M Shih, Aaron D Tward, Aldons J Lusis, Charles Timchalk, Rebecca J Richter, Lucio G Costa, Clement E Furlong. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism.
Pharmacogenetics and genomics.
2005 Aug; 15(8):589-98. doi:
10.1097/01.fpc.0000167327.08034.d2. [PMID: 16007003] - Eric S Peeples, Lawrence M Schopfer, Ellen G Duysen, Reggie Spaulding, Troy Voelker, Charles M Thompson, Oksana Lockridge. Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry.
Toxicological sciences : an official journal of the Society of Toxicology.
2005 Feb; 83(2):303-12. doi:
10.1093/toxsci/kfi023. [PMID: 15525694] - Ramesh R Dalvi, Prasad S Dalvi, Candace Lane. Cytochrome P450-mediated activation and toxicity of chlorpyrifos in male and female rats.
Veterinary and human toxicology.
2004 Dec; 46(6):297-9. doi:
NULL. [PMID: 15587241] - Subramanya Karanth, Jing Liu, Kenneth Olivier, Carey Pope. Interactive toxicity of the organophosphorus insecticides chlorpyrifos and methyl parathion in adult rats.
Toxicology and applied pharmacology.
2004 Apr; 196(2):183-90. doi:
10.1016/j.taap.2003.12.014. [PMID: 15081265] - A A Kousba, T S Poet, Charles Timchalk. Characterization of the in vitro kinetic interaction of chlorpyrifos-oxon with rat salivary cholinesterase: a potential biomonitoring matrix.
Toxicology.
2003 Jun; 188(2-3):219-32. doi:
10.1016/s0300-483x(03)00090-8. [PMID: 12767693] - Gary B Quistad, Daniel K Nomura, Susan E Sparks, Yoffi Segall, John E Casida. Cannabinoid CB1 receptor as a target for chlorpyrifos oxon and other organophosphorus pesticides.
Toxicology letters.
2002 Sep; 135(1-2):89-93. doi:
10.1016/s0378-4274(02)00251-5. [PMID: 12243867] - C Timchalk, R J Nolan, A L Mendrala, D A Dittenber, K A Brzak, J L Mattsson. A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans.
Toxicological sciences : an official journal of the Society of Toxicology.
2002 Mar; 66(1):34-53. doi:
10.1093/toxsci/66.1.34. [PMID: 11861971] - J R Richardson, H W Chambers, J E Chambers. Analysis of the additivity of in vitro inhibition of cholinesterase by mixtures of chlorpyrifos-oxon and azinphos-methyl-oxon.
Toxicology and applied pharmacology.
2001 Apr; 172(2):128-39. doi:
10.1006/taap.2001.9140. [PMID: 11298499] - D S Barber, M Ehrich. Esterase inhibition in SH-SY5Y human neuroblastoma cells following exposure to organophosphorus compounds for 28 days.
In vitro & molecular toxicology.
2001; 14(2):129-35. doi:
10.1089/10979330152560522. [PMID: 11690566] - C E Furlong, W F Li, V H Brophy, G P Jarvik, R J Richter, D M Shih, A J Lusis, L G Costa. The PON1 gene and detoxication.
Neurotoxicology.
2000 Aug; 21(4):581-7. doi:
NULL. [PMID: 11022865] - J L Mattsson, J P Maurissen, R J Nolan, K A Brzak. Lack of differential sensitivity to cholinesterase inhibition in fetuses and neonates compared to dams treated perinatally with chlorpyrifos.
Toxicological sciences : an official journal of the Society of Toxicology.
2000 Feb; 53(2):438-46. doi:
10.1093/toxsci/53.2.438. [PMID: 10696792] - C Sams, H J Mason. Detoxification of organophosphates by A-esterases in human serum.
Human & experimental toxicology.
1999 Nov; 18(11):653-8. doi:
10.1191/096032799678839581. [PMID: 10602389] - D Josse, W Xie, P Masson, L M Schopfer, O Lockridge. Tryptophan residue(s) as major components of the human serum paraoxonase active site.
Chemico-biological interactions.
1999 May; 119-120(?):79-84. doi:
10.1016/s0009-2797(99)00016-2. [PMID: 10421441] - G Amitai, D Moorad, R Adani, B P Doctor. Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon.
