Buparvaquone (BioDeep_00000176874)
human metabolite blood metabolite
代谢物信息卡片
3-[(4-tert-butylcyclohexyl)methyl]-4-hydroxy-1,2-dihydronaphthalene-1,2-dione
化学式: C21H26O3 (326.1881846)
中文名称: 布帕伐醌
谱图信息:
最多检出来源 Mus musculus(blood) 33.33%
分子结构信息
SMILES: CC(C)(C)C1CCC(CC1)CC2=C(C3=CC=CC=C3C(=O)C2=O)O
InChI: InChI=1S/C21H26O3/c1-21(2,3)14-10-8-13(9-11-14)12-17-18(22)15-6-4-5-7-16(15)19(23)20(17)24/h4-7,13-14,22H,8-12H2,1-3H3
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 71768
- HMDB: HMDB0249441
- ChEMBL: CHEMBL3182074
- ChEMBL: CHEMBL292009
- Wikipedia: Buparvaquone
- chemspider: 64807
- CAS: 88426-33-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shuxiao Su, Shuaiyang Zhao, Junlong Liu, Chuhan Zhang, Haohan Zhu, Guiquan Guan, Hong Yin, Jianxun Luo. Establishment and application of TaqMan real-time PCR method for detection of Theileria annulata resistant to buparvaquone.
Veterinary parasitology.
2024 Jun; 328(?):110183. doi:
10.1016/j.vetpar.2024.110183. [PMID: 38608378] - Lis Marie Monteiro, Raimar Löbenberg, Eduardo José Barbosa, Gabriel Lima Barros de Araujo, Paula Keiko Sato, Edite Kanashiro, Raissa H de Araujo Eliodoro, Mussya Rocha, Vera Lúcia Teixeira de Freitas, Nikoletta Fotaki, Nádia Araci Bou-Chacra. Oral administration of buparvaquone nanostructured lipid carrier enables in vivo activity against Leishmania infantum.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2022 Feb; 169(?):106097. doi:
10.1016/j.ejps.2021.106097. [PMID: 34910988] - Luana Pereira Borba-Santos, Thayná Lopes Barreto, Taissa Vila, Kung Darh Chi, Fabiana Dos Santos Monti, Marconi Rodrigues de Farias, Daniela S Alviano, Celuta S Alviano, Débora O Futuro, Vitor Ferreira, Wanderley de Souza, Kelly Ishida, Sonia Rozental. In Vitro and In Vivo Antifungal Activity of Buparvaquone against Sporothrix brasiliensis.
Antimicrobial agents and chemotherapy.
2021 08; 65(9):e0069921. doi:
10.1128/aac.00699-21. [PMID: 34152816] - Heena V Maithania, Bhabani S Mohanty, Pradip R Chaudhari, Abdul Samad, Padma V Devarajan. Shape mediated splenotropic delivery of buparvaquone loaded solid lipid nanoparticles.
Drug delivery and translational research.
2020 02; 10(1):159-167. doi:
10.1007/s13346-019-00670-x. [PMID: 31468307] - Lis Marie Monteiro, Raimar Löbenberg, Nikoletta Fotaki, Gabriel Lima Barros de Araújo, Paulo Cesar Cotrim, Nádia Bou-Chacra. Co-delivery of buparvaquone and polymyxin B in a nanostructured lipid carrier for leishmaniasis treatment.
Journal of global antimicrobial resistance.
2019 09; 18(?):279-283. doi:
10.1016/j.jgar.2019.06.006. [PMID: 31202979] - Kapil Kumar Gupta, Mukesh Srivastava, Vikrant Sudan, Shanker Kumar Singh, Soumen Choudhury, Daya Shanker. Variation in cardiac markers and electrocardiographic alterations in young calves naturally infected with bovine tropical theileriosis.
Tropical animal health and production.
2018 Aug; 50(6):1227-1230. doi:
10.1007/s11250-018-1548-0. [PMID: 29455427] - Lindsay Smith, Dolores R Serrano, Marion Mauger, Francisco Bolás-Fernández, Maria Auxiliadora Dea-Ayuela, Aikaterini Lalatsa. Orally Bioavailable and Effective Buparvaquone Lipid-Based Nanomedicines for Visceral Leishmaniasis.
Molecular pharmaceutics.
