7-Nitro-2,3-Dioxo-2,3-Dihydroquinoxaline-6-Carbonitrile (BioDeep_00000177365)

   

human metabolite blood metabolite


代谢物信息卡片


7-Nitro-2,3-Dioxo-2,3-Dihydroquinoxaline-6-Carbonitrile

化学式: C9H2N4O4 (230.0076)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: C1=C(C(=CC2=C1N=C(C(=N2)[O])[O])[N+](=O)[O-])C#N
InChI: InChI=1S/C9H2N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Ayelet Orenbuch, Lee Shalev, Vincenzo Marra, Isaac Sinai, Yotam Lavy, Joy Kahn, Jemima J Burden, Kevin Staras, Daniel Gitler. Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Mar; 32(12):3969-80. doi: 10.1523/jneurosci.5058-11.2012. [PMID: 22442064]
  • László Héja, Gabriella Nyitrai, Orsolya Kékesi, Arpád Dobolyi, Pál Szabó, Richárd Fiáth, István Ulbert, Borbála Pál-Szenthe, Miklós Palkovits, Julianna Kardos. Astrocytes convert network excitation to tonic inhibition of neurons. BMC biology. 2012 Mar; 10(?):26. doi: 10.1186/1741-7007-10-26. [PMID: 22420899]
  • Natsuko Kumamoto, Yan Gu, Jia Wang, Stephen Janoschka, Ken-Ichi Takemaru, Joel Levine, Shaoyu Ge. A role for primary cilia in glutamatergic synaptic integration of adult-born neurons. Nature neuroscience. 2012 Feb; 15(3):399-405, S1. doi: 10.1038/nn.3042. [PMID: 22306608]
  • Chessa S Scullin, Lawrence C Tafoya, Michael C Wilson, L Donald Partridge. Presynaptic residual calcium and synaptic facilitation at hippocampal synapses of mice with altered expression of SNAP-25. Brain research. 2012 Jan; 1431(?):1-12. doi: 10.1016/j.brainres.2011.10.035. [PMID: 22119397]
  • Yoshimasa Komatsuzaki, Yusuke Hatanaka, Gen Murakami, Hideo Mukai, Yasushi Hojo, Minoru Saito, Tetsuya Kimoto, Suguru Kawato. Corticosterone induces rapid spinogenesis via synaptic glucocorticoid receptors and kinase networks in hippocampus. PloS one. 2012; 7(4):e34124. doi: 10.1371/journal.pone.0034124. [PMID: 22509272]
  • Eiji Shigetomi, Xiaoping Tong, Kelvin Y Kwan, David P Corey, Baljit S Khakh. TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nature neuroscience. 2011 Dec; 15(1):70-80. doi: 10.1038/nn.3000. [PMID: 22158513]
  • Alfredo J Garcia, Shakil A Khan, Ganesh K Kumar, Nanduri R Prabhakar, Jan-Marino Ramirez. Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus. Journal of neurophysiology. 2011 Dec; 106(6):3045-55. doi: 10.1152/jn.00550.2010. [PMID: 21849609]
  • Chul-Kyu Park, Ning Lü, Zhen-Zhong Xu, Tong Liu, Charles N Serhan, Ru-Rong Ji. Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Oct; 31(42):15072-85. doi: 10.1523/jneurosci.2443-11.2011. [PMID: 22016541]
  • Erwan Michard, Pedro T Lima, Filipe Borges, Ana Catarina Silva, Maria Teresa Portes, João E Carvalho, Matthew Gilliham, Lai-Hua Liu, Gerhard Obermeyer, José A Feijó. Glutamate receptor-like genes form Ca2+ channels in pollen tubes and are regulated by pistil D-serine. Science (New York, N.Y.). 2011 Apr; 332(6028):434-7. doi: 10.1126/science.1201101. [PMID: 21415319]
  • Eugene Dimitrov, Ted Björn Usdin. Tuberoinfundibular peptide of 39 residues modulates the mouse hypothalamic-pituitary-adrenal axis via paraventricular glutamatergic neurons. The Journal of comparative neurology. 2010 Nov; 518(21):4375-94. doi: 10.1002/cne.22462. [PMID: 20853513]
  • Matthew S Grubb, Juan Burrone. Channelrhodopsin-2 localised to the axon initial segment. PloS one. 2010 Oct; 5(10):e13761. doi: 10.1371/journal.pone.0013761. [PMID: 21048938]
  • Adam W Hantman, Thomas M Jessell. Clarke's column neurons as the focus of a corticospinal corollary circuit. Nature neuroscience. 2010 Oct; 13(10):1233-9. doi: 10.1038/nn.2637. [PMID: 20835249]
  • Nahoko Kasai, Chandra S Ramanujan, Ichiro Fujimoto, Akiyoshi Shimada, John F Ryan, Keiichi Torimitsu. AFM observation of single, functioning ionotropic glutamate receptors reconstituted in lipid bilayers. Biochimica et biophysica acta. 2010 Jul; 1800(7):655-61. doi: 10.1016/j.bbagen.2010.03.002. [PMID: 20307628]
