Carbazochrome (BioDeep_00000176994)
human metabolite blood metabolite
代谢物信息卡片
化学式: C10H12N4O3 (236.0909362)
中文名称: 卡巴克洛
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CC(C2=CC(=C(C=C21)O)N=NC(=O)N)O
InChI: InChI=1S/C10H12N4O3/c1-14-4-9(16)5-2-6(12-13-10(11)17)8(15)3-7(5)14/h2-3,9,15-16H,4H2,1H3,(H2,11,17)
描述信息
B - Blood and blood forming organs > B02 - Antihemorrhagics > B02B - Vitamin k and other hemostatics
D006401 - Hematologic Agents > D003029 - Coagulants > D006490 - Hemostatics
C78275 - Agent Affecting Blood or Body Fluid > C78311 - Hemostatic Agent
Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent[1].
同义名列表
13 个代谢物同义名
N-[(3,6-Dihydroxy-1-methyl-2,3-dihydro-1H-indol-5-yl)imino]carbamimidate; [(3,6-dihydroxy-1-methyl-2,3-dihydro-1H-indol-5-yl)imino]urea; (3,6-dihydroxy-1-methyl-2,3-dihydroindol-5-yl)iminourea; Adrenochrome semicarbazone sodium sulfonate; Carbazochrome sodium sulfonate; Adrenochrome semicarbazone; Carbazochrome salicylate; Adrenochromazone; Carbazochrome; Adrenoxyl; Adrenosem; AC-17; Adona
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:31349
- PubChem: 2557
- HMDB: HMDB0249613
- DrugBank: DB09012
- ChEMBL: CHEMBL2051960
- ChEMBL: CHEMBL4789892
- chemspider: 24816153
- CAS: 69-81-8
- medchemexpress: HY-B1587
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Xiaqing Zhou, Yongsan Li, Shuang Chen, Ya-Nan Fu, Shihui Wang, Guofeng Li, Lei Tao, Yen Wei, Xing Wang, Jun F Liang. Dynamic agent of an injectable and self-healing drug-loaded hydrogel for embolization therapy.
Colloids and surfaces. B, Biointerfaces.
2018 Dec; 172(?):601-607. doi:
10.1016/j.colsurfb.2018.09.016. [PMID: 30219579] - Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Katsuhiko Noguchi, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto. Pelvic venous congestion induces lower urinary tract dysfunction in rats.
Biomedical research (Tokyo, Japan).
2018; 39(6):269-277. doi:
10.2220/biomedres.39.269. [PMID: 30531156] - Hitoshi Oh-oka, Tetsuo Yamada, Hiromitsu Noto, Tomokazu Umeyama, Katsumi Kadekawa, Katsuhiro Ashitomi, Saori Nishijima, Kimio Sugaya. Effect of carbazochrome sodium sulfonate on refractory chronic prostatitis.
International journal of urology : official journal of the Japanese Urological Association.
2014 Nov; 21(11):1162-6. doi:
10.1111/iju.12533. [PMID: 24964194] - Xingjiang Hu, Yunliang Zheng, Guolan Wu, Jian Liu, Meixiang Zhu, Huili Zhou, You Zhai, Lihua Wu, Jianzhong Shen-Tu. Optimization of solid phase extraction clean up and validation of quantitative determination of carbazochrome sodium sulfonate in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Mar; 951-952(?):1-6. doi:
10.1016/j.jchromb.2014.01.014. [PMID: 24487058] - Saori Nishijima, Kimio Sugaya, Katsumi Kadekawa, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto. High-dose tranilast administration to rats creates interstitial cystitis-like symptoms with increased vascular permeability.
Life sciences.
2013 Nov; 93(23):897-903. doi:
10.1016/j.lfs.2013.10.010. [PMID: 24157455] - Xiao-Juan Gan, Shao-Pu Liu, Zhong-Fang Liu, Xiao-Li Hu, Jing Tian, Jia-Xing Xue. Fluorescence quenching method for the determination of carbazochrome sodium sulfonate with aromatic amino acids.
Luminescence : the journal of biological and chemical luminescence.
2013 May; 28(3):265-9. doi:
10.1002/bio.2375. [PMID: 22544487] - Heran Wang, Min Li, Jianming Hu, Chenhong Wang, Shanshan Xu, Charles C Han. Multiple targeted drugs carrying biodegradable membrane barrier: anti-adhesion, hemostasis, and anti-infection.
Biomacromolecules.
2013 Apr; 14(4):954-61. doi:
10.1021/bm301997e. [PMID: 23448620] - Xiaojuan Gan, Shaopu Liu, Zhongfang Liu, Xiaoli Hu, Zhiping Cui, Yaqiong Wang. Determination of carbazochrome by fluorescence quenching method.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2012 Nov; 97(?):161-6. doi:
10.1016/j.saa.2012.05.062. [PMID: 22750685] - Mukesh Maheshwari, Jessica K Roberts, Brent Desutter, Karen T Duong, Joseph Tingling, Janelle N Fawver, Hayley E Schall, Michael Kahle, Ian V J Murray. Hydralazine modifies Aβ fibril formation and prevents modification by lipids in vitro.
Biochemistry.
2010 Dec; 49(49):10371-80. doi:
10.1021/bi101249p. [PMID: 21058733] - Min Song, Hua Zhao, Li Wang, Lin Yang, Taijun Hang, Aidong Wen. Development and validation of a robust LC-MS-MS with atmospheric pressure chemical ionization for quantitation of carbazochrome sodium sulfonate in human plasma: application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2010 Sep; 24(9):990-9. doi:
10.1002/bmc.1397. [PMID: 20146401] - S Tassniyom, S Vasanawathana, T Dhiensiri, A Nisalak, A Chirawatkul. Failure of carbazochrome sodium sulfonate (AC-17) to prevent dengue vascular permeability or shock: a randomized, controlled trial.
The Journal of pediatrics.
1997 Oct; 131(4):525-8. doi:
10.1016/s0022-3476(97)70055-6. [PMID: 9386652] - D Shen, L Shen, A L Wang. [Effect of xiaoyu pian on new platelet aggregation defect].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
1994 Oct; 14(10):589-91. doi:
". [PMID: 7719089] - Y Funahara, Sumarmo, A Shirahata, S R Harun, R Setiabudy-Dharma, M A Nathin, T W Karjomanggolo, L A Tamaela. Protection against marked plasma leakage in dengue haemorrhagic fever by infusion of carbazochrome sodium sulfonate (AC-17).
The Southeast Asian journal of tropical medicine and public health.
1987 Sep; 18(3):356-61. doi:
NULL. [PMID: 2963380] - M Yagame, Y Tomino, M Miura, T Suga, M Endoh, Y Nomoto, H Sakai. Clinical effect of dipyridamole in patients with IgA nephropathy.
The Tokai journal of experimental and clinical medicine.
1986 Nov; 11(5):329-33. doi:
NULL. [PMID: 2960035] - A P VAN LERBERGHE, A R BERGERON. [Experiments with a new blood substitute adrenoxyl].
Annales belges de medecine militaire. Belgisch tijdschrift voor militaire geneeskunde.
1954 Jun; 107(6-7):100-7. doi:
NULL. [PMID: 13207800] - C HEYMANS, R CHARLIER. [Experimental research on adrenochrome semicarbazone as a constituent of a blood plasma substitute].
Archives internationales de pharmacodynamie et de therapie.
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