1-(3-Methylbenzoyl)-1H-indazole-3-carbonitrile (BioDeep_00000177268)
human metabolite blood metabolite
代谢物信息卡片
1-(3-Methylbenzoyl)-1H-indazole-3-carbonitrile
化学式: C16H11N3O (261.0902076)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 95.45%
分子结构信息
SMILES: CC1=CC(=CC=C1)C(=O)N2C3=CC=CC=C3C(=N2)C#N
InChI: InChI=1S/C16H11N3O/c1-11-5-4-6-12(9-11)16(20)19-15-8-3-2-7-13(15)14(10-17)18-19/h2-9H,1H3
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
同义名列表
13 个代谢物同义名
1-(3-Methylbenzoyl)-1H-indazole-3-carbonitrile; 1-(3-methylbenzoyl)indazole-3-carbonitrile; Proteinase inhibitory proteins, secretory; Proteinase inhibitory peptides, secretory; Peptidase inhibitory proteins, secretory; Peptidase inhibitory peptides, secretory; Protease inhibitory proteins, secretory; Protease inhibitory peptides, secretory; Inhibitors, neutrophil elastase; Elastase inhibitors, neutrophil; Elastase inhibitor, neutrophil; Inhibitor, neutrophil elastase; Neutrophil elastase inhibitors
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 71818549
- HMDB: HMDB0249950
- ChEMBL: CHEMBL2409450
- MeSH: Proteinase Inhibitory Proteins, Secretory
- chemspider: 30820011
- CAS: 1448314-31-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tsong-Long Hwang, Jing-Yi Lin, Liang-Mou Kuo, Ganesh Kumar Dhandabani, Pei-Wen Hsieh. Design and synthesis of sirtinol analogs as human neutrophil elastase inhibitors.
Bioorganic & medicinal chemistry letters.
2023 Nov; ?(?):129544. doi:
10.1016/j.bmcl.2023.129544. [PMID: 37939864] - Fumiki Yamashita, Takashi Kaieda, Takeshi Shimomura, Makiko Kawaguchi, Chen-Yong Lin, Michael D Johnson, Hiroyuki Tanaka, Takumi Kiwaki, Tsuyoshi Fukushima, Hiroaki Kataoka. Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor-1.
The FEBS journal.
2022 Jun; 289(12):3422-3439. doi:
10.1111/febs.16348. [PMID: 35020274] - Guang-Jie Nie, Jian Liu, Ai-Mei Zou, Shao-Feng Zhan, Jia-Kang Liang, Yi Sui, Yu-Ning Chen, Wei-Shen Yao. Methylation- and homologous recombination deficiency-related mutant genes predict the prognosis of lung adenocarcinoma.
Journal of clinical laboratory analysis.
2022 Apr; 36(4):e24277. doi:
10.1002/jcla.24277. [PMID: 35238419] - Claire Barbieux, Mathilde Bonnet des Claustres, Matthias Fahrner, Evgeniya Petrova, Lam C Tsoi, Olivier Gouin, Florent Leturcq, Pascale Nicaise-Roland, Christine Bole, Vivien Béziat, Emmanuelle Bourrat, Oliver Schilling, Johann E Gudjonsson, Alain Hovnanian. Netherton syndrome subtypes share IL-17/IL-36 signature with distinct IFN-α and allergic responses.
The Journal of allergy and clinical immunology.
2022 04; 149(4):1358-1372. doi:
10.1016/j.jaci.2021.08.024. [PMID: 34543653] - Aykut Colakerol, Serhat Suzan, Mustafa Zafer Temiz, Serkan Gonultas, Serdar Aykan, Sule Ozsoy, Suat Hayri Kucuk, Emrah Yuruk, Engin Kandırali, Atilla Semercioz. Tissue neutrophil elastase contributes to extracorporeal shock wave lithotripsy-induced kidney damage and the neutrophil elastase inhibitor, sivelestat, attenuates kidney damage with gratifying immunohistopathological and biochemical findings: an experimental study.
Urolithiasis.
2022 Feb; 50(1):103-112. doi:
10.1007/s00240-021-01287-x. [PMID: 34778918] - Yali Sun, Xianfei Ding, Yuqing Cui, Hongyi Li, Dong Wang, Huoyan Liang, Shaohua Liu, Xiaojuan Zhang, Haixu Wang, Tongwen Sun. Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats.
Frontiers in cellular and infection microbiology.
2022; 12(?):818391. doi:
10.3389/fcimb.2022.818391. [PMID: 35372122] - Zeguo Jia, Lei Liu, Shiqian Zhang, Xiaotong Zhao, Li Luo, Yizhong Tang, Bing Shen, Mingwei Chen. Proteomics changes after negative pressure wound therapy in diabetic foot ulcers.
Molecular medicine reports.
2021 12; 24(6):. doi:
10.3892/mmr.2021.12474. [PMID: 34608502] - Yingying Sun, Jie Jin, Hongyan Jing, Yingying Lu, Qingqing Zhu, Changjuan Shu, Qinghua Zhang, Dadao Jing. ITIH4 is a novel serum biomarker for early gastric cancer diagnosis.
Clinica chimica acta; international journal of clinical chemistry.
2021 Dec; 523(?):365-373. doi:
10.1016/j.cca.2021.10.022. [PMID: 34687700] - Alan A S Silva, Tamiris R F Raimundo, Noemia A P Mariani, Hélio Kushima, Maria Christina W Avellar, Mariano G Buffone, Fabíola F Paula-Lopes, Marcelo T Moura, Erick J R Silva. Dissecting EPPIN protease inhibitor domains in sperm motility and fertilizing ability: repercussions for male contraceptive development.
