N-(2-Methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide (BioDeep_00000177271)

   

human metabolite blood metabolite


代谢物信息卡片


N-[(2-methoxyphenyl)methyl]-N-(4-phenoxypyridin-3-yl)acetamide

化学式: C21H20N2O3 (348.147385)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 92.31%

分子结构信息

SMILES: CC(=O)N(CC1=CC=CC=C1OC)C2=C(C=CN=C2)OC3=CC=CC=C3
InChI: InChI=1S/C21H20N2O3/c1-16(24)23(15-17-8-6-7-11-20(17)25-2)19-14-22-13-12-21(19)26-18-9-4-3-5-10-18/h3-14H,15H2,1-2H3

描述信息

同义名列表

3 个代谢物同义名

N-[(2-methoxyphenyl)methyl]-N-(4-phenoxypyridin-3-yl)acetamide; N-(2-Methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide; PBR28 CPD



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Anna H Boerwinkle, Jeremy F Strain, Tricia Burdo, John Doyle, Jon Christensen, Yi Su, Julie K Wisch, Sarah A Cooley, Florin Vaida, Mandy D Smith, Hussain Jafri, Robert H Paul, Tammie L S Benzinger, Beau M Ances. Comparison of [11C]-PBR28 Binding Between Persons Living With HIV and HIV-Uninfected Individuals. Journal of acquired immune deficiency syndromes (1999). 2020 10; 85(2):244-251. doi: 10.1097/qai.0000000000002435. [PMID: 32658129]
  • A Forsberg, J Lampa, J Estelius, S Cervenka, L Farde, C Halldin, M Lekander, C Olgart Höglund, E Kosek. Disease activity in rheumatoid arthritis is inversely related to cerebral TSPO binding assessed by [11C]PBR28 positron emission tomography. Journal of neuroimmunology. 2019 09; 334(?):577000. doi: 10.1016/j.jneuroim.2019.577000. [PMID: 31260948]
  • Sung Won Kim, Corinde E Wiers, Ryan Tyler, Ehsan Shokri-Kojori, Yeon Joo Jang, Amna Zehra, Clara Freeman, Veronica Ramirez, Elsa Lindgren, Gregg Miller, Elizabeth A Cabrera, Tyler Stodden, Min Guo, Şükrü B Demiral, Nancy Diazgranados, Luke Park, Jeih-San Liow, Victor Pike, Cheryl Morse, Leandro F Vendruscolo, Robert B Innis, George F Koob, Dardo Tomasi, Gene-Jack Wang, Nora D Volkow. Influence of alcoholism and cholesterol on TSPO binding in brain: PET [11C]PBR28 studies in humans and rodents. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2018 08; 43(9):1832-1839. doi: 10.1038/s41386-018-0085-x. [PMID: 29777199]
  • W Gordon Frankle, Rajesh Narendran, Andrew T Wood, Fumitaka Suto, Michael L Himes, Michiyoshi Kobayashi, Tomoya Ohno, Akinori Yamauchi, Katsukuni Mitsui, Kevin Duffy, Mark Bruce. Brain translocator protein occupancy by ONO-2952 in healthy adults: A Phase 1 PET study using [11 C]PBR28. Synapse (New York, N.Y.). 2017 07; 71(7):. doi: 10.1002/syn.21970. [PMID: 28245513]
  • Katsukuni Mitsui, Noriko Morimoto, Tomohiro Niwa, Yoshiyuki Yamaura, Hiroyuki Ohba, Hideo Tsukada, Seishi Katsumata. Quantification of ONO-2952 Occupancy of 18-kDaTranslocator Protein in Conscious Monkey Brains using Positron Emission Tomography. The Journal of pharmacology and experimental therapeutics. 2017 03; 360(3):457-465. doi: 10.1124/jpet.116.238568. [PMID: 27986860]
  • N J Kalk, Q Guo, D Owen, R Cherian, D Erritzoe, A Gilmour, A S Ribeiro, J McGonigle, A Waldman, P Matthews, J Cavanagh, I McInnes, K Dar, R Gunn, E A Rabiner, A R Lingford-Hughes. Decreased hippocampal translocator protein (18 kDa) expression in alcohol dependence: a [11C]PBR28 PET study. Translational psychiatry. 2017 01; 7(1):e996. doi: 10.1038/tp.2016.264. [PMID: 28072413]
  • Jaime H Vera, Qi Guo, James H Cole, Adriano Boasso, Louise Greathead, Peter Kelleher, Eugenii A Rabiner, Nicola Kalk, Courtney Bishop, Roger N Gunn, Paul M Matthews, Alan Winston. Neuroinflammation in treated HIV-positive individuals: A TSPO PET study. Neurology. 2016 04; 86(15):1425-1432. doi: 10.1212/wnl.0000000000002485. [PMID: 26911637]
