Carbocromen (BioDeep_00000177006)
human metabolite blood metabolite
代谢物信息卡片
Ethyl 2-({3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-chromen-7-yl}oxy)acetic acid
化学式: C20H27NO5 (361.18891320000006)
中文名称: 延通心
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)CCC1=C(C2=C(C=C(C=C2)OCC(=O)OCC)OC1=O)C
InChI: InChI=1S/C20H27NO5/c1-5-21(6-2)11-10-17-14(4)16-9-8-15(12-18(16)26-20(17)23)25-13-19(22)24-7-3/h8-9,12H,5-7,10-11,13H2,1-4H3
描述信息
C - Cardiovascular system > C01 - Cardiac therapy > C01D - Vasodilators used in cardiac diseases
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
13 个代谢物同义名
Ethyl 2-({3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-chromen-7-yl}oxy)acetic acid; ethyl 2-({3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-chromen-7-yl}oxy)acetate; ethyl ({3-[2-(diethylamino)ethyl]-4-methyl-2-oxochromen-7-yl}oxy)acetate; Hydrochloride, chromonar; Chromonar hydrochloride; Carbochromene; Carbochromen; Carbocromene; Intercordin; carbocromen; Intensain; Chromonar; Cardiocap
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135525
- PubChem: 12604
- HMDB: HMDB0249632
- DrugBank: DB13279
- ChEMBL: CHEMBL163672
- Wikipedia: Carbocromen
- MeSH: Chromonar
- CAS: 804-10-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Feng Dong, Liya Yin, Hamayak Sisakian, Tatevik Hakobyan, Lacey S Jeong, Hirva Joshi, Ellianna Hoff, Selena Chandler, Geetika Srivastava, Abdur Rahman Jabir, Kelly Kimball, Yeong-Renn Chen, Chwen-Lih Chen, Patrick T Kang, Parisa Shabani, Lindsay Shockling, Thomas Pucci, Karlina Kegecik, Christopher Kolz, Zhenyu Jia, William M Chilian, Vahagn Ohanyan. Takotsubo syndrome is a coronary microvascular disease: experimental evidence.
European heart journal.
2023 06; 44(24):2244-2253. doi:
10.1093/eurheartj/ehad274. [PMID: 37170610] - Patricia Rodrigo-Armenteros, Solange Kapetanovic-García, Lander Antón-Méndez, Juan José Gómez-Muga, Edurne Bedia-Del Río, María Ángeles Fernández-Cuesta, Juan Carlos García-Moncó. Akinetic mutism and status epilepticus due to Epstein Barr virus encephalitis.
Clinical neurology and neurosurgery.
2019 Oct; 185(?):105492. doi:
10.1016/j.clineuro.2019.105492. [PMID: 31470359] - Claudio Bucolo, Francesco Maugeri, Adriana Maltese, Keith W Ward. Retinal and systemic pharmacokinetics of the anti-inflammatory drug cloricromene following oral administration in the rat and rabbit.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2007 Jun; 23(3):257-63. doi:
10.1089/jop.2006.141. [PMID: 17593009] - R Pignatello, A Maltese, F Maugeri, C Bucolo. Enhancement of availability of cloricromene at brain level by a lipophilic prodrug.
The Journal of pharmacy and pharmacology.
2006 Jul; 58(7):1001-5. doi:
10.1211/jpp.58.7.0017. [PMID: 16805962] - A Ianaro, P Maffia, G Grassia, P Di Meglio, R Sorrentino, R d'Emmanuele di Villa Bianca, M Di Rosa, A Ialenti. Cloricromene in endotoxemia: role of NF-kappaB.
Naunyn-Schmiedeberg's archives of pharmacology.
2004 Aug; 370(2):140-5. doi:
10.1007/s00210-004-0956-z. [PMID: 15322736] - M L Bondì, G Fontana, B Carlisi, G Giammona. Preparation and characterization of solid lipid nanoparticles containing cloricromene.
Drug delivery.
2003 Oct; 10(4):245-50. doi:
10.1080/drd_10_4_245. [PMID: 14612340] - E Ribaldi, A M Mezzasoma, E Francescangeli, M Prosdocimi, G G Nenci, G Goracci, P Gresele. Inhibition of PAF synthesis by stimulated human polymorphonuclear leucocytes with cloricromene, an inhibitor of phospholipase A2 activation.
British journal of pharmacology.
1996 Jul; 118(6):1351-8. doi:
10.1111/j.1476-5381.1996.tb15544.x. [PMID: 8832056] - A Saitta, M Bonaiuto, G Giordano, M N Saitta, M Castaldo, M Cinquegrani, G Squadrito, P Canale, D Altavilla, G M Campo, A P Caputi, F Squadrito. Effects of cloricromene on the levels of endothelin and on the microcirculatory function in peripheral atherosclerotic arteriopathies.
Pharmacology.