Molecular human reproduction.
2021 11; 27(12):. doi:
10.1093/molehr/gaab066. [PMID: 34792600] - Lela Lackey, Aaztli Coria, Auyon J Ghosh, Phil Grayeski, Abigail Hatfield, Vijay Shankar, John Platig, Zhonghui Xu, Silvia B V Ramos, Edwin K Silverman, Victor E Ortega, Michael H Cho, Craig P Hersh, Brian D Hobbs, Peter Castaldi, Alain Laederach. Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease.
PLoS genetics.
2021 11; 17(11):e1009912. doi:
10.1371/journal.pgen.1009912. [PMID: 34784346] - Fei Tian, Peiyun Wang, Dan Lin, Jiajia Dai, Qibing Liu, Yu Guan, Yang Zhan, Yichen Yang, Wenpeng Wang, Jiefu Wang, Jia Liu, Lei Zheng, Yan Zhuang, Jun Hu, Junfeng Wang, Dalu Kong, Kegan Zhu. Exosome-delivered miR-221/222 exacerbates tumor liver metastasis by targeting SPINT1 in colorectal cancer.
Cancer science.
2021 Sep; 112(9):3744-3755. doi:
10.1111/cas.15028. [PMID: 34125460] - Blas Larrauri, C Garren Hester, Haixiang Jiang, Vojislav D Miletic, Alejandro Malbran, Konrad Bork, Allen Kaplan, Michael Frank. Analysis of cold activation of the contact system in hereditary angioedema with normal C1 inhibitor.
Molecular immunology.
2021 08; 136(?):150-160. doi:
10.1016/j.molimm.2021.06.009. [PMID: 34153620] - Grace Hogan, Pierce Geoghegan, Tomás P Carroll, Jennifer Clarke, Oisín F McElvaney, Oliver J McElvaney, Noel G McElvaney, Gerard F Curley. α1-Antitrypsin: Key Player or Bystander in Acute Respiratory Distress Syndrome?.
Anesthesiology.
2021 05; 134(5):792-808. doi:
10.1097/aln.0000000000003727. [PMID: 33721888] - Min Xu, Liang Wang, Jiawen Yin, Jinglin Xiong, Qing Guo, Wenlin Yang. Establishment of an induced pluripotent stem cell line (SAHGMUi001-A) from a patient with Netherton syndrome carrying SPINK5 mutation.
Stem cell research.
2021 03; 51(?):102213. doi:
10.1016/j.scr.2021.102213. [PMID: 33556917] - A Osada, I Matsumoto, N Mikami, A Ohyama, I Kurata, Y Kondo, H Tsuboi, A Ishigami, Y Sano, T Arai, N Ise, T Sumida. Citrullinated inter-alpha-trypsin inhibitor heavy chain 4 in arthritic joints and its potential effect in the neutrophil migration.
Clinical and experimental immunology.
2021 03; 203(3):385-399. doi:
10.1111/cei.13556. [PMID: 33238047] - Yating Ma, Ruibing Li, Jianan Wang, Wencan Jiang, Xiaozhou Yuan, Jiayue Cui, Chengbin Wang. ITIH4, as an inflammation biomarker, mainly increases in bacterial bloodstream infection.
Cytokine.
2021 02; 138(?):155377. doi:
10.1016/j.cyto.2020.155377. [PMID: 33348064] - Pablo Fuentes-Prior. Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection.
The Journal of biological chemistry.
2021 Jan; 296(?):100135. doi:
10.1074/jbc.rev120.015980. [PMID: 33268377] - Adeleh Sahebnasagh, Fatemeh Saghafi, Mohammadreza Safdari, Masoud Khataminia, Afsaneh Sadremomtaz, Zeinab Talaei, Hassan Rezai Ghaleno, Mahdi Bagheri, Solomon Habtemariam, Razieh Avan. Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
Journal of clinical pharmacy and therapeutics.
2020 Dec; 45(6):1515-1519. doi:
10.1111/jcpt.13251. [PMID: 32860252] - Shota Ozawa, Masaya Matsubayashi, Hitoki Nanaura, Motoko Yanagita, Kiyoshi Mori, Katsuhiko Asanuma, Nobuyuki Kajiwara, Kazuyuki Hayashi, Hiroshi Ohashi, Masato Kasahara, Hideki Yokoi, Hiroaki Kataoka, Eiichiro Mori, Takahiko Nakagawa. Proteolytic cleavage of Podocin by Matriptase exacerbates podocyte injury.
The Journal of biological chemistry.
2020 11; 295(47):16002-16012. doi:
10.1074/jbc.ra120.013721. [PMID: 32907879] - Deanna L Plubell, Alex M Fenton, Sara Rosario, Paige Bergstrom, Phillip A Wilmarth, Wayne M Clark, Neil A Zakai, Joseph F Quinn, Jessica Minnier, Nabil J Alkayed, Sergio Fazio, Nathalie Pamir. High-Density Lipoprotein Carries Markers That Track With Recovery From Stroke.
Circulation research.
2020 10; 127(10):1274-1287. doi:
10.1161/circresaha.120.316526. [PMID: 32844720] - Mireille Laforge, Carole Elbim, Corinne Frère, Miryana Hémadi, Charbel Massaad, Philippe Nuss, Jean-Jacques Benoliel, Chrystel Becker. Tissue damage from neutrophil-induced oxidative stress in COVID-19.
Nature reviews. Immunology.
2020 09; 20(9):515-516. doi:
10.1038/s41577-020-0407-1. [PMID: 32728221] - Mahmoud M A Mohamed, Ismail Amr El-Shimy, Muhammad Abdul Hadi. Neutrophil Elastase Inhibitors: A potential prophylactic treatment option for SARS-CoV-2-induced respiratory complications?.