  • Christine M Sandiego, Jean-Dominique Gallezot, Brian Pittman, Nabeel Nabulsi, Keunpoong Lim, Shu-Fei Lin, David Matuskey, Jae-Yun Lee, Kevin C O'Connor, Yiyun Huang, Richard E Carson, Jonas Hannestad, Kelly P Cosgrove. Imaging robust microglial activation after lipopolysaccharide administration in humans with PET. Proceedings of the National Academy of Sciences of the United States of America. 2015 Oct; 112(40):12468-73. doi: 10.1073/pnas.1511003112. [PMID: 26385967]
  • Matthew D Walker, Katherine Dinelle, Rick Kornelsen, Nathan V Lee, Qing Miao, Mike Adam, Christine Takhar, Edwin Mak, Michael Schulzer, Matthew J Farrer, Vesna Sossi. [11C]PBR28 PET imaging is sensitive to neuroinflammation in the aged rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2015 Aug; 35(8):1331-8. doi: 10.1038/jcbfm.2015.54. [PMID: 25833342]
  • Samuel D Banister, Corinne Beinat, Shane M Wilkinson, Bin Shen, Cecilia Bartoli, Silvia Selleri, Eleonora Da Pozzo, Claudia Martini, Frederick T Chin, Michael Kassiou. Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO). European journal of medicinal chemistry. 2015 Mar; 93(?):392-400. doi: 10.1016/j.ejmech.2015.02.004. [PMID: 25725375]
  • Rajesh Narendran, Brian J Lopresti, Neale Scott Mason, Lora Deuitch, Jennifer Paris, Michael L Himes, Chowdari V Kodavali, Vishwajit L Nimgaonkar. Cocaine abuse in humans is not associated with increased microglial activation: an 18-kDa translocator protein positron emission tomography imaging study with [11C]PBR28. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Jul; 34(30):9945-50. doi: 10.1523/jneurosci.0928-14.2014. [PMID: 25057196]
  • Byung Seok Moon, Bom Sahn Kim, Chansoo Park, Jae Ho Jung, Youn Woo Lee, Ho-Young Lee, Dae Yoon Chi, Byung Chul Lee, Sang Eun Kim. [(18)F]Fluoromethyl-PBR28 as a potential radiotracer for TSPO: preclinical comparison with [(11)C]PBR28 in a rat model of neuroinflammation. Bioconjugate chemistry. 2014 Feb; 25(2):442-50. doi: 10.1021/bc400556h. [PMID: 24400917]
  • Ryuji Nakao, Nahid Amini, Christer Halldin. Simultaneous determination of protein-free and total positron emission tomography radioligand concentrations in plasma using high-performance frontal analysis followed by mixed micellar liquid chromatography: application to [11C]PBR28 in human plasma. Analytical chemistry. 2013 Sep; 85(18):8728-34. doi: 10.1021/ac401742v. [PMID: 23978238]
  • Nahid Amini, Ryuji Nakao, Magnus Schou, Christer Halldin. Identification of PET radiometabolites by cytochrome P450, UHPLC/Q-ToF-MS and fast radio-LC: applied to the PET radioligands [11C]flumazenil, [18F]FE-PE2I, and [11C]PBR28. Analytical and bioanalytical chemistry. 2013 Feb; 405(4):1303-10. doi: 10.1007/s00216-012-6541-2. [PMID: 23180082]
  • Jonas Hannestad, Jean-Dominique Gallezot, Thomas Schafbauer, Keunpoong Lim, Tracy Kloczynski, Evan D Morris, Richard E Carson, Yu-Shin Ding, Kelly P Cosgrove. Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates. NeuroImage. 2012 Oct; 63(1):232-9. doi: 10.1016/j.neuroimage.2012.06.055. [PMID: 22776451]
  • William C Kreisl, Masahiro Fujita, Yota Fujimura, Nobuyo Kimura, Kimberly J Jenko, Pavitra Kannan, Jinsoo Hong, Cheryl L Morse, Sami S Zoghbi, Robert L Gladding, Steven Jacobson, Unsong Oh, Victor W Pike, Robert B Innis. Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker. NeuroImage. 2010 Feb; 49(4):2924-32. doi: 10.1016/j.neuroimage.2009.11.056. [PMID: 19948230]
  • Alan A Wilson, Armando Garcia, Jun Parkes, Patrick McCormick, Karin A Stephenson, Sylvain Houle, Neil Vasdev. Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors. Nuclear medicine and biology. 2008 Apr; 35(3):305-14. doi: 10.1016/j.nucmedbio.2007.12.009. [PMID: 18355686]