Madam (BioDeep_00000177261)
human metabolite blood metabolite
代谢物信息卡片
2-({2-[(dimethylamino)methyl]phenyl}sulfanyl)-5-methylaniline
化学式: C16H20N2S (272.13471200000004)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 11.11%
分子结构信息
SMILES: CC1=CC(=C(C=C1)SC2=CC=CC=C2CN(C)C)N
InChI: InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ryosuke Arakawa, Akihiro Takano, Christer Halldin. Serotonin and Norepinephrine Transporter Occupancy of Tramadol in Nonhuman Primate Using Positron Emission Tomography.
The international journal of neuropsychopharmacology.
2019 01; 22(1):53-56. doi:
10.1093/ijnp/pyy089. [PMID: 30346535] - Joonas Majuri, Juho Joutsa, Jarkko Johansson, Valerie Voon, Riitta Parkkola, Hannu Alho, Eveliina Arponen, Valtteri Kaasinen. Serotonin transporter density in binge eating disorder and pathological gambling: A PET study with [11C]MADAM.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2017 12; 27(12):1281-1288. doi:
10.1016/j.euroneuro.2017.09.007. [PMID: 29032922] - P Fazio, M Schain, K Varnäs, C Halldin, L Farde, A Varrone. Mapping the distribution of serotonin transporter in the human brainstem with high-resolution PET: Validation using postmortem autoradiography data.
NeuroImage.
2016 06; 133(?):313-320. doi:
10.1016/j.neuroimage.2016.03.019. [PMID: 26994829] - Granville J Matheson, Martin Schain, Rita Almeida, Johan Lundberg, Zsolt Cselényi, Jacqueline Borg, Andrea Varrone, Lars Farde, Simon Cervenka. Diurnal and seasonal variation of the brain serotonin system in healthy male subjects.
NeuroImage.
2015 May; 112(?):225-231. doi:
10.1016/j.neuroimage.2015.03.007. [PMID: 25772667] - Hristina Jovanovic, Ljiljana Kocoska-Maras, Angelique Flöter Rådestad, Christer Halldin, Jacqueline Borg, Angelica Lindén Hirschberg, Anna-Lena Nordström. Effects of estrogen and testosterone treatment on serotonin transporter binding in the brain of surgically postmenopausal women--a PET study.
NeuroImage.
2015 Feb; 106(?):47-54. doi:
10.1016/j.neuroimage.2014.11.003. [PMID: 25462800] - Fabienne Gourand, Nahid Amini, Zhisheng Jia, Sharon Stone-Elander, Denis Guilloteau, Louisa Barré, Christer Halldin. [11C]MADAM Used as a Model for Understanding the Radiometabolism of Diphenyl Sulfide Radioligands for Positron Emission Tomography (PET).
PloS one.
2015; 10(9):e0137160. doi:
10.1371/journal.pone.0137160. [PMID: 26367261] - F Gourand, P Emond, J P Bergström, A Takano, B Gulyás, D Guilloteau, L Barré, C Halldin. A radiometabolite study of the serotonin transporter PET radioligand [(11)C]MADAM.
Nuclear medicine and biology.
2014 Jul; 41(6):501-6. doi:
10.1016/j.nucmedbio.2014.03.022. [PMID: 24857865] - Per Stenkrona, Christer Halldin, Johan Lundberg. 5-HTT and 5-HT(1A) receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2013 Oct; 23(10):1190-8. doi:
10.1016/j.euroneuro.2013.01.002. [PMID: 23428337] - Linnea Karlsson, Lauri Tuominen, Antti Huotarinen, Sami Leppämäki, Elina Sihvola, Semi Helin, Maria Sipilä, Pekka Tani, Jussi Hirvonen, Jarmo Hietala, Hasse Karlsson. Serotonin transporter in attention-deficit hyperactivity disorder--preliminary results from a positron emission tomography study.
Psychiatry research.
2013 May; 212(2):164-5. doi:
10.1016/j.pscychresns.2013.02.001. [PMID: 23566552] - L Tuominen, J Salo, J Hirvonen, K Någren, P Laine, T Melartin, E Isometsä, J Viikari, C R Cloninger, O Raitakari, J Hietala, L Keltikangas-Järvinen. Temperament, character and serotonin activity in the human brain: a positron emission tomography study based on a general population cohort.
Psychological medicine.
2013 Apr; 43(4):881-94. doi:
10.1017/s003329171200164x. [PMID: 22850434] - Johan Lundberg, Mikael Tiger, Mikael Landén, Christer Halldin, Lars Farde. Serotonin transporter occupancy with TCAs and SSRIs: a PET study in patients with major depressive disorder.
The international journal of neuropsychopharmacology.
2012 Sep; 15(8):1167-72. doi:
10.1017/s1461145711001945. [PMID: 22243688] - Martin Schain, Miklós Tóth, Zsolt Cselényi, Per Stenkrona, Christer Halldin, Lars Farde, Andrea Varrone. Quantification of serotonin transporter availability with [11C]MADAM--a comparison between the ECAT HRRT and HR systems.
