Cefozopran (BioDeep_00000177122)
human metabolite blood metabolite
代谢物信息卡片
1-({7-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl}methyl)imidazo[1,2-b]pyridazin-1-ium
化学式: C19H17N9O5S2 (515.0794032)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 75%
分子结构信息
SMILES: CON=C(C(=O)NC1C2SCC(C[N+]3=C4C=CC=NN4C=C3)=C(N2C1=O)C([O-])=O)C1=NSC(N)=N1
InChI: InChI=1S/C19H17N9O5S2/c1-33-24-11(14-23-19(20)35-25-14)15(29)22-12-16(30)28-13(18(31)32)9(8-34-17(12)28)7-26-5-6-27-10(26)3-2-4-21-27/h2-6,12,17H,7-8H2,1H3,(H3-,20,22,23,25,29,31,32)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nuggehally R Srinivas. Interspecies scaling of excretory amounts using allometry - retrospective analysis with rifapentine, aztreonam, carumonam, pefloxacin, miloxacin, trovafloxacin, doripenem, imipenem, cefozopran, ceftazidime, linezolid for urinary excretion and rifapentine, cabotegravir, and dolutegravir for fecal excretion.
Xenobiotica; the fate of foreign compounds in biological systems.
2016 Sep; 46(9):784-92. doi:
10.3109/00498254.2015.1121554. [PMID: 26711252] - G L Wu, J Z Shentu, H L Zhou, M X Zhu, X J Hu, J Liu, L H Wu. Pharmacokinetics of cefozopran by single and multiple intravenous infusions in healthy Chinese volunteers.
Drugs in R&D.
2015 Mar; 15(1):63-70. doi:
10.1007/s40268-014-0075-3. [PMID: 25644122] - Wang-Wei Guo, Qi Shen, Yong-Ping Qin, Ying Wang, Lei Wang, Jia Miao, Feng Nan, Jin Xiang, Qin Yu, Mao-Zhi Liang. [Pharmacokinetics of injected cefozopran hydrochloride in healthy volunteers].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2012 Sep; 43(5):711-4. doi:
NULL. [PMID: 23230745] - Kazuro Ikawa, Toshihiro Kozumi, Kayo Ikeda, Norifumi Morikawa, Ryoji Kobayashi. Population pharmacokinetic modeling and pharmacodynamic assessment of cefozopran in pediatric patients.
The Japanese journal of antibiotics.
2009 Oct; 62(5):435-44. doi:
. [PMID: 20055120] - Kayo Ikeda, Kazuro Ikawa, Norifumi Morikawa, Hiroki Ohge, Taijiro Sueda. Determination of total cefozopran concentrations in human peritoneal fluid by HPLC with cefepime as an internal standard: Comparative pharmacokinetics in the fluid and plasma.
Journal of pharmaceutical and biomedical analysis.
2009 May; 49(4):1075-81. doi:
10.1016/j.jpba.2009.01.026. [PMID: 19233585] - Kazuro Ikawa, Hiroshige Mikamo, Norifumi Morikawa, Kayo Ikeda, Teruhiko Tamaya. Penetration into and exposure of cefozopran in pelvic retroperitoneal space exudate.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2008 Apr; 14(2):170-1. doi:
10.1007/s10156-008-0590-7. [PMID: 18622684] - Kenichi Nomura, Norifumi Morikawa, Kazuro Ikawa, Kayo Ikeda, Yoshiko Fujimoto, Daisuke Shimizu, Kyoko Taniguchi, Kazuho Shimura, Yuko Kanbayashi, Toshiaki Komori, Yosuke Matsumoto, Naohisa Fujita, Chihiro Shimazaki, Masafumi Taniwaki. Optimized dosage and frequency of cefozopran for patients with febrile neutropenia based on population pharmacokinetic and pharmacodynamic analysis.
The Journal of antimicrobial chemotherapy.
2008 Apr; 61(4):892-900. doi:
10.1093/jac/dkn038. [PMID: 18276604] - Kazuro Ikawa, Norifumi Morikawa, Kayo Ikeda, Hiroki Ohge, Taijiro Sueda. Development of breakpoints of cephems for intraabdominal infections based on pharmacokinetics and pharmacodynamics in the peritoneal fluid of patients.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2008 Apr; 14(2):141-6. doi:
10.1007/s10156-008-0598-z. [PMID: 18622678] - Kazuro Ikawa, Kenichi Nomura, Norifumi Morikawa, Kayo Ikeda, Hiroki Ohge, Taijiro Sueda, Masafumi Taniwaki. Pharmacokinetic-pharmacodynamic target attainment analysis of cefozopran in Japanese adult patients.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2008 Apr; 14(2):130-6. doi:
10.1007/s10156-008-0589-0. [PMID: 18622676] - Kayo Ikeda, Norifumi Morikawa, Misa Kuribayashi, Kazuro Ikawa, Kenichi Nomura, Masafumi Taniwaki. Real-time therapeutic drug monitoring of cefozopran in plasma using high-performance liquid chromatography with ultraviolet detection.
