2-((2-((Dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (BioDeep_00000177263)
human metabolite blood metabolite
代谢物信息卡片
2-((2-((Dimethylamino)methyl)phenyl)thio)-5-iodophenylamine
化学式: C15H17IN2S (384.01571520000005)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: CN(C)CC1=CC=CC=C1SC1=C(N)C=C(I)C=C1
InChI: InChI=1S/C15H17IN2S/c1-18(2)10-11-5-3-4-6-14(11)19-15-8-7-12(16)9-13(15)17/h3-9H,10,17H2,1-2H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chih-Hsing Wu, Chin-Sung Chang, Yen Kuang Yang, Lie-Hang Shen, Wei-Jen Yao. Comparison of brain serotonin transporter using [I-123]-ADAM between obese and non-obese young adults without an eating disorder.
PloS one.
2017; 12(2):e0170886. doi:
10.1371/journal.pone.0170886. [PMID: 28182708] - Rong-Jiang Zhao, Shih-Hsien Lin, Lan-Ting Lee, I Hui Lee, Po See Chen, Kao Chin Chen, Yen Kuang Yang. Probing the Serotonin Transporter Availability Among Male Cigarette Smokers: A SPECT Study With [123I] ADAM.
Journal of addiction medicine.
2016 Mar; 10(2):89-92. doi:
10.1097/adm.0000000000000191. [PMID: 26742023] - Yuan-Hwa Chou, Jiing-Feng Lirng, Wen-Chi Hsieh, Yen-Chen Chiu, Yi-An Tu, Shyh-Jen Wang. Neither cortisol nor brain-derived neurotrophic factor is associated with serotonin transporter in bipolar disorder.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2016 Feb; 26(2):280-287. doi:
10.1016/j.euroneuro.2015.12.011. [PMID: 26706694] - Yuan-Hwa Chou, Wen-Chi Hsieh, Li-Chi Chen, Jiing-Feng Lirng, Shyh-Jen Wang. Association between the serotonin transporter and cytokines: Implications for the pathophysiology of bipolar disorder.
Journal of affective disorders.
2016 Feb; 191(?):29-35. doi:
10.1016/j.jad.2015.10.056. [PMID: 26630394] - Shih-Hsien Lin, I Hui Lee, Kao Chin Chen, Po See Chen, Nan Tsing Chiu, Wei Jen Yao, Yen Kuang Yang. Serotonin transporter availability may moderate the association between perceiving stress and depressive tendencies - A SPECT with 5-HTTLPR genotyping study.
Progress in neuro-psychopharmacology & biological psychiatry.
2015 Aug; 61(?):24-9. doi:
10.1016/j.pnpbp.2015.03.009. [PMID: 25816791] - H C Tsai, S-H Lin, P S Chen, H H Chang, I H Lee, T L Yeh, K C Chen, N T Chiu, W J Yao, M-H Liao, Y K Yang. Quantifying midbrain serotonin transporter in depression: a preliminary study of diagnosis and naturalistic treatment outcome.
Pharmacopsychiatry.
2015 Mar; 48(2):58-64. doi:
10.1055/s-0034-1396800. [PMID: 25626060] - P C Hsieh, K C Chen, T L Yeh, I H Lee, P S Chen, W J Yao, N-T Chiu, C-C Chen, M-H Liao, Y K Yang. Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder - a preliminary two-ligand SPECT study.
European psychiatry : the journal of the Association of European Psychiatrists.
2014 Sep; 29(7):414-8. doi:
10.1016/j.eurpsy.2013.11.004. [PMID: 24439516] - Maarika Liik, Malle Paris, Liina Vahter, Katrin Gross-Paju, Sulev Haldre. 123I-ADAM SPET imaging of serotonin transporter in patients with epilepsy and comorbid depression.
BMC neurology.
2013 Dec; 13(?):204. doi:
10.1186/1471-2377-13-204. [PMID: 24341899] - Hsiang Yu Huang, I Hui Lee, Kao Chin Chen, Shih-Hsien Lin, Tzung Lieh Yeh, Po See Chen, Nan-Tsing Chiu, We Jen Yao, Chia-Chieh Chen, Mei-Hsiu Liao, Yen Kuang Yang. Serotonin transporter availability in the midbrain and perceived social support in healthy volunteers.