Critical care (London, England).
2020 06; 24(1):311. doi:
10.1186/s13054-020-03023-0. [PMID: 32513225] - Signe Skovbjerg, Lasse Holt-Danborg, Annika W Nonboe, Zebin Hong, Ásdís K Frost, Christine R Schar, Cecilia C Thomas, Lars Vitved, Jan K Jensen, Lotte K Vogel. Inhibition of an active zymogen protease: the zymogen form of matriptase is regulated by HAI-1 and HAI-2.
The Biochemical journal.
2020 05; 477(9):1779-1794. doi:
10.1042/bcj20200182. [PMID: 32338287] - Tu'uhevaha J Kaitu'u-Lino, Teresa M MacDonald, Ping Cannon, Tuong-Vi Nguyen, Richard J Hiscock, Nick Haan, Jenny E Myers, Roxanne Hastie, Kirsten M Dane, Anna L Middleton, Intissar Bittar, Amanda N Sferruzzi-Perri, Natasha Pritchard, Alesia Harper, Natalie J Hannan, Valerie Kyritsis, Nick Crinis, Lisa Hui, Susan P Walker, Stephen Tong. Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction.
Nature communications.
2020 05; 11(1):2411. doi:
10.1038/s41467-020-16346-x. [PMID: 32415092] - Blas Larrauri, C Garren Hester, Haixiang Jiang, Vojislav D Miletic, Alejandro Malbran, Konrad Bork, Allen Kaplan, Michael Frank. sgp120 and the contact system in hereditary angioedema: A diagnostic tool in HAE with normal C1 inhibitor.
Molecular immunology.
2020 03; 119(?):27-34. doi:
10.1016/j.molimm.2020.01.003. [PMID: 31955064] - Michael Rose, Sarah Bringezu, Laura Godfrey, David Fiedler, Nadine T Gaisa, Maximilian Koch, Christian Bach, Susanne Füssel, Alexander Herr, Doreen Hübner, Jörg Ellinger, David Pfister, Ruth Knüchel, Manfred P Wirth, Manja Böhme, Edgar Dahl. ITIH5 and ECRG4 DNA Methylation Biomarker Test (EI-BLA) for Urine-Based Non-Invasive Detection of Bladder Cancer.
International journal of molecular sciences.
2020 Feb; 21(3):. doi:
10.3390/ijms21031117. [PMID: 32046186] - Chun-Che Tseng, Bailing Jia, Robert B Barndt, Yang-Hong Dai, Yu Hsin Chen, Po-Wen A Du, Jehng-Kang Wang, Hung-Jen Tang, Chen-Yong Lin, Michael D Johnson. The intracellular seven amino acid motif EEGEVFL is required for matriptase vesicle sorting and translocation to the basolateral plasma membrane.
PloS one.
2020; 15(2):e0228874. doi:
10.1371/journal.pone.0228874. [PMID: 32049977] - Yuxuan Fan, Wei Yang, Qingxia Yan, Chunrui Chen, Jinhua Li. Genome-Wide Identification and Expression Analysis of the Protease Inhibitor Gene Families in Tomato.
Genes.
2019 12; 11(1):. doi:
10.3390/genes11010001. [PMID: 31861342] - Ningning Zhang, Tristen Wright, Paige Caraway, Jianfeng Xu. Enhanced secretion of human α1-antitrypsin expressed with a novel glycosylation module in tobacco BY-2 cell culture.
Bioengineered.
2019 12; 10(1):87-97. doi:
10.1080/21655979.2019.1604037. [PMID: 30957636] - Lourdes Soler, Natalia García, Marta Andrés, Ramón Armengol, Fermín Lampreave, María A Alava, Matilde Piñeiro. Development and validation of an ELISA for the quantification of bovine ITIH4 in serum and milk.
Veterinary immunology and immunopathology.
2019 Nov; 217(?):109922. doi:
10.1016/j.vetimm.2019.109922. [PMID: 31450165] - Krishna Kant, Anil K Tomar, Pankaj Sharma, Bishwajit Kundu, Sarman Singh, Savita Yadav. Human Epididymis Protein 4 Quantification and Interaction Network Analysis in Seminal Plasma.
Protein and peptide letters.
2019 Jul; 26(6):458-465. doi:
10.2174/0929866526666190327124919. [PMID: 30919767] - Naohiko Nakamura, Etsuro Hatano, Kohta Iguchi, Motohiko Sato, Hiroaki Kawaguchi, Iwao Ohtsu, Takaki Sakurai, Nobuhiro Aizawa, Hiroko Iijima, Shuhei Nishiguchi, Takuya Tomono, Yukihiro Okuda, Seidai Wada, Satoru Seo, Kojiro Taura, Shinji Uemoto, Masaya Ikegawa. Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study.
BMC cancer.
2019 Jun; 19(1):621. doi:
10.1186/s12885-019-5825-8. [PMID: 31238892] - Henrik Watz, Johannes Nagelschmitz, Anne Kirsten, Frauke Pedersen, Dorina van der Mey, Stephan Schwers, Tiemo-Joerg Bandel, Klaus F Rabe. Safety and efficacy of the human neutrophil elastase inhibitor BAY 85-8501 for the treatment of non-cystic fibrosis bronchiectasis: A randomized controlled trial.
Pulmonary pharmacology & therapeutics.