Journal of pharmaceutical and biomedical analysis.
2007 Dec; 45(5):811-6. doi:
10.1016/j.jpba.2007.08.004. [PMID: 17869473] - Kazuro Ikawa, Norifumi Morikawa, Shusaku Matsuda, Kayo Ikeda, Hiroki Ohge, Yoshio Takesue, Taijiro Sueda. Peritoneal penetration and pharmacodynamic exposure of intravenous cefozopran in abdominal surgery patients.
International journal of antimicrobial agents.
2007 Oct; 30(4):352-5. doi:
10.1016/j.ijantimicag.2007.06.001. [PMID: 17644344] - Toshihiro Kitahashi, Itaru Furuta. Development and validation of a MEKC method for the direct determination of cefozopran in human serum.
Journal of pharmaceutical and biomedical analysis.
2004 Feb; 34(2):409-14. doi:
10.1016/s0731-7085(03)00498-9. [PMID: 15013155] - Kiyohito Ishikawa, Shinzaburo Miyakawa, Toshiyuki Tanaka, Yorio Naide, Ryoichi Shiroki, Kiyotaka Hoshinaga. [The trend and susceptibility to antibacterial agents of enterococcus species from urinary tract infections].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
2004 Jan; 95(1):25-34. doi:
10.5980/jpnjurol1989.95.25. [PMID: 14978938] - Toshihiro Hamada, Eisaku Ueta, Hiroyuki Kodama, Tokio Osaki. The excretion of cephem antibiotics into saliva is inversely associated with their plasma protein-binding activities.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.
2002 Feb; 31(2):109-16. doi:
10.1046/j.0904-2512.2001.00015.x. [PMID: 11896833] - M Fukuda, K Endo, S Takinami, N Kawai, K Tominaga, S Maesaki, M Bessho, T Yamazaki. [Clinical effects of combination therapy with cefozopran and amikacin for infections in patients with hematological disorders].
The Japanese journal of antibiotics.
2001 Feb; 54(2):88-94. doi:
. [PMID: 11338682] - T Abe, M Sugiura, Y Nakazato, S Hashira, K Yoshimura, Y Kondoh, Y Kawaoi, T Tajima, S Nagai, N Funamoto, S Sugimori, S Nishimura. [Pharmacokinetic, bacteriological and clinical studies on cefozopran in neonates].
The Japanese journal of antibiotics.
1997 Dec; 50(12):936-44. doi:
. [PMID: 9545670] - R Fujii, A Okuno, K Fujita, F Kakuya, S Maruyama, H Sakata, F Inyaku, T Abe, S Hashira, Y Nakazato, M Sugiura, T Tajima, S Nagai, N Funamoto, S Sugimori, S Nishimura, K Yoshimura, Y Kondoh, Y Kawaoi, I Terashima, H Meguro, Y Takeuchi, M Kantake, K Sunakawa, M Yagisawa. [Pharmacokinetic, bacteriological and clinical studies on cefozopran in neonates and premature infants. A study of cefozopran in the perinatal co-research group].
The Japanese journal of antibiotics.
1996 Jul; 49(7):678-702. doi:
. [PMID: 8828070] - R Fujii, K Sunakawa, Y Sato, T Yokota, K Yoshimura, Y Kondoh, Y Kawaoi, I Terashima, H Meguro, K Niinou, Y Toyonaga, T Ishihara, N Iwai, H Nakamura, K Kuno, Y Miyajima, M Sakurai, M Itoh, H Kawasaki, S Suga, H Kamiya, T Fujiwara, T Inui, K Taniguchi, M Nakayama. [Optimum dose study of cefozopran in the pediatric field].
The Japanese journal of antibiotics.
1996 Jul; 49(7):663-77. doi:
. [PMID: 8828069] - T Haruta, K Okura, S Kuroki, H Nikami, Y Kobayashi. [Transferability of cefozopran to cerebrospinal fluid in rabbits with meningitis caused by Staphylococcus aureus].
The Japanese journal of antibiotics.
