Carbutamide (BioDeep_00000177035)

   

human metabolite blood metabolite


代谢物信息卡片


N-(4-Aminobenzenesulphonyl)butane-1-carbamimidic acid

化学式: C11H17N3O3S (271.0990572)
中文名称: 氨磺丁脲
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCN=C(O)NS(=O)(=O)C1=CC=C(N)C=C1
InChI: InChI=1S/C11H17N3O3S/c1-2-3-8-13-11(15)14-18(16,17)10-6-4-9(12)5-7-10/h4-7H,2-3,8,12H2,1H3,(H2,13,14,15)

描述信息

A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BB - Sulfonylureas
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C97936 - Sulfonylurea Antidiabetic Agent
D007004 - Hypoglycemic Agents

同义名列表

19 个代谢物同义名

N-(4-Aminobenzenesulphonyl)butane-1-carbamimidic acid; N-(4-aminobenzenesulfonyl)butane-1-carbamimidic acid; N-(4-Aminobenzenesulphonyl)butane-1-carbamimidate; N-(4-Aminobenzenesulfonyl)butane-1-carbamimidate; 1-(4-Aminophenyl)sulphonyl-3-butylurea; Servier brand OF carbutamide; Sulfaninylbutylurea; Aminophenurobutane; Butylcarbamide; Carbutamide; Glybutamide; Glucidoral; Bucarban; Diabetal; Bukarban; alentin; Invenol; Oranyl; Oranil