Journal of psychosomatic research.
2013 Dec; 75(6):577-81. doi:
10.1016/j.jpsychores.2013.09.006. [PMID: 24290049] - Hsin Chun Tsai, Shih-Hsien Lin, I Hui Lee, Po See Chen, Kao Chin Chen, Tzung Lieh Yeh, Wei Jen Yao, Nan-Tsing Chiu, Ru-Band Lu, Yen Kuang Yang. Probing the association between dexamethasone-induced cortisol suppression and serotonin transporter availability among drug-free patients with major depressive disorder--a small-sample SPECT study with [¹²³I]ADAM.
Psychoneuroendocrinology.
2013 Nov; 38(11):2805-9. doi:
10.1016/j.psyneuen.2013.06.001. [PMID: 23816429] - Chao-Chuan Wang, Hui-Ching Lin, Yun-Han Chan, Po-Wu Gean, Yen Kung Yang, Po See Chen. 5-HT1A-receptor agonist modified amygdala activity and amygdala-associated social behavior in a valproate-induced rat autism model.
The international journal of neuropsychopharmacology.
2013 Oct; 16(9):2027-39. doi:
10.1017/s1461145713000473. [PMID: 23823694] - Jay D Amsterdam, Andrew B Newberg, Cory F Newman, Justine Shults, Nancy Wintering, Irene Soeller. Change over time in brain serotonin transporter binding in major depression: effects of therapy measured with [(123) I]-ADAM SPECT.
Journal of neuroimaging : official journal of the American Society of Neuroimaging.
2013 Oct; 23(4):469-76. doi:
10.1111/jon.12035. [PMID: 23751132] - Pinguan Zheng, Brian P Lieberman, Karl Ploessl, Laetitia Lemoine, Sara Miller, Hank F Kung. A new single-photon emission computed tomography (SPECT) imaging agent for serotonin transporters: [(125)I]Flip-IDAM, (2-((2-((dimethylamino)methyl)-4-iodophenyl)thio)phenyl)methanol.
Bioorganic & medicinal chemistry letters.
2013 Feb; 23(3):869-72. doi:
10.1016/j.bmcl.2012.11.043. [PMID: 23265880] - K W Chang, M C Lin, S Y Lee, H Y Chen, C C Chen, Y K Fu. Effects of [123I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague-Dawley rats.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2012 Nov; 70(11):2646-51. doi:
10.1016/j.apradiso.2012.06.024. [PMID: 22960183] - Shih-Hsien Lin, Kao Chin Chen, Sheng-Yu Lee, Wei Jen Yao, Nan-Tsing Chiu, I Hui Lee, Po See Chen, Tzung Lieh Yeh, Mei-Hsiu Liao, Ru-Band Lu, Yen Kuang Yang. The association between availability of serotonin transporters and time to relapse in heroin users: a two-isotope SPECT small sample pilot study.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2012 Sep; 22(9):647-50. doi:
10.1016/j.euroneuro.2012.01.002. [PMID: 22335891] - Hsiang-Yi Tsai, I Hui Lee, Tzung Lieh Yeh, Wei Jen Yao, Kao Chin Chen, Po See Chen, Nan-Tsing Chiu, Ru-Band Lu, Yen Kuang Yang. Association between the dexamethasone suppression test and serotonin transporter availability in healthy volunteer: a SPECT with [(123)I] ADAM study.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2012 Sep; 22(9):641-6. doi:
10.1016/j.euroneuro.2012.01.009. [PMID: 22356823] - Andrew B Newberg, Jay D Amsterdam, Nancy Wintering, Justine Shults. Low brain serotonin transporter binding in major depressive disorder.
Psychiatry research.
