Chlorethylclonidine (BioDeep_00000177399)

   

human metabolite blood metabolite


代谢物信息卡片


N-(2,6-dichloro-4-{[(2-chloroethyl)(methyl)amino]methyl}phenyl)-4,5-dihydro-1H-imidazol-2-amine

化学式: C13H17Cl3N4 (334.0519)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: CN(CCCl)CC1=CC(=C(C(=C1)Cl)NC2=NCCN2)Cl
InChI: InChI=1S/C13H17Cl3N4/c1-20(5-2-14)8-9-6-10(15)12(11(16)7-9)19-13-17-3-4-18-13/h6-7H,2-5,8H2,1H3,(H2,17,18,19)

描述信息

D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D009676 - Noxae > D000477 - Alkylating Agents

同义名列表

3 个代谢物同义名

N-(2,6-dichloro-4-{[(2-chloroethyl)(methyl)amino]methyl}phenyl)-4,5-dihydro-1H-imidazol-2-amine; Chloroethylclonidine; Chlorethylclonidine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Aldo A Rodríguez-Menchaca, Ivan A Aréchiga-Figueroa, José A Sánchez-Chapula. The molecular basis of chloroethylclonidine block of inward rectifier (Kir2.1 and Kir4.1) K(+) channels. Pharmacological reports : PR. 2016 Apr; 68(2):383-9. doi: 10.1016/j.pharep.2015.10.005. [PMID: 26922543]
  • Ashfaq Ahmad, Munavvar A Sattar, Maleeha Azam, Mohammed H Abdulla, Safia A Khan, Fayyaz Hashmi, Nor A Abdullah, Edward J Johns. Cystathione gamma lyase/Hydrogen Sulphide Pathway Up Regulation Enhances the Responsiveness of α1A and α1B-Adrenoreceptors in the Kidney of Rats with Left Ventricular Hypertrophy. PloS one. 2016; 11(5):e0154995. doi: 10.1371/journal.pone.0154995. [PMID: 27191852]
  • R N Kazi, A S Munavvar, N A Abdullah, A H Khan, E J Johns. Influence of high dietary sodium intake on the functional subtypes of alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats. Autonomic & autacoid pharmacology. 2009 Jan; 29(1-2):25-31. doi: 10.1111/j.1474-8673.2009.00428.x. [PMID: 19302553]
  • A Armenia, Munavvar Abdul Sattar, Nor Azizan Abdullah, Md Abdul Hye Khan, Edward James Johns. Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension. Acta pharmacologica Sinica. 2008 May; 29(5):564-72. doi: 10.1111/j.1745-7254.2008.00788.x. [PMID: 18430364]
  • Md Abdul Hye Khan, Munavvar-Abdul Sattar, Nor Azizan Abdullah, Edward James Johns. Alpha1B-adrenoceptors mediate adrenergically-induced renal vasoconstrictions in rats with renal impairment. Acta pharmacologica Sinica. 2008 Feb; 29(2):193-203. doi: 10.1111/j.1745-7254.2008.00727.x. [PMID: 18215348]
  • Abdul H Khan, Munavvar A Sattar, Nor A Abdullah, Edward J Johns. Influence of cisplatin-induced renal failure on the alpha(1)-adrenoceptor subtype causing vasoconstriction in the kidney of the rat. European journal of pharmacology. 2007 Aug; 569(1-2):110-8. doi: 10.1016/j.ejphar.2007.04.063. [PMID: 17559832]
  • James C Dodge, Lori L Badura. Noradrenergic regulation of prolactin secretion at the level of the paraventricular nucleus of the hypothalamus: functional significance of the alpha-1b and beta-adrenergic receptor subtypes. Brain research. 2004 Aug; 1016(2):240-6. doi: 10.1016/j.brainres.2004.05.009. [PMID: 15246860]
  • A Armenia, A S Munavvar, N A Abdullah, A Helmi, E J Johns. The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats. British journal of pharmacology. 2004 Jun; 142(4):719-26. doi: 10.1038/sj.bjp.0705842. [PMID: 15172958]
