2-Pyrrol-1-yl-1H-imidazole (BioDeep_00000177347)
human metabolite blood metabolite
代谢物信息卡片
2-(1H-pyrrol-1-yl)-1H-imidazole
化学式: C7H7N3 (133.0639942)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN(C=C1)C2=NC=CN2
InChI: InChI=1S/C7H7N3/c1-2-6-10(5-1)7-8-3-4-9-7/h1-6H,(H,8,9)
描述信息
同义名列表
数据库引用编号
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Timothy W Synold, Bixin Xi, Jun Wu, Yun Yen, Benjamin C Li, Fei Yang, John W Phillips, Nicholas G Nickols, Peter B Dervan. Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice.
Cancer chemotherapy and pharmacology.
2012 Oct; 70(4):617-25. doi:
10.1007/s00280-012-1954-3. [PMID: 22907527] - Amanda E Hargrove, Jevgenij A Raskatov, Jordan L Meier, David C Montgomery, Peter B Dervan. Characterization and solubilization of pyrrole-imidazole polyamide aggregates.
Journal of medicinal chemistry.
2012 Jun; 55(11):5425-32. doi:
10.1021/jm300380a. [PMID: 22607187] - Daman Kumari, Karen Usdin. Is Friedreich ataxia an epigenetic disorder?.
Clinical epigenetics.
2012 Jan; 4(1):2. doi:
10.1186/1868-7083-4-2. [PMID: 22414340] - Tomonori Kamei, Takahiko Aoyama, Chihiro Tanaka, Takafumi Nagashima, Yukio Aoyama, Hiroyuki Hayashi, Hiroki Nagase, Takahiro Ueno, Noboru Fukuda, Yoshiaki Matsumoto. Quantitation of pyrrole-imidazole polyamide in rat plasma by high-performance liquid chromatography coupled with UV detection.
Journal of biomedicine & biotechnology.
2012; 2012(?):715928. doi:
10.1155/2012/715928. [PMID: 22778554] - Mamiko Kajiwara, Takahiro Ueno, Noboru Fukuda, Hiroyuki Matsuda, Toshibumi Shimokawa, Maki Kitai, Akiko Tsunemi, Yoshinobu Fuke, Takayuki Fujita, Koichi Matsumoto, Yoshiaki Matsumoto, Chisei Ra, Masayoshi Soma. Development of pyrrole-imidazole polyamide targeting fc receptor common gamma chain for the treatment of immune-complex related renal disease.
Biological & pharmaceutical bulletin.
2012; 35(11):2028-35. doi:
10.1248/bpb.b12-00614. [PMID: 22971693] - Hiroyuki Matsuda, Noboru Fukuda, Takahiro Ueno, Mayumi Katakawa, Xiaofei Wang, Takayoshi Watanabe, Sei-Ichi Matsui, Takahiko Aoyama, Kosuke Saito, Toshikazu Bando, Yoshiaki Matsumoto, Hiroaki Nagase, Koichi Matsumoto, Hiroshi Sugiyama. Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-β1 promoter.
Kidney international.
2011 Jan; 79(1):46-56. doi:
10.1038/ki.2010.330. [PMID: 20861821] - Min Chen, Hiroyuki Matsuda, Linghua Wang, Takayoshi Watanabe, Makoto T Kimura, Jun Igarashi, Xiaofei Wang, Tohru Sakimoto, Noboru Fukuda, Mitsuru Sawa, Hiroki Nagase. Pretranscriptional regulation of Tgf-beta1 by PI polyamide prevents scarring and accelerates wound healing of the cornea after exposure to alkali.
Molecular therapy : the journal of the American Society of Gene Therapy.
2010 Mar; 18(3):519-27. doi:
10.1038/mt.2009.263. [PMID: 19920805] - Xiaofei Wang, Hiroki Nagase, Takayoshi Watanabe, Hiroyuki Nobusue, Tsukasa Suzuki, Yukihiro Asami, Yui Shinojima, Hiroyuki Kawashima, Keiko Takagi, Rajeev Mishra, Jun Igarashi, Makoto Kimura, Tadatoshi Takayama, Noboru Fukuda, Hiroshi Sugiyama. Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide.