2019 06; 56(?):86-93. doi:
10.1016/j.pupt.2019.03.009. [PMID: 30917927] - Thomas F McElrath, David E Cantonwine, Arun Jeyabalan, Robert C Doss, Gail Page, James M Roberts, Brian Brohman, Zhen Zhang, Kevin P Rosenblatt. Circulating microparticle proteins obtained in the late first trimester predict spontaneous preterm birth at less than 35 weeks' gestation: a panel validation with specific characterization by parity.
American journal of obstetrics and gynecology.
2019 05; 220(5):488.e1-488.e11. doi:
10.1016/j.ajog.2019.01.220. [PMID: 30690014] - Michaela Kohlová, Célia Gomes Amorim, Alberto Araújo, Alice Santos-Silva, Petr Solich, Maria Conceição B S M Montenegro. The biocompatibility and bioactivity of hemodialysis membranes: their impact in end-stage renal disease.
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs.
2019 Mar; 22(1):14-28. doi:
10.1007/s10047-018-1059-9. [PMID: 30006787] - Yong Jiang, Xiaohu Zheng, Defeng Jiao, Peng Chen, Yechuan Xu, Haiming Wei, Yeben Qian. Peptidase inhibitor 15 as a novel blood diagnostic marker for cholangiocarcinoma.
EBioMedicine.
2019 Feb; 40(?):422-431. doi:
10.1016/j.ebiom.2018.12.063. [PMID: 30638862] - John C Rowe, Zayed Attia, Eunsoo Kim, Estelle Cormet-Boyaka, Prosper N Boyaka. A Novel Supplementation Approach to Enhance Host Response to Sublingual Vaccination.
Scientific reports.
2019 01; 9(1):715. doi:
10.1038/s41598-018-36370-8. [PMID: 30679470] - Xiao Jiang, Xiao-Yan Bai, Bowen Li, Yanan Li, Kangkai Xia, Miao Wang, Shujing Li, Huijian Wu. Plasma Inter-Alpha-Trypsin Inhibitor Heavy Chains H3 and H4 Serve as Novel Diagnostic Biomarkers in Human Colorectal Cancer.
Disease markers.
2019; 2019(?):5069614. doi:
10.1155/2019/5069614. [PMID: 31481982] - Lan Li, Bum-Chae Choi, Ji Eun Ryoo, Sang-Jin Song, Chang-Zhu Pei, Kwang Yul Lee, Jinyoung Paek, Kwang-Hyun Baek. Opposing roles of inter-α-trypsin inhibitor heavy chain 4 in recurrent pregnancy loss.
EBioMedicine.
2018 Nov; 37(?):535-546. doi:
10.1016/j.ebiom.2018.10.029. [PMID: 30348621] - Friederike Grosse-Holz, Luisa Madeira, Muhammad Awais Zahid, Molly Songer, Jiorgos Kourelis, Mary Fesenko, Sabrina Ninck, Farnusch Kaschani, Markus Kaiser, Renier A L van der Hoorn. Three unrelated protease inhibitors enhance accumulation of pharmaceutical recombinant proteins in Nicotiana benthamiana.
Plant biotechnology journal.
2018 10; 16(10):1797-1810. doi:
10.1111/pbi.12916. [PMID: 29509983] - Soe Soe Htwe, Hidenori Wake, Keyue Liu, Kiyoshi Teshigawara, Barbara S Stonestreet, Yow-Pin Lim, Masahiro Nishibori. Inter-α inhibitor proteins maintain neutrophils in a resting state by regulating shape and reducing ROS production.
Blood advances.
2018 08; 2(15):1923-1934. doi:
10.1182/bloodadvances.2018018986. [PMID: 30093530] - Xiaohan Li, Bo Li, Boan Li, Tongsheng Guo, Zhiqiang Sun, Xiaoxi Li, Lin Chen, Weijiao Chen, Peng Chen, Yuanli Mao, Yanjun Zeng. ITIH4: Effective Serum Marker, Early Warning and Diagnosis, Hepatocellular Carcinoma.
Pathology oncology research : POR.
2018 Jul; 24(3):663-670. doi:
10.1007/s12253-017-0285-4. [PMID: 28828637] - Eun-Jung Lee, Seung-Hyun Yang, Kyoung-Jin Kim, Hyejung Cha, Seo Jin Lee, Ji-Hye Kim, Junkyu Song, Kyung-Hee Chun, Jinsil Seong. Inter-alpha Inhibitor H4 as a Potential Biomarker Predicting the Treatment Outcomes in Patients with Hepatocellular Carcinoma.
Cancer research and treatment.
2018 Jul; 50(3):646-657. doi:
10.4143/crt.2016.550. [PMID: 28724284] - Roni Lehmann-Werman, Judith Magenheim, Joshua Moss, Daniel Neiman, Ofri Abraham, Sheina Piyanzin, Hai Zemmour, Ilana Fox, Talya Dor, Markus Grompe, Giora Landesberg, Bao-Li Loza, Abraham Shaked, Kim Olthoff, Benjamin Glaser, Ruth Shemer, Yuval Dor. Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA.
JCI insight.
2018 06; 3(12):. doi:
10.1172/jci.insight.120687. [PMID: 29925683] - Jieru Wang, Xiaojie Zhu, Xuekai Xiong, Pan Ge, Han Liu, Ningning Ren, Farhan Anwar Khan, Xia Zhou, Li Zhang, Xu Yuan, Xi Chen, Yingyu Chen, Changmin Hu, Ian D Robertson, Huanchun Chen, Aizhen Guo. Identification of potential urine proteins and microRNA biomarkers for the diagnosis of pulmonary tuberculosis patients.
Emerging microbes & infections.