Biochemical pharmacology.
1998 Aug; 56(3):293-9. doi:
10.1016/s0006-2952(98)00035-5. [PMID: 9744565] - C E Furlong, W F Li, L G Costa, R J Richter, D M Shih, A J Lusis. Genetically determined susceptibility to organophosphorus insecticides and nerve agents: developing a mouse model for the human PON1 polymorphism.
Neurotoxicology.
1998 Aug; 19(4-5):645-50. doi:
. [PMID: 9745924] - D M Shih, L Gu, Y R Xia, M Navab, W F Li, S Hama, L W Castellani, C E Furlong, L G Costa, A M Fogelman, A J Lusis. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis.
Nature.
1998 Jul; 394(6690):284-7. doi:
10.1038/28406. [PMID: 9685159] - S R Mortensen, S Brimijoin, M J Hooper, S Padilla. Comparison of the in vitro sensitivity of rat acetylcholinesterase to chlorpyrifos-oxon: what do tissue IC50 values represent?.
Toxicology and applied pharmacology.
1998 Jan; 148(1):46-9. doi:
10.1006/taap.1997.8287. [PMID: 9465262] - C L Lanning, R L Fine, C W Sachs, U S Rao, J J Corcoran, M B Abou-Donia. Chlorpyrifos oxon interacts with the mammalian multidrug resistance protein, P-glycoprotein.
Journal of toxicology and environmental health.
1996 Mar; 47(4):395-407. doi:
10.1080/009841096161726. [PMID: 8600291] - W F Li, C E Furlong, L G Costa. Paraoxonase protects against chlorpyrifos toxicity in mice.
Toxicology letters.
1995 Apr; 76(3):219-26. doi:
10.1016/0378-4274(95)80006-y. [PMID: 7539166] - L G Costa, B E McDonald, S D Murphy, G S Omenn, R J Richter, A G Motulsky, C E Furlong. Serum paraoxonase and its influence on paraoxon and chlorpyrifos-oxon toxicity in rats.
Toxicology and applied pharmacology.
1990 Mar; 103(1):66-76. doi:
10.1016/0041-008x(90)90263-t. [PMID: 1690462] - C E Furlong, R J Richter, S L Seidel, L G Costa, A G Motulsky. Spectrophotometric assays for the enzymatic hydrolysis of the active metabolites of chlorpyrifos and parathion by plasma paraoxonase/arylesterase.
Analytical biochemistry.
1989 Aug; 180(2):242-7. doi:
10.1016/0003-2697(89)90424-7. [PMID: 2479288] - L G Sultatos. Factors affecting the hepatic biotransformation of the phosphorothioate pesticide chlorpyrifos.
Toxicology.
1988 Oct; 51(2-3):191-200. doi:
10.1016/0300-483x(88)90149-7. [PMID: 2459806] - C E Furlong, R J Richter, S L Seidel, A G Motulsky. Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos oxon and paraoxon.
American journal of human genetics.
1988 Sep; 43(3):230-8. doi:
. [PMID: 2458038] - M I Mackness, C H Walker. Multiple forms of sheep serum A-esterase activity associated with the high-density lipoprotein.
The Biochemical journal.
1988 Mar; 250(2):539-45. doi:
10.1042/bj2500539. [PMID: 2451511] - Y Ogawa, S Suzuki, O Uchida, E Kamata, M Saito, T Umemura, M Wakana, T Kaneko, Y Kurokawa, M Tobe. [28-day repeated dose toxicity test of chlorpyrifos in Wistar rat].
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences.
1988; ?(106):48-54. doi:
NULL. [PMID: 2471565] - L G Sultatos, K M Basker, M Shao, S D Murphy. The interaction of the phosphorothioate insecticides chlorpyrifos and parathion and their oxygen analogues with bovine serum albumin.
Molecular pharmacology.
1984 Jul; 26(1):99-104. doi:
NULL. [PMID: 6205248] - L G Sultatos, M Shao, S D Murphy. The role of hepatic biotransformation in mediating the acute toxicity of the phosphorothionate insecticide chlorpyrifos.
Toxicology and applied pharmacology.
1984 Mar; 73(1):60-8. doi:
10.1016/0041-008x(84)90053-x. [PMID: 6200955]