cefteram pivoxil (BioDeep_00000177129)

   

human metabolite blood metabolite


代谢物信息卡片


{7-[2-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(5-methyl-2H-1,2,3,4-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carbonyloxy}methyl 2,2-dimethylpropanoic acid

化学式: C22H27N9O7S2 (593.1474792000001)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 99.05%

分子结构信息

SMILES: CON=C(C(=O)NC1C2SCC(CN3N=NC(C)=N3)=C(N2C1=O)C(=O)OCOC(=O)C(C)(C)C)C1=CSC(N)=N1
InChI: InChI=1S/C22H27N9O7S2/c1-10-26-29-30(27-10)6-11-7-39-18-14(25-16(32)13(28-36-5)12-8-40-21(23)24-12)17(33)31(18)15(11)19(34)37-9-38-20(35)22(2,3)4/h8,14,18H,6-7,9H2,1-5H3,(H2,23,24)(H,25,32)

描述信息

同义名列表

5 个代谢物同义名

{7-[2-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(5-methyl-2H-1,2,3,4-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carbonyloxy}methyl 2,2-dimethylpropanoic acid; {7-[2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(5-methyl-2H-1,2,3,4-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carbonyloxy}methyl 2,2-dimethylpropanoate; {7-[2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(5-methyl-1,2,3,4-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carbonyloxy}methyl 2,2-dimethylpropanoate; Cefteram pivoxil; Tomiron