Cancer science.
2010 Mar; 101(3):759-66. doi:
10.1111/j.1349-7006.2009.01435.x. [PMID: 20085585] - Laurence Colin, Carine Van Lint. Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies.
Retrovirology.
2009 Dec; 6(?):111. doi:
10.1186/1742-4690-6-111. [PMID: 19961595] - Noboru Fukuda, Yoshiko Tahira, Hiroyuki Matsuda, Koichi Matsumoto. Transforming growth factor-beta as a treatment target in renal diseases.
Journal of nephrology.
2009 Nov; 22(6):708-15. doi:
NULL. [PMID: 19967649] - Takashi Nagashima, Takahiko Aoyama, Tsubasa Yokoe, Akiko Fukasawa, Noboru Fukuda, Takahiro Ueno, Hiroshi Sugiyama, Hiroki Nagase, Yoshiaki Matsumoto. Pharmacokinetic modeling and prediction of plasma pyrrole-imidazole polyamide concentration in rats using simultaneous urinary and biliary excretion data.
Biological & pharmaceutical bulletin.
2009 May; 32(5):921-7. doi:
10.1248/bpb.32.921. [PMID: 19420765] - Takashi Nagashima, Takahiko Aoyama, Akiko Fukasawa, Satoshi Watabe, Noboru Fukuda, Takahiro Ueno, Hiroshi Sugiyama, Hiroki Nagase, Yoshiaki Matsumoto. Determination of pyrrole-imidazole polyamide in rat plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Apr; 877(11-12):1070-6. doi:
10.1016/j.jchromb.2009.02.041. [PMID: 19286430] - Takahiro Ueno, Noboru Fukuda, Akiko Tsunemi, En-Hui Yao, Hiroyuki Matsuda, Kazunobu Tahira, Taro Matsumoto, Koichi Matsumoto, Yoshiaki Matsumoto, Hiroki Nagase, Hiroshi Sugiyama, Tatsuya Sawamura. A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function.
Journal of hypertension.
2009 Mar; 27(3):508-16. doi:
10.1097/hjh.0b013e3283207fe1. [PMID: 19330905] - Akiko Fukasawa, Takahiko Aoyama, Takashi Nagashima, Noboru Fukuda, Takahiro Ueno, Hiroshi Sugiyama, Hiroki Nagase, Yoshiaki Matsumoto. Pharmacokinetics of pyrrole-imidazole polyamides after intravenous administration in rat.
Biopharmaceutics & drug disposition.
2009 Mar; 30(2):81-9. doi:
10.1002/bdd.648. [PMID: 19226654] - Akiko Fukasawa, Takashi Nagashima, Takahiko Aoyama, Noboru Fukuda, Hiroyuki Matsuda, Takahiro Ueno, Hiroshi Sugiyama, Hiroki Nagase, Yoshiaki Matsumoto. Optimization and validation of a high-performance liquid chromatographic method with UV detection for the determination of pyrrole-imidazole polyamides in rat plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Nov; 859(2):272-5. doi:
10.1016/j.jchromb.2007.09.032. [PMID: 17950049] - Hiroyuki Matsuda, Noboru Fukuda, Takahiro Ueno, Yoshiko Tahira, Hirohito Ayame, Wen Zhang, Toshikazu Bando, Hiroshi Sugiyama, Satoshi Saito, Koichi Matsumoto, Hideo Mugishima, Kazuo Serie. Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-beta1 promoter for treatment of progressive renal diseases.
Journal of the American Society of Nephrology : JASN.
2006 Feb; 17(2):422-32. doi:
10.1681/asn.2005060650. [PMID: 16371433] - Noboru Fukuda. Development of gene therapies for cardiovascular and renal diseases by nucleic acid medicines.
Medicinal chemistry (Shariqah (United Arab Emirates)).
2006 Jan; 2(1):13-9. doi:
10.2174/157340606775197723. [PMID: 16787351]
