Butaxamine (BioDeep_00000176886)
human metabolite blood metabolite
代谢物信息卡片
化学式: C15H25NO3 (267.18343400000003)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 83.33%
分子结构信息
SMILES: CC(C(C1=C(C=CC(=C1)OC)OC)O)NC(C)(C)C
InChI: InChI=1S/C15H25NO3/c1-10(16-15(2,3)4)14(17)12-9-11(18-5)7-8-13(12)19-6/h7-10,14,16-17H,1-6H3
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
D007004 - Hypoglycemic Agents
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 18026
- HMDB: HMDB0249458
- ChEMBL: CHEMBL289093
- MeSH: Butoxamine
- chemspider: 17030
- CAS: 33997-55-6
- CAS: 2922-20-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Naoya Kamio, Takuma Suzuki, Yuto Watanabe, Yoshitomo Suhara, Naomi Osakabe. A single oral dose of flavan-3-ols enhances energy expenditure by sympathetic nerve stimulation in mice.
Free radical biology & medicine.
2016 Feb; 91(?):256-63. doi:
10.1016/j.freeradbiomed.2015.12.030
. [PMID: 26738802] - Chunhua Zhang, Yun-Yun Rui, Yuan-Yuan Zhou, Zhong Ju, Hong-Hong Zhang, Chuang-Ying Hu, Ying Xiao, Guang-Yin Xu. Adrenergic β2-receptors mediates visceral hypersensitivity induced by heterotypic intermittent stress in rats.
PloS one.
2014; 9(4):e94726. doi:
10.1371/journal.pone.0094726
. [PMID: 24733123] - Michitsugu Arai, Takuma Sato, Shoko Takeuchi, Shigemi Goto, Akifumi Togari. Dose effects of butoxamine, a selective β2-adrenoceptor antagonist, on bone metabolism in spontaneously hypertensive rat.
European journal of pharmacology.
2013 Feb; 701(1-3):7-13. doi:
10.1016/j.ejphar.2012.12.016
. [PMID: 23321373] - Yuping Pei, Xiaoguang Bai, Hui Dong, Han Han, Zishen Zhang, Hailong Dong, Lichao Hou, Lize Xiong. β2-adrenergic receptor antagonist butoxamine partly abolishes the protection of 100\% oxygen treatment against zymosan-induced generalized inflammation in mice.
Shock (Augusta, Ga.).
2011 Sep; 36(3):272-8. doi:
10.1097/shk.0b013e31822413a4
. [PMID: 21617579] - Haruto Kato, Masahiko Kawaguchi, Satoki Inoue, Katsuji Hirai, Hitoshi Furuya. The effects of beta-adrenoceptor antagonists on proinflammatory cytokine concentrations after subarachnoid hemorrhage in rats.
Anesthesia and analgesia.
2009 Jan; 108(1):288-95. doi:
10.1213/ane.0b013e318187bb93
. [PMID: 19095864] - Min Jung Park, Christopher B Guest, Meredith B Barnes, Jonathan Martin, Uzma Ahmad, Jason M York, Gregory G Freund. Blocking of beta-2 adrenergic receptors hastens recovery from hypoglycemia-associated social withdrawal.
Psychoneuroendocrinology.
2008 Nov; 33(10):1411-8. doi:
10.1016/j.psyneuen.2008.08.005
. [PMID: 18814973] - Elena Grossini, Claudio Molinari, David A S G Mary, Ezio Ghigo, Gianni Bona, Giovanni Vacca. Intracoronary ghrelin infusion decreases coronary blood flow in anesthetized pigs.
Endocrinology.
2007 Feb; 148(2):806-12. doi:
10.1210/en.2006-1230
. [PMID: 17110424] - Peter Spijker, Nagarajan Vaidehi, Peter L Freddolino, Peter A J Hilbers, William A Goddard. Dynamic behavior of fully solvated beta2-adrenergic receptor, embedded in the membrane with bound agonist or antagonist.
Proceedings of the National Academy of Sciences of the United States of America.
