10-Acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide (BioDeep_00000177285)
human metabolite blood metabolite
代谢物信息卡片
9-(Acetyloxy)-2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboximidate
化学式: C17H16N2O3 (296.1160866)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OC1CC2=CC=CC=C2N(C(N)=O)C2=CC=CC=C12
InChI: InChI=1S/C17H16N2O3/c1-11(20)22-16-10-12-6-2-4-8-14(12)19(17(18)21)15-9-5-3-7-13(15)16/h2-9,16H,10H2,1H3,(H2,18,21)
描述信息
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D049990 - Membrane Transport Modulators
同义名列表
10 个代谢物同义名
9-(Acetyloxy)-2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboximidate; 9-(Acetyloxy)-2-azatricyclo[9.4.0.0,]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboximidate; 2-carbamoyl-2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-9-yl acetate; 10-Acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide; 10-Acetoxy-10,11-dihydro-5H-dibenz(b,F)azepine-5-carboxamide; Eslicarbazepine acetate; BIA-2-093; BIA 2-093; Zebinix; Aptiom
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Reem Odi, Valentina Franco, Emilio Perucca, Meir Bialer. Bioequivalence and switchability of generic antiseizure medications (ASMs): A re-appraisal based on analysis of generic ASM products approved in Europe.
Epilepsia.
2021 02; 62(2):285-302. doi:
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Revista de neurologia.
2020 Nov; 71(s01):S1-S17. doi:
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Revista de neurologia.
2020 Jul; 71(2):54-60. doi:
10.33588/rn.7102.2019207. [PMID: 32627160] - Scott Mintzer, Tawnya Constantino, Barry Gidal, Parul Bhargava, Todd Grinnell, David Blum. Markers of bone and lipid metabolism with eslicarbazepine acetate monotherapy.
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2019 12; 158(?):106216. doi:
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Acta neurologica Scandinavica.
2018 Sep; 138(3):203-211. doi:
10.1111/ane.12950. [PMID: 29732549] - Soujanya Sunkaraneni, Elizabeth A Ludwig, Julie A Passarell, David Blum, Todd Grinnell, Jill Fiedler-Kelly. Population Pharmacokinetics and Exposure-Response Analyses of Eslicarbazepine Acetate Efficacy and Safety in Monotherapy of Partial-Onset Seizures.
Journal of clinical pharmacology.
2018 07; 58(7):927-938. doi:
10.1002/jcph.1086. [PMID: 29528499] - Soujanya Sunkaraneni, David Blum, Elizabeth Ludwig, Vaishali Chudasama, Jill Fiedler-Kelly, Marketa Marvanova, Jacquelyn Bainbridge, Luann Phillips. Population Pharmacokinetic Evaluation and Missed-Dose Simulations for Eslicarbazepine Acetate Monotherapy in Patients With Partial-Onset Seizures.
Clinical pharmacology in drug development.
2018 03; 7(3):287-297. doi:
10.1002/cpdd.382. [PMID: 28881418] - Scott Mintzer, Robert T Wechsler, Joanne B Rogin, Barry E Gidal, Matthias Schwab, Elinor Ben-Menachem, Mar Carreño, Patrício Soares da Silva, Joana Moreira, Yan Li, David Blum, Todd Grinnell. Effects of adjunctive eslicarbazepine acetate on serum lipids in patients with partial-onset seizures: Impact of concomitant statins and enzyme-inducing antiepileptic drugs.
Epilepsy research.
2018 03; 141(?):83-89. doi:
10.1016/j.eplepsyres.2018.02.001. [PMID: 29499473] - Pedro Jesús Serrano-Castro, Javier Fernández-Pérez, Francisco Javier López-González, Manuel Toledo-Argany, José Carlos Estévez-María, Antonio Arjona-Padillo, Vicente Bertol-Alegre, José Angel Mauri-Llerda, Diego Tortosa-Conesa, Jesús Ruiz-Giménez, Rosa Querol-Pascual, Alberto García-Martínez, José Manuel Molto-Jorda, Manuel Payán-Ortiz, José Francisco Maestre-Moreno, José Galván-Espinosa. Eslicarbazepine acetate and carotid intima-media thickness in epileptic patients.
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2017 12; 138(?):81-87. doi:
10.1016/j.eplepsyres.2017.10.018. [PMID: 29096133] - Patrizia Pulitano, Valentina Franco, Oriano Mecarelli, Marianna Brienza, Chiara Davassi, Emilio Russo. Effects of eslicarbazepine acetate on lipid profile and sodium levels in patients with epilepsy.
