Ccris 6547 (BioDeep_00000177084)

   

human metabolite blood metabolite


代谢物信息卡片


N-[1-[[1-[[1-[[2-[[1-[[1-[(1-amino-4-methyl-1-oxopentan-2-yl)amino]-4-methylpentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carbonylamino)pentanediamide

化学式: C56H79N15O9 (1105.6184884)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(CNC(CC(C)C)C(=O)N)NC(=O)C(CC1=CN=CN1)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCC(=O)N)NC(=O)C4CC5=C(CN4)NC6=CC=CC=C56
InChI: InChI=1S/C56H79N15O9/c1-29(2)18-35(25-61-42(50(58)74)19-30(3)4)66-55(79)45(21-34-24-59-28-64-34)68-48(73)27-63-56(80)49(31(5)6)71-51(75)32(7)65-54(78)44(20-33-23-60-39-14-10-8-12-36(33)39)70-52(76)41(16-17-47(57)72)69-53(77)43-22-38-37-13-9-11-15-40(37)67-46(38)26-62-43/h8-15,23-24,28-32,35,41-45,49,60-62,67H,16-22,25-27H2,1-7H3,(H2,57,72)(H2,58,74)(H,59,64)(H,63,80)(H,65,78)(H,66,79)(H,68,73)(H,69,77)(H,70,76)(H,71,75)

描述信息

D020011 - Protective Agents > D016588 - Anticarcinogenic Agents
D000970 - Antineoplastic Agents

同义名列表

4 个代谢物同义名

N-[1-[[1-[[1-[[2-[[1-[[1-[(1-amino-4-methyl-1-oxopentan-2-yl)amino]-4-methylpentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carbonylamino)pentanediamide; N-(1-{[1-({1-[({[1-({1-[(1-carbamoyl-3-methylbutyl)amino]-4-methylpentan-2-yl}carbamoyl)-2-(1H-imidazol-5-yl)ethyl]carbamoyl}methyl)carbamoyl]-2-methylpropyl}carbamoyl)ethyl]carbamoyl}-2-(1H-indol-3-yl)ethyl)-2-({1H,2H,3H,4H,9H-pyrido[3,4-b]indol-3-yl}formamido)pentanediamide; N-(1-{[1-({1-[({[1-({1-[(1-carbamoyl-3-methylbutyl)amino]-4-methylpentan-2-yl}carbamoyl)-2-(3H-imidazol-4-yl)ethyl]carbamoyl}methyl)carbamoyl]-2-methylpropyl}carbamoyl)ethyl]carbamoyl}-2-(1H-indol-3-yl)ethyl)-2-{1H,2H,3H,4H,9H-pyrido[3,4-b]indol-3-ylformamido}pentanediamide; Ccris 6547