  • Luigi Bozzo, Jean-Yves Chatton. Inhibitory effects of (2S, 3S)-3-[3-[4-(trifluoromethyl)benzoylamino]benzyloxy]aspartate (TFB-TBOA) on the astrocytic sodium responses to glutamate. Brain research. 2010 Feb; 1316(?):27-34. doi: 10.1016/j.brainres.2009.12.028. [PMID: 20026319]
  • Hwan-Ching Tai, Henrike Besche, Alfred L Goldberg, Erin M Schuman. Characterization of the Brain 26S Proteasome and its Interacting Proteins. Frontiers in molecular neuroscience. 2010; 3(?):. doi: 10.3389/fnmol.2010.00012. [PMID: 20717473]
  • Ibolya Bodnár, Zsuzsanna Bánky, Dóra Zelena, Béla Halász. Glutamate receptor antagonist infused into the hypothalamic suprachiasmatic nuclei interferes with the diurnal fluctuations in plasma prolactin and corticosterone levels and injected into the mesencephalic dorsal raphe nucleus attenuates the suckling stimulus-induced release of prolactin of the rat. Brain research bulletin. 2009 Aug; 80(1-2):9-16. doi: 10.1016/j.brainresbull.2009.06.005. [PMID: 19539728]
  • Thomas P Jensen, Lucy E Buckby, Ruth M Empson. Reduced expression of the 'fast' calcium transporter PMCA2a during homeostatic plasticity. Molecular and cellular neurosciences. 2009 Jul; 41(3):364-72. doi: 10.1016/j.mcn.2009.04.011. [PMID: 19410650]
  • Claudie Hooper, Fleur Pinteaux-Jones, Victoria A H Fry, Ioanna G Sevastou, David Baker, Simon J Heales, Jennifer M Pocock. Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood-brain barrier damage. Journal of neurochemistry. 2009 May; 109(3):694-705. doi: 10.1111/j.1471-4159.2009.05953.x. [PMID: 19187440]
  • Katie R Famous, Vidhya Kumaresan, Ghazaleh Sadri-Vakili, Heath D Schmidt, Dale F Mierke, Jang-Ho J Cha, R Christopher Pierce. Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Oct; 28(43):11061-70. doi: 10.1523/jneurosci.1221-08.2008. [PMID: 18945913]
  • Winyoo Chowanadisai, Bo Lönnerdal, Shannon L Kelleher. Zip6 (LIV-1) regulates zinc uptake in neuroblastoma cells under resting but not depolarizing conditions. Brain research. 2008 Mar; 1199(?):10-9. doi: 10.1016/j.brainres.2008.01.015. [PMID: 18272141]
  • Jing-Jer Ke, Hsiun-Ing Chen, Chauying J Jen, Yu-Min Kuo, Chianfang G Cherng, Yen-Ping N Tsai, Ming-Che Ho, Chia-Wen Tsai, Lung Yu. Mutual enhancement of central neurotoxicity induced by ketamine followed by methamphetamine. Toxicology and applied pharmacology. 2008 Mar; 227(2):239-47. doi: 10.1016/j.taap.2007.10.017. [PMID: 18076959]
  • Wei-Zhong Wang, Li-Gang Wang, Lie Gao, Wei Wang. Contribution of AMPA/kainate receptors in the rostral ventrolateral medulla to the hypotensive and sympathoinhibitory effects of clonidine. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 Sep; 293(3):R1232-8. doi: 10.1152/ajpregu.00233.2007. [PMID: 17581836]
  • Nanping Wu, Carlos Cepeda, Xiaoxi Zhuang, Michael S Levine. Altered corticostriatal neurotransmission and modulation in dopamine transporter knock-down mice. Journal of neurophysiology. 2007 Jul; 98(1):423-32. doi: 10.1152/jn.00971.2006. [PMID: 17522168]
  • Long Chen, Joseph D Bohanick, Makoto Nishihara, Jeremy K Seamans, Charles R Yang. Dopamine D1/5 receptor-mediated long-term potentiation of intrinsic excitability in rat prefrontal cortical neurons: Ca2+-dependent intracellular signaling. Journal of neurophysiology. 2007 Mar; 97(3):2448-64. doi: 10.1152/jn.00317.2006. [PMID: 17229830]
  • Marko Kreft, Mija Blaganje, Sonja Grilc, Marjan Rupnik, Robert Zorec. Glutamate stimulation increases hormone release in rat melanotrophs. Neuroscience letters. 2006 Sep; 404(3):299-302. doi: 10.1016/j.neulet.2006.06.021. [PMID: 16814468]