2012 May; 202(2):161-7. doi:
10.1016/j.pscychresns.2011.12.015. [PMID: 22698760] - Ming Hui Chou, Kao Chin Chen, Tzung Lieh Yeh, I Hui Lee, Wei Jen Yao, Po See Chen, Kang-Wei Chang, Mei-Hsiu Liao, Yen Kuang Yang. Association between somatization subscale score and serotonin transporter availability in healthy volunteers--a single photon emission computed tomography study with [¹²³I] ADAM.
Psychopharmacology.
2012 Feb; 219(4):1011-6. doi:
10.1007/s00213-011-2431-0. [PMID: 21845388] - Ju-Wei Hsu, Shyh-Jen Wang, Chun-Lung Lin, Wen-Chi Hsieh, Jiing-Feng Lirng, Yuh-Chiang Shen, Mei-Hsiu Liao, Yuan-Hwa Chou. Short term vs. long term test-retest reproducibility of ¹²³I-ADAM for the binding of serotonin transporters in the human brain.
Psychiatry research.
2011 Dec; 194(3):224-229. doi:
10.1016/j.pscychresns.2011.04.011. [PMID: 22079655] - Yu Shian Cheng, Kao Chin Chen, Yen Kuang Yang, Po See Chen, Tzung Lieh Yeh, I Hui Lee, Yun-Hsuan Chang, Mei-Hsiu Liao. No seasonal variation in human midbrain serotonin transporter availability in Taiwan.
Psychiatry research.
2011 Dec; 194(3):396-399. doi:
10.1016/j.pscychresns.2011.04.005. [PMID: 22041533] - I Hui Lee, Yen Kuang Yang, Po See Chen, Hui Chun Huang, Tzung Lieh Yeh, Ru-Band Lu, Nan-Tsing Chiu, Wei Jen Yao, Shih-Hsien Lin. Loudness dependence of auditory evoked potentials (LDAEP) correlates with the availability of dopamine transporters and serotonin transporters in healthy volunteers-a two isotopes SPECT study.
Psychopharmacology.
2011 Apr; 214(3):617-24. doi:
10.1007/s00213-010-2064-8. [PMID: 21072504] - Pei-Shen Ho, Mei-Chen Shih, Kuo-Hsing Ma, Wen-Sheng Huang, Kellen Kai-Jen Ho, Che-Hung Yen, Ru-Band Lu, San-Yuan Huang. Availability of the serotonin transporter in patients with alcohol dependence.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2011 Mar; 12(2):134-42. doi:
10.3109/15622975.2010.503813. [PMID: 20642399] - Pei Chun Hsieh, I Hui Lee, Tzung Lieh Yeh, Kao Chin Chen, Hui Chun Huang, Po See Chen, Yen Kuang Yang, Wei Jen Yao, Ru-Band Lu, Nan Tsing Chiu. Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression - a dual-isotope SPECT study.
Psychiatry research.
2010 Dec; 184(3):157-61. doi:
10.1016/j.pscychresns.2010.09.004. [PMID: 21030217] - Kang-Wei Chang, Chia-Chieh Chen, Shih-Ying Lee, Lie-Hang Shen, Hsin-Ell Wang. Development of acute and subacute toxicity with the serotonin transporter radiopharmaceutical, ADAM.
Drug and chemical toxicology.
2010 Oct; 33(4):393-402. doi:
10.3109/01480540903530753. [PMID: 20550426] - Elsmarieke van de Giessen, Jan Booij. The SPECT tracer [123I]ADAM binds selectively to serotonin transporters: a double-blind, placebo-controlled study in healthy young men.
European journal of nuclear medicine and molecular imaging.
2010 Aug; 37(8):1507-11. doi:
10.1007/s00259-010-1424-2. [PMID: 20309682] - Yuan-Hwa Chou, Shyh-Jen Wang, Chun-Lung Lin, Wei-Chung Mao, Shin-Min Lee, Mei-Hsiu Liao. Decreased brain serotonin transporter binding in the euthymic state of bipolar I but not bipolar II disorder: a SPECT study.
Bipolar disorders.