2006 Mar; 103(13):4882-7. doi:
10.1073/pnas.0511329103
. [PMID: 16551744] - S N Patiyal, S S Katoch. Tissue specific and variable collagen proliferation in Swiss albino mice treated with clenbuterol.
Physiological research.
2006; 55(1):97-103. doi:
10.33549/physiolres.930677
. [PMID: 15857157] - E Grossini, C Molinari, A Battaglia, D A S G Mary, F Ribichini, N Surico, G Vacca. Human placental lactogen decreases regional blood flow in anesthetized pigs.
Journal of vascular research.
2006; 43(2):205-13. doi:
10.1159/000090950
. [PMID: 16410683] - Emilie Gauthier, Cécile Rahuel, Marie Paule Wautier, Wassim El Nemer, Pierre Gane, Jean Luc Wautier, Jean Pierre Cartron, Yves Colin, Caroline Le Van Kim. Protein kinase A-dependent phosphorylation of Lutheran/basal cell adhesion molecule glycoprotein regulates cell adhesion to laminin alpha5.
The Journal of biological chemistry.
2005 Aug; 280(34):30055-62. doi:
10.1074/jbc.m503293200
. [PMID: 15975931] - Aya Suenaga, Hiroshi Ueki. Effect of orthovanadate on platelet aggregation induced by platelet-activating factor.
Biological & pharmaceutical bulletin.
2004 Nov; 27(11):1859-63. doi:
10.1248/bpb.27.1859
. [PMID: 15516737] - Claudia Anesini, Sebastian Turner, Enri Borda, Graciela Ferraro, Jorge Coussio. Effect of Larrea divaricata Cav. extract and nordihydroguaiaretic acid upon peroxidase secretion in rat submandibulary glands.
Pharmacological research.
2004 May; 49(5):441-8. doi:
10.1016/j.phrs.2003.10.014
. [PMID: 14998553] - G Vacca, A Battaglia, E Chiorboli, E Grossini, D A Mary, C Molinari, G Bona. Haemodynamic effects of the intravenous administration of growth hormone in anaesthetized pigs.
Pflugers Archiv : European journal of physiology.
1998 Jul; 436(2):159-67. doi:
10.1007/s004240050618
. [PMID: 9594014] - S K Kaan, Q B Mei, C H Cho. A mechanistic study of beta-adrenoceptor antagonists on ethanol-induced gastric damage.
European journal of pharmacology.
1996 Dec; 317(1):115-22. doi:
10.1016/s0014-2999(96)00705-4
. [PMID: 8982727] - L Watkins, A Sherwood, D S Goldstein, W Maixner. Mechanisms underlying cardiovascular defense reaction evoked by dorsal periaqueductal gray stimulation.
The American journal of physiology.
1993 Nov; 265(5 Pt 2):R1155-61. doi:
10.1152/ajpregu.1993.265.5.r1155
. [PMID: 8238618] - K Yokotani, Y Okuma, Y Osumi. Release of endogenous noradrenaline from the vascularly perfused rat stomach in vitro: modulation by pre- and postsynaptic adrenoceptors.
The Journal of pharmacology and experimental therapeutics.
1992 Feb; 260(2):728-33. doi:
NULL
. [PMID: 1346643] - M Irwin, R L Hauger, L Jones, M Provencio, K T Britton. Sympathetic nervous system mediates central corticotropin-releasing factor induced suppression of natural killer cytotoxicity.
The Journal of pharmacology and experimental therapeutics.
1990 Oct; 255(1):101-7. doi:
NULL
. [PMID: 2120421] - A Sugarman, T Kahn. Calcium channel blockers enhance extrarenal potassium disposal in the rat.
The American journal of physiology.
1986 Apr; 250(4 Pt 2):F695-701. doi:
10.1152/ajprenal.1986.250.4.f695
. [PMID: 3083698] - L D Katz, J D'Avella, R A DeFronzo. Effect of epinephrine on renal potassium excretion in the isolated perfused rat kidney.
The American journal of physiology.
