Carboxy-ethyl-hydroxychroman (BioDeep_00000177021)
human metabolite blood metabolite
代谢物信息卡片
2-ethyl-2-hydroxy-3,4-dihydro-2H-1-benzopyran-3-carboxylic acid
化学式: C12H14O4 (222.0892044)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 93.1%
分子结构信息
SMILES: CCC1(C(CC2=CC=CC=C2O1)C(=O)O)O
InChI: InChI=1S/C12H14O4/c1-2-12(15)9(11(13)14)7-8-5-3-4-6-10(8)16-12/h3-6,9,15H,2,7H2,1H3,(H,13,14)
相关代谢途径
Reactome(0)
BioCyc(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Christopher Masterjohn, Eunice Mah, Yi Guo, Sung I Koo, Richard S Bruno. γ-Tocopherol abolishes postprandial increases in plasma methylglyoxal following an oral dose of glucose in healthy, college-aged men.
The Journal of nutritional biochemistry.
2012 Mar; 23(3):292-8. doi:
10.1016/j.jnutbio.2010.12.007. [PMID: 21543210] - Syed Fairus, Rosnah M Nor, Hwee M Cheng, Kalyana Sundram. Alpha-tocotrienol is the most abundant tocotrienol isomer circulated in plasma and lipoproteins after postprandial tocotrienol-rich vitamin E supplementation.
Nutrition journal.
2012 Jan; 11(?):5. doi:
10.1186/1475-2891-11-5. [PMID: 22252050] - Wan-Hsuan Chen, Yi-Jen Li, Ming-Shyong Wang, Zhi-Chyang Kang, Huei-Ling Huang, Huey-Mei Shaw. Elevation of tissue α-tocopherol levels by conjugated linoleic acid in C57BL/6J mice is not associated with changes in vitamin E absorption or α-carboxyethyl hydroxychroman production.
Nutrition (Burbank, Los Angeles County, Calif.).
2012 Jan; 28(1):59-66. doi:
10.1016/j.nut.2011.04.006. [PMID: 21872434] - Tomono Uchida, Saki Nomura, Tomio Ichikawa, Chisato Abe, Saiko Ikeda. Tissue distribution of vitamin E metabolites in rats after oral administration of tocopherol or tocotrienol.
Journal of nutritional science and vitaminology.
2011; 57(5):326-32. doi:
10.3177/jnsv.57.326. [PMID: 22293209] - Maret G Traber, Debbie J Mustacich, Laura C Sullivan, Scott W Leonard, Amelia Ahern-Rindell, Nancy Kerkvliet. Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice.
The Journal of nutritional biochemistry.
2010 Dec; 21(12):1193-9. doi:
10.1016/j.jnutbio.2009.10.005. [PMID: 20153623] - Helene Freiser, Qing Jiang. Optimization of the enzymatic hydrolysis and analysis of plasma conjugated gamma-CEHC and sulfated long-chain carboxychromanols, metabolites of vitamin E.
Analytical biochemistry.
2009 May; 388(2):260-5. doi:
10.1016/j.ab.2009.02.027. [PMID: 19250920] - Joo-Youn Cho, Dong Wook Kang, Xiaochao Ma, Sung-Hoon Ahn, Kristopher W Krausz, Hans Luecke, Jeffrey R Idle, Frank J Gonzalez. Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation.
Journal of lipid research.
2009 May; 50(5):924-37. doi:
10.1194/jlr.m800647-jlr200. [PMID: 19141872] - Anna R Proteggente, Cristina Rota, John Majewicz, Gerald Rimbach, Anne Marie Minihane, Klaus Kraemer, John K Lodge. Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) alpha-tocopherol: a biokinetic study in apoE4 male subjects.
Free radical biology & medicine.
2006 Jun; 40(12):2080-91. doi:
10.1016/j.freeradbiomed.2006.02.006. [PMID: 16785022] - Rakesh Sachdeva, Beena Thomas, Xinhe Wang, Jiyan Ma, Kenneth H Jones, Patrick G Hatcher, David G Cornwell. Tocopherol metabolism using thermochemolysis: chemical and biological properties of gamma-tocopherol, gamma-carboxyethyl-hydroxychroman, and their quinones.
Chemical research in toxicology.
2005 Jun; 18(6):1018-25. doi:
10.1021/tx0496441. [PMID: 15962937] - Scott W Leonard, Elaine Paterson, Jeffrey K Atkinson, Rajasekhar Ramakrishnan, Carroll E Cross, Maret G Traber. Studies in humans using deuterium-labeled alpha- and gamma-tocopherols demonstrate faster plasma gamma-tocopherol disappearance and greater gamma-metabolite production.
Free radical biology & medicine.
2005 Apr; 38(7):857-66. doi:
10.1016/j.freeradbiomed.2004.12.001. [PMID: 15749381] - Maret G Traber. Vitamin E regulation.
Current opinion in gastroenterology.
2005 Mar; 21(2):223-7. doi:
10.1097/01.mog.0000153359.13525.b4. [PMID: 15711217] - Scott W Leonard, Richard S Bruno, Rajasekhar Ramakrishnan, Tammy Bray, Maret G Traber. Cigarette smoking increases human vitamin E requirements as estimated by plasma deuterium-labeled CEHC.
Annals of the New York Academy of Sciences.
2004 Dec; 1031(?):357-60. doi:
10.1196/annals.1331.044. [PMID: 15753169] - Francesco Galli, Umberto Buoncristiani, Carmela Conte, Cristina Aisa, Ardesio Floridi. Vitamin E in uremia and dialysis patients.
Annals of the New York Academy of Sciences.
2004 Dec; 1031(?):348-51. doi:
10.1196/annals.1331.041. [PMID: 15753167] - Jan Frank, Afaf Kamal-Eldin, Maret G Traber. Consumption of sesame oil muffins decreases the urinary excretion of gamma-tocopherol metabolites in humans.
Annals of the New York Academy of Sciences.
2004 Dec; 1031(?):365-7. doi:
10.1196/annals.1331.046. [PMID: 15753171] - F Galli, A G Floridi, A Floridi, U Buoncristiani. Accumulation of vitamin E metabolites in the blood of renal failure patients.
Clinical nutrition (Edinburgh, Scotland).
2004 Apr; 23(2):205-12. doi:
10.1016/s0261-5614(03)00128-6. [PMID: 15030960] - Jonathan Himmelfarb, Jane Kane, Ellen McMonagle, Eric Zaltas, Steve Bobzin, Sekhar Boddupalli, Stephen Phinney, Guy Miller. Alpha and gamma tocopherol metabolism in healthy subjects and patients with end-stage renal disease.
Kidney international.
2003 Sep; 64(3):978-91. doi:
10.1046/j.1523-1755.2003.00151.x. [PMID: 12911548] - Francesco Galli, Rosalind Lee, Christina Dunster, Frank J Kelly. Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of alpha- and gamma-tocopherol in human plasma.
Free radical biology & medicine.
2002 Feb; 32(4):333-40. doi:
10.1016/s0891-5849(01)00800-0. [PMID: 11841923] - J K Lodge, J Ridlington, S Leonard, H Vaule, M G Traber. Alpha- and gamma-tocotrienols are metabolized to carboxyethyl-hydroxychroman derivatives and excreted in human urine.
Lipids.
2001 Jan; 36(1):43-8. doi:
10.1007/s11745-001-0666-z. [PMID: 11214728]