2010 May; 12(3):312-8. doi:
10.1111/j.1399-5618.2010.00800.x. [PMID: 20565438] - I-Hsun Li, Wen-Sheng Huang, Chin-Bin Yeh, Mei-Hsiu Liao, Chia-Chieh Chen, Lie-Hang Shen, Jiang-Chuan Liu, Kuo-Hsing Ma. Dual-isotope single-photon emission computed tomography for dopamine and serotonin transporters in normal and Parkinsonian monkey brains.
Nuclear medicine and biology.
2009 Aug; 36(6):605-11. doi:
10.1016/j.nucmedbio.2009.03.003. [PMID: 19647166] - Kuo-Hsing Ma, Jong-Kang Lee, San-Yuan Huang, Chin-Bin Yeh, Yi-Chun Shen, Lie-Hang Shen, Chia-Chieh Chen, Ren-Shyan Liu, Jiang-Chuan Liu, Wen-Sheng Huang. Simultaneous [99mTc]TRODAT-1 and [123I]ADAM brain SPECT in nonhuman primates.
Molecular imaging and biology.
2009 Jul; 11(4):253-62. doi:
10.1007/s11307-009-0197-0. [PMID: 19225845] - Yuan-Hwa Chou, Bang-Hung Yang, Ming-Yi Chung, Shih-Pei Chen, Tung-Ping Su, Chia-Chieh Chen, Shyh-Jen Wang. Imaging the serotonin transporter using (123)I-ADAM in the human brain.
Psychiatry research.
2009 Apr; 172(1):38-43. doi:
10.1016/j.pscychresns.2008.12.006. [PMID: 19239985] - Kuo-Hsing Ma, Wen-Sheng Huang, San-Yuan Huang, Cheng-Yi Cheng, Ching-Yuan Chen, Lie-Hang Shen, Jiang-Chuan Liu, Ying-Kai Fu. Imaging serotonin transporters using [123I]ADAM SPECT in a parkinsonian primate model.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2008 Dec; 66(12):1799-803. doi:
10.1016/j.apradiso.2008.06.033. [PMID: 18703341] - Bang-Hung Yang, Shyh-Jen Wang, Yuan-Hwa Chou, Tung-Ping Su, Shih-Pei Chen, Jih-Shian Lee, Jyh-Cheng Chen. Evaluation of reference tissue model and tissue ratio method for 5-HTT using [(123)I] ADAM tracer.
Computer methods and programs in biomedicine.
2008 Dec; 92(3):294-8. doi:
10.1016/j.cmpb.2008.02.011. [PMID: 18440664] - Sylvie Mavel, Johnny Vercouillie, Lucette Garreau, Tiziana Raguza, Aina Westrheim Ravna, Sylvie Chalon, Denis Guilloteau, Patrick Emond. Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging.
Bioorganic & medicinal chemistry.
2008 Oct; 16(19):9050-5. doi:
10.1016/j.bmc.2008.08.002. [PMID: 18793858] - Jennifer D Lundgren, Andrew B Newberg, Kelly C Allison, Nancy A Wintering, Karl Ploessl, Albert J Stunkard. 123I-ADAM SPECT imaging of serotonin transporter binding in patients with night eating syndrome: a preliminary report.
Psychiatry research.
2008 Apr; 162(3):214-20. doi:
10.1016/j.pscychresns.2007.07.006. [PMID: 18281200] - Vibe G Frokjaer, Lars H Pinborg, Jacob Madsen, Robin de Nijs, Claus Svarer, Aase Wagner, Gitte M Knudsen. Evaluation of the Serotonin Transporter Ligand 123I-ADAM for SPECT Studies on Humans.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2008 Feb; 49(2):247-54. doi:
10.2967/jnumed.107.046102. [PMID: 18199621] - Mark Slifstein. Revisiting an old issue: the discrepancy between tissue ratio-derived binding parameters and kinetic modeling-derived parameters after a bolus of the serotonin transporter radioligand 123I-ADAM.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2008 Feb; 49(2):176-8. doi:
10.2967/jnumed.107.046631. [PMID: 18245741] - Walter Koch, Nadine Schaaff, Gabriele Pöpperl, Christoph Mulert, Georg Juckel, Markus Reicherzer, Christoff Ehmer-von Geiso, Hans-Jürgen Möller, Ulrich Hegerl, Klaus Tatsch, Oliver Pogarell. [I-123] ADAM and SPECT in patients with borderline personality disorder and healthy control subjects.