1984 Aug; 247(2 Pt 2):F331-8. doi:
10.1152/ajprenal.1984.247.2.f331
. [PMID: 6465325] - A Sugarman, D M Kaji, R M Stein, T Kahn. Extrarenal potassium transport and the beta 2-adrenergic system.
The Journal of laboratory and clinical medicine.
1984 Jun; 103(6):912-21. doi:
NULL
. [PMID: 6144715] - E S Borda, A M Genaro, G A Cremaschi, M E Sales, L Sterin-Borda. Beta-adrenergic inhibitory effect of alloimmune antibody on isolated oviductal tract of mice.
European journal of pharmacology.
1984 Apr; 100(2):195-200. doi:
10.1016/0014-2999(84)90222-x
. [PMID: 6329774] - C E Gauwerky, N L Bersch, D W Golde. Beta 2 receptor-mediated stimulation of Friend erythroleukemia cell growth by thyroid hormones.
Experimental hematology.
1981 Sep; 9(8):821-8. doi:
. [PMID: 6276212]
- B Ahrén, I Lundquist. Effects of selective and non-selective beta-adrenergic agents on insulin secretion in vivo.
European journal of pharmacology.
1981 Apr; 71(1):93-104. doi:
10.1016/0014-2999(81)90390-3
. [PMID: 6113155] - J L Osborn, G F DiBona, M D Thames. Beta-1 receptor mediation of renin secretion elicited by low-frequency renal nerve stimulation.
The Journal of pharmacology and experimental therapeutics.
1981 Feb; 216(2):265-9. doi:
NULL
. [PMID: 6257884] - C Gauwerky, D W Golde. Hormonal effects on cell proliferation in a human erythroleukemia cell line (K562).
Blood.
1980 Nov; 56(5):886-91. doi:
NULL
. [PMID: 6932980] - E Borda, J Sauvage, L Sterin-Borda, M F Gimeno, A L Gimeno. Adrenoceptors involved in the contractile activity of islated pregnant rat uterus.
European journal of pharmacology.
1979 Jun; 56(1-2):61-7. doi:
10.1016/0014-2999(79)90433-3
. [PMID: 223858] - J G Hilton, C H Wells. Effects of beta adrenergic blocking agents upon thermal trauma induced cardiovascular changes.
Archives internationales de pharmacodynamie et de therapie.
1979 Apr; 238(2):296-304. doi:
NULL
. [PMID: 38760] - F Przala, D M Gross, B Beckman, J W Fisher. Influence of albuterol on erythropoietin production and erythroid progenitor cell activation.
The American journal of physiology.
1979 Mar; 236(3):H422-6. doi:
10.1152/ajpheart.1979.236.3.h422
. [PMID: 426077] - Y Shibouta, K Nishikawa, S Kikuchi, K Shimamoto. Renal effects of propranolol, practolol and butoxamine in pentobarbital-anesthetized rats.
European journal of pharmacology.
1979 Jan; 53(2):201-8. doi:
10.1016/0014-2999(79)90166-3
. [PMID: 759198] - J V Dunne, C J Peters, T L Moore, J H Vaughan. Differential effects of propranolol on lymphocyte rosette formation and response to plant mitogens.
Arthritis and rheumatism.
1978 Sep; 21(7):767-73. doi:
10.1002/art.1780210705
. [PMID: 697947] - F Przala, D M Gross, B Beckman, J W Fisher. Influence of albuterol on erythropoietin and erythroid stem cell activation.
Haematologica.
1978 Aug; 63(4):395-404. doi:
. [PMID: 100380]
- R J Lefkowitz. Editorial: Selectivity in beta-adrenergic responses: clinical implications.
Circulation.
1974 May; 49(5):783-6. doi:
10.1161/01.cir.49.5.783
. [PMID: 4151328] - D Porte. A receptor mechanism for the inhibition of insulin release by epinephrine in man.
The Journal of clinical investigation.
1967 Jan; 46(1):86-94. doi:
10.1172/jci105514
. [PMID: 6018752]