2018 Apr; 7(1):63. doi:
10.1038/s41426-018-0066-5. [PMID: 29636444] - Hoshimi Kawaguchi, Isao Matsumoto, Atsumu Osada, Izumi Kurata, Hiroshi Ebe, Yuki Tanaka, Asuka Inoue, Naoto Umeda, Yuya Kondo, Hiroto Tsuboi, Yasuhiro Shinkai, Yoshito Kumagai, Akihito Ishigami, Takayuki Sumida. Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis.
Arthritis research & therapy.
2018 04; 20(1):66. doi:
10.1186/s13075-018-1562-7. [PMID: 29636082] - Aaron C Mitchell, Deepti Kannan, Sean A Hunter, R Andres Parra Sperberg, Cheryl H Chang, Jennifer R Cochran. Engineering a potent inhibitor of matriptase from the natural hepatocyte growth factor activator inhibitor type-1 (HAI-1) protein.
The Journal of biological chemistry.
2018 04; 293(14):4969-4980. doi:
10.1074/jbc.m117.815142. [PMID: 29386351] - Elsa Bronze-da-Rocha, Alice Santos-Silva. Neutrophil Elastase Inhibitors and Chronic Kidney Disease.
International journal of biological sciences.
2018; 14(10):1343-1360. doi:
10.7150/ijbs.26111. [PMID: 30123081] - Tooba Naz Shamsi, Romana Parveen, Huma Naz, Md Anzarul Haque, Sadaf Fatima. Biophysical insight into structure-function relation of Allium sativum Protease Inhibitor by thermal, chemical and pH-induced modulation using comprehensive spectroscopic analysis.
International journal of biological macromolecules.
2017 Oct; 103(?):415-423. doi:
10.1016/j.ijbiomac.2017.05.075. [PMID: 28528000] - Ramesh Tati, Ann-Charlotte Kristoffersson, Minola Manea Hedström, Matthias Mörgelin, Jörgen Wieslander, Cees van Kooten, Diana Karpman. Neutrophil Protease Cleavage of Von Willebrand Factor in Glomeruli - An Anti-thrombotic Mechanism in the Kidney.
EBioMedicine.
2017 Feb; 16(?):302-311. doi:
10.1016/j.ebiom.2017.01.032. [PMID: 28139439] - Ai Kanemaru, Koji Yamamoto, Makiko Kawaguchi, Tsuyoshi Fukushima, Chen-Yong Lin, Michael D Johnson, Eric Camerer, Hiroaki Kataoka. Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer-associated fibroblasts by paracrine activation of protease-activated receptor 2.
International journal of cancer.
2017 Jan; 140(1):130-141. doi:
10.1002/ijc.30426. [PMID: 27615543] - Shining Loo, Antony Kam, Tianshu Xiao, Giang K T Nguyen, Chuan Fa Liu, James P Tam. Identification and Characterization of Roseltide, a Knottin-type Neutrophil Elastase Inhibitor Derived from Hibiscus sabdariffa.
Scientific reports.
2016 12; 6(?):39401. doi:
10.1038/srep39401. [PMID: 27991569] - Michael Regn, Bernhard Laggerbauer, Claudia Jentzsch, Deepak Ramanujam, Andrea Ahles, Sonja Sichler, Julia Calzada-Wack, Rory R Koenen, Attila Braun, Bernhard Nieswandt, Stefan Engelhardt. Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium.
Journal of molecular and cellular cardiology.
2016 Oct; 99(?):57-64. doi:
10.1016/j.yjmcc.2016.08.010. [PMID: 27539859] - Jornt Spit, Michiel Holtof, Liesbet Badisco, Lucia Vergauwen, Elise Vogel, Dries Knapen, Jozef Vanden Broeck. Transcriptional Analysis of The Adaptive Digestive System of The Migratory Locust in Response to Plant Defensive Protease Inhibitors.
Scientific reports.
2016 09; 6(?):32460. doi:
10.1038/srep32460. [PMID: 27581362] - Q Wang, X Su, X Jiang, X Dong, Y Fan, J Zhang, C Yu, W Gao, S Shi, J Jiang, W Jiang, T Wei. iTRAQ technology-based identification of human peripheral serum proteins associated with depression.
Neuroscience.
2016 08; 330(?):291-325. doi:
10.1016/j.neuroscience.2016.05.055. [PMID: 27268281] - Zebin Hong, Laura De Meulemeester, Annemarie Jacobi, Jan Skov Pedersen, J Preben Morth, Peter A Andreasen, Jan K Jensen. Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN.
The Journal of biological chemistry.
2016 Jul; 291(27):14340-14355. doi:
10.1074/jbc.m115.707240. [PMID: 27189939] - Lorenzo Di Cesare Mannelli, Laura Micheli, Lorenzo Cinci, Mario Maresca, Claudia Vergelli, Alessandra Pacini, Mark T Quinn, Maria Paola Giovannoni, Carla Ghelardini. Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis.
Rheumatology (Oxford, England).
2016 07; 55(7):1285-94. doi:
10.1093/rheumatology/kew055. [PMID: 27032424] - Katariina Hannula-Jouppi, Satu-Leena Laasanen, Mette Ilander, Laetitia Furio, Mirja Tuomiranta, Riitta Marttila, Leila Jeskanen, Valtteri Häyry, Mervi Kanerva, Sirpa Kivirikko, Marja-Leena Tuomi, Hannele Heikkilä, Satu Mustjoki, Alain Hovnanian, Annamari Ranki. Intrafamily and Interfamilial Phenotype Variation and Immature Immunity in Patients With Netherton Syndrome and Finnish SPINK5 Founder Mutation.
JAMA dermatology.