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mi-Kyoung Kim, Hyun-Joo Park, Yeon Kim, Soo-Kyung Bae, Hyung Joon Kim, Moon-Kyoung Bae. Involvement of Gastrin-Releasing Peptide Receptor in the Regulation of Adipocyte Differentiation in 3T3-L1 Cells. International journal of molecular sciences. 2018 Dec; 19(12):. doi: 10.3390/ijms19123971. [PMID: 30544709]
  • Fabricia Petronilho, Francieli Vuolo, Letícia Selinger Galant, Larissa Constantino, Cristiane Damiani Tomasi, Vinicius Renne Giombelli, Cláudio Teodoro de Souza, Sabrina da Silva, Denise Frediani Barbeiro, Francisco Garcia Soriano, Emílio Luiz Streck, Cristiane Ritter, Alfeu Zanotto-Filho, Matheus Augusto Pasquali, Daniel Pens Gelain, José Luiz Rybarczyk-Filho, José Cláudio Fonseca Moreira, Norman L Block, Rafael Roesler, Gilberto Schwartsmann, Andrew V Schally, Felipe Dal-Pizzol. Gastrin-releasing peptide receptor antagonism induces protection from lethal sepsis: involvement of toll-like receptor 4 signaling. Molecular medicine (Cambridge, Mass.). 2012 Oct; 18(?):1209-19. doi: 10.2119/molmed.2012.00083. [PMID: 22735756]
  • P G Oliveira, R Grespan, L G Pinto, L Meurer, J C T Brenol, R Roesler, G Schwartsmann, F Q Cunha, R M Xavier. Protective effect of RC-3095, an antagonist of the gastrin-releasing peptide receptor, in experimental arthritis. Arthritis and rheumatism. 2011 Oct; 63(10):2956-65. doi: 10.1002/art.30486. [PMID: 21953084]
  • Fabricia Petronilho, João H Araújo, Amanda V Steckert, Gislaine T Rezin, Gabriela K Ferreira, Rafael Roesler, Gilberto Schwartsmann, Felipe Dal-Pizzol, Emilio L Streck. Effect of a gastrin-releasing peptide receptor antagonist and a proton pump inhibitor association in an animal model of gastritis. Peptides. 2009 Aug; 30(8):1460-5. doi: 10.1016/j.peptides.2009.04.026. [PMID: 19505518]
  • P G Oliveira, C V Brenol, M I Edelweiss, J C T Brenol, F Petronilho, R Roesler, F Dal-Pizzol, G Schwartsmann, R M Xavier. Effects of an antagonist of the bombesin/gastrin-releasing peptide receptor on complete Freund's adjuvant-induced arthritis in rats. Peptides. 2008 Oct; 29(10):1726-31. doi: 10.1016/j.peptides.2008.05.031. [PMID: 18590783]
  • G Schwartsmann, L P DiLeone, M Horowitz, D Schunemann, A Cancella, A S Pereira, M Richter, F Souza, A Brondani da Rocha, F H Souza, P Pohlmann, G De Nucci. A phase I trial of the bombesin/gastrin-releasing peptide (BN/GRP) antagonist RC3095 in patients with advanced solid malignancies. Investigational new drugs. 2006 Sep; 24(5):403-12. doi: 10.1007/s10637-006-6886-5. [PMID: 16505950]
  • Felipe Dal-Pizzol, Luciane Pons Di Leone, Cristiane Ritter, Márcio Rodrigo Martins, Adalisa Reinke, Daniel Pens Gelain, Alfeu Zanotto-Filho, Luiz Fernando de Souza, Michael Andrades, Denise Frediani Barbeiro, Elena Aida Bernard, Martin Cammarota, Lia R M Bevilaqua, Francisco Garcia Soriano, José Cláudio, Fonseca Moreira, Rafael Roesler, Gilberto Schwartsmann. Gastrin-releasing peptide receptor antagonist effects on an animal model of sepsis. American journal of respiratory and critical care medicine. 2006 Jan; 173(1):84-90. doi: 10.1164/rccm.200507-1118oc. [PMID: 16192447]
  • Alberto S Pereira, Luciane DiLeone, Fabiano H Souza, Sergio Lilla, Marc Richter, Gilberto Schwartsmann, Gilberto De Nucci. Quantification of the bombesin/gastrin releasing peptide antagonist RC-3095 by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Feb; 816(1-2):321-6. doi: 10.1016/j.jchromb.2004.11.041. [PMID: 15664365]
  • I Chatzistamou, A V Schally, K Szepeshazi, K Groot, F Hebert, J M Arencibia. Inhibition of growth of ES-2 human ovarian cancers by bombesin antagonist RC-3095, and luteinizing hormone-releasing hormone antagonist Cetrorelix. Cancer letters. 2001 Sep; 171(1):37-45. doi: 10.1016/s0304-3835(01)00543-2. [PMID: 11485826]
  • M Miyazaki, N Lamharzi, A V Schally, G Halmos, K Szepeshazi, K Groot, R Z Cai. Inhibition of growth of MDA-MB-231 human breast cancer xenografts in nude mice by bombesin/gastrin-releasing peptide (GRP) antagonists RC-3940-II and RC-3095. European journal of cancer (Oxford, England : 1990). 1998 Apr; 34(5):710-7. doi: 10.1016/s0959-8049(97)10123-x. [PMID: 9713279]
  • K Szepeshazi, A V Schally, G Halmos, N Lamharzi, K Groot, J E Horvath. A single in vivo administration of bombesin antagonist RC-3095 reduces the levels and mRNA expression of epidermal growth factor receptors in MXT mouse mammary cancers. Proceedings of the National Academy of Sciences of the United States of America. 1997 Sep; 94(20):10913-8. doi: 10.1073/pnas.94.20.10913. [PMID: 9380734]