1996 May; 49(5):517-21. doi:
NULL. [PMID: 8752865] - R Fujii, T Abe, T Tajima, I Terashima, H Meguro. Pharmacokinetics and clinical effects of cefozopran in pediatric patients.
The Japanese journal of antibiotics.
1996 Jan; 49(1):17-33. doi:
. [PMID: 8851304] - Y Toyonaga, T Ishihara, K Hatakeyama, T Sano, K Kawamura, K Seo, H Nakamura. [Pharmacokinetic and clinical evaluation of cefozopran in the pediatric field].
The Japanese journal of antibiotics.
1994 Nov; 47(11):1495-513. doi:
. [PMID: 7853680] - K Kuno, A Ogawa, F Hayakawa, H Takahashi, M Kondo, A Okumura. [Pharmacokinetic and clinical studies of cefozopran in the field of pediatrics].
The Japanese journal of antibiotics.
1994 Nov; 47(11):1514-20. doi:
. [PMID: 7853681] - T Tajima, Y Kondo, S Negishi, S Kawashima, N Hagiwara, T Iizuka, K Kubota, T Abe. [Pharmacokinetic, bacteriological and clinical studies on cefozopran in children].
The Japanese journal of antibiotics.
1994 Nov; 47(11):1457-63. doi:
. [PMID: 7853676] - K Kitamura, T Ihara, H Kamiya, E Azuma, M Itoh, M Sakurai. [Pharmacokinetic and clinical studies of cefozopran in the field of pediatrics].
The Japanese journal of antibiotics.
1994 Nov; 47(11):1536-43. doi:
. [PMID: 7853683] - Y Kaino, K Kida, H Matsuda. [Pharmacokinetic and clinical studies on cefozopran in the field of pediatrics].
The Japanese journal of antibiotics.
1994 Nov; 47(11):1565-75. doi:
. [PMID: 7853687] - N Iwai, H Nakamura, M Miyazu, Y Watanabe, Y Taneda. [Pharmacokinetic and clinical evaluation of cefozopran in the pediatric field].
The Japanese journal of antibiotics.
1994 Nov; 47(11):1521-35. doi:
. [PMID: 7853682] - T Motohiro, S Handa, S Yamada, H Sasaki, S Oki, Y Yoshinaga, K Oda, M Aramaki, Y Sakata, F Yamashita. [Pharmacokinetic, bacteriological and clinical studies on cefozopran in the pediatric field].
The Japanese journal of antibiotics.
1994 Nov; 47(11):1589-611. doi:
. [PMID: 7853690] - H Meguro, R Fujii, I Terashima. [Clinical evaluation of cefozopran in the pediatric field].
The Japanese journal of antibiotics.
1994 Nov; 47(11):1464-72. doi:
. [PMID: 7853677] - K Niinou, H Sato. [Studies on cefozopran in the pediatric field].
The Japanese journal of antibiotics.
1994 Nov; 47(11):1473-84. doi:
. [PMID: 7853678] - H Akita, Y Sato, S Iwata, T Yokota, K Sunakawa. [Pharmacokinetic and clinical studies on cefozopran in pediatrics].
The Japanese journal of antibiotics.
1994 Nov; 47(11):1485-94. doi:
. [PMID: 7853679] - R Fujii, T Abe, T Tajima, I Terashima, H Meguro, S Nakazawa, H Sato, K Niinou, K Sunakawa, T Yokota. [Pharmacokinetic and clinical studies with cefozopran in the pediatric field. Pediatric Study Group of Cefozopran].
The Japanese journal of antibiotics.
1994 Jan; 47(1):102-23. doi:
. [PMID: 8114268] - W Paulfeuerborn, H J Müller, K Borner, P Koeppe, H Lode. Comparative pharmacokinetics and serum bactericidal activities of SCE-2787 and ceftazidime.
Antimicrobial agents and chemotherapy.
1993 Sep; 37(9):1835-41. doi:
10.1128/aac.37.9.1835. [PMID: 8239592] - K Borner, E Borner, H Lode. Determination of a new cephalosporin, SCE-2787, in serum and urine by high-performance liquid chromatography.
Journal of chromatography.
1993 May; 615(1):174-9. doi:
10.1016/0378-4347(93)80306-o. [PMID: 8340458] - Y Kita, T Yamazaki, A Imada. Comparative pharmacokinetics of SCE-2787 and related antibiotics in experimental animals.
Antimicrobial agents and chemotherapy.
1992 Nov; 36(11):2481-6. doi:
10.1128/aac.36.11.2481. [PMID: 1489192]