  • S L Parker, M S Parker. Ligand association with the rabbit kidney and brain Y1, Y2 and Y5-like neuropeptide Y (NPY) receptors shows large subtype-related differences in sensitivity to chaotropic and alkylating agents. Regulatory peptides. 2000 Feb; 87(1-3):59-72. doi: 10.1016/s0167-0115(99)00110-x. [PMID: 10710289]
  • M Salomonsson, K Brännström, W J Arendshorst. alpha(1)-adrenoceptor subtypes in rat renal resistance vessels: in vivo and in vitro studies. American journal of physiology. Renal physiology. 2000 Jan; 278(1):F138-47. doi: 10.1152/ajprenal.2000.278.1.f138. [PMID: 10644665]
  • M Yang, J Reese, S Cotecchia, M C Michel. Murine alpha1-adrenoceptor subtypes. I. Radioligand binding studies. The Journal of pharmacology and experimental therapeutics. 1998 Aug; 286(2):841-7. doi: NULL. [PMID: 9694940]
  • L Xiao, M A Scofield, W B Jeffries. Molecular cloning, expression and characterization of cDNA encoding a mouse alpha1a-adrenoceptor. British journal of pharmacology. 1998 May; 124(1):213-21. doi: 10.1038/sj.bjp.0701812. [PMID: 9630362]
  • A Marjamaki, M Pihlavisto, V Cockcroft, P Heinonen, J M Savola, M Scheinin. Chloroethylclonidine binds irreversibly to exposed cysteines in the fifth membrane-spanning domain of the human alpha2A-adrenergic receptor. Molecular pharmacology. 1998 Mar; 53(3):370-6. doi: 10.1124/mol.53.3.370. [PMID: 9495800]
  • W Zhu, Y Zhang, C Han. Characterization of subtype of alpha1-adrenoceptor mediating vasoconstriction in perfused rat hind limb. European journal of pharmacology. 1997 Jun; 329(1):55-61. doi: 10.1016/s0014-2999(97)10104-2. [PMID: 9218684]
  • R Büscher, C Heeks, K Taguchi, M C Michel. Comparison of guinea-pig, bovine and rat alpha 1-adrenoceptor subtypes. British journal of pharmacology. 1996 Feb; 117(4):703-11. doi: 10.1111/j.1476-5381.1996.tb15247.x. [PMID: 8646417]
  • M A Sattar, E J Johns. alpha1-Adrenoceptor subtypes mediating antinatriuresis in Wistar and stroke-prone spontaneously hypertensive rats. European journal of pharmacology. 1995 Dec; 294(2-3):727-36. doi: 10.1016/0014-2999(95)00637-0. [PMID: 8750739]
  • L M Canessa, M M Piccio, P Vachvanichsanong, A Sidhu, C C Porter, J E Robillard, R A Felder, P A Jose. Alpha 1B-adrenergic receptors in rat renal microvessels. Kidney international. 1995 Nov; 48(5):1412-9. doi: 10.1038/ki.1995.430. [PMID: 8544397]
  • N Moriyama, S Kurimoto, O Inagaki, M Takanashi, K Hamada, K Kawabe. Renal aging change of alpha 1-adrenoceptor in Wistar rats. General pharmacology. 1995 Mar; 26(2):347-51. doi: 10.1016/0306-3623(94)00176-n. [PMID: 7590085]
  • M Abdul Sattar, E J Johns. Alpha 1-adrenoceptor subtypes mediating adrenergic vasoconstriction in kidney, one-clip Goldblatt and deoxycorticosterone acetate-salt hypertensive rats. Journal of cardiovascular pharmacology. 1994 Sep; 24(3):420-8. doi: 10.1097/00005344-199409000-00010. [PMID: 7528298]
  • T M Laz, C Forray, K E Smith, J A Bard, P J Vaysse, T A Branchek, R L Weinshank. The rat homologue of the bovine alpha 1c-adrenergic receptor shows the pharmacological properties of the classical alpha 1A subtype. Molecular pharmacology. 1994 Sep; 46(3):414-22. doi: NULL. [PMID: 7935320]
  • S K Ambler, M F Leite. Regulation of atrial natriuretic peptide secretion by alpha 1-adrenergic receptors: the role of different second messenger pathways. Journal of molecular and cellular cardiology. 1994 Mar; 26(3):391-402. doi: 10.1006/jmcc.1994.1048. [PMID: 8028022]