2016 Apr; 152(4):435-42. doi:
10.1001/jamadermatol.2015.5827. [PMID: 26865388] - Britta Frederiksen-Møller, Jan S Jørgensen, Mie R Hansen, Oliver Krigslund, Lotte K Vogel, Louise B Andersen, Boye L Jensen. Prostasin and matriptase (ST14) in placenta from preeclamptic and healthy pregnant women.
Journal of hypertension.
2016 Feb; 34(2):298-306. doi:
10.1097/hjh.0000000000000795. [PMID: 26867056] - Xue Fei Tan, Dae Wook Kim, Yeong Hun Song, Jeong Yoon Kim, Heung Joo Yuk, Yan Wang, Marcus J Curtis-Long, Ki Hun Park. Human neutrophil elastase inhibitory potential of flavonoids from Campylotropis hirtella and their kinetics.
Journal of enzyme inhibition and medicinal chemistry.
2016; 31(sup1):16-22. doi:
10.3109/14756366.2015.1118683. [PMID: 27558014] - Chungang Gu, Richard J Lewis, Andrew S Wells, Per H Svensson, Vinayak P Hosagrahara, Eskil Johnsson, Gösta Hallström. Lipid Peroxide-Mediated Oxidative Rearrangement of the Pyrazinone Carboxamide Core of Neutrophil Elastase Inhibitor AZD9819 in Blood Plasma Samples.
Drug metabolism and disposition: the biological fate of chemicals.
2015 Oct; 43(10):1441-9. doi:
10.1124/dmd.115.065136. [PMID: 26203069] - Natalya G Kormosh, Tatyana V Davidova, Vladimir N Kopyltsov, Marina V Serebryakova, Aigul O Kabieva, Konstantin E Voyushin, Suriya M Sitdikova, Berick S Amandzholov, Michail V Kiselevskii, Fedor V Donenko. Conformational changes in inter-α-trypsin inhibitor heavy chain 4 activate its tumor-specific activity in mice with B16 melanoma.
Molecular medicine reports.
2015 Sep; 12(3):4483-4493. doi:
10.3892/mmr.2015.3961. [PMID: 26094694] - Yung-Fong Tsai, Tsong-Long Hwang. Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).
Expert opinion on therapeutic patents.
2015; 25(10):1145-58. doi:
10.1517/13543776.2015.1061998. [PMID: 26118988] - Kang-Yun Lee, Po-Hao Feng, Shu-Chuan Ho, Kai-Jen Chuang, Tzu-Tao Chen, Chien-Ling Su, Wen-Te Liu, Hsiao-Chi Chuang. Inter-alpha-trypsin inhibitor heavy chain 4: a novel biomarker for environmental exposure to particulate air pollution in patients with chronic obstructive pulmonary disease.
International journal of chronic obstructive pulmonary disease.
2015; 10(?):831-41. doi:
10.2147/copd.s81611. [PMID: 25977605] - Xinliang Ding, Jie Zhang. [The association study between Eppin gene polymorphisms and idiopathic male infertility].
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].
2014 Dec; 48(12):1072-7. doi:
NULL. [PMID: 25619219] - Sarika Namjoshi, Istvan Toth, Joanne T Blanchfield, Nicholas Trotter, Ricardo L Mancera, Heather A E Benson. Enhanced transdermal peptide delivery and stability by lipid conjugation: epidermal permeation, stereoselectivity and mechanistic insights.
Pharmaceutical research.
2014 Dec; 31(12):3304-12. doi:
10.1007/s11095-014-1420-5. [PMID: 24842663] - Jayme S Bosler, Kelvin P Davies, Genevieve S Neal-Perry. Peptides in seminal fluid and their role in infertility: a potential role for opiorphin inhibition of neutral endopeptidase activity as a clinically relevant modulator of sperm motility: a review.
Reproductive sciences (Thousand Oaks, Calif.).
2014 Nov; 21(11):1334-40. doi:
10.1177/1933719114536473. [PMID: 24855109] - Melanie M Ivancic, Amy A Irving, Kelli G Jonakin, William F Dove, Michael R Sussman. The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats.
Cancer prevention research (Philadelphia, Pa.).
2014 Nov; 7(11):1160-9. doi:
10.1158/1940-6207.capr-14-0056. [PMID: 25200834] - Peter M Elias, Joan S Wakefield. Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis.
The Journal of allergy and clinical immunology.
2014 Oct; 134(4):781-791.e1. doi:
10.1016/j.jaci.2014.05.048. [PMID: 25131691] - Choong-Kyun Noh, Soon Sun Kim, Dong-Kyu Kim, Hyun-Young Lee, Hyo Jung Cho, So Young Yoon, Gil Ho Lee, Sun A Hyun, Yu Jeong Kim, Ho Joong Kim, Joo An Hwang, Seun Joo Ahn, Sung Jae Shin, Kee Myung Lee, Byung Moo Yoo, Sung Won Cho, Jae Youn Cheong. Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and prognostic indicator in patients with hepatitis B virus-associated hepatocellular carcinoma.
Clinical biochemistry.
2014 Sep; 47(13-14):1257-61. doi:
10.1016/j.clinbiochem.2014.05.002. [PMID: 24836184] - Kevin Brown Chandler, Zuzana Brnakova, Miloslav Sanda, Shuo Wang, Stephanie H Stalnaker, Robert Bridger, Peng Zhao, Lance Wells, Nathan J Edwards, Radoslav Goldman. Site-specific glycan microheterogeneity of inter-alpha-trypsin inhibitor heavy chain H4.
Journal of proteome research.
2014 Jul; 13(7):3314-29. doi:
10.1021/pr500394z. [PMID: 24884609] - Christina Tobin Kåhrström. Oomycetes: adaptation after jumping ship.
Nature reviews. Microbiology.