NeuroImage.
2012 Mar; 60(1):800-7. doi:
10.1016/j.neuroimage.2011.12.047. [PMID: 22227138] - Eduard Maron, Innar Tõru, Jussi Hirvonen, Lauri Tuominen, Ville Lumme, Veiko Vasar, Jakov Shlik, David J Nutt, Semi Helin, Kjell Någren, Jari Tiihonen, Jarmo Hietala. Gender differences in brain serotonin transporter availability in panic disorder.
Journal of psychopharmacology (Oxford, England).
2011 Jul; 25(7):952-9. doi:
10.1177/0269881110389207. [PMID: 21148024] - Sylvie Mavel, Nathalie Meheux, Denis Guilloteau, Patrick Emond. Synthesis and in vitro evaluation of fluorinated diphenyloxide derivatives and sulfur analogs as serotonin transporter ligands.
Bioorganic & medicinal chemistry.
2010 Jan; 18(1):236-41. doi:
10.1016/j.bmc.2009.10.062. [PMID: 19926484] - Hristina Jovanovic, Per Karlsson, Asta Cerin, Christer Halldin, Anna-Lena Nordström. 5-HT(1A) receptor and 5-HTT binding during the menstrual cycle in healthy women examined with [(11)C] WAY100635 and [(11)C] MADAM PET.
Psychiatry research.
2009 Apr; 172(1):31-7. doi:
10.1016/j.pscychresns.2008.07.002. [PMID: 19118985] - Sylvie Mavel, Johnny Vercouillie, Lucette Garreau, Tiziana Raguza, Aina Westrheim Ravna, Sylvie Chalon, Denis Guilloteau, Patrick Emond. Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging.
Bioorganic & medicinal chemistry.
2008 Oct; 16(19):9050-5. doi:
10.1016/j.bmc.2008.08.002. [PMID: 18793858] - Uta Funke, Steffen Fischer, Achim Hiller, Matthias Scheunemann, Winnie Deuther-Conrad, Peter Brust, Jörg Steinbach. 3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinoline-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: chemical synthesis, evaluation in vitro and radiofluorination.
Bioorganic & medicinal chemistry letters.
2008 Aug; 18(16):4727-30. doi:
10.1016/j.bmcl.2008.06.077. [PMID: 18644726] - Hristina Jovanovic, Johan Lundberg, Per Karlsson, Asta Cerin, Tomoyuki Saijo, Andrea Varrone, Christer Halldin, Anna-Lena Nordström. Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET.
NeuroImage.
2008 Feb; 39(3):1408-19. doi:
10.1016/j.neuroimage.2007.10.016. [PMID: 18036835] - Johan Lundberg, Jacqueline Borg, Christer Halldin, Lars Farde. A PET study on regional coexpression of 5-HT1A receptors and 5-HTT in the human brain.
Psychopharmacology.
2007 Dec; 195(3):425-33. doi:
10.1007/s00213-007-0928-3. [PMID: 17874074] - Johan Lundberg, Jacob Strøyer Christophersen, Kamilla Buchberg Petersen, Henrik Loft, Christer Halldin, Lars Farde. PET measurement of serotonin transporter occupancy: a comparison of escitalopram and citalopram.
The international journal of neuropsychopharmacology.
2007 Dec; 10(6):777-85. doi:
10.1017/s1461145706007486. [PMID: 17201996] - Johnny Vercouillie, Winnie Deuther-Conrad, Matthias Scheunemann, Patrick Emond, Steffen Fischer, Uta Funke, Jörg Steinbach, Denis Guilloteau, Peter Brust. New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET.
Bioorganic & medicinal chemistry letters.
2007 Sep; 17(17):4991-5. doi:
10.1016/j.bmcl.2007.02.082. [PMID: 17658253] - Lutea A A de Jong, C Margot Jeronimus-Stratingh, Thomas I F H Cremers. Development of a multiplex non-radioactive receptor assay: the benzodiazepine receptor, the serotonin transporter and the beta-adrenergic receptor.
Rapid communications in mass spectrometry : RCM.
2007; 21(4):567-72. doi:
10.1002/rcm.2869. [PMID: 17245793] - Johan Lundberg, Christer Halldin, Lars Farde. Measurement of serotonin transporter binding with PET and [11C]MADAM: a test-retest reproducibility study.
Synapse (New York, N.Y.).
2006 Sep; 60(3):256-63. doi:
10.1002/syn.20297. [PMID: 16752362] - Sylvie Chalon, Hakan Hall, Wadad Saba, Lucette Garreau, Frédéric Dollé, Christer Halldin, Patrick Emond, Michel Bottlaender, Jean-Bernard Deloye, Julie Helfenbein, Jean-Claude Madelmont, Sylvie Bodard, Zoïa Mincheva, Jean-Claude Besnard, Denis Guilloteau. Pharmacological characterization of (E)-N-(4-fluorobut-2-enyl)-2beta-carbomethoxy-3beta-(4'-tolyl)nortropane (LBT-999) as a highly promising fluorinated ligand for the dopamine transporter.