  • M A Sattar, E J Johns. Evidence for an alpha 1-adrenoceptor subtype mediating adrenergic vasoconstriction in Wistar normotensive and stroke-prone spontaneously hypertensive rat kidney. Journal of cardiovascular pharmacology. 1994 Feb; 23(2):232-9. doi: . [PMID: 7511752]
  • R Büscher, P A Insel, M C Michel. Is SDZ NVI-085 an alpha 1-adrenoceptor subtype-selective agonist?. Life sciences. 1994; 54(14):999-1007. doi: 10.1016/0024-3205(94)00502-8. [PMID: 7908116]
  • S M Gopalakrishnan, C Chen, M F Lokhandwala. Identification of alpha 1-adrenoceptor subtypes in rat renal proximal tubules. European journal of pharmacology. 1993 Dec; 250(3):469-72. doi: 10.1016/0014-2999(93)90036-h. [PMID: 7906656]
  • M C Michel, J Kerker, T A Branchek, C Forray. Selective irreversible binding of chloroethylclonidine at alpha 1- and alpha 2-adrenoceptor subtypes. Molecular pharmacology. 1993 Dec; 44(6):1165-70. doi: NULL. [PMID: 8264553]
  • M C Michel, R Büscher, J Kerker, H Kraneis, W Erdbrügger, O E Brodde. Alpha 1-adrenoceptor subtype affinities of drugs for the treatment of prostatic hypertrophy. Evidence for heterogeneity of chloroethylclonidine-resistant rat renal alpha 1-adrenoceptor. Naunyn-Schmiedeberg's archives of pharmacology. 1993 Oct; 348(4):385-95. doi: 10.1007/bf00171338. [PMID: 7506392]
  • M Eltze, R Boer. The adrenoceptor agonist, SDZ NVI 085, discriminates between alpha 1A- and alpha 1B-adrenoceptor subtypes in vas deferens, kidney and aorta of the rat. European journal of pharmacology. 1992 Dec; 224(2-3):125-36. doi: 10.1016/0014-2999(92)90796-7. [PMID: 1361446]
  • D R Blue, R L Vimont, D E Clarke. Evidence for a noradrenergic innervation to alpha 1A-adrenoceptors in rat kidney. British journal of pharmacology. 1992 Oct; 107(2):414-7. doi: 10.1111/j.1476-5381.1992.tb12760.x. [PMID: 1358392]
  • A M Elhawary, W A Pettinger, D W Wolff. Subtype-selective alpha-1 adrenoceptor alkylation in the rat kidney and its effect on the vascular pressor response. The Journal of pharmacology and experimental therapeutics. 1992 Feb; 260(2):709-13. doi: NULL. [PMID: 1346641]
  • F Feng, W A Pettinger, P W Abel, W B Jeffries. Regional distribution of alpha 1-adrenoceptor subtypes in rat kidney. The Journal of pharmacology and experimental therapeutics. 1991 Jul; 258(1):263-8. doi: NULL. [PMID: 1677042]
  • K Klijn, S R Slivka, K Bell, P A Insel. Renal alpha 1-adrenergic receptor subtypes: MDCK-D1 cells, but not rat cortical membranes possess a single population of receptors. Molecular pharmacology. 1991 Mar; 39(3):407-13. doi: NULL. [PMID: 1848662]
  • K M Wilson, K P Minneman. Different pathways of [3H]inositol phosphate formation mediated by alpha 1a- and alpha 1b-adrenergic receptors. The Journal of biological chemistry. 1990 Oct; 265(29):17601-6. doi: 10.1016/s0021-9258(18)38206-1. [PMID: 2170387]
  • C D Han, K M Wilson, K P Minneman. Alpha 1-adrenergic receptor subtypes and formation of inositol phosphates in dispersed hepatocytes and renal cells. Molecular pharmacology. 1990 Jun; 37(6):903-10. doi: NULL. [PMID: 2163016]
  • C Han, P W Abel, K P Minneman. Heterogeneity of alpha 1-adrenergic receptors revealed by chlorethylclonidine. Molecular pharmacology. 1987 Oct; 32(4):505-10. doi: NULL. [PMID: 2890094]