3-Aminopropyl(diethoxymethyl)phosphinic acid (BioDeep_00000177190)
human metabolite blood metabolite
代谢物信息卡片
化学式: C8H20NO4P (225.112989)
中文名称: (3-氨丙基)(二乙氧基甲基)膦酸水合物
谱图信息:
最多检出来源 Mus musculus(blood) 4%
分子结构信息
SMILES: CCOC(OCC)P(=O)(CCCN)O
InChI: InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)
描述信息
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018756 - GABA Antagonists
CGP 35348?is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM.?CGP 35348 shows affinity for the GABAB receptor only[1]. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage[2].
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 107699
- HMDB: HMDB0249851
- ChEMBL: CHEMBL40157
- CAS: 123690-79-9
- medchemexpress: HY-103530
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kushal Kumar, Harmanpreet Kaur, Rahul Deshmukh. Neuroprotective role of GABAB receptor modulation against streptozotocin-induced behavioral and biochemical abnormalities in rats.
Neuroscience.
2017 08; 357(?):67-74. doi:
10.1016/j.neuroscience.2017.05.054. [PMID: 28596118] - Quratulane Gillani, Muhammad Ali, Furhan Iqbal. Effect of GABAB receptor antagonists (CGP 35348 and CGP 55845) on serum interleukin 6 and 18 concentrations in albino mice following neonatal hypoxia ischemia insult.
Pakistan journal of pharmaceutical sciences.
2016 Sep; 29(5):1503-1508. doi:
NULL. [PMID: 27731803] - Liang Zhang, Robert G Wither, Min Lang, Chiping Wu, Elena Sidorova-Darmos, Hristo Netchev, Catherine B Matolcsy, Orlando Carter Snead, James H Eubanks. A Role for Diminished GABA Transporter Activity in the Cortical Discharge Phenotype of MeCP2-Deficient Mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2016 May; 41(6):1467-76. doi:
10.1038/npp.2015.323. [PMID: 26499511] - Ravi Kant Tyagi, Rohit Bisht, Jatin Pant, Puneet Kumar, Abu Bakar Abdul Majeed, Atish Prakash. Possible role of GABA-B receptor modulation in MPTP induced Parkinson's disease in rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2015 Feb; 67(2):211-7. doi:
10.1016/j.etp.2014.12.001. [PMID: 25547370] - Lei Ding, Run Gao, Xiao-Qing Xiong, Xing-Ya Gao, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. GABA in Paraventricular Nucleus Regulates Adipose Afferent Reflex in Rats.
PloS one.
2015; 10(8):e0136983. doi:
10.1371/journal.pone.0136983. [PMID: 26317425] - Cristina Romei, Elisa Luccini, Maurizio Raiteri, Luca Raiteri. GABA(B) presynaptic receptors modulate glycine exocytosis from mouse spinal cord and hippocampus glycinergic nerve endings.
Pharmacological research.
2009 Mar; 59(3):154-9. doi:
10.1016/j.phrs.2008.12.004. [PMID: 19135152] - Guillermo Gonzalez-Burgos, Diana C Rotaru, Aleksey V Zaitsev, Nadezhda V Povysheva, David A Lewis. GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons.
Journal of neurophysiology.
2009 Feb; 101(2):533-47. doi:
10.1152/jn.91161.2008. [PMID: 19073797] - Madhu P Sirivelu, Robert Burnett, Andrew C Shin, Charlotte Kim, P S MohanKumar, Sheba M J MohanKumar. Interaction between GABA and norepinephrine in interleukin-1beta-induced suppression of the luteinizing hormone surge.
Brain research.
2009 Jan; 1248(?):107-14. doi:
10.1016/j.brainres.2008.10.057. [PMID: 19014915] - Ming-Kui Zhong, Zhen Shi, Li-Min Zhou, Juan Gao, Zhao-Hui Liao, Wei Wang, Xing-Ya Gao, Guo-Qing Zhu. Regulation of cardiac sympathetic afferent reflex by GABA(A) and GABA(B) receptors in paraventricular nucleus in rats.
The European journal of neuroscience.
2008 Jun; 27(12):3226-32. doi:
10.1111/j.1460-9568.2008.06261.x. [PMID: 18554298] - Alissa R Hicks, Daniel R Kapusta, Kurt J Varner. Mechanisms underlying the sympathomimetic cardiovascular responses elicited by gamma-hydroxybutyrate.
Journal of cardiovascular pharmacology.
2004 Dec; 44(6):631-8. doi:
10.1097/00005344-200412000-00002. [PMID: 15550780] - Thomas D Lambert, Jenny Howard, Andy Plant, Steve Soffe, Alan Roberts. Mechanisms and significance of reduced activity and responsiveness in resting frog tadpoles.
The Journal of experimental biology.
2004 Mar; 207(Pt 7):1113-25. doi:
10.1242/jeb.00866. [PMID: 14978054] - Maneesh Gupta, Rachel Greven, Erwin E W Jansen, Cornelis Jakobs, Boris M Hogema, Wolfgang Froestl, O Carter Snead, Hilke Bartels, Markus Grompe, K Michael Gibson. Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria).
The Journal of pharmacology and experimental therapeutics.
2002 Jul; 302(1):180-7. doi:
10.1124/jpet.302.1.180. [PMID: 12065715] - J L Goudreau, E J Wagner, K J Lookingland, K E Moore. gamma-Aminobutyric acid receptor-mediated regulation of periventricular-hypophysial dopaminergic neurons: possible role in mediating stress- and 5-hydroxytryptamine-induced decreases in neuronal activity.
The Journal of pharmacology and experimental therapeutics.
1994 Nov; 271(2):1000-6. doi:
. [PMID: 7965762] - A Häusler, G Monnet, O Peter. Involvement of GABAB receptors in the regulation of the hypothalamo-pituitary-adrenocortical (HPA) axis in rats.
The Journal of steroid biochemistry and molecular biology.
1993 Dec; 46(6):767-71. doi:
10.1016/0960-0760(93)90317-p. [PMID: 8274410]