Amosulalol (BioDeep_00000176997)

   

human metabolite blood metabolite


代谢物信息卡片


5-(1-hydroxy-2-{[2-(2-methoxyphenoxy)ethyl]amino}ethyl)-2-methylbenzene-1-sulfonamide

化学式: C18H24N2O5S (380.1405854)
中文名称: 氨磺洛尔
谱图信息: 最多检出来源 Homo sapiens(blood) 20%

分子结构信息

SMILES: CC1=C(C=C(C=C1)C(CNCCOC2=CC=CC=C2OC)O)S(=O)(=O)N
InChI: InChI=1S/C18H24N2O5S/c1-13-7-8-14(11-18(13)26(19,22)23)15(21)12-20-9-10-25-17-6-4-3-5-16(17)24-2/h3-8,11,15,20-21H,9-10,12H2,1-2H3,(H2,19,22,23)

描述信息

C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents

同义名列表

3 个代谢物同义名

5-(1-hydroxy-2-{[2-(2-methoxyphenoxy)ethyl]amino}ethyl)-2-methylbenzene-1-sulfonamide; 5-(1-Hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methylbenzenesulfonamide; Amosulalol



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Katsuhiro Suzuki, Hidetaka Kamimura. Pharmacokinetics and metabolism of an alpha,beta-blocker, amosulalol hydrochloride, in mice: biliary excretion of carbamoyl glucuronide. Biological & pharmaceutical bulletin. 2007 Aug; 30(8):1580-5. doi: 10.1248/bpb.30.1580. [PMID: 17666826]
  • Hye Sun Gwak, Eun Sun Noh, Nah Young Lee, In Koo Chun. Determination of amosulalol in human plasma using solid-phase extraction combined with liquid chromatography and ultraviolet detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Apr; 818(2):109-13. doi: 10.1016/j.jchromb.2004.06.029. [PMID: 15734149]
  • S Takada, A Numabe, N Hirawa, S Yagi, Y Uehara. Thromboxane inhibition potentiates antihypertensive effects of alpha 1 adrenoceptor antagonists in the rat. Prostaglandins, leukotrienes, and essential fatty acids. 1997 Feb; 56(2):127-34. doi: 10.1016/s0952-3278(97)90509-3. [PMID: 9051722]
  • K Ando, H Noda, E Ogata, T Fujita. Hemodynamic and endocrine changes associated with hypotensive action of amosulalol in essential hypertension. Journal of cardiovascular pharmacology. 1992 Jul; 20(1):7-10. doi: NULL. [PMID: 1383633]
  • Y Inoue, K Yaga, M Nishimura, K Okafuji, Y Fujii, Y Nagasaka, M Tanaka, N Fujita, K Kaku, T Kaneko. Antihypertensive and metabolic effects of long-term treatment with amosulalol in non-insulin dependent diabetics. Current medical research and opinion. 1992; 12(9):564-71. doi: 10.1185/03007999209111523. [PMID: 1582238]
  • S Oishi, M Sasaki, M Ohno, T Umeda, T Sato. Periodic fluctuation of blood pressure and its management in a patient with pheochromocytoma. Case report and review of the literature. Japanese heart journal. 1988 May; 29(3):389-99. doi: 10.1536/ihj.29.389. [PMID: 3050197]
  • K Honda, T Takenaka, K Shiono, A Miyata-Osawa, C Nakagawa. Autonomic and antihypertensive activity of oral amosulalol (YM-09538), a combined alpha- and beta-adrenoceptor blocking agent in conscious rats. Japanese journal of pharmacology. 1985 May; 38(1):31-41. doi: 10.1254/jjp.38.31. [PMID: 2862302]
  • H Kamimura, H Sasaki, S Kawamura. Metabolism of amosulalol hydrochloride in man: quantitative comparison with laboratory animals. Xenobiotica; the fate of foreign compounds in biological systems. 1985 May; 15(5):413-20. doi: 10.3109/00498258509045012. [PMID: 3929481]
  • M Nakashima, M Asano, S Ohguchi, H Hashimoto, T Seki, M Miyazaki, T Takenaka. Amosulalol, a combined alpha and beta adrenoceptor antagonist: kinetics after intravenous and oral doses. Clinical pharmacology and therapeutics. 1984 Oct; 36(4):436-43. doi: 10.1038/clpt.1984.201. [PMID: 6478731]
  • H Kamimura, H Sasaki, S Kawamura. Pharmacokinetics of amosulalol, an alpha, beta-adrenoceptor blocker, in rats, dogs and monkeys. Xenobiotica; the fate of foreign compounds in biological systems. 1984 Aug; 14(8):613-20. doi: 10.3109/00498258409151459. [PMID: 6149656]
  • H Sasaki, H Kamimura, H Kaniwa, S Kawamura, M Takaichi, T Yokoshima. Disposition and metabolism of amosulalol hydrochloride, a new combined alpha- and beta-adrenoceptor blocking agent, in rats, dogs and monkeys. Xenobiotica; the fate of foreign compounds in biological systems. 1984 Aug; 14(8):621-31. doi: 10.3109/00498258409151460. [PMID: 6149657]
  • H Kamimura, H Sasaki, S Kawamura, M Shimizu, H Matsumoto, Y Kobayashi. Determination of the alpha, beta-adrenoceptor blocker YM-09538 in urine by gas chromatography with a nitrogen-sensitive detector. Journal of chromatography. 1983 Jun; 275(1):81-7. doi: 10.1016/s0378-4347(00)84346-7. [PMID: 6135704]
  • H Kamimura, H Sasaki, S Kawamura. Determination of the alpha,beta-adrenoceptor blocker YM-09538 in plasma by high-performance liquid chromatography with fluorescence detection. Journal of chromatography. 1981 Sep; 225(1):115-21. doi: 10.1016/s0378-4347(00)80250-9. [PMID: 7298739]