2-Hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenoxy]propyl]amino]ethoxy]benzamide (BioDeep_00000177196)
human metabolite blood metabolite
代谢物信息卡片
1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazoylyl)phenoxy)-2-propanol methanesulfonate
化学式: C23H25F3N4O5 (494.1777)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CN1C=C(N=C1C1=CC=C(OCC(O)CNCCOC2=CC(C(N)=O)=C(O)C=C2)C=C1)C(F)(F)F
InChI: InChI=1S/C23H25F3N4O5/c1-30-12-20(23(24,25)26)29-22(30)14-2-4-16(5-3-14)35-13-15(31)11-28-8-9-34-17-6-7-19(32)18(10-17)21(27)33/h2-7,10,12,15,28,31-32H,8-9,11,13H2,1H3,(H2,27,33)
描述信息
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
同义名列表
6 个代谢物同义名
1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazoylyl)phenoxy)-2-propanol methanesulfonate; 2-hydroxy-5-{2-[(2-hydroxy-3-{4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy}propyl)amino]ethoxy}benzamide; 2-Hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenoxy]propyl]amino]ethoxy]benzamide; 2-hydroxy-5-{2-[(2-hydroxy-3-{4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenoxy}propyl)amino]ethoxy}benzamide; 2-Hydroxy-5-(2-(hydroxy-3-(4-((1-methyl-4-trifluoromethyl)-1H-imidazol-2-yl)phenoxy)propyl)aminoethoxy)benzamide; CGP-20712-a
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:91628
- PubChem: 2685
- HMDB: HMDB0249859
- ChEMBL: CHEMBL280822
- chemspider: 2584
- CAS: 137888-49-4
- CAS: 81015-67-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Paramita M Ghosh, Zhen-Ju Shu, Bing Zhu, Zhongding Lu, Yuji Ikeno, Jeffrey L Barnes, Chih-Ko Yeh, Bin-Xian Zhang, Michael S Katz, Amrita Kamat. Role of β-adrenergic receptors in regulation of hepatic fat accumulation during aging.
The Journal of endocrinology.
2012 Jun; 213(3):251-61. doi:
10.1530/joe-11-0406. [PMID: 22457517] - Hao Zhen Cui, Hye Ran Choi, Deok Ho Choi, Kyung Woo Cho, Dae Gill Kang, Ho Sub Lee. Aqueous extract of Zanthoxylum schinifolium elicits contractile and secretory responses via beta1-adrenoceptor activation in beating rabbit atria.
Journal of ethnopharmacology.
2009 Nov; 126(2):300-7. doi:
10.1016/j.jep.2009.08.025. [PMID: 19703535] - Melinda Wuest, Birgit Eichhorn, Marc O Grimm, Manfred P Wirth, Ursula Ravens, Alberto J Kaumann. Catecholamines relax detrusor through beta 2-adrenoceptors in mouse and beta 3-adrenoceptors in man.
The Journal of pharmacology and experimental therapeutics.
2009 Jan; 328(1):213-22. doi:
10.1124/jpet.108.142562. [PMID: 18820136] - Qin Wu, Zhi Zhao, Hong Sun, Yan-ling Hao, Chang-dong Yan, Shu-ling Gu. Oestrogen changed cardiomyocyte contraction and beta-adrenoceptor expression in rat hearts subjected to ischaemia-reperfusion.
Experimental physiology.
2008 Sep; 93(9):1034-43. doi:
10.1113/expphysiol.2007.041939. [PMID: 18469068] - Mafía D Carceles, Teodomiro Fuentes, Vicente Aroca, Jesús Lopez, Jesús Hernández. Effects of milrinone on contractility and cyclic adenosine monophosphate production induced by beta1- and beta2-adrenergic receptor activation in human myocardium.
Clinical therapeutics.
2007 Aug; 29(8):1718-24. doi:
10.1016/j.clinthera.2007.08.009. [PMID: 17919552] - K Leineweber, C Schwiebert, R Büscher, M C Michel. Is cyclic AMP formation desensitized in patients with end-stage renal failure?.
Autonomic & autacoid pharmacology.
2005 Jan; 25(1):25-32. doi:
10.1111/j.1474-8673.2004.00329.x. [PMID: 15659151] - Fabrice Jaffré, Jacques Callebert, Alexandre Sarre, Nelly Etienne, Canan G Nebigil, Jean-Marie Launay, Luc Maroteaux, Laurent Monassier. Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts.
Circulation.
2004 Aug; 110(8):969-74. doi:
10.1161/01.cir.0000139856.20505.57. [PMID: 15302781] - Andreas Bundkirchen, Klara Brixius, Birgit Bölck, Quang Nguyen, Robert H G Schwinger. Beta 1-adrenoceptor selectivity of nebivolol and bisoprolol. A comparison of [3H]CGP 12.177 and [125I]iodocyanopindolol binding studies.
European journal of pharmacology.
2003 Jan; 460(1):19-26. doi:
10.1016/s0014-2999(02)02875-3. [PMID: 12535855] - W S Akers, A Cross, R Speth, L P Dwoskin, L A Cassis. Renin-angiotensin system and sympathetic nervous system in cardiac pressure-overload hypertrophy.