  • K Groot, J E Horvàth, R Z Cai, A V Schally. Development of a radioimmunoassay for a pseudononapeptide bombesin/GRP antagonist with antitumor activity. International journal of peptide and protein research. 1995 Jun; 45(6):561-6. doi: 10.1111/j.1399-3011.1995.tb01320.x. [PMID: 7558587]
  • J Pinski, A V Schally, G Halmos, K Szepeshazi, K Groot. Somatostatin analogues and bombesin/gastrin-releasing peptide antagonist RC-3095 inhibit the growth of human glioblastomas in vitro and in vivo. Cancer research. 1994 Nov; 54(22):5895-901. doi: NULL. [PMID: 7954420]
  • J Pinski, A V Schally, G Halmos, K Szepeshazi, K Groot, K O'Byrne, R Z Cai. Effects of somatostatin analogue RC-160 and bombesin/gastrin-releasing peptide antagonists on the growth of human small-cell and non-small-cell lung carcinomas in nude mice. British journal of cancer. 1994 Nov; 70(5):886-92. doi: 10.1038/bjc.1994.415. [PMID: 7947094]
  • J Pinski, G Halmos, T Yano, K Szepeshazi, Y Qin, T Ertl, A V Schally. Inhibition of growth of MKN45 human gastric-carcinoma xenografts in nude mice by treatment with bombesin/gastrin-releasing-peptide antagonist (RC-3095) and somatostatin analogue RC-160. International journal of cancer. 1994 May; 57(4):574-80. doi: 10.1002/ijc.2910570422. [PMID: 7910153]
  • T Yano, J Pinski, K Szepeshazi, G Halmos, S Radulovic, K Groot, A V Schally. Inhibitory effect of bombesin/gastrin-releasing peptide antagonist RC-3095 and luteinizing hormone-releasing hormone antagonist SB-75 on the growth of MCF-7 MIII human breast cancer xenografts in athymic nude mice. Cancer. 1994 Feb; 73(4):1229-38. doi: 10.1002/1097-0142(19940215)73:4<1229::aid-cncr2820730417>3.0.co;2-1. [PMID: 8313327]
  • J Pinski, H Reile, G Halmos, K Groot, A V Schally. Inhibitory effects of somatostatin analogue RC-160 and bombesin/gastrin-releasing peptide antagonist RC-3095 on the growth of the androgen-independent Dunning R-3327-AT-1 rat prostate cancer. Cancer research. 1994 Jan; 54(1):169-74. doi: NULL. [PMID: 7903203]
  • J Pinski, A V Schally, G Halmos, K Szepeshazi. Effect of somatostatin analog RC-160 and bombesin/gastrin releasing peptide antagonist RC-3095 on growth of PC-3 human prostate-cancer xenografts in nude mice. International journal of cancer. 1993 Dec; 55(6):963-7. doi: 10.1002/ijc.2910550615. [PMID: 7902829]
  • J Pinski, G Halmos, K Szepeshazi, A V Schally. Antagonists of bombesin/gastrin-releasing peptides as adjuncts to agonists of luteinizing hormone-releasing hormone in the treatment of experimental prostate cancer. Cancer. 1993 Dec; 72(11):3263-70. doi: 10.1002/1097-0142(19931201)72:11<3263::aid-cncr2820721122>3.0.co;2-v. [PMID: 8242552]
  • J Pinski, G Halmos, A V Schally. Somatostatin analog RC-160 and bombesin/gastrin-releasing peptide antagonist RC-3095 inhibit the growth of androgen-independent DU-145 human prostate cancer line in nude mice. Cancer letters. 1993 Jul; 71(1-3):189-96. doi: 10.1016/0304-3835(93)90115-p. [PMID: 8103419]
  • S J Konturek, J Tasler, J Bilski, M Cieszkowski, R Z Cai, A V Schally. Antagonism of receptors for gastrin, cholecystokinin and GRP/bombesin in postprandial stimulation of exocrine pancreas in dogs. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 1993 Mar; 44(1):43-53. doi: . [PMID: 8390873]
  • J Pinski, T Yano, A V Schally. Inhibitory effects of the new bombesin receptor antagonist RC-3095 on the luteinizing hormone release in rats. Neuroendocrinology. 1992 Dec; 56(6):831-7. doi: 10.1159/000126313. [PMID: 1369591]
  • J Pinski, T Yano, Z Rekasi, R Z Cai, S Radulovic, A V Schally. High potency of a new bombesin antagonist (RC-3095) in inhibiting serum gastrin levels; comparison of different routes of administration. Regulatory peptides. 1992 Oct; 41(3):185-93. doi: 10.1016/0167-0115(92)90112-8. [PMID: 1438988]
  • J Pinski, T Yano, K Groot, R Z Cai, S Radulovic, A V Schally. Endocrine effects of new bombesin/gastrin-releasing peptide antagonists in rats. The American journal of physiology. 1992 Oct; 263(4 Pt 1):E712-7. doi: 10.1152/ajpendo.1992.263.4.e712. [PMID: 1415689]
  • T Yano, J Pinski, K Groot, A V Schally. Stimulation by bombesin and inhibition by bombesin/gastrin-releasing peptide antagonist RC-3095 of growth of human breast cancer cell lines. Cancer research. 1992 Aug; 52(16):4545-7. doi: NULL. [PMID: 1643647]
  • S R Milovanovic, S Radulovic, K Groot, A V Schally. Inhibition of growth of PC-82 human prostate cancer line xenografts in nude mice by bombesin antagonist RC-3095 or combination of agonist [D-Trp6]-luteinizing hormone-releasing hormone and somatostatin analog RC-160. The Prostate. 1992; 20(4):269-80. doi: 10.1002/pros.2990200403. [PMID: 1376910]