2-[[2-[(Dimethylamino)methyl]phenyl]thio]-5-fluoroaniline (BioDeep_00000177242)
human metabolite blood metabolite
代谢物信息卡片
2-({2-[(dimethylamino)methyl]phenyl}sulfanyl)-5-fluoroaniline
化学式: C15H17FN2S (276.10964140000004)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 85.71%
分子结构信息
SMILES: CN(C)CC1=CC=CC=C1SC1=C(N)C=C(F)C=C1
InChI: InChI=1S/C15H17FN2S/c1-18(2)10-11-5-3-4-6-14(11)19-15-8-7-12(16)9-13(15)17/h3-9H,10,17H2,1-2H3
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:125631
- PubChem: 10265481
- HMDB: HMDB0249921
- ChEMBL: CHEMBL190860
- chemspider: 8440960
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Cheng-Tsung Liu, Yuahn-Sieh Huang, Hsin-Chien Chen, Kuo-Hsing Ma, Chih-Hung Wang, Chuang-Hsin Chiu, Jui-Hu Shih, Hsiao-Hsien Kang, Chyng-Yann Shiue, I-Hsun Li. Evaluation of brain SERT with 4-[18F]-ADAM/micro-PET and hearing protective effects of dextromethorphan in hearing loss rat model.
Toxicology and applied pharmacology.
2019 09; 378(?):114604. doi:
10.1016/j.taap.2019.114604. [PMID: 31153898] - Cheng-Yi Cheng, Ta-Kai Chou, Chyng-Yann Shiue. Fully automated one-pot two-step synthesis of 4-[(18)F]-ADAM, a potent serotonin transporter imaging agent.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2016 Apr; 110(?):8-15. doi:
10.1016/j.apradiso.2015.12.052. [PMID: 26748018] - Jui-Hu Shih, Kuo-Hsing Ma, Chien-Fu F Chen, Cheng-Yi Cheng, Li-Heng Pao, Shao-Ju Weng, Yuahn-Sieh Huang, Chyng-Yann Shiue, Ming-Kung Yeh, I-Hsun Li. Evaluation of brain SERT occupancy by resveratrol against MDMA-induced neurobiological and behavioral changes in rats: A 4-[¹⁸F]-ADAM/small-animal PET study.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2016 Jan; 26(1):92-104. doi:
10.1016/j.euroneuro.2015.11.001. [PMID: 26612383] - Yi-Wei Yeh, Pei-Shen Ho, Chun-Yen Chen, Shin-Chang Kuo, Chih-Sung Liang, Che-Hung Yen, Chang-Chih Huang, Chyng-Yann Shiue, Wen-Sheng Huang, Kuo-Hsing Ma, Ru-Band Lu, San-Yuan Huang. Suicidal ideation modulates the reduction in serotonin transporter availability in male military conscripts with major depression: A 4-[18F]-ADAM PET study.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2015 Oct; 16(7):502-12. doi:
10.3109/15622975.2015.1048722. [PMID: 26068129] - Yi-Wei Yeh, Pei-Shen Ho, Shin-Chang Kuo, Chun-Yen Chen, Chih-Sung Liang, Che-Hung Yen, Chang-Chih Huang, Kuo-Hsing Ma, Chyng-Yann Shiue, Wen-Sheng Huang, Jia-Fwu Shyu, Fang-Jung Wan, Ru-Band Lu, San-Yuan Huang. Disproportionate Reduction of Serotonin Transporter May Predict the Response and Adherence to Antidepressants in Patients with Major Depressive Disorder: A Positron Emission Tomography Study with 4-[18F]-ADAM.
The international journal of neuropsychopharmacology.
2015 Jan; 18(7):pyu120. doi:
10.1093/ijnp/pyu120. [PMID: 25568284] - Yi-Wei Yeh, Pei-Shen Ho, Chun-Yen Chen, Shin-Chang Kuo, Chih-Sung Liang, Kuo-Hsing Ma, Chyng-Yann Shiue, Wen-Sheng Huang, Cheng-Yi Cheng, Tzu-Yun Wang, Ru-Band Lu, San-Yuan Huang. Incongruent reduction of serotonin transporter associated with suicide attempts in patients with major depressive disorder: a positron emission tomography study with 4-[18F]-ADAM.
The international journal of neuropsychopharmacology.