American journal of physiology. Heart and circulatory physiology.
2000 Dec; 279(6):H2797-806. doi:
10.1152/ajpheart.2000.279.6.h2797. [PMID: 11087234] - T J Visser, A van Waarde, P Doze, P H Elsinga, T W van der Mark, J Kraan, K Ensing, W Vaalburg. Characterisation of beta2-adrenoceptors, using the agonist [11C]formoterol and positron emission tomography.
European journal of pharmacology.
1998 Nov; 361(1):35-41. doi:
10.1016/s0014-2999(98)00694-3. [PMID: 9851539] - R P Xiao, E D Tomhave, D J Wang, X Ji, M O Boluyt, H Cheng, E G Lakatta, W J Koch. Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases.
The Journal of clinical investigation.
1998 Mar; 101(6):1273-82. doi:
10.1172/jci1335. [PMID: 9502768] - G Flügge, O Ahrens, E Fuchs. Beta-adrenoceptors in the tree shrew brain. II. Time-dependent effects of chronic psychosocial stress on [125I]iodocyanopindolol bindings sites.
Cellular and molecular neurobiology.
1997 Aug; 17(4):417-32. doi:
10.1023/a:1026387311220. [PMID: 9262868] - A J Hoey, M L Matthews, T W Badran, G G Pegg, M N Sillence. Cardiovascular effects of clenbuterol are beta 2-adrenoceptor-mediated in steers.
Journal of animal science.
1995 Jun; 73(6):1754-65. doi:
10.2527/1995.7361754x. [PMID: 7673070] - B Mandon, E Siga, A Champigneulle, M Imbert-Teboul, J M Elalouf. Molecular analysis of beta-adrenergic receptor subtypes in rat collecting duct: effects on cell cAMP and Ca2+ levels.
The American journal of physiology.
1995 Jun; 268(6 Pt 2):F1070-80. doi:
10.1152/ajprenal.1995.268.6.f1070. [PMID: 7611448] - E M Rohlfs, K W Daniel, R T Premont, L P Kozak, S Collins. Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines.
The Journal of biological chemistry.
1995 May; 270(18):10723-32. doi:
10.1074/jbc.270.18.10723. [PMID: 7738011] - E Nisoli, C Tonello, M O Carruba. SR 58611A: a novel thermogenic beta-adrenoceptor agonist.
European journal of pharmacology.
1994 Jul; 259(2):181-6. doi:
10.1016/0014-2999(94)90508-8. [PMID: 7957612] - V I Tarizzo, R P Coppes, C Dahlöf, J Zaagsma. Pre- and postganglionic stimulation-induced noradrenaline overflow is markedly facilitated by a prejunctional beta 2-adrenoceptor-mediated control mechanism in the pithed rat.
Naunyn-Schmiedeberg's archives of pharmacology.
1994 Jun; 349(6):570-7. doi:
10.1007/bf01258461. [PMID: 7969507] - S Collins, K W Daniel, E M Rohlfs, V Ramkumar, I L Taylor, T W Gettys. Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice.
Molecular endocrinology (Baltimore, Md.).
1994 Apr; 8(4):518-27. doi:
10.1210/mend.8.4.7914350. [PMID: 7914350] - A Ota, H Matsui, M Asakura, T Nagatsu. Distribution of beta 1- and beta 2-adrenoceptor subtypes in various mouse tissues.
Neuroscience letters.
1993 Sep; 160(1):96-100. doi:
10.1016/0304-3940(93)90922-8. [PMID: 7902545] - L H Tung, G Jackman, B Campbell, S Louis, D Iakovidis, W J Louis. Partial agonist activity of celiprolol.
Journal of cardiovascular pharmacology.
1993 Mar; 21(3):484-8. doi:
10.1097/00005344-199303000-00020. [PMID: 7681512] - M Grino, C Oliver. Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines.
Endocrinology.
1992 Dec; 131(6):2763-8. doi:
10.1210/endo.131.6.1359963. [PMID: 1359963] - A van Waarde, J G Meeder, P K Blanksma, J Bouwer, G M Visser, P H Elsinga, A M Paans, W Vaalburg, K I Lie. Suitability of CGP-12177 and CGP-26505 for quantitative imaging of beta-adrenoceptors.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.
1992 Oct; 19(7):711-8. doi:
10.1016/0883-2897(92)90130-q. [PMID: 1356953] - A Van Ermen, E Van de Velde, P Vanscheeuwijck, N Fraeyman. Influence of age on the beta 1- and beta 2-adrenergic receptors in rat liver.
Molecular pharmacology.
1992 Oct; 42(4):649-55. doi:
NULL. [PMID: 1331756] - C Nanoff, M Freissmuth, E Tuisl, W Schütz. A different desensitization pattern of cardiac beta-adrenoceptor subtypes by prolonged in vivo infusion of isoprenaline.
Journal of cardiovascular pharmacology.
1989 Feb; 13(2):198-203. doi:
10.1097/00005344-198902000-00004. [PMID: 2468946]
