Carboquone (BioDeep_00000177019)

   

human metabolite blood metabolite


代谢物信息卡片


{2-[2,5-bis(aziridin-1-yl)-4-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl]-2-methoxyethoxy}carboximidic acid

化学式: C15H19N3O5 (321.1325)
中文名称: 卡波醌
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(=O)C(=C(C1=O)N2CC2)C(COC(=O)N)OC)N3CC3
InChI: InChI=1S/C15H19N3O5/c1-8-11(17-3-4-17)14(20)10(9(22-2)7-23-15(16)21)12(13(8)19)18-5-6-18/h9H,3-7H2,1-2H3,(H2,16,21)

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents > L01AC - Ethylene imines
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D000477 - Alkylating Agents
D000970 - Antineoplastic Agents

同义名列表

6 个代谢物同义名

{2-[2,5-bis(aziridin-1-yl)-4-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl]-2-methoxyethoxy}carboximidic acid; [2-[2,5-Bis(aziridin-1-yl)-4-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl]-2-methoxyethyl] carbamic acid; Carbazilquinone; Carboquinone; carboquone; Esquinon



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ken Morimoto, Masae Koh. Postoperative adjuvant use of carmofur for early breast cancer. Osaka city medical journal. 2003 Dec; 49(2):77-83. doi: . [PMID: 15179836]
  • H Ito. [Experimental study and clinical application of a new combination chemotherapy with cis-platinum, adriamycin and carboquone in patients with advanced prostate cancer]. Nihon Ika Daigaku zasshi. 1995 Oct; 62(5):456-68. doi: 10.1272/jnms1923.62.456. [PMID: 7499463]
  • J Okada, Y Masuyama, T Kondo. An analysis of first-order release kinetics from albumin microspheres. Journal of microencapsulation. 1992 Jan; 9(1):9-18. doi: 10.3109/02652049209021218. [PMID: 1613648]
  • J Okada, S Asano, T Kondo. A new concept for interpretation of first-order release from albumin microspheres. Journal of microencapsulation. 1991 Oct; 8(4):483-96. doi: 10.3109/02652049109021872. [PMID: 1798019]
  • S T Lin. [Study on chemosensitivity test (in vitro) of cultured human urogenital carcinoma cell lines by MTT assay]. Nihon Ika Daigaku zasshi. 1990 Apr; 57(2):127-36. doi: 10.1272/jnms1923.57.127. [PMID: 1694861]
  • G Ueda, Y Abe, M Yoshida, T Fujiwara. Embryonal carcinoma of the ovary: a six-year survival. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 1990 Mar; 31(3):287-92. doi: 10.1016/0020-7292(90)91025-l. [PMID: 1690671]
  • M Akashi, M Ohta, S Kitagawa, Y Furukawa, K Takeda, K Muroi, N Komatsu, K Ikeda, A Ohsaka, M Yoshida. [Treatment of multiple myeloma: renal function in relation to its prognosis]. [Rinsho ketsueki] The Japanese journal of clinical hematology. 1988 Nov; 29(11):1991-7. doi: NULL. [PMID: 3236408]
  • Y Maehara, H Anai, H Kusumoto, T Kusumoto, K Sugimachi. Colorectal carcinoma in vitro is more sensitive to 1-hexylcarbamoyl-5-fluorouracil compared with six other antitumor drugs: carboquone, Adriamycin, mitomycin C, aclacinomycin A, cisplatin, 5-fluorouracil. Diseases of the colon and rectum. 1988 Jan; 31(1):62-7. doi: 10.1007/bf02552573. [PMID: 3130239]
  • T Uchibayashi, H Hisazumi, T Asari, K Kobashi, T Amano, K Naito. [An in vitro chemosensitivity study using the human tumor clonogenic assay in urological malignancies: a preliminary report]. Hinyokika kiyo. Acta urologica Japonica. 1987 Oct; 33(10):1575-80. doi: NULL. [PMID: 3445845]
  • N Kobayashi. [Experimental and clinical study of a new embolic material in the treatment of malignant tumor--gelatin sponge containing carboquone]. Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica. 1987 Sep; 47(9):1127-44. doi: NULL. [PMID: 3432057]