The Journal of pharmacology and experimental therapeutics.
2006 Apr; 317(1):147-52. doi:
10.1124/jpet.105.096792. [PMID: 16339913] - Johnny Vercouillie, Sylvie Mavel, Laurent Galineau, Tiziana Ragusa, Robert Innis, Michael Kassiou, Sylvie Chalon, Frédéric Dollé, Jean-Claude Besnard, Denis Guilloteau, Patrick Emond. Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands.
Bioorganic & medicinal chemistry letters.
2006 Mar; 16(5):1297-300. doi:
10.1016/j.bmcl.2005.11.066. [PMID: 16337793] - Christer Halldin, Johan Lundberg, Judit Sóvágó, Balázs Gulyás, Denis Guilloteau, Johnny Vercouillie, Patrick Emond, Sylvie Chalon, Jari Tarkiainen, Jukka Hiltunen, Lars Farde. [(11)C]MADAM, a new serotonin transporter radioligand characterized in the monkey brain by PET.
Synapse (New York, N.Y.).
2005 Dec; 58(3):173-83. doi:
10.1002/syn.20189. [PMID: 16138320] - Johan Lundberg, Ikuo Odano, Hans Olsson, Christer Halldin, Lars Farde. Quantification of 11C-MADAM binding to the serotonin transporter in the human brain.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2005 Sep; 46(9):1505-15. doi:
NULL. [PMID: 16157534] - Nachwa Jarkas, Jonathan McConathy, Ronald J Voll, Mark M Goodman. Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands.
Journal of medicinal chemistry.
2005 Jun; 48(13):4254-65. doi:
10.1021/jm050079o. [PMID: 15974579] - Yiyun Huang, Sung-A Bae, Zhihong Zhu, Ningning Guo, Bryan L Roth, Marc Laruelle. Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents.
Journal of medicinal chemistry.
2005 Apr; 48(7):2559-70. doi:
10.1021/jm0400808. [PMID: 15801845] - Betina Elfving, Ove Wiborg. Binding of S-citalopram and paroxetine discriminates between species.
Synapse (New York, N.Y.).
2005 Mar; 55(4):280-2. doi:
10.1002/syn.20116. [PMID: 15668984] - Nachwa Jarkas, Jonathan McConathy, John R Votaw, Ronald J Voll, Eugene Malveaux, Vernon M Camp, Larry Williams, Robin R Goodman, Clinton D Kilts, Mark M Goodman. Synthesis and characterization of EADAM: a selective radioligand for mapping the brain serotonin transporters by positron emission tomography.
Nuclear medicine and biology.
2005 Jan; 32(1):75-86. doi:
10.1016/j.nucmedbio.2004.07.001. [PMID: 15691664] - Laurent Galineau, Ercem Kodas, Denis Guilloteau, Marie-Paule Vilar, Sylvie Chalon. Ontogeny of the dopamine and serotonin transporters in the rat brain: an autoradiographic study.
Neuroscience letters.
2004 Jun; 363(3):266-71. doi:
10.1016/j.neulet.2004.04.007. [PMID: 15182957] - A K Larsen, L T Brennum, J Egebjerg, C Sánchez, C Halldin, P H Andersen. Selectivity of (3)H-MADAM binding to 5-hydroxytryptamine transporters in vitro and in vivo in mice; correlation with behavioural effects.
British journal of pharmacology.
2004 Mar; 141(6):1015-23. doi:
10.1038/sj.bjp.0705693. [PMID: 14993096] - Sylvie Chalon, Jari Tarkiainen, Lucette Garreau, Hakan Hall, Patrick Emond, Johnny Vercouillie, Lars Farde, Philippe Dasse, Katarina Varnas, Jean-Claude Besnard, Christer Halldin, Denis Guilloteau. Pharmacological characterization of N,N-dimethyl-2-(2-amino-4-methylphenyl thio)benzylamine as a ligand of the serotonin transporter with high affinity and selectivity.
The Journal of pharmacology and experimental therapeutics.
2003 Jan; 304(1):81-7. doi:
10.1124/jpet.102.042226. [PMID: 12490578] - Shunichi Oya, Seok Rye Choi, Heinz Coenen, Hank F Kung. New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine).
Journal of medicinal chemistry.
2002 Oct; 45(21):4716-23. doi:
10.1021/jm020167y. [PMID: 12361398] - Patrick Emond, Johnny Vercouillie, Robert Innis, Sylvie Chalon, Sylvie Mavel, Yves Frangin, Christer Halldin, Jean-Claude Besnard, Denis Guilloteau. Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.
Journal of medicinal chemistry.
2002 Mar; 45(6):1253-8. doi:
10.1021/jm010939a. [PMID: 11881994]