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Guillaume Hoizey, Denis Lamiable, Thierry Trenque, Arnaud Robinet, Laurent Binet, Matthieu L Kaltenbach, Sandrine Havet, Hervé Millart. Identification and quantification of 8 sulfonylureas with clinical toxicology interest by liquid chromatography-ion-trap tandem mass spectrometry and library searching. Clinical chemistry. 2005 Sep; 51(9):1666-72. doi: 10.1373/clinchem.2005.050864. [PMID: 16020498]
  • Awad M Ahmed. History of diabetes mellitus. Saudi medical journal. 2002 Apr; 23(4):373-8. doi: NULL. [PMID: 11953758]
  • Y Imamura, T Koga, T Migita, A Ryu, M Otagiri, M Nozawa, H Akita. Characterization of acetohexamide reductases purified from rabbit liver, kidney, and heart: structural requirements for substrates and inhibitors. Journal of biochemistry. 1997 Apr; 121(4):705-10. doi: 10.1093/oxfordjournals.jbchem.a021643. [PMID: 9163521]
  • Y Imamura, M Sonoda, M Otagiri, H Ichibagase. [Serum protein binding of carbutamide in normal and alloxan diabetic rabbits]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1985 Oct; 105(10):1004-7. doi: 10.1248/yakushi1947.105.10_1004. [PMID: 4093854]
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  • Y Imamura, M Sonoda, K Arimori, H Ichibagase. Effect of simultaneous administration of drugs on absorption and excretion. X. Plasma protein binding of carbutamide in rabbits. Chemical & pharmaceutical bulletin. 1979 Feb; 27(2):463-7. doi: 10.1248/cpb.27.463. [PMID: 445682]
  • W E Müller, U Wollert. Circular dichroism studies on the interaction of sulfonylureas with bovine and human serum albumin. Research communications in chemical pathology and pharmacology. 1976 Mar; 13(3):551-4. doi: NULL. [PMID: 819976]
  • P D Lang, P Wahl, Ch Hassalacher, J Vollmar. [Effect of methylpyrazole-carboxylic acid on carbohydrate and lipid metabolisms in patients with diabetes mellitus]. Arzneimittel-Forschung. 1975 Jan; 25(1):117-20. doi: ". [PMID: 807221]
  • B Nilsson, A Agren. Complex formation between macromolecules and drugs. X. Binding of tolbutamide, chlorpropamide and carbutamide to human serum albumin, and the competition between tolbutamide or chlorpropamide and carbutamide or 4-sulfanilamido-2,6-dimethylpyrimidine for binding sites on human serum albumin. Acta pharmaceutica Suecica. 1974 Sep; 11(4):391-400. doi: . [PMID: 4412551]
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  • W Berger, P Spring. [Changes of pharmacokinetics of oral antidiabetics from drug interference and renal insufficiency]. Deutsche medizinische Wochenschrift (1946). 1970 Dec; 95(50):2525-7. doi: 10.1055/s-0028-1108869. [PMID: 5488752]
  • E Krüger-Thiemer, P Bünger, J K Seydel. [Pharmacokinetics of blood glucose lowering sulfonamides]. Acta diabetologica latina. 1969 Sep; 6 Suppl 1(?):74-104. doi: ". [PMID: 4906027]
  • E J Ariëns. [Oral antidiabetics. Dose, plasma concentration and effect]. Acta diabetologica latina. 1969 Sep; 6 Suppl 1(?):143-76. doi: NULL. [PMID: 4392071]
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  • H Fürstenberg, J F Bussmann, F H Schmidt, H Stork, G Bauer. [Excretion of oral antidiabetics of the sulfonylurea-series through choledochus drainage]. Arzneimittel-Forschung. 1969 Jun; 19(6):1016-9. doi: NULL. [PMID: 5820028]
  • S Z Bromberg-Sznek, Z Maj. [Studies on carbohydrate metabolism in patients with chronic renal failure]. Polskie Archiwum Medycyny Wewnetrznej. 1969 Jun; 42(6):853-63. doi: NULL. [PMID: 5806671]
  • O Mantel, J Fiet, C Dreux, J Canivet. [Development, after oral dose of carbutamide in diabetics, of plasma levels of glucose, insulin, free fatty acids and sulfonamide]. Journees annuelles de diabetologie de l'Hotel-Dieu. 1969; 10(?):293-300. doi: NULL. [PMID: 5376987]
  • H Theile, S Aust. [The effect of L-leucine on blood sugar and serum phosphate in rabbits]. Acta biologica et medica Germanica. 1969; 22(3):673-5. doi: NULL. [PMID: 5363937]
  • J M Hershman, K Konerding. Effects of sulfonylurea drugs on the thyroid and serum protein binding of thyroxine in the rat. Endocrinology. 1968 Jul; 83(1):74-8. doi: 10.1210/endo-83-1-74. [PMID: 5659433]
  • M Bourel, M Simon, P Lenoir, J Turpin, A Chauvel, R Breton. [Hypoglycemia induced by hypoglycemic sulfamides. 4 cases including of voluntary massive poisoning]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris. 1968 Jun; 44(28):1879-83. doi: NULL. [PMID: 4302328]
  • F Gjedde. Studies on the insulin-like activity of serum. 3. The influence of the pancreas on the insulin-like activity of serum. Acta endocrinologica. 1968 Mar; 57(3):505-28. doi: 10.1530/acta.0.0570505. [PMID: 4170212]
  • G Marquié, R Agid. [Modification by certain hypoglycemic sulfonamides of lipid disturbances induced by cholesterol administration in rabbits]. Comptes rendus des seances de la Societe de biologie et de ses filiales. 1968; 162(2):563-8. doi: ". [PMID: 4237632]
  • M Krámer, P Balogh. [Attempts of modification of the serum lipid fractions in diabetics]. Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten. 1968; 28(5):345-51. doi: NULL. [PMID: 5731589]
  • H Tuchmann-Duplessis. [The teratogenic risk]. Archives d'anatomie, d'histologie et d'embryologie normales et experimentales. 1968; 51(5):719-25. doi: ". [PMID: 4917890]
  • L De Beer, P J De Schepper. Metabolic effects of hypoglycemic sulfonylureas. II. In vitro effect of sulfonylureas on cell-free protein synthesis and energy metabolism in rat tissues. Biochemical pharmacology. 1967 Dec; 16(12):2355-67. doi: 10.1016/0006-2952(67)90221-3. [PMID: 6075396]