Journal of psychiatry & neuroscience : JPN.
2007 Jul; 32(4):234-40. doi:
NULL. [PMID: 17653291] - Anu K Koskela, Anna Keski-Rahkonen, Elina Sihvola, Tomi Kauppinen, Jaakko Kaprio, Aapo Ahonen, Aila Rissanen. Serotonin transporter binding of [123I]ADAM in bulimic women, their healthy twin sisters, and healthy women: a SPET study.
BMC psychiatry.
2007 May; 7(?):19. doi:
10.1186/1471-244x-7-19. [PMID: 17511889] - Yen Kuang Yang, Wei Jen Yao, Tzung Lieh Yeh, I Hui Lee, Kao Ching Chen, Ru Band Lu. Association between serotonin transporter availability and hostility scores in healthy volunteers - a single photon emission computed tomography study with [(123)I] ADAM.
Psychiatry research.
2007 Apr; 154(3):281-4. doi:
10.1016/j.pscychresns.2006.11.010. [PMID: 17349781] - Julia Sacher, Susanne Asenbaum, Nikolas Klein, Thomas Geiss-Granadia, Nilufar Mossaheb, Christian Poetzi, Trawat Attarbaschi, Rupert Lanzenberger, Christoph Spindelegger, Alexander Rabas, Georg Heinze, Robert Dudczak, Siegfried Kasper, Johannes Tauscher. Binding kinetics of 123I[ADAM] in healthy controls: a selective SERT radioligand.
The international journal of neuropsychopharmacology.
2007 Apr; 10(2):211-8. doi:
10.1017/s1461145706006511. [PMID: 16487452] - Nikolas Klein, Julia Sacher, Thomas Geiss-Granadia, Nilufar Mossaheb, Trawat Attarbaschi, Rupert Lanzenberger, Christoph Spindelegger, Alexander Holik, Susanne Asenbaum, Robert Dudczak, Johannes Tauscher, Siegfried Kasper. Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study.
Psychopharmacology.
2007 Apr; 191(2):333-9. doi:
10.1007/s00213-006-0666-y. [PMID: 17235610] - Ana M Catafau, Victor Perez, Pedro Plaza, Juan-Carlos Pascual, Santiago Bullich, Marina Suarez, Maria M Penengo, Iluminada Corripio, Dolors Puigdemont, Monica Danus, Javier Perich, Enric Alvarez. Serotonin transporter occupancy induced by paroxetine in patients with major depression disorder: a 123I-ADAM SPECT study.
Psychopharmacology.
2006 Dec; 189(2):145-53. doi:
10.1007/s00213-006-0540-y. [PMID: 17033844] - Ralf Uebelhack, Leonora Franke, Nathalie Herold, Michael Plotkin, Holger Amthauer, Roland Felix. Brain and platelet serotonin transporter in humans-correlation between [123I]-ADAM SPECT and serotonergic measurements in platelets.
Neuroscience letters.
2006 Oct; 406(3):153-8. doi:
10.1016/j.neulet.2006.06.004. [PMID: 16934400] - N Klein, J Sacher, T Geiss-Granadia, T Attarbaschi, N Mossaheb, R Lanzenberger, C Pötzi, A Holik, C Spindelegger, S Asenbaum, R Dudczak, J Tauscher, S Kasper. In vivo imaging of serotonin transporter occupancy by means of SPECT and [123I]ADAM in healthy subjects administered different doses of escitalopram or citalopram.
Psychopharmacology.
2006 Oct; 188(3):263-72. doi:
10.1007/s00213-006-0486-0. [PMID: 16955282] - N Herold, K Uebelhack, L Franke, H Amthauer, L Luedemann, H Bruhn, R Felix, R Uebelhack, M Plotkin. Imaging of serotonin transporters and its blockade by citalopram in patients with major depression using a novel SPECT ligand [123I]-ADAM.
