Carboxyethyllysine (BioDeep_00000177030)
human metabolite blood metabolite
代谢物信息卡片
6-amino-2-[(2-carboxyethyl)amino]hexanoic acid
化学式: C9H18N2O4 (218.1267)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 15.44%
分子结构信息
SMILES: C(CCN)CC(C(=O)O)NCCC(=O)O
InChI: InChI=1S/C9H18N2O4/c10-5-2-1-3-7(9(14)15)11-6-4-8(12)13/h7,11H,1-6,10H2,(H,12,13)(H,14,15)
数据库引用编号
分类词条
相关代谢途径
Reactome()
BioCyc()
PlantCyc()
代谢反应
个相关的代谢反应过程信息。
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH()
PlantCyc()
COVID-19 Disease Map()
PathBank()
PharmGKB()
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Armand M A Linkens, Alfons J H M Houben, Abraham A Kroon, Miranda T Schram, Tos T J M Berendschot, Carroll A B Webers, Marleen van Greevenbroek, Ronald M A Henry, Bastiaan de Galan, Coen D A Stehouwer, Simone J M P Eussen, Casper G Schalkwijk. Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function-the Maastricht Study.
The American journal of clinical nutrition.
2022 02; 115(2):444-455. doi:
10.1093/ajcn/nqab302. [PMID: 34581759] - Hikari Sugawa, Ayuka Yachi, Yuki Fujimoto, Ryoji Nagai. Accumulation of Nε-(carboxyethyl) lysine in Caenorhabditis elegans is correlated with the formation of ketone body.
Journal of biochemistry.
2021 Dec; 170(5):587-592. doi:
10.1093/jb/mvab079. [PMID: 34213548] - Agnieszka Nowak, Brygida Przywara-Chowaniec, Aleksandra Damasiewicz-Bodzek, Dominika Blachut, Ewa Nowalany-Kozielska, Krystyna Tyrpień-Golder. Advanced Glycation End-Products (AGEs) and Their Soluble Receptor (sRAGE) in Women Suffering from Systemic Lupus Erythematosus (SLE).
Cells.
2021 12; 10(12):. doi:
10.3390/cells10123523. [PMID: 34944030] - Svetlana Baskal, Adrian Post, Daan Kremer, Alexander Bollenbach, Stephan J L Bakker, Dimitrios Tsikas. Urinary excretion of amino acids and their advanced glycation end-products (AGEs) in adult kidney transplant recipients with emphasis on lysine: furosine excretion is associated with cardiovascular and all-cause mortality.
Amino acids.
2021 Nov; 53(11):1679-1693. doi:
10.1007/s00726-021-03091-8. [PMID: 34693489] - Elom K Aglago, Casper G Schalkwijk, Heinz Freisling, Veronika Fedirko, David J Hughes, Li Jiao, Christina C Dahm, Anja Olsen, Anne Tjønneland, Verena Katzke, Theron Johnson, Matthias B Schulze, Krasimira Aleksandrova, Giovanna Masala, Sabina Sieri, Vittorio Simeon, Rosario Tumino, Alessandra Macciotta, Bas Bueno-de-Mesquita, Guri Skeie, Inger Torhild Gram, Torkjel Sandanger, Paula Jakszyn, Maria-Jose Sánchez, Pilar Amiano, Sandra M Colorado-Yohar, Aurelio Barricarte Gurrea, Aurora Perez-Cornago, Ana-Lucia Mayén, Elisabete Weiderpass, Marc J Gunter, Alicia K Heath, Mazda Jenab. Plasma concentrations of advanced glycation end-products and colorectal cancer risk in the EPIC study.
Carcinogenesis.
2021 05; 42(5):705-713. doi:
10.1093/carcin/bgab026. [PMID: 33780524] - Remy J H Martens, Natascha J H Broers, Bernard Canaud, Maarten H L Christiaans, Tom Cornelis, Adelheid Gauly, Marc M H Hermans, Constantijn J A M Konings, Frank M van der Sande, Jean L J M Scheijen, Frank Stifft, Joris J J M Wirtz, Jeroen P Kooman, Casper G Schalkwijk. Relations of advanced glycation endproducts and dicarbonyls with endothelial dysfunction and low-grade inflammation in individuals with end-stage renal disease in the transition to renal replacement therapy: A cross-sectional observational study.
PloS one.
2019; 14(8):e0221058. doi:
10.1371/journal.pone.0221058. [PMID: 31408493] - Jean L J M Scheijen, Nordin M J Hanssen, Marleen M van Greevenbroek, Carla J Van der Kallen, Edith J M Feskens, Coen D A Stehouwer, Casper G Schalkwijk. Dietary intake of advanced glycation endproducts is associated with higher levels of advanced glycation endproducts in plasma and urine: The CODAM study.
Clinical nutrition (Edinburgh, Scotland).
2018 06; 37(3):919-925. doi:
10.1016/j.clnu.2017.03.019. [PMID: 29381139] - Ching-Yu Lin, Jau-Jiuan Sheu, I-Shih Tsai, Sen-Te Wang, Li-Yu Yang, I-Uen Hsu, Hui-Wen Chang, Horng-Mo Lee, Shu-Huei Kao, Ching-Kuo Lee, Chien-Ho Chen, Yung-Feng Lin. Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141-147 in Taiwanese with Alzheimer's disease.
Clinical biochemistry.
2018 Jun; 56(?):75-82. doi:
10.1016/j.clinbiochem.2018.04.009. [PMID: 29680706] - Juraj Koska, Aramesh Saremi, Scott Howell, Gideon Bahn, Barbora De Courten, Henry Ginsberg, Paul J Beisswenger, Peter D Reaven. Advanced Glycation End Products, Oxidation Products, and Incident Cardiovascular Events in Patients With Type 2 Diabetes.
Diabetes care.
2018 03; 41(3):570-576. doi:
10.2337/dc17-1740. [PMID: 29208654] - Pauline Bc Linssen, Ronald Ma Henry, Casper G Schalkwijk, Jacqueline M Dekker, Giel Nijpels, Hans-Peter Brunner-La Rocca, Coen DA Stehouwer. Serum advanced glycation endproducts are associated with left ventricular dysfunction in normal glucose metabolism but not in type 2 diabetes: The Hoorn Study.
Diabetes & vascular disease research.
2016 07; 13(4):278-85. doi:
10.1177/1479164116640680. [PMID: 27190078] - Barbora de Courten, Maximilian Pj de Courten, Georgia Soldatos, Sonia L Dougherty, Nora Straznicky, Markus Schlaich, Karly C Sourris, Vibhasha Chand, Jean Ljm Scheijen, Bronwyn A Kingwell, Mark E Cooper, Casper G Schalkwijk, Karen Z Walker, Josephine M Forbes. Diet low in advanced glycation end products increases insulin sensitivity in healthy overweight individuals: a double-blind, randomized, crossover trial.
The American journal of clinical nutrition.
2016 Jun; 103(6):1426-33. doi:
10.3945/ajcn.115.125427. [PMID: 27030534]
