1-(3',4'-Dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid (BioDeep_00000177370)
human metabolite blood metabolite
代谢物信息卡片
化学式: C16H11Cl2FO2 (324.012)
中文名称:
谱图信息:
最多检出来源 Danio rerio(blood) 55.56%
分子结构信息
SMILES: C1CC1(C2=CC(=C(C=C2)C3=CC(=C(C=C3)Cl)Cl)F)C(=O)O
InChI: InChI=1S/C16H11Cl2FO2/c17-12-4-1-9(7-13(12)18)11-3-2-10(8-14(11)19)16(5-6-16)15(20)21/h1-4,7-8H,5-6H2,(H,20,21)
描述信息
D004791 - Enzyme Inhibitors > D000091062 - Gamma Secretase Inhibitors and Modulators
C471 - Enzyme Inhibitor
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Lixia Qiang, Yanxia Guan, Xiangshun Li, Li Liu, Yanshuang Mu, Aki Sugano, Yutaka Takaoka, Toshiyuki Sakaeda, Bruno P Imbimbo, Ken-Ichi Yamamura, Shoude Jin, Zhenghua Li. CSP-1103 (CHF5074) stabilizes human transthyretin in healthy human subjects.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
2017 Mar; 24(1):42-51. doi:
10.1080/13506129.2017.1308348. [PMID: 28393633] - Yanshuang Mu, Shoude Jin, Jingling Shen, Aki Sugano, Yutaka Takaoka, Lixia Qiang, Bruno P Imbimbo, Ken-ichi Yamamura, Zhenghua Li. CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci.
FEBS letters.
2015 Mar; 589(7):849-56. doi:
10.1016/j.febslet.2015.02.020. [PMID: 25728271] - Joel Ross, Sanjiv Sharma, Jaron Winston, Margarita Nunez, Gabriella Bottini, Massimo Franceschi, Elio Scarpini, Enrico Frigerio, Francesco Fiorentini, Mercedes Fernandez, Sandra Sivilia, Luciana Giardino, Laura Calza, Dottie Norris, Helen Cicirello, Daniela Casula, Bruno P Imbimbo. CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study.
Current Alzheimer research.
2013 Sep; 10(7):742-53. doi:
10.2174/13892037113149990144. [PMID: 23968157] - Bruno P Imbimbo, Enrico Frigerio, Massimo Breda, Francesco Fiorentini, Mercedes Fernandez, Sandra Sivilia, Luciana Giardino, Laura Calzà, Dottie Norris, Daniela Casula, Magdy Shenouda. Pharmacokinetics and pharmacodynamics of CHF5074 after short-term administration in healthy subjects.
Alzheimer disease and associated disorders.
2013 Jul; 27(3):278-86. doi:
10.1097/wad.0b013e3182622ace. [PMID: 22922591] - Sandra Sivilia, Luca Lorenzini, Alessandro Giuliani, Marco Gusciglio, Mercedes Fernandez, Vito Antonio Baldassarro, Chiara Mangano, Luca Ferraro, Vladimiro Pietrini, Maria Francesca Baroc, Arturo R Viscomi, Simone Ottonello, Gino Villetti, Bruno P Imbimbo, Laura Calzà, Luciana Giardino. Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.
BMC neuroscience.
2013 Apr; 14(?):44. doi:
10.1186/1471-2202-14-44. [PMID: 23560952] - Hairuo Peng, Tina Talreja, Zhili Xin, J Hernan Cuervo, Gnanasambandam Kumaravel, Michael J Humora, Lin Xu, Ellen Rohde, Lawrence Gan, Mi-Young Jung, Melanie N Shackett, Sowmya Chollate, Anthone W Dunah, Pamela A Snodgrass-Belt, H Moore Arnold, Arthur G Taveras, Kenneth J Rhodes, Robert H Scannevin. Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator.
ACS medicinal chemistry letters.
2011 Oct; 2(10):786-91. doi:
10.1021/ml200175q. [PMID: 24900267] - Bruno P Imbimbo, Elda Del Giudice, Davide Colavito, Antonello D'Arrigo, Maurizio Dalle Carbonare, Gino Villetti, Fabrizio Facchinetti, Roberta Volta, Vladimiro Pietrini, Maria F Baroc, Lutgarde Serneels, Bart De Strooper, Alberta Leon. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
The Journal of pharmacology and experimental therapeutics.
2007 Dec; 323(3):822-30. doi:
10.1124/jpet.107.129007. [PMID: 17895400] - Bruno P Imbimbo, Elda Del Giudice, Valentina Cenacchi, Roberta Volta, Gino Villetti, Fabrizio Facchinetti, Benedetta Riccardi, Paola Puccini, Nadia Moretto, Francesca Grassi, Simone Ottonello, Alberta Leon. In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents.
Pharmacological research.
2007 Apr; 55(4):318-28. doi:
10.1016/j.phrs.2006.12.010. [PMID: 17292621] - Ilaria Peretto, Stefano Radaelli, Carlo Parini, Michele Zandi, Luca F Raveglia, Giulio Dondio, Laura Fontanella, Paola Misiano, Chiara Bigogno, Andrea Rizzi, Benedetta Riccardi, Marcello Biscaioli, Silvia Marchetti, Paola Puccini, Silvia Catinella, Ivano Rondelli, Valentina Cenacchi, Pier Tonino Bolzoni, Paola Caruso, Gino Villetti, Fabrizio Facchinetti, Elda Del Giudice, Nadia Moretto, Bruno P Imbimbo. Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.
Journal of medicinal chemistry.
2005 Sep; 48(18):5705-20. doi:
10.1021/jm0502541. [PMID: 16134939]
