2-Phenylpyrazolo(4,3-c)quinolin-3(5H)-one (BioDeep_00000177202)

   

human metabolite blood metabolite


代谢物信息卡片


2-phenyl-1H,2H,3H-pyrazolo[4,3-c]quinolin-3-one

化学式: C16H11N3O (261.0902076)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 94.44%

分子结构信息

SMILES: C1=CC=C(C=C1)N2C(=O)C3=C(N2)C4=CC=CC=C4N=C3
InChI: InChI=1S/C16H11N3O/c20-16-13-10-17-14-9-5-4-8-12(14)15(13)18-19(16)11-6-2-1-3-7-11/h1-10,18H

描述信息

D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D003292 - Convulsants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018756 - GABA Antagonists
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists

同义名列表

3 个代谢物同义名

2-phenyl-1H,2H,3H-pyrazolo[4,3-c]quinolin-3-one; 2-phenyl-1H-pyrazolo[4,3-c]quinolin-3-one; 2-Phenylpyrazolo(4,3-c)quinolin-3(5H)-one



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • C Yurdaydin, Z Q Gu, G Nowak, C Fromm, A G Holt, A S Basile. Benzodiazepine receptor ligands are elevated in an animal model of hepatic encephalopathy: relationship between brain concentration and severity of encephalopathy. The Journal of pharmacology and experimental therapeutics. 1993 May; 265(2):565-71. doi: NULL. [PMID: 8388453]
  • R M Eisenberg. Sound vibration, a non-invasive stress: antagonism by diazepam. Psychopharmacology. 1993; 110(4):467-70. doi: 10.1007/bf02244654. [PMID: 7870918]
  • R M Eisenberg, C Johnson. Effects of beta-carboline-ethyl ester on plasma corticosterone--a parallel with antagonist-precipitated diazepam withdrawal. Life sciences. 1989; 44(20):1457-66. doi: 10.1016/0024-3205(89)90324-x. [PMID: 2725178]
  • M Jedrychowski, E K Schmidt, P R Bieck. High-performance liquid chromatographic determination of a new pyrazoloquinoline type benzodiazepine receptor antagonist and its hydroxy metabolite. Arzneimittel-Forschung. 1988 Apr; 38(4):495-7. doi: NULL. [PMID: 2840916]
  • K D Mullen, J V Martin, W B Mendelson, M L Bassett, E A Jones. Could an endogenous benzodiazepine ligand contribute to hepatic encephalopathy?. Lancet (London, England). 1988 Feb; 1(8583):457-9. doi: 10.1016/s0140-6736(88)91245-7. [PMID: 2893876]
  • I W Reimann, M Jedrychowski, R Schulz, K H Antonin, A Roth, P R Bieck. Pharmacokinetic and pharmacodynamic effects of the novel benzodiazepine antagonist 2-phenylpyrazolo[4,3-c]quinolin-3(5H)-one in humans. Arzneimittel-Forschung. 1987 Oct; 37(10):1174-8. doi: NULL. [PMID: 2893624]
  • S Pellow, S E File. The effects of putative anxiogenic compounds (FG 7142, CGS 8216 and Ro 15-1788) on the rat corticosterone response. Physiology & behavior. 1985 Oct; 35(4):587-90. doi: 10.1016/0031-9384(85)90145-3. [PMID: 2999846]
  • S E File, S Pellow. The anxiogenic action of RO 5-4864 in the social interaction test: effect of chlordiazepoxide, RO 15-1788 and CGS 8216. Naunyn-Schmiedeberg's archives of pharmacology. 1985 Jan; 328(3):225-8. doi: 10.1007/bf00515545. [PMID: 2984580]
  • S Pellow, S E File. Behavioural actions of Ro 5-4864: a peripheral-type benzodiazepine?. Life sciences. 1984 Jul; 35(3):229-40. doi: 10.1016/0024-3205(84)90106-1. [PMID: 6087055]
  • A Bizzi, M R Ricci, E Veneroni, M Amato, S Garattini. Benzodiazepine receptor antagonists reverse the effect of diazepam on plasma corticosterone in stressed rats. The Journal of pharmacy and pharmacology. 1984 Feb; 36(2):134-5. doi: 10.1111/j.2042-7158.1984.tb03014.x. [PMID: 6143804]
  • R G Lister, D J Greenblatt, S E File. A pharmacokinetic study of CGS-8216, a benzodiazepine receptor ligand, in the rat. Psychopharmacology. 1984; 84(3):420-2. doi: 10.1007/bf00555224. [PMID: 6096912]
  • S Tsuji, K Nakagawa, T Fukushima. Genetically controlled quantitative variation of ornithine transcarbamylase in the chick kidney. Biochemical genetics. 1983 Oct; 21(9-10):857-69. doi: 10.1007/bf00483945. [PMID: 6419722]
  • P Skolnick, M M Schweri, S M Paul, J V Martin, R L Wagner, W B Mendelson. 3-carboethoxy-beta-carboline (beta-CCE) elicits electroencephalographic seizures in rats: reversal by the benzodiazepine antagonist CGS 8216. Life sciences. 1983 May; 32(21):2439-45. doi: 10.1016/0024-3205(83)90369-7. [PMID: 6855447]
  • H H Borden, R W Harris, W E Mosher. A waterborne outbreak of gastroenteritis in western New York State. American journal of public health and the nation's health. 1970 Feb; 60(2):283-8. doi: 10.2105/ajph.60.2.283. [PMID: 5460971]