  • Noreen F Rossi, Haiping Chen. Aminopropionic acid receptors in paraventricular nucleus mediate pressor and vasopressin responses to endothelin-1 in subfornical organ. Experimental biology and medicine (Maywood, N.J.). 2006 Jun; 231(6):1075-80. doi: . [PMID: 16741052]
  • Mark C Farso, Fiona Y Carroll, Philip M Beart. Establishment of primary cultures of rat olfactory bulb under serum-free conditions for studies of cellular injury. Cell and tissue research. 2006 Feb; 323(2):343-9. doi: 10.1007/s00441-005-0056-5. [PMID: 16189719]
  • Ibolya Bodnár, Zsuzsanna Bánky, Béla Halász. Non-NMDA glutamate receptor antagonist injected into the hypothalamic paraventricular nucleus inhibits the prolactin response to formalin stress of male rats. Neurochemical research. 2006 Feb; 31(2):201-8. doi: 10.1007/s11064-005-9009-3. [PMID: 16518578]
  • Kerstin Wirkner, Attila Köfalvi, Wolfgang Fischer, Albrecht Günther, Heike Franke, Helke Gröger-Arndt, Wolfgang Nörenberg, Emília Madarász, E Sylvester Vizi, Dietmar Schneider, Beáta Sperlágh, Peter Illes. Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia. Journal of neurochemistry. 2005 Dec; 95(5):1421-37. doi: 10.1111/j.1471-4159.2005.03465.x. [PMID: 16313518]
  • Sotirios Keros, John J Hablitz. Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortex. Journal of neurophysiology. 2005 Sep; 94(3):2073-85. doi: 10.1152/jn.00520.2005. [PMID: 15987761]
  • Helga Susanne E Haas, Roswitha Pfragner, Veronika Siegl, Elisabeth Ingolic, Elfgard Heintz, Konrad Schauenstein. Glutamate receptor-mediated effects on growth and morphology of human histiocytic lymphoma cells. International journal of oncology. 2005 Sep; 27(3):867-74. doi: NULL. [PMID: 16077940]
  • Tai-Xiang Xu, Neng Gong, Tian-Le Xu. Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission. Neuroreport. 2005 Aug; 16(11):1227-31. doi: 10.1097/00001756-200508010-00019. [PMID: 16012354]
  • Agathe Roubertie, Hassan Boukhaddaoui, Victor Sieso, Anne de Saint-Martin, Arielle Lellouch-Tubiana, Edouard Hirsch, Bernard Echenne, Jean Valmier. Antiglial cell autoantibodies and childhood epilepsy: a case report. Epilepsia. 2005 Aug; 46(8):1308-12. doi: 10.1111/j.1528-1167.2005.53004.x. [PMID: 16060945]
  • Ibolya Bodnár, Zsuzsanna Bánky, György M Nagy, Béla Halász. Non-NMDA glutamate receptor antagonist injected into the hypothalamic paraventricular nucleus blocks the suckling stimulus-induced release of prolactin. Brain research bulletin. 2005 Mar; 65(2):163-8. doi: 10.1016/j.brainresbull.2005.01.001. [PMID: 15763183]
  • So Young Kang, Ki Yong Lee, Sang Hyun Sung, Young Choong Kim. Four new neuroprotective dihydropyranocoumarins from Angelica gigas. Journal of natural products. 2005 Jan; 68(1):56-9. doi: 10.1021/np049705v. [PMID: 15679317]
  • Hiroyuki W Kitamura, Hiroki Hamanaka, Masahiko Watanabe, Koji Wada, Chiharu Yamazaki, Shinobu C Fujita, Toshiya Manabe, Nobuyuki Nukina. Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E. Neuroscience letters. 2004 Oct; 369(3):173-8. doi: 10.1016/j.neulet.2004.07.084. [PMID: 15464259]
  • Ernst Seiffert, Jens P Dreier, Sebastian Ivens, Ingo Bechmann, Oren Tomkins, Uwe Heinemann, Alon Friedman. Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Sep; 24(36):7829-36. doi: 10.1523/jneurosci.1751-04.2004. [PMID: 15356194]
  • Rachel Hopper, Barrie Lancaster, John Garthwaite. On the regulation of NMDA receptors by nitric oxide. The European journal of neuroscience. 2004 Apr; 19(7):1675-82. doi: 10.1111/j.1460-9568.2004.03306.x. [PMID: 15078541]
  • Susumu Tomita, Masaki Fukata, Roger A Nicoll, David S Bredt. Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science (New York, N.Y.). 2004 Mar; 303(5663):1508-11. doi: 10.1126/science.1090262. [PMID: 15001777]