  • K Naito, H Hisazumi, T Asari, K Kobashi, T Amano, T Uchibayashi. [An in vitro chemosensitivity study using human tumor clonogenic assay in urologic malignancies]. Hinyokika kiyo. Acta urologica Japonica. 1986 Dec; 32(12):1959-66. doi: NULL. [PMID: 3825833]
  • T Osawa. [Chemotherapy of renal cell carcinoma. II. Adriamycin and carboquone combined chemotherapy]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology. 1986 Nov; 77(11):1805-13. doi: 10.5980/jpnjurol1928.77.11_1805. [PMID: 3573463]
  • H Takahagi, K Inoue, M Horiguchi. Drug monitoring by a fully automated high-performance liquid chromatographic technique, involving direct injection of plasma. Journal of chromatography. 1986 Feb; 352(?):369-79. doi: 10.1016/s0021-9673(01)83394-x. [PMID: 3457796]
  • D D Mickey. Combined therapeutic effects of an immunomodulator, PSK, and chemotherapy with carboquone on rat bladder carcinoma. Cancer chemotherapy and pharmacology. 1985; 15(1):54-8. doi: 10.1007/bf00257295. [PMID: 4006049]
  • T Kakizoe, K Matsumoto, Y Nishio, M Ohtani, N Miyazawa. Chemotherapy by bronchial arterial infusion for pulmonary metastases of renal cell carcinoma. The Journal of urology. 1984 Jun; 131(6):1053-5. doi: 10.1016/s0022-5347(17)50803-4. [PMID: 6427476]
  • T Shinkai, N Saijo, K Tominaga, K Eguchi, E Shimizu, K Takahashi, Y Sasaki, H Ohkura. [The value of carcinoembryonic antigens in patients with advanced lung cancer: in relation to chemotherapy]. Gan to kagaku ryoho. Cancer & chemotherapy. 1984 May; 11(5):1056-63. doi: NULL. [PMID: 6202246]
  • M Maeyama, C Tayama, S Inoue, C Tajima, Y Onizuka, N Tanaka, M Nakayama, T Iwamasa. Serial serum determination on alpha-fetoprotein as a marker of the effect of postoperative chemotherapy in ovarian endodermal sinus tumor. Gynecologic oncology. 1984 Jan; 17(1):104-16. doi: 10.1016/0090-8258(84)90064-7. [PMID: 6198243]
  • T Monna, T Kanno, T Marumo, S Harihara, T Kuroki, S Yamamoto, N Kobayashi, M Sato, K Nakamura, H Nakatsuka, Y Onoyama, R Yamada. A comparison of transcatheter arterial embolization with one shot therapy for the patients with hepatic cell carcinoma. Gastroenterologia Japonica. 1982 Dec; 17(6):542-9. doi: 10.1007/bf02779132. [PMID: 6298047]
  • M Hisaoka, T Morioka, A Yagita. Determination of carboquone in plasma and ascites by high performance liquid chromatography after intravenous and intraperitoneal administration in man. Gan. 1982 Apr; 73(2):161-6. doi: NULL. [PMID: 7117751]
  • M Hisaoka, K Tsukada, T Morioka. Studies on liposome-encapsulated carboquone II. Effect of liposomal encapsulation of carboquone on distribution and clearance in animals. Journal of pharmacobio-dynamics. 1982 Jan; 5(1):18-26. doi: 10.1248/bpb1978.5.18. [PMID: 7077518]
  • M Itami, R Yamada, H Nakatsuka, K Nakamura, M Sato, N Kobayashi, S Takashima, K Minakuchi, A Yamashita, Y Onoyama. [New embolic material for therapeutic embolization of malignant tumor--gelatin sponge containing carbazilquinone (author's transl)]. Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica. 1981 Jan; 41(1):75-8. doi: NULL. [PMID: 7232114]
  • T Müller. [Radioenzymatic simultaneous determination of epinephrine and norepinephrine in plasma (author's transl)]. Arzneimittel-Forschung. 1978; 28(8):1304. doi: NULL. [PMID: 37851]