  • P J De Schepper. Metabolic effects of hypoglycemic sulfonylureas. I. In vitro effect of sulfonylureas on leucine incorporation and metabolism and on respiration of rat tissues. Biochemical pharmacology. 1967 Dec; 16(12):2337-53. doi: 10.1016/0006-2952(67)90220-1. [PMID: 6075395]
  • W Puls, G Kroneberg. [Effect of oral antidiabetics on the unesterified fatty acid content of rat plasma]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie. 1967; 257(1):53-4. doi: NULL. [PMID: 4231866]
  • E Góth, G Miklós. Diabetes mellitus in pituitary insufficiency. Acta medica Academiae Scientiarum Hungaricae. 1967; 23(4):319-24. doi: NULL. [PMID: 5600726]
  • J Dangoumau, C Beraud, F J Traissac, P Fourment. [Individual variations in the metabolism of carbutamide]. Therapie. 1966 May; 21(3):571-86. doi: NULL. [PMID: 5942124]
  • I P Palva, O O Mustala. Glycodiazine as oral antidiabetic compared to carbutamide and chlorpropamide. Annales medicinae internae Fenniae. 1965; 54(3):117-9. doi: NULL. [PMID: 5854021]
  • D P Mertz. [On the degree of distribution of chemotherapeutically effective substances in the body fluid spaces. Studies on tolbutamide]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin. 1965; 71(?):957-61. doi: NULL. [PMID: 5877732]
  • B TOTH, B KELENTEY, K CZINDER. [IN VIVO HYDROLYSIS OF SULFONAMIDE-N4-GLYCOSIDES AND THEIR LINKAGE TO PROTEINS]. Kiserletes orvostudomany. 1964 Apr; 16(?):126-31. doi: NULL. [PMID: 14155556]
  • S SZUECS, G CSAPO. SERUM TOTAL LIPID AND LIPOPROTEIN FRACTIONS IN DIABETIC PATIENTS TREATED WITH INSULIN OR CARBUTAMIDE. The American journal of the medical sciences. 1963 Dec; 246(?):710-3. doi: NULL. [PMID: 14085229]
  • Z SZUECS, G CSAPO. [STUDY ON THE TOTAL SERUM LIPOID LEVEL AND LIPOPROTEIN FRACTIONS IN DIABETICS TREATED WITH INSULIN AND BUCARBAN]. Orvosi hetilap. 1963 Nov; 104(?):2170-1. doi: NULL. [PMID: 14098522]
  • M B BHIDE, R AIMAN. MECHANISM OF ACTION OF ORAL ANTIDIABETIC DRUGS: POTENTIATION OF PLASMA EFFECT AND INSULIN EFFECT ON GLUCOSE UPTAKE OF THE RAT DIAPHRAGM. The Indian journal of medical research. 1963 Jul; 51(?):733-6. doi: NULL. [PMID: 14073628]
  • E S TRUNCHENKOVA. [ON THE EFFECT OF ANTIDIABETIC SULFANILAMIDE PREPARATIONS ON FAT-LIPOID METABOLISM IN DIABETES MELLITUS]. Klinicheskaia meditsina. 1963 Jul; 41(?):63-7. doi: ". [PMID: 14071115]
  • M BRETAN, L KAMMERER. [Insulin-like activity of the plasma during Bucarban treatment. (Data on the mechanism of action of the sulfanilylureas)]. Orvosi hetilap. 1962 Oct; 103(?):1981-5. doi: NULL. [PMID: 14015308]
  • S TAKEUCHI, M TAKAGI, Y KOBAYASHI. Plasma insulin activity following the administration of BZ 55 (N-sulfanylyl-N'-n-butyl-carbamide) in dogs. Endocrinologia japonica. 1961 Mar; 8(?):57-67. doi: 10.1507/endocrj1954.8.57. [PMID: 13774982]
  • V FISTER, A BENAS. The influence of oral hypoglycaemic agents (carbutamide and tolbutamide) on the serum proteins of normal rats. The Journal of endocrinology. 1960 Jun; 20(?):320-4. doi: 10.1677/joe.0.0200320. [PMID: 13700025]
  • R AIMAN, N CHAUDHARY. Mechanism of action of oral antidiabetic drugs. British journal of pharmacology and chemotherapy. 1959 Sep; 14(?):377-9. doi: 10.1111/j.1476-5381.1959.tb00261.x. [PMID: 13792172]
  • J CHRISTOPHE, J MAYER. Effects of chronic treatment with carbutamide on distribution and biosynthesis of fatty acids and cholesterol in obese-hyperglycemic mice. The American journal of physiology. 1959 Mar; 196(3):603-6. doi: 10.1152/ajplegacy.1959.196.3.603. [PMID: 13627232]
  • C PETROVIC, C PILGRIM, H SUDHOF. [Behavior of maximal tubular re-resorption for glucose after N1-sulfanilyl-N2-n-butylcarbamide administration in the dog]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie. 1959; 235(2):96-102. doi: NULL. [PMID: 13632853]
  • S SZUCS, A TISZAI. Effect of carbutamide on blood levels of glucose, potassium and inorganic phosphate; studies of the serum in diabetic and healthy man and pancreatectomized dogs. Diabetes. 1958 Jul; 7(4):288-92. doi: 10.2337/diab.7.4.288. [PMID: 13561862]
  • G HARTEL, S PUNSAR, A LOUHIJA. [Effect of high doses of N1-sulfanilyl-N2-n-butylcarbamide on the regression of experimental atherosclerosis, spontaneous atherosclerosis and serum cholesterol levels of male chicken]. Arzneimittel-Forschung. 1958 May; 8(5):301-4. doi: NULL. [PMID: 13535384]
  • E CUGUDDA, B GUAZZI, A MANCINI. [Sulfonamides in blood and urine during carbutamide therapy of diabetes mellitus]. Minerva medica. 1958 Apr; 49(32):1511-2. doi: NULL. [PMID: 13552332]
  • R CATTANEO, A M PELOCCHINO, C PRINOTTI. [The blood lipid picture in diabetics treated with carbutamide]. Minerva medica. 1958 Apr; 49(32):1516. doi: ". [PMID: 13552334]
  • F GRIGNANI, P BRUNETTI, G SERPI. [Effect of carbutamide and tolbutamide serum glucose, pyruvic acid, lactic acid and ketone bodies in oral glucose tolerance test]. Minerva medica. 1958 Apr; 49(32):1521-2. doi: NULL. [PMID: 13552340]
  • S SIGNORELLI. [Negative aspects of carbutamide and tolbutamide therapy]. Minerva medica. 1958 Apr; 49(30):1399-405. doi: NULL. [PMID: 13552268]
  • Z SZUCS, A TISZAI, I LASZLO. [Acute effects of N1-sulfanyl-N2-n-butylcarbamide (BZ-55) on the sugar, potassium and inorganic phosphorus levels of the serum in diabetics and healthy man]. Orvosi hetilap. 1958 Feb; 99(7):227-9. doi: NULL. [PMID: 13542029]
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