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2017 Dec; 53(?):1-3. doi:
10.1016/j.seizure.2017.09.023. [PMID: 29078086] - Naama Levy-Cooperman, Kerri A Schoedel, Bijan Chakraborty, David Blum, Hailong Cheng. Abuse liability assessment of eslicarbazepine acetate in healthy male and female recreational sedative users: A Phase I randomized controlled trial.
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BMC neuroscience.
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Epilepsia.
2013 Aug; 54(8):1453-61. doi:
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Epilepsia.
2013 Jan; 54(1):108-16. doi:
10.1111/j.1528-1167.2012.03595.x. [PMID: 22812691] - Meir Bialer, Patricio Soares-da-Silva. Pharmacokinetics and drug interactions of eslicarbazepine acetate.
Epilepsia.
2012 Jun; 53(6):935-46. doi:
10.1111/j.1528-1167.2012.03519.x. [PMID: 22612290] - Amilcar Falcão, Eliane Fuseau, Teresa Nunes, Luis Almeida, Patricio Soares-da-Silva. Pharmacokinetics, drug interactions and exposure-response relationship of eslicarbazepine acetate in adult patients with partial-onset seizures: population pharmacokinetic and pharmacokinetic/pharmacodynamic analyses.
CNS drugs.
2012 Jan; 26(1):79-91. doi:
10.2165/11596290-000000000-00000. [PMID: 22171585] - Cinzia Fattore, Emilio Perucca. Novel medications for epilepsy.
Drugs.
2011 Nov; 71(16):2151-78. doi:
10.2165/11594640-000000000-00000. [PMID: 22035515] - Ana I Loureiro, Carlos Fernandes-Lopes, Maria J Bonifácio, Lyndon C Wright, Patricio Soares-da-Silva. Hepatic UDP-glucuronosyltransferase is responsible for eslicarbazepine glucuronidation.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Sep; 39(9):1486-94. doi:
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Epilepsy research.
2011 Sep; 96(1-2):132-9. doi:
10.1016/j.eplepsyres.2011.05.013. [PMID: 21680153] - A I Loureiro, C Fernandes-Lopes, L C Wright, P Soares-da-Silva. Development and validation of an enantioselective liquid-chromatography/tandem mass spectrometry method for the separation and quantification of eslicarbazepine acetate, eslicarbazepine, R-licarbazepine and oxcarbazepine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Sep; 879(25):2611-8. doi:
10.1016/j.jchromb.2011.07.019. [PMID: 21816689] - B J Steinhoff, E Trinka, A S Wendling. [Abrupt switch from extended-release oxcarbazepine to eslicarbazepine acetate].
Der Nervenarzt.
2011 Jun; 82(6):764-7. doi:
10.1007/s00115-010-3177-3. [PMID: 21052972] - Ana Fortuna, Joana Bicker, Gilberto Alves, Amílcar Falcão, Patrício Soares-da-Silva. A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5-carboxamide derivatives in mouse plasma and brain tissue: eslicarbazepine acetate, carbamazepine and main metabolites.
Journal of separation science.
2011 Jun; 34(12):1391-401. doi:
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Nutrition journal.
2010 Dec; 9(?):71. doi:
10.1186/1475-2891-9-71. [PMID: 21194458] - Markus Rauchenzauner, Gerhard Luef. Update on treatment of partial onset epilepsy: role of eslicarbazepine.
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Therapeutic drug monitoring.
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Biopharmaceutics & drug disposition.
2010 Jul; 31(5-6):362-6. doi:
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Current medical research and opinion.
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Analytical and bioanalytical chemistry.
2010 Jun; 397(4):1605-15. doi:
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Fundamental & clinical pharmacology.
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Fundamental & clinical pharmacology.
2008 Oct; 22(5):529-36. doi:
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European journal of clinical pharmacology.
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International journal of clinical pharmacology and therapeutics.
2008 Mar; 46(3):119-30. doi:
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Drugs in R&D.
2008; 9(6):447-54. doi:
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2007 Jul; 28(5):249-56. doi:
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Drugs in R&D.
2005; 6(5):253-60. doi:
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Drugs in R&D.
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2004 Aug; 44(8):906-18. doi:
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Drugs in R&D.
2003; 4(5):269-84. doi:
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