Journal of neural transmission (Vienna, Austria : 1996).
2006 May; 113(5):659-70. doi:
10.1007/s00702-005-0429-7. [PMID: 16465456] - Jan Booij, Maartje M L de Win. Brain kinetics of the new selective serotonin transporter tracer [(123)I]ADAM in healthy young adults.
Nuclear medicine and biology.
2006 Feb; 33(2):185-91. doi:
10.1016/j.nucmedbio.2005.10.005. [PMID: 16546672] - Kun-Ju Lin, Chia-Yih Liu, Shiaw-Pyng Wey, Ing-Tsung Hsiao, Jay Wu, Ying-Kai Fu, Tzu-Chen Yen. Brain SPECT imaging and whole-body biodistribution with [(123)I]ADAM - a serotonin transporter radiotracer in healthy human subjects.
Nuclear medicine and biology.
2006 Feb; 33(2):193-202. doi:
10.1016/j.nucmedbio.2005.10.006. [PMID: 16546673] - Kjell Erlandsson, Tharani Sivananthan, Dominic Lui, Andrea Spezzi, Caroline E Townsend, Song Mu, Richard Lucas, Steven Warrington, Peter J Ell. Measuring SSRI occupancy of SERT using the novel tracer [123I]ADAM: a SPECT validation study.
European journal of nuclear medicine and molecular imaging.
2005 Nov; 32(11):1329-36. doi:
10.1007/s00259-005-1912-y. [PMID: 16133377] - Ana M Catafau, Víctor Pérez, María M Penengo, Santiago Bullich, Mónica Danús, Dolors Puigdemont, Juan C Pascual, Iluminada Corripio, Jordi Llop, Javier Perich, Enric Alvarez. SPECT of serotonin transporters using 123I-ADAM: optimal imaging time after bolus injection and long-term test-retest in healthy volunteers.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2005 Aug; 46(8):1301-9. doi:
NULL. [PMID: 16085586] - Nachwa Jarkas, Jonathan McConathy, Ronald J Voll, Mark M Goodman. Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands.
Journal of medicinal chemistry.
2005 Jun; 48(13):4254-65. doi:
10.1021/jm050079o. [PMID: 15974579] - Andrew B Newberg, Jay D Amsterdam, Nancy Wintering, Karl Ploessl, Randel L Swanson, Justine Shults, Abass Alavi. 123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2005 Jun; 46(6):973-7. doi:
NULL. [PMID: 15937308] - Yiyun Huang, Sung-A Bae, Zhihong Zhu, Ningning Guo, Bryan L Roth, Marc Laruelle. Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents.
Journal of medicinal chemistry.
2005 Apr; 48(7):2559-70. doi:
10.1021/jm0400808. [PMID: 15801845] - Hank F Kung, Suzanne Newman, Seok-Rye Choi, Shunichi Oya, Catherine Hou, Zhi-Ping Zhuang, Paul D Acton, Karl Plössl, Jeffrey Winkler, Mei-Ping Kung. 2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent.
Journal of medicinal chemistry.
2004 Oct; 47(21):5258-64. doi:
10.1021/jm049917p. [PMID: 15456270] - Xin-Xian Ye, Jyh-Cheng Chen, Ren-Shen Liu, Shiaw-Pyng Wey, Jin-Shin Lee, Chia-Chieh Chen, Ying-Kai Fu, Gann Ting, Jeng-Jong Hwang. Microautoradiography of [123I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors.
Nuclear medicine and biology.
2004 Jul; 31(5):557-62. doi:
10.1016/j.nucmedbio.2003.12.002. [PMID: 15219272] - Wen-Sheng Huang, Kuo-Hsing Ma, Cheng-Yi Cheng, Cheng-Yu Chen, Ying-Kai Fu, Yuan-Hwa Chou, Shiaw-Pyng Wey, Jian-Chuan Liu. Imaging serotonin transporters with 123I-ADAM brain SPECT in healthy non-human primates.