2014 Apr; 12(4):236-7. doi:
10.1038/nrmicro3234. [PMID: 24531615] - Suomeng Dong, Remco Stam, Liliana M Cano, Jing Song, Jan Sklenar, Kentaro Yoshida, Tolga O Bozkurt, Ricardo Oliva, Zhenyu Liu, Miaoying Tian, Joe Win, Mark J Banfield, Alexandra M E Jones, Renier A L van der Hoorn, Sophien Kamoun. Effector specialization in a lineage of the Irish potato famine pathogen.
Science (New York, N.Y.).
2014 Jan; 343(6170):552-5. doi:
10.1126/science.1246300. [PMID: 24482481] - Gitta Coaker. Botany. Pathogen specialization.
Science (New York, N.Y.).
2014 Jan; 343(6170):496-7. doi:
10.1126/science.1250171. [PMID: 24482473] - Wenwen Lu, Xinhua Wan, Bin Liu, Xianfang Rong, Lei Zhu, Pingping Li, Jiang Li, Ling Wang, Liying Cui, Xiaoliang Wang. Specific changes of serum proteins in Parkinson's disease patients.
PloS one.
2014; 9(4):e95684. doi:
10.1371/journal.pone.0095684. [PMID: 24769800] - Bai-Yao Wu, Shiao-Pieng Lee, Hui-Chung Hsiao, Han Chiu, Chi-Yung Chen, Yee Hui Yeo, Herng-Sheng Lee, Ya-Wen Chen, Malvika Kaul, Hiroaki Kataoka, Michael D Johnson, Jehng-Kang Wang, Chen-Yong Lin. Matriptase expression and zymogen activation in human pilosebaceous unit.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
2014 Jan; 62(1):50-9. doi:
10.1369/0022155413505599. [PMID: 24004857] - Jun Cao, Quanyan Liu. Protective effects of sivelestat in a caerulein-induced rat acute pancreatitis model.
Inflammation.
2013 Dec; 36(6):1348-56. doi:
10.1007/s10753-013-9674-3. [PMID: 23794035] - Arisa Akagi, Akihiko Kitoh, Catharina S Moniaga, Atsushi Fujimoto, Hiroki Fujikawa, Yutaka Shimomura, Yoshiki Miyachi, Kenji Kabashima. Case of Netherton syndrome with an elevated serum thymus and activation-regulated chemokine level.
The Journal of dermatology.
2013 Sep; 40(9):752-3. doi:
10.1111/1346-8138.12209. [PMID: 23802543] - Tengfei Zhang, Dan Zhao, Qiming Wang, Xiying Yu, Yaling Cui, Liping Guo, Shih Hsin Lu. MicroRNA-1322 regulates ECRG2 allele specifically and acts as a potential biomarker in patients with esophageal squamous cell carcinoma.
Molecular carcinogenesis.
2013 Aug; 52(8):581-90. doi:
10.1002/mc.21880. [PMID: 22315007] - Hirotaka Tanaka, Masamitsu Shimazawa, Masafumi Takata, Hideo Kaneko, Kazuhiro Tsuruma, Tsunehiko Ikeda, Hitoshi Warita, Masashi Aoki, Mitsunori Yamada, Hitoshi Takahashi, Isao Hozumi, Hiroshi Minatsu, Takashi Inuzuka, Hideaki Hara. ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis.
Journal of neurology.
2013 Jul; 260(7):1782-97. doi:
10.1007/s00415-013-6877-3. [PMID: 23436019] - Jia-ke Chai, Jian-hua Cai, Hu-ping Deng, Xiao-fang Zou, Wei Liu, Qing-gang Hu, Chuan-an Shen, Hui-nan Yin, Xi-bo Zhang, Yun-fei Chi, Li Ma, Rui Feng. Role of neutrophil elastase in lung injury induced by burn-blast combined injury in rats.
Burns : journal of the International Society for Burn Injuries.
2013 Jun; 39(4):745-53. doi:
10.1016/j.burns.2012.08.005. [PMID: 22999209] - N J Shimwell, R T Bryan, W Wei, N D James, K K Cheng, M P Zeegers, P J Johnson, A Martin, D G Ward. Combined proteome and transcriptome analyses for the discovery of urinary biomarkers for urothelial carcinoma.
British journal of cancer.
2013 May; 108(9):1854-61. doi:
10.1038/bjc.2013.157. [PMID: 23591195] - Robert Stockley, Anthony De Soyza, Kulasiri Gunawardena, John Perrett, Kristina Forsman-Semb, Neil Entwistle, Noel Snell. Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis.
Respiratory medicine.
2013 Apr; 107(4):524-33. doi:
10.1016/j.rmed.2012.12.009. [PMID: 23433769] - Huan-Chin Tseng, Robert Kuo-Kuang Lee, Yuh-Ming Hwu, Chung-Hao Lu, Ming-Huei Lin, Sheng-Hsiang Li. Mechanisms underlying the inhibition of murine sperm capacitation by the seminal protein, SPINKL.
Journal of cellular biochemistry.
2013 Apr; 114(4):888-98. doi:
10.1002/jcb.24428. [PMID: 23097296] - Brian R Larsen, Simon D R Steffensen, Nis V L Nielsen, Stine Friis, Sine Godiksen, Jette Bornholdt, Christoffer Soendergaard, Annika W Nonboe, Martin N Andersen, Steen S Poulsen, Roman Szabo, Thomas H Bugge, Chen-Yong Lin, Hanne Skovbjerg, Jan K Jensen, Lotte K Vogel. Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase.
Experimental cell research.