1996 Jan; 52(1):8-15. doi:
10.1159/000139355. [PMID: 8966205] - D Altavilla, F Squadrito, P Canale, M Ioculano, G M Campo, G Squadrito, A Saitta, A P Caputi. Tumor necrosis factor induces E-selectin production in splanchnic artery occlusion shock.
The American journal of physiology.
1995 Apr; 268(4 Pt 2):H1412-7. doi:
10.1152/ajpheart.1995.268.4.h1412. [PMID: 7537468] - G Calapai, F Squadrito, A Rizzo, M C Marciano, G M Campo, A P Caputi. Multiple actions of the coumarine derivative cloricromene and its protective effects on ischemic brain injury.
Naunyn-Schmiedeberg's archives of pharmacology.
1995 Feb; 351(2):209-15. doi:
10.1007/bf00169335. [PMID: 7770103] - F Squadrito, D Altavilla, P Canale, M Ioculano, G M Campo, L Ammendolia, M Ferlito, B Zingarelli, G Squadrito, A Saitta. Participation of tumour necrosis factor and nitric oxide in the mediation of vascular dysfunction in splanchnic artery occlusion shock.
British journal of pharmacology.
1994 Dec; 113(4):1153-8. doi:
10.1111/j.1476-5381.1994.tb17118.x. [PMID: 7889268] - G Davì, C Giammaresi, I Catalano, A Calà, M Prosdocimi, S Alvino, S Piva, A Notarbartolo. Platelet aggregation, ATP release and cytoplasmic Ca2+ movement: the effects of cloricromene.
Thrombosis research.
1994 Oct; 76(2):121-31. doi:
10.1016/0049-3848(94)90183-x. [PMID: 7863464] - G Orefice, A Grasso, N Fazio, G Del Vecchio, G Volpe, M Coppola, A D'Alessio, P B Carrieri. No effect of cloricromen on some coagulation parameters in patients with ischaemic cerebrovascular disease.
The Journal of international medical research.
1994 Sep; 22(5):287-91. doi:
10.1177/030006059402200506. [PMID: 7867874] - G Mancuso, V Cusumano, J A Cook, E Smith, F Squadrito, G Blandino, G Teti. Efficacy of tumor necrosis factor alpha and eicosanoid inhibitors in experimental models of neonatal sepsis.
FEMS immunology and medical microbiology.
1994 Jun; 9(1):49-54. doi:
10.1111/j.1574-695x.1994.tb00473.x. [PMID: 7920463] - G Aliev, R Cirillo, E Salvatico, M Paro, M Prosdocimi. Changes in vessel ultrastructure during ischemia and reperfusion of rabbit hindlimb: implications for therapeutic intervention.
Microvascular research.
1993 Jul; 46(1):65-76. doi:
10.1006/mvre.1993.1035. [PMID: 8412853] - M Stasi, P Gresele, M Prosdocimi, S Porcellati, E Quero, G Pieretti, G G Nenci, G Goracci. Cloricromene inhibits G-protein-mediated activation of phospholipase A2 in human platelets.
Journal of lipid mediators.
1993 Jul; 7(3):253-67. doi:
". [PMID: 8219005] - P Gresele, E Ribaldi, A M Mezzasoma, E Quero, M Stasi, M Prosdocimi, G Goracci, G G Nenci. Cloricromene inhibits leukotriene formation by human polymorphonuclear leucocytes by suppressing arachidonate release from membrane phospholipids.
Biochemical pharmacology.
1993 Jan; 45(1):123-30. doi:
10.1016/0006-2952(93)90384-9. [PMID: 8381001] - F Squadrito, A Saitta, D Altavilla, G M Campo, M Ioculano, G Squadrito, A P Caputi. [Tumor necrosis factor in myocardial ischemia and reperfusion].
Cardiologia (Rome, Italy).
1993 Jan; 38(1):45-51. doi:
NULL. [PMID: 8388776] - F Squadrito, D Altavilla, B Zingarelli, M Ioculano, G Calapai, G M Campo, A Miceli, M Prosdocimi, A P Caputi. The effect of cloricromene, a coumarine derivative, on leukocyte accumulation, myocardial necrosis and TNF-alpha production in myocardial ischaemia-reperfusion injury.
Life sciences.
1993; 53(4):341-55. doi:
10.1016/0024-3205(93)90753-p. [PMID: 8392130] - R Cirillo, E Salvatico, G Aliev, M Prosdocimi. Effect of cloricromene during ischemia and reperfusion of rabbit hindlimb: evidence for an involvement of leukocytes in reperfusion-mediated tissue and vascular injury.
Journal of cardiovascular pharmacology.
1992 Dec; 20(6):969-75. doi:
10.1097/00005344-199212000-00018. [PMID: 1282601] - R Mariot, L Zangirolami, P Bellato, S Chen, G Pieraccini, G Moneti. Determination of the coumarin derivative cloricromene acid in rabbit plasma and platelets.
Journal of chromatography.
