Carmoxirole (BioDeep_00000177050)
human metabolite blood metabolite
代谢物信息卡片
化学式: C24H26N2O2 (374.1994176)
中文名称: 盐酸卡莫昔罗
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CC=C1C2=CC=CC=C2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)O
InChI: InChI=1S/C24H26N2O2/c27-24(28)20-9-10-23-22(16-20)21(17-25-23)8-4-5-13-26-14-11-19(12-15-26)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,25H,4-5,8,12-15H2,(H,27,28)
描述信息
C78272 - Agent Affecting Nervous System > C66884 - Dopamine Agonist
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:64200
- PubChem: 57364
- HMDB: HMDB0249686
- ChEMBL: CHEMBL70159
- chemspider: 51715
- CAS: 98323-83-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- JaeSeung Hong, JingHui Feng, JinKoo Lee, HeeJung Lee, YunBeom Sim, JungSeok Park, HongWon Suh. The role of spinally located dopamine D2 receptors in the regulation of the blood glucose level in mice.
Pharmacological reports : PR.
2020 Dec; 72(6):1666-1675. doi:
10.1007/s43440-020-00126-x. [PMID: 32627115] - Giorgio Marchese, Stefania Ruiu, Paola Casti, Francesco Bartholini, Pierluigi Saba, Gian Luigi Gessa, Luca Pani. Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effect.
European journal of pharmacology.
2002 Jun; 447(1):109-14. doi:
10.1016/s0014-2999(02)01896-4. [PMID: 12106810] - M van der Ent, A F van den Heuvel, W J Remme. Neurohumoral response to carmoxirole, a selective dopamine (D2) receptor agonist, in patients with chronic moderate heart failure.
Cardiovascular drugs and therapy.
1998 Sep; 12(4):387-94. doi:
10.1023/a:1007776918751. [PMID: 9825185] - R Kirsten, M Breidert, K Sparwasser, J G Ochs, K Hesse, K Nelson. Carmoxirole inhibits platelet aggregation in vitro and ex vivo.
International journal of clinical pharmacology and therapeutics.
1995 Feb; 33(2):76-80. doi:
NULL. [PMID: 7757314] - P Lijnen, V Petrov, T Tjandramaga, R Verbesselt, A Amery. Erythrocyte and platelet cationic concentrations and transport systems in normal volunteers treated with carmoxirole.
Methods and findings in experimental and clinical pharmacology.
1993 Sep; 15(7):483-90. doi:
NULL. [PMID: 7902890] - L C Rump, E Schwertfeger, M J Schuster, U Schaible, A Frankenschmidt, P J Schollmeyer. Dopamine DA2-receptor activation inhibits noradrenaline release in human kidney slices.
Kidney international.
1993 Jan; 43(1):197-204. doi:
10.1038/ki.1993.32. [PMID: 8094472] - L C Rump, E Schwertfeger, U Schaible, M J Schuster, A Frankenschmidt, P Schollmeyer. Dopamine receptor modulation of noradrenaline release by carmoxirole in human cortical kidney slices.
European journal of clinical pharmacology.
1993; 44 Suppl 1(?):S47-9. doi:
10.1007/bf01428393. [PMID: 8097997] - W Meyer, K U Bühring, K Steiner, W Ungethüm, E Schnurr. Pharmacokinetics and first clinical experiences with an antihypertensive dopamine (DA2) agonist.
European heart journal.
1992 Sep; 13 Suppl D(?):121-8. doi:
10.1093/eurheartj/13.suppl_d.121. [PMID: 1356782] - G Haeusler, I Lues, K O Minck, P Schelling, C A Seyfried. Pharmacological basis for antihypertensive therapy with a novel dopamine agonist.
European heart journal.
1992 Sep; 13 Suppl D(?):129-35. doi:
10.1093/eurheartj/13.suppl_d.129. [PMID: 1356783] - L C Rump, K Wilde, C Bohmann, P Schollmeyer. Effects of the novel dopamine DA2-receptor agonist carmoxirole (EMD 45609) on noradrenergic and purinergic neurotransmission in rat isolated kidney.
Naunyn-Schmiedeberg's archives of pharmacology.
1992 Mar; 345(3):300-8. doi:
10.1007/bf00168691. [PMID: 1352381]