2014 Oct; 18(3):. doi:
10.1093/ijnp/pyu065. [PMID: 25522405] - Wen-Sheng Huang, San-Yuan Huang, Pei-Shen Ho, Kuo-Hsing Ma, Ya-Yao Huang, Chin-Bin Yeh, Ren-Syuan Liu, Cheng-Yi Cheng, Chyng-Yann Shiue. PET imaging of the brain serotonin transporters (SERT) with N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) in humans: a preliminary study.
European journal of nuclear medicine and molecular imaging.
2013 Jan; 40(1):115-24. doi:
10.1007/s00259-012-2250-5. [PMID: 23053324] - Yu-An Chen, Wen-Sheng Huang, Yaoh-Shiang Lin, Cheng-Yi Cheng, Ren-Shyan Liu, Shyh-Jen Wang, I-Hsun Li, San-Yuan Huang, Chyng-Yann Shiue, Cheng-Yu Chen, Kuo-Hsing Ma. Characterization of 4-[18F]-ADAM as an imaging agent for SERT in non-human primate brain using PET: a dynamic study.
Nuclear medicine and biology.
2012 Feb; 39(2):279-85. doi:
10.1016/j.nucmedbio.2011.08.002. [PMID: 22136885] - Ya-Yao Huang, Kuo-Hsing Ma, Ta-Wei Tseng, Ta-Kai Chou, Hanna Ng, Jon C Mirsalis, Ying-Kai Fu, Tieh-Chi Chu, Wen-Sheng Huang, Chyng-Yann Shiue. Biodistribution, toxicity and radiation dosimetry studies of the serotonin transporter radioligand 4-[18F]-ADAM in rats and monkeys.
European journal of nuclear medicine and molecular imaging.
2010 Mar; 37(3):545-55. doi:
10.1007/s00259-009-1281-z. [PMID: 19820930] - Ya-Yao Huang, Wen-Sheng Huang, Tieh-Chi Chu, Chyng-Yann Shiue. An improved synthesis of 4-[18F]-ADAM, a potent serotonin transporter imaging agent.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2009 Jun; 67(6):1063-7. doi:
10.1016/j.apradiso.2009.02.090. [PMID: 19339192] - Kuo-Hsing Ma, Wen-Sheng Huang, Yu-Yeh Kuo, Chi-Jiun Peng, Nien-Hsien Liou, Ren-Shyan Liu, Jeng-Jong Hwang, Jiang-Chuan Liu, Haw-Jan Chen, Chyng-Yann Shiue. Validation of 4-[18F]-ADAM as a SERT imaging agent using micro-PET and autoradiography.
NeuroImage.
2009 Apr; 45(3):687-93. doi:
10.1016/j.neuroimage.2008.12.060. [PMID: 19211037] - Chi-Jiun Peng, Ya-Yao Huang, Wen-Sheng Huang, Chyng-Yann Shiue. An automated synthesis of N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) for imaging serotonin transporters.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2008 May; 66(5):625-31. doi:
10.1016/j.apradiso.2007.11.009. [PMID: 18226534] - Yiyun Huang, Sung-A Bae, Zhihong Zhu, Ningning Guo, Bryan L Roth, Marc Laruelle. Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents.
Journal of medicinal chemistry.
2005 Apr; 48(7):2559-70. doi:
10.1021/jm0400808. [PMID: 15801845] - Ping Fang, Grace G Shiue, Tomokazu Shimazu, Joel H Greenberg, Chyng-Yann Shiue. Synthesis and evaluation of N,N-dimethyl-2-(2-amino-5-[18F]fluorophenylthio)benzylamine (5-[18F]-ADAM) as a serotonin transporter imaging agent.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2004 Dec; 61(6):1247-54. doi:
10.1016/j.apradiso.2004.03.003. [PMID: 15388117] - Grace G Shiue, Seok-Rye Choi, Ping Fang, Catherine Hou, Paul D Acton, Chris Cardi, Janet R Saffer, Joel H Greenberg, Joel S Karp, Hank F Kung, Chyng-Yann Shiue. N,N-dimethyl-2-(2-amino-4-(18)F-fluorophenylthio)-benzylamine (4-(18)F-ADAM): an improved PET radioligand for serotonin transporters.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2003 Dec; 44(12):1890-7. doi:
. [PMID: 14660713] - Grace G Shiue, Ping Fang, Chyng-Yann Shiue. Synthesis of N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine as a serotonin transporter imaging agent.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2003 Feb; 58(2):183-91. doi:
10.1016/s0969-8043(02)00271-3. [PMID: 12573317]