2013 Apr; 319(6):918-29. doi:
10.1016/j.yexcr.2013.01.008. [PMID: 23333561] - Naoki Fujimura, Hideaki Obara, Koichi Suda, Hiroya Takeuchi, Taku Miyasho, Kazufumi Kawasako, Wenlin Du, Shingo Yamada, Shigeshi Ono, Kenji Matsumoto, Sachiko Matsuda, Hiroshi Yagi, Minoru Kitago, Masahiro Shinoda, Osamu Itano, Minoru Tanabe, Michiie Sakamoto, Ikuro Maruyama, Yuko Kitagawa. Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats.
The Journal of surgical research.
2013 Mar; 180(1):e31-6. doi:
10.1016/j.jss.2012.04.037. [PMID: 22595015] - Vera Kloten, Birte Becker, Kirsten Winner, Michael G Schrauder, Peter A Fasching, Tobias Anzeneder, Jürgen Veeck, Arndt Hartmann, Ruth Knüchel, Edgar Dahl. Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening.
Breast cancer research : BCR.
2013 Jan; 15(1):R4. doi:
10.1186/bcr3375. [PMID: 23320751] - Asish K Ghosh, Sheila B Murphy, Raj Kishore, Douglas E Vaughan. Global gene expression profiling in PAI-1 knockout murine heart and kidney: molecular basis of cardiac-selective fibrosis.
PloS one.
2013; 8(5):e63825. doi:
10.1371/journal.pone.0063825. [PMID: 23724005] - Qiaojun Wen, Linda Y Liu, Ting Yang, Cantas Alev, Shuaibin Wu, David K Stevenson, Guojun Sheng, Atul J Butte, Xuefeng B Ling. Peptidomic Identification of Serum Peptides Diagnosing Preeclampsia.
PloS one.
2013; 8(6):e65571. doi:
10.1371/journal.pone.0065571. [PMID: 23840341] - ". [Heterologous expression, purification, and properties of a chymotrypsin inhibitor isolated from potatoes].
Prikladnaia biokhimiia i mikrobiologiia.
2013 Jan; 49(1):34-40. doi:
". [PMID: 23662448] - Seigo Miyoshi, Hironobu Hamada, Ryoji Ito, Hitoshi Katayama, Kazunori Irifune, Toshimitsu Suwaki, Norihiko Nakanishi, Takanori Kanematsu, Kentaro Dote, Mayuki Aibiki, Takafumi Okura, Jitsuo Higaki. Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
Drug design, development and therapy.
2013; 7(?):305-16. doi:
10.2147/dddt.s42004. [PMID: 23596346] - Chia-Lin Lee, Tsong-Long Hwang, Chieh-Yu Peng, Chao-Jung Chen, Yuan-Shiun Chang, Yang-Chang Wu. Anti-neutrophilic inflammatory secondary metabolites from the traditional Chinese medicine, Tiankuizi.
Natural product communications.
2012 Dec; 7(12):1623-6. doi:
. [PMID: 23413568] - Koji Izumi, Yi Li, Yichun Zheng, Jennifer Gordetsky, Jorge L Yao, Hiroshi Miyamoto. Seminal plasma proteins in prostatic carcinoma: increased nuclear semenogelin I expression is a predictor of biochemical recurrence after radical prostatectomy.
Human pathology.
2012 Nov; 43(11):1991-2000. doi:
10.1016/j.humpath.2012.02.008. [PMID: 22617231] - María Belén Fernández, Mariana Romina Pagano, Gustavo Raúl Daleo, María Gabriela Guevara. Hydrophobic proteins secreted into the apoplast may contribute to resistance against Phytophthora infestans in potato.
Plant physiology and biochemistry : PPB.
2012 Nov; 60(?):59-66. doi:
10.1016/j.plaphy.2012.07.017. [PMID: 22902798] - J Stuart Elborn, John Perrett, Kristina Forsman-Semb, Joanna Marks-Konczalik, Kulasiri Gunawardena, Neil Entwistle. Efficacy, safety and effect on biomarkers of AZD9668 in cystic fibrosis.
The European respiratory journal.
2012 Oct; 40(4):969-76. doi:
10.1183/09031936.00194611. [PMID: 22267768] - Nadnudda Rodthongkum, Rajasekhar Ramireddy, S Thayumanavan, W Vachet Richard. Selective enrichment and sensitive detection of peptide and protein biomarkers in human serum using polymeric reverse micelles and MALDI-MS.
The Analyst.
2012 Feb; 137(4):1024-30. doi:
10.1039/c2an16089g. [PMID: 22193368] - Wei Tao, Qian-Bing Miao, Ya-Bing Zhu, Yu-Sheng Shu. Inhaled neutrophil elastase inhibitor reduces oleic acid-induced acute lung injury in rats.
Pulmonary pharmacology & therapeutics.
2012 Feb; 25(1):99-103. doi:
10.1016/j.pupt.2011.12.006. [PMID: 22210005] - Karine Morcel, Bruno Dallapiccola, Laurent Pasquier, Tanguy Watrin, Laura Bernardini, Daniel Guerrier. Clinical utility gene card for: Mayer-Rokitansky-Küster-Hauser syndrome.
European journal of human genetics : EJHG.
2012 Feb; 20(2):. doi:
10.1038/ejhg.2011.158. [PMID: 21897448] - Anja C Hörger, Muhammad Ilyas, Wolfgang Stephan, Aurélien Tellier, Renier A L van der Hoorn, Laura E Rose. Balancing selection at the tomato RCR3 Guardee gene family maintains variation in strength of pathogen defense.
PLoS genetics.
2012; 8(7):e1002813. doi:
10.1371/journal.pgen.1002813. [PMID: 22829777]