Ceranapril (BioDeep_00000177168)
human metabolite blood metabolite
代谢物信息卡片
化学式: C21H33N2O6P (440.20761280000005)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 5.08%
分子结构信息
SMILES: C1CC(N(C1)C(=O)C(CCCCN)OP(=O)(CCCCC2=CC=CC=C2)O)C(=O)O
InChI: InChI=1S/C21H33N2O6P/c22-14-6-4-13-19(20(24)23-15-8-12-18(23)21(25)26)29-30(27,28)16-7-5-11-17-9-2-1-3-10-17/h1-3,9-10,18-19H,4-8,11-16,22H2,(H,25,26)(H,27,28)
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sarah J O'Meara, B Therese Kinsella. The effect of the farnesyl protein transferase inhibitor SCH66336 on isoprenylation and signalling by the prostacyclin receptor.
The Biochemical journal.
2005 Feb; 386(Pt 1):177-89. doi:
10.1042/bj20041290. [PMID: 15469414] - A M Marino, S Chong, S A Dando, K J Kripalani, M S Bathala, R A Morrison. Distribution of the dipeptide transporter system along the gastrointestinal tract of rats based on absorption of a stable and specific probe, SQ-29852.
Journal of pharmaceutical sciences.
1996 Mar; 85(3):282-6. doi:
10.1021/js950017t. [PMID: 8699329] - R Morishita, H Rakugi, J Higaki, N Tomita, F Nakamura, H Yu, T Katsuya, H Mikami, T Ogihara. Differential regulation of brain angiotensin II in genetically hypertensive and normotensive rats after nephrectomy.
Blood pressure.
1994 Jul; 3(4):265-9. doi:
10.3109/08037059409102268. [PMID: 7994453] - P Raddatz, K O Minck, F Rippmann, C J Schmitges. Non-peptide renin inhibitors containing 2-(((3-phenylpropyl)phosphoryl)oxy)alkanoic acid moieties as P2-P3 replacements.
Journal of medicinal chemistry.
1994 Feb; 37(4):486-97. doi:
10.1021/jm00030a008. [PMID: 8120867] - K Kohara, K B Brosnihan, C M Ferrario. Angiotensin(1-7) in the spontaneously hypertensive rat.
Peptides.
1993 Sep; 14(5):883-91. doi:
10.1016/0196-9781(93)90063-m. [PMID: 8284265] - K Kishi, M Ikeda. Chronic effects of SQ29,852, a new angiotensin converting enzyme (ACE) inhibitor with a phosphonic acid group, in experimental hypertensive rats.
General pharmacology.
1993 Jul; 24(4):863-6. doi:
10.1016/0306-3623(93)90160-y. [PMID: 8224740] - J Sasaki, S Koga, K Kato, M Takii, K Sakai, K Kawasaki, M Kagimoto, Y Doi, K Takada, A Sakaue. Hypotensive effects and influence on serum lipids of SQ29,852, a new angiotensin converting enzyme inhibitor, in patients with essential hypertension: a comparison with atenolol.
International journal of clinical pharmacology, therapy, and toxicology.
1993 Feb; 31(2):83-8. doi:
NULL. [PMID: 8458681] - B Z Chen, F A Mendelsohn. Effect of acute and chronic administration of ceronapril on angiotensin converting enzyme in plasma, kidney, lung, brain regions and cerebrospinal fluid of rats.
Neuropharmacology.
1992 Sep; 31(9):929-35. doi:
10.1016/0028-3908(92)90132-9. [PMID: 1331844] - J I Tu, J Brennan, B Stouffer, S Mantha, N Turabi, H M Tsay. Radioimmunoassay for ceronapril, a new angiotensin-converting enzyme inhibitor, and its application to a pharmacokinetic study in healthy male volunteers.
Therapeutic drug monitoring.
1992 Jun; 14(3):209-19. doi:
10.1097/00007691-199206000-00007. [PMID: 1412607] - N Ohara, M Takizawa, S Yokota, N Ogawa, H Katsumura, H Ono. Hypotensive effect of a phosphorus-containing novel angiotensin converting enzyme inhibitor, (S)-1-[6-amino-2[[hydroxy(4-phenylbutyl)phosphinyl] oxy]-1-oxohexyl]-L-proline (SQ 29,852) in conscious hypertensive dogs.
Journal of pharmacobio-dynamics.
1992 Jun; 15(6):267-76. doi:
10.1248/bpb1978.15.267. [PMID: 1432566] - J M DeForrest, T L Waldron, C Harvey, R Scalese, S Hammerstone, J R Powell, D Karanewsky. Ceranapril (SQ 29,852), an orally active inhibitor of angiotensin converting enzyme (ACE).
Journal of cardiovascular pharmacology.
1990 Jul; 16(1):121-7. doi:
10.1097/00005344-199007000-00017. [PMID: 1696654] - K Hiwada, Y Inoue, T Kokubu. Effect of SQ29,852, a new angiotensin converting enzyme (ACE) inhibitor with a phosphonic acid group, on the activity of angiotensin converting enzyme from human kidney.
General pharmacology.
1990; 21(4):555-8. doi:
10.1016/0306-3623(90)90714-w. [PMID: 2165961] - H Kadin, H G Brittain, E Ivashkiv, A I Cohen. Body fluid analysis of a phosphonic acid angiotensin-converting enzyme inhibitor using high-performance liquid chromatography and post-column derivatization with o-phthalaldehyde.
Journal of chromatography.
1989 Jan; 487(1):135-41. doi:
10.1016/s0378-4347(00)83015-7. [PMID: 2715256] - D W Cushman, F L Wang, W C Fung, G J Grover, C M Harvey, R J Scalese, S L Mitch, J M DeForrest. Comparisons in vitro, ex vivo, and in vivo of the actions of seven structurally diverse inhibitors of angiotensin converting enzyme (ACE).
British journal of clinical pharmacology.
1989; 28 Suppl 2(?):115S-130S; discussion 130S. doi:
10.1111/j.1365-2125.1989.tb03587.x. [PMID: 2557876]