1992 Apr; 576(1):143-8. doi:
10.1016/0378-4347(92)80185-s. [PMID: 1500448] - F Squadrito, D Altavilla, G M Campo, G Calapai, M Ioculano, B Zingarelli, A Saitta, M Prosdocimi, A P Caputi. Cloricromene, a coumarine derivative, protects against lethal endotoxin shock in rats.
European journal of pharmacology.
1992 Jan; 210(2):107-13. doi:
10.1016/0014-2999(92)90660-v. [PMID: 1601052] - R Sturniolo, F Squadrito, G M Campo, R Vinci, A Calatroni, M Prosdocimi, A P Caputi. Protective effect of cloricromene, a coumarine derivative, in hypovolemic hemorrhagic shock in the rat.
Journal of cardiovascular pharmacology.
1991 Feb; 17(2):261-6. doi:
10.1097/00005344-199102000-00012. [PMID: 1709231] - A F el Walily, M A elSayed, M H Barary, S M Sabry. Determination of the chromonar hydrochloride metabolite in urine using derivative spectroscopy.
Journal of pharmaceutical and biomedical analysis.
1991; 9(5):417-20. doi:
10.1016/0731-7085(91)80166-7. [PMID: 1932277] - R Sturniolo, F Squadrito, D Altavilla, G R Trimarchi, M Prosdocimi, A P Caputi. Cloricromene improves survival rate and peritoneal macrophage function in splanchnic artery occlusion shock in rats.
Circulatory shock.
1989 Jul; 28(3):267-77. doi:
NULL. [PMID: 2766481] - R A Travagli, A Zatta, N Banzatto, M Finesso, R Mariot, F Tessari, M Prosdocimi. Molecular aspects of cloricromene (AD6) distribution in human platelets and its pharmacological effects.
Thrombosis research.
1989 May; 54(4):327-38. doi:
10.1016/0049-3848(89)90091-1. [PMID: 2763271] - G Bianciardi, P Toti, G Weber. The increase of the openings of the surface-connected canalicular system in weakly stimulated platelets is prevented by a carbochromen derivative. A computerized morphometric analysis of freeze-etched human platelet plasma-membrane.
Pharmacological research communications.
1987 Sep; 19(9):579-89. doi:
10.1016/0031-6989(87)90112-3. [PMID: 3432323] - G Bianciardi, A Vittoria, P Toti, M Franchi, G Martelli, T Di Perri, G Weber. Ultrastructural modifications of the platelet plasma membrane in vascular diseases and the effect of a carbochromen derivative as studied by freeze-fracture and computer measurement.
Atherosclerosis.
1986 Nov; 62(2):173-8. doi:
10.1016/0021-9150(86)90064-x. [PMID: 2948512] - M Prosdocimi, A Zatta, A Gorio, A Zanetti, E Dejana. Action of AD6 (8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxycarbonylmet hox y coumarin) on human platelets in vitro.
Naunyn-Schmiedeberg's archives of pharmacology.
1986 Mar; 332(3):305-10. doi:
10.1007/bf00504872. [PMID: 3012375] - M Schubothe, F Vetterlein, G Schmidt. Density of plasma-perfused capillaries in the rat heart during carbocromene-induced vasodilation.
Basic research in cardiology.
1983 Mar; 78(2):113-23. doi:
10.1007/bf01906665. [PMID: 6870741] - D C Warltier, G J Gross, H L Brooks. Coronary steal-induced increase in myocardial infarct size after pharmacologic coronary vasodilation.
The American journal of cardiology.
1980 Jul; 46(1):83-90. doi:
10.1016/0002-9149(80)90609-8. [PMID: 7386397] - J Scholtholt, V B Fiedler, H Göbel. [The effects of oral carbocromen on the therapeutic and toxic effects of digitalis].
Arzneimittel-Forschung.
1980; 30(1):9-12. doi:
NULL. [PMID: 7370078] - L A Todosienko. [Effect of intencordin on the phase structure of the systole of left ventricle and amino acid content of blood serum in ischemic heart disease].
Vrachebnoe delo.
1979 Jan; ?(1):16-21. doi:
NULL. [PMID: 425457] - M Woyke, H Cwajda, J Wójcicki. Platelet aggregation and adhesiveness as well as blood lipids level in dogs treated with di-(1-isoquinolinyl)-di-(pyridyl-2')-butane and carbocromen.
Polish journal of pharmacology and pharmacy.
1978 Jan; 30(1):77-81. doi:
NULL. [PMID: 643741] - E Schraven. [Regulation of lipid and carbohydrate metabolism of the heart by carbocromen (author's transl)].
Arzneimittel-Forschung.
1976 Feb; 26(2):197-200. doi:
". [PMID: 947199] - M Rubegni, D Provvedi, P G Bellini, C Bandinelli, G De Mauro. [Anti-platelet aggregating drugs in the prevention of thromboembolic diseases].
Minerva medica.
1975 May; 66(36):1689-703. doi:
NULL. [PMID: 236525]