2018 07; 15(7):2570-2583. doi:
10.1021/acs.molpharmaceut.8b00097. [PMID: 29762040] - Lis Marie Monteiro, Raimar Löbenberg, Paulo Cesar Cotrim, Gabriel Lima Barros de Araujo, Nádia Bou-Chacra. Buparvaquone Nanostructured Lipid Carrier: Development of an Affordable Delivery System for the Treatment of Leishmaniases.
BioMed research international.
2017; 2017(?):9781603. doi:
10.1155/2017/9781603. [PMID: 28255558] - Guilherme Carneiro, Marta Gontijo Aguiar, Ana Paula Fernandes, Lucas Antônio Miranda Ferreira. Drug delivery systems for the topical treatment of cutaneous leishmaniasis.
Expert opinion on drug delivery.
2012 Sep; 9(9):1083-97. doi:
10.1517/17425247.2012.701204. [PMID: 22724539] - Gantala Venkatesh, M I A Majid, S M Mansor, N K Nair, Simon L Croft, V Navaratnam. In vitro and in vivo evaluation of self-microemulsifying drug delivery system of buparvaquone.
Drug development and industrial pharmacy.
2010 Jun; 36(6):735-45. doi:
10.3109/03639040903460446. [PMID: 20136493] - Gantala Venkatesh, M I A Majid, S Ramanathan, S M Mansor, N K Nair, Simon L Croft, V Navaratnam. Optimization and validation of RP-HPLC-UV method with solid-phase extraction for determination of buparvaquone in human and rabbit plasma: application to pharmacokinetic study.
Biomedical chromatography : BMC.
2008 May; 22(5):535-41. doi:
10.1002/bmc.965. [PMID: 18205140] - G R Muraguri, P N Ngumi, D Wesonga, S G Ndungu, J M Wanjohi, K Bang, A Fox, J Dunne, N McHardy. Clinical efficacy and plasma concentrations of two formulations of buparvaquone in cattle infected with East Coast fever (Theileria parva infection).
Research in veterinary science.
2006 Aug; 81(1):119-26. doi:
10.1016/j.rvsc.2005.09.012. [PMID: 16289157] - M Gwamaka, J A Matovelo, M M A Mtambo, G K Mbassa, R M Maselle, S Boniphace. The effect of dexamethasone and promethazine in combination with buparvaquone in the management of East Coast fever.
The Onderstepoort journal of veterinary research.
2004 Jun; 71(2):119-28. doi:
10.4102/ojvr.v71i2.274. [PMID: 15373334] - Martin Baumgartner, Pavla Angelisová, Niclas Setterblad, Nuala Mooney, Dirk Werling, Václav Horejsí, Gordon Langsley. Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes.
Blood.
2003 Mar; 101(5):1874-81. doi:
10.1182/blood-2002-02-0456. [PMID: 12411311] - M Naziroğlu, C E Saki, M Sevgili. The effect of buparvaquone treatment on the levels of some antioxidant vitamins, lipid peroxidation and glutathione peroxidase in cattle with theileriosis.
Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B.
1999 May; 46(4):233-9. doi:
10.1111/j.0931-1793.1999.0_222.x. [PMID: 10379233] - G M Wilkie, E Kirvar, E M Thomas, O Sparagano, C G Brown. Stage-specific activity in vitro on the Theileria infection process of serum from calves treated prophylactically with buparvaquone.
Veterinary parasitology.
1998 Dec; 80(2):127-36. doi:
10.1016/s0304-4017(98)00204-0. [PMID: 9870365] - R Hashemi-Fesharki. Chemotherapeutic value of parvaquone and buparvaquone against Theileria annulata infection of cattle.
Research in veterinary science.
1991 Mar; 50(2):204-7. doi:
10.1016/0034-5288(91)90107-y. [PMID: 2034901] - N P Stewart, A J de Vos, N McHardy, N F Standfast. Elimination of Theileria buffeli infections from cattle by concurrent treatment with buparvaquone and primaquine phosphate.
Tropical animal health and production.
1990 May; 22(2):116-22. doi:
10.1007/bf02239836. [PMID: 2115213] - L D Kinabo, J A Bogan. Parvaquone and buparvaquone: HPLC analysis and comparative pharmacokinetics in cattle.
Acta tropica.
1988 Mar; 45(1):87-94. doi:
NULL. [PMID: 2896450]