Buflomedil (BioDeep_00000176865)

   

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


4-(pyrrolidin-1-yl)-1-(2,4,6-trimethoxyphenyl)butan-1-one

化学式: C17H25NO4 (307.178349)
中文名称: 丁洛地尔
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC(=C(C(=C1)OC)C(=O)CCCN2CCCC2)OC
InChI: InChI=1S/C17H25NO4/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18/h11-12H,4-10H2,1-3H3

描述信息

C - Cardiovascular system > C04 - Peripheral vasodilators > C04A - Peripheral vasodilators
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor

同义名列表

23 个代谢物同义名

4-(pyrrolidin-1-yl)-1-(2,4,6-trimethoxyphenyl)butan-1-one; 2,4,6-Trimethoxyphenyl-3-pyrrolidine propyl ketone; Buflomedil pyridoxal phosphate; Buflomedil hydrochloride; Buflomedil-ratiopharm; Buflomedil heumann; Buflomedil von CT; Buflomedil stada; Buflomedil lindo; buflo 1a Pharma; buflo-Puren; Blufomedil; Buflohexal; Buflomedil; Fonzylane; buflo-POS; Bufomedil; buflo AbZ; Sinoxis; Bufedil; Lofton; Loftyl; Buflomedil



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Santanu Kaity, Animesh Ghosh. Comparative bio-safety and in vivo evaluation of native or modified locust bean gum-PVA IPN microspheres. International journal of biological macromolecules. 2015 Jan; 72(?):883-93. doi: 10.1016/j.ijbiomac.2014.09.036. [PMID: 25307127]
  • Santanu Kaity, Jinu Isaac, P Mahesh Kumar, Anirbandeep Bose, Tin Wui Wong, Animesh Ghosh. Microwave assisted synthesis of acrylamide grafted locust bean gum and its application in drug delivery. Carbohydrate polymers. 2013 Oct; 98(1):1083-94. doi: 10.1016/j.carbpol.2013.07.037. [PMID: 23987450]
  • Li Ren, Chun Yang, Yan Peng, Fan Li, Ying-Hui Li, Heng Zheng. Application of a high performance liquid chromatography-tandem mass spectrometry method for determination of buflomedil in human plasma for a bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Sep; 935(?):41-6. doi: 10.1016/j.jchromb.2013.07.010. [PMID: 23939201]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Seung Ha Park, Deok Woo Kim, Min Ah Lee, Sang Chul Yoo, Seung Chul Rhee, Sang Hwan Koo, Geun Hye Seol, Eun Young Cho. Effectiveness of mesotherapy on body contouring. Plastic and reconstructive surgery. 2008 Apr; 121(4):179e-185e. doi: 10.1097/01.prs.0000304611.71480.0a. [PMID: 18349597]
  • Isabelle Marie, Fabien Hervé, Etienne Primard, Nicole Cailleux, Hervé Levesque. Long-term follow-up of hypothenar hammer syndrome: a series of 47 patients. Medicine. 2007 Nov; 86(6):334-343. doi: 10.1097/md.0b013e31815c95d3. [PMID: 18004178]
  • Li Ding, Bin Gong, Xiaoxiang Chu, Jingjing Hu, Hen