Nuclear medicine communications.
2004 May; 25(5):515-9. doi:
10.1097/00006231-200405000-00014. [PMID: 15100512] - Andrew B Newberg, Karl Plössl, P David Mozley, James B Stubbs, Nancy Wintering, Michelle Udeshi, Abass Alavi, Tomi Kauppinen, Hank F Kung. Biodistribution and imaging with (123)I-ADAM: a serotonin transporter imaging agent.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2004 May; 45(5):834-41. doi:
NULL. [PMID: 15136634] - Sylvie Chalon, Cécile Bronquard, Johnny Vercouillie, Ercem Kodas, Lucette Garreau, Sylvie Bodard, Patrick Emond, Jean-Claude Besnard, Denis Guilloteau. ADAM is an effective tool for in vivo study of serotonergic function: validation in rat models.
Synapse (New York, N.Y.).
2004 May; 52(2):136-42. doi:
10.1002/syn.20012. [PMID: 15034919] - Kun-Ju Lin, Tzu-Chen Yen, Shiaw-Pyng Wey, Jeng-Jong Hwang, Xin-Xian Ye, Kai-Yuan Tzen, Ying-Kai Fu, Jin-Chung Chen. Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2004 Apr; 45(4):673-81. doi:
NULL. [PMID: 15073265] - Tomi A Kauppinen, Kim A Bergström, Pertti Heikman, Jukka Hiltunen, Aapo K Ahonen. Biodistribution and radiation dosimetry of [123I]ADAM in healthy human subjects: preliminary results.
European journal of nuclear medicine and molecular imaging.
2003 Jan; 30(1):132-6. doi:
10.1007/s00259-002-1027-7. [PMID: 12483421] - Shunichi Oya, Seok Rye Choi, Heinz Coenen, Hank F Kung. New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine).
Journal of medicinal chemistry.
2002 Oct; 45(21):4716-23. doi:
10.1021/jm020167y. [PMID: 12361398] - Kun-Ju Lin, Xin-Xian Ye, Tzu-Chen Yen, Shiaw-Pyng Wey, Kai-Yuan Tzen, Gann Ting, Jeng-Jong Hwang. Biodistribution study of [(123)I] ADAM in mice: correlation with whole body autoradiography.
Nuclear medicine and biology.
2002 Aug; 29(6):643-50. doi:
10.1016/s0969-8051(02)00323-2. [PMID: 12234588] - Patrick Emond, Johnny Vercouillie, Robert Innis, Sylvie Chalon, Sylvie Mavel, Yves Frangin, Christer Halldin, Jean-Claude Besnard, Denis Guilloteau. Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.
Journal of medicinal chemistry.
2002 Mar; 45(6):1253-8. doi:
10.1021/jm010939a. [PMID: 11881994] - Byoung Se Lee, Soyoung Chu, Bon-Su Lee, Dae Yoon Chi, Yun Seon Song, Changbae Jin. Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines.
Bioorganic & medicinal chemistry letters.
2002 Mar; 12(5):811-5. doi:
10.1016/s0960-894x(02)00028-8. [PMID: 11859009] - P D Acton, S R Choi, C Hou, K Plössl, H F Kung. Quantification of serotonin transporters in nonhuman primates using [(123)I]ADAM and SPECT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2001 Oct; 42(10):1556-62. doi:
NULL. [PMID: 11585873] - S R Choi, C Hou, S Oya, M Mu, M P Kung, M Siciliano, P D Acton, H F Kung. Selective in vitro and in vivo binding of [(125)I]ADAM to serotonin transporters in rat brain.
Synapse (New York, N.Y.).
2000 Dec; 38(4):403-12. doi:
10.1002/1098-2396(20001215)38:4<403::aid-syn5>3.0.co;2-z. [PMID: 11044887] - S Oya, S R Choi, C Hou, M Mu, M P Kung, P D Acton, M Siciliano, H F Kung. 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand.
Nuclear medicine and biology.
2000 Apr; 27(3):249-54. doi:
10.1016/s0969-8051(00)00084-6. [PMID: 10832081]