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fangmi Wei, Rong Zhu, Wenhui Zhao, Jing Yang, Zheng Cai, Qin Hu. Pharmacokinetics and bioequivalence studies of cefteram pivoxil in healthy Chinese volunteers. European journal of drug metabolism and pharmacokinetics. 2009 Jul; 34(3-4):157-62. doi: 10.1007/bf03191167. [PMID: 20166432]
  • Jianjun Zou, Bin Di, Chun Yong Wu, Qin Hu, Jian Hua Li, Yubing Zhu, Hongwei Fan, DaWei Xiao, Guang Ji Wang. Pharmacokinetic and bioequivalence comparison of a single 100-mg dose of cefteram pivoxil powder suspension and tablet formulations: a randomized-sequence, open-label, two-period crossover study in healthy Chinese adult male volunteers. Clinical therapeutics. 2008 Apr; 30(4):654-60. doi: 10.1016/j.clinthera.2008.04.003. [PMID: 18498914]
  • Yu-Jin Suh, Young-Mok Lee, Jeung-Hee Choi, Chang-Hee Suh, Dong-Ho Nahm, Hae-Sim Park. Heterogeneity of IgE response to cefteram pivoxil was noted in 2 patients with cefteram-induced occupational asthma. The Journal of allergy and clinical immunology. 2003 Jul; 112(1):209-10. doi: 10.1067/mai.2003.1525. [PMID: 12847502]
  • F Matsumoto, I Sakurai, M Morita, T Takahashi, N Mori, T Sugihara, A Sakai, S Yamaji, Y Akaike, K Yano. Effects of the quantity of water and milk ingested concomitantly with AS-924, a novel ester-type cephem antibiotic, on its pharmacokinetics. International journal of antimicrobial agents. 2001 Nov; 18(5):471-6. doi: 10.1016/s0924-8579(01)00447-2. [PMID: 11711263]
  • K Totsuka, K Shimizu, N Mori, T Sugihara, A Sakai, S Yamaji, Y Michisuji, Y Shinohara, A Kubo, H Tokuoka. Effect of antacid pretreatment on the pharmacokinetics of AS-924, a novel ester-type cephem antibiotic--comparison with cefteram-pivoxil. International journal of antimicrobial agents. 2001 Nov; 18(5):477-82. doi: 10.1016/s0924-8579(01)00445-9. [PMID: 11711264]
  • T Ito, N Sugiyama, M Kobayashi, K Kidouchi, T Itoh, O Uemura, K Sugiyama, H Togari. Alteration of ammonia and carnitine levels in short-term treatment with pivalic acid-containing prodrug. The Tohoku journal of experimental medicine. 1995 Jan; 175(1):43-53. doi: 10.1620/tjem.175.43. [PMID: 7610459]
  • Y Kusunoki, K Osana, H Yoshioka. [Identification of pivaloylcarnitine in urine of patients with pivoxil therapy]. No to hattatsu = Brain and development. 1992 Sep; 24(5):494-6. doi: NULL. [PMID: 1389335]
  • J Shimada, A Saito, K Shiba, M Kaji, S Hori, M Yoshida, T Miyahara. [Effects of antacids on absorption, excretion and metabolism of cefteram pivoxil]. The Japanese journal of antibiotics. 1990 Aug; 43(8):1353-70. doi: NULL. [PMID: 2178195]
  • H Nakamura, N Iwai. [Pharmacokinetic studies on oral antibiotics in pediatrics. II. A pharmacokinetic study on cefteram pivoxil in pediatrics]. The Japanese journal of antibiotics. 1989 Sep; 42(9):1981-2003. doi: NULL. [PMID: 2810759]
  • H Sato, A Narita, S Nakazawa, H Suzuki, K Matsumoto, Y Nakanishi, K Niino, S Nakazawa. [Clinical studies on cefteram pivoxil granules in pediatrics]. The Japanese journal of antibiotics. 1989 Sep; 42(9):1948-62. doi: NULL. [PMID: 2810757]
  • M Minamitani, K Hachimori, K Kaneda. [A clinical study on cefteram pivoxil in the field of pediatrics]. The Japanese journal of antibiotics. 1989 Sep; 42(9):1938-47. doi: NULL. [PMID: 2810756]
  • T Nishimura, K Tabuki, T Takashima, S Aoki, M Takagi. [Laboratory and clinical studies of cefteram pivoxil in pediatric field]. The Japanese journal of antibiotics. 1989 Sep; 42(9):2004-15. doi: NULL. [PMID: 2810760]
  • T Motohiro, Y Yoshinaga, K Oda, M Aramaki, A Kawakami, K Tanaka, T Koga, S Tomita, Y Sakata, F Yamashita. [Pharmacokinetic and clinical studies of cefteram pivoxil granule in the pediatric field]. The Japanese journal of antibiotics. 1989 Sep; 42(9):2023-61. doi: NULL. [PMID: 2810762]
  • Y Toyonaga, H Imai, M Sugita, Y Fukushima, M Yamazaki, M Hori. [Bacteriological, pharmacokinetic and clinical studies on cefteram pivoxil in the pediatric field]. The Japanese journal of antibiotics. 1989 Aug; 42(8):1799-814. doi: . [PMID: 2810743]
  • F Hayakawa, K Kuno, A Ogawa, Y Nakao, H Takeuchi, Y Ando, O Kito. [Laboratory and clinical studies on cefteram pivoxil in the field of pediatrics]. The Japanese journal of antibiotics. 1989 Aug; 42(8):1849-59. doi: . [PMID: 2810748]
  • Y Wagatsuma, A Takase, N Fukushima, A Ishikawa, S Takahashi. [Clinical evaluation of cefteram pivoxil fine granules in pediatric infections]. The Japanese journal of antibiotics. 1989 Aug; 42(8):1735-44. doi: NULL. [PMID: 2810737]
  • G Suzuki, A Watanabe. [Laboratory and clinical studies on cefteram pivoxil in pediatric field]. The Japanese journal of antibiotics. 1989 Aug; 42(8):1751-60. doi: NULL. [PMID: 2810739]
  • H Sakata, H Kakehashi, K Fujita, H Yoshioka, K Iseki, K Murono, Y Takahashi. [Clinical and pharmacokinetic evaluation of cefteram pivoxil in children]. The Japanese journal of antibiotics. 1989 Aug; 42(8):1727-34. doi: NULL. [PMID: 2810736]
  • S Iwata, K Yamada, Y Kin, T Yokota, Y Kusumoto, Y Sato, H Akita, S Nanri, T Oikawa, K Sunakawa. [The influence of cefteram pivoxil on the intestinal bacterial flora]. The Japanese journal of antibiotics. 1989 Aug; 42(8):1761-79. doi: NULL. [PMID: 2810740]
  • T Shinozaki, C Nonaka, K Togasaki. [Clinical studies on cefteram pivoxil in the field of pediatrics]. The Japanese journal of antibiotics. 1989 Aug; 42(8):1837-44. doi: NULL. [PMID: 2810746]
  • J Shimada, A Saito, K Shiba, T Yamaji, T Hojo, M Kaji, S Hori, S Okuda, T Miyahara. [Pharmacokinetic studies of a new oral cephem T-2588. Pharmacokinetics in gastrectomized volunteers and the renal excretory system in healthy volunteers]. The Japanese journal of antibiotics. 1986 Oct; 39(10):2701-9. doi: NULL. [PMID: 3806955]
  • H Nakada, Y Kawamura, T Shibata, Y Nojima, T Sanzen, K Yoshida, T Yoneda. [A subacute oral toxicity study of T-2588 in juvenile rats]. The Japanese journal of antibiotics. 1986 Sep; 39(9):2285-300. doi: NULL. [PMID: 3795478]
  • I Saikawa, T Maeda, Y Nakashima, H Sakai, H Hayakawa, M Onoda, H Matsutani. [Studies on absorption, distribution and excretion of 14C labeled pivaloyloxymethyl (+)-(6R,7R)- 7-[(Z)-2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]- 3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia- 1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (14C-T-2588) in rats and mice]. The Japanese journal of antibiotics. 1986 Apr; 39(4):979-90. doi: NULL. [PMID: 3761551]
  • S Hirai, T Kodama, T Hiraiwa, N Abe, H Arai, S Ono, M Omori, Y Nakada, K Hashiba, K Tanada. [General pharmacology of T-2588, a new oral cephem antibiotic]. The Japanese journal of antibiotics. 1986 Apr; 39(4):958-78. doi: NULL. [PMID: 3761550]
  • A Takai. [Immunological studies on the antigenicity of the cephem antibiotic T-2588]. The Japanese journal of antibiotics. 1985 Jun; 38(6):1693-702. doi: NULL. [PMID: 3840213]
  • M K Samson, R L Stephens, S Rivkin, M Opipari, T Maloney, C W Groppe, R Fisher. Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study. Cancer treatment reports. 1979 Sep; 63(9-10):1663-7. doi: . [PMID: 91435]