  • Charles L Howe, Allan J Bieber, Arthur E Warrington, Larry R Pease, Moses Rodriguez. Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody. Neurobiology of disease. 2004 Feb; 15(1):120-31. doi: 10.1016/j.nbd.2003.09.002. [PMID: 14751777]
  • Linda M Chicoine, Vishnu Suppiramaniam, Thirumalini Vaithianathan, Gerald Gianutsos, Ben A Bahr. Sulfate- and size-dependent polysaccharide modulation of AMPA receptor properties. Journal of neuroscience research. 2004 Feb; 75(3):408-16. doi: 10.1002/jnr.10871. [PMID: 14743454]
  • Sang Jeong Kim, Yu Shin Kim, Joseph P Yuan, Ronald S Petralia, Paul F Worley, David J Linden. Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Nature. 2003 Nov; 426(6964):285-91. doi: 10.1038/nature02162. [PMID: 14614461]
  • Do-Hoon Kim, Yoo-Sun Moon, Jun-Sub Jung, Hong-Won Suh, Dong-Keun Song. Route-dependent effects of the non-NMDA receptor antagonist CNQX on plasma corticosterone levels in mice. Progress in neuro-psychopharmacology & biological psychiatry. 2003 Sep; 27(6):1055-8. doi: 10.1016/s0278-5846(03)00147-7. [PMID: 14499323]
  • Rudi D'Hooge, Gerda Van de Vijver, Pierre-Paul Van Bogaert, Bart Marescau, Raymond Vanholder, Peter P De Deyn. Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins. Kidney international. 2003 May; 63(5):1764-75. doi: 10.1046/j.1523-1755.2003.00912.x. [PMID: 12675852]
  • M A Belenky, N Sagiv, J-M Fritschy, Y Yarom. Presynaptic and postsynaptic GABAA receptors in rat suprachiasmatic nucleus. Neuroscience. 2003; 118(4):909-23. doi: 10.1016/s0306-4522(03)00062-9. [PMID: 12732237]
  • Asa Laestadius, Agneta Richter-Dahlfors, Anita Aperia. Dual effects of Escherichia coli alpha-hemolysin on rat renal proximal tubule cells. Kidney international. 2002 Dec; 62(6):2035-42. doi: 10.1046/j.1523-1755.2002.00661.x. [PMID: 12427127]
  • So Ra Kim, Ki Yong Lee, Kyung Ah Koo, Sang Hyun Sung, Na-Gyong Lee, Jinwoong Kim, Young Choong Kim. Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots. Journal of natural products. 2002 Nov; 65(11):1696-9. doi: 10.1021/np0202172. [PMID: 12444706]
  • Seong-Soo Choi, Eun-Jung Han, Tae-Hee Lee, Jin-Koo Lee, Ki-Jung Han, Han-Kyu Lee, Hong-Won Suh. Antinociceptive mechanisms of platycodin D administered intracerebroventricularly in the mouse. Planta medica. 2002 Sep; 68(9):794-8. doi: 10.1055/s-2002-34396. [PMID: 12357389]
  • M C Arufe, R Durán, D Perez-Vences, M Alfonso. Endogenous excitatory amino acid neurotransmission regulates thyroid-stimulating hormone and thyroid hormone secretion in conscious freely moving male rats. Endocrine. 2002 Apr; 17(3):193-7. doi: 10.1385/endo:17:3:193. [PMID: 12108519]
  • Elena Alberdi, María Victoria Sánchez-Gómez, Aida Marino, Carlos Matute. Ca(2+) influx through AMPA or kainate receptors alone is sufficient to initiate excitotoxicity in cultured oligodendrocytes. Neurobiology of disease. 2002 Mar; 9(2):234-43. doi: 10.1006/nbdi.2001.0457. [PMID: 11895374]
  • G S McGillem, R F Dacheux. Rabbit cone bipolar cells: correlation of their morphologies with whole-cell recordings. Visual neuroscience. 2001 Sep; 18(5):675-85. doi: 10.1017/s0952523801185019. [PMID: 11925003]
  • D P Li, D B Averill, H L Pan. Differential roles for glutamate receptor subtypes within commissural NTS in cardiac-sympathetic reflex. American journal of physiology. Regulatory, integrative and comparative physiology. 2001 Sep; 281(3):R935-43. doi: 10.1152/ajpregu.2001.281.3.r935. [PMID: 11507011]
  • J M Langosch, X Y Zhou, M Heinen, S S Chatterjee, M Nöldner, J Walden. Effects of Hypericum perforatum L. on evoked potentials in guinea pig hippocampal slices. Pharmacopsychiatry. 2001 Jul; 34 Suppl 1(?):S83-8. doi: 10.1055/s-2001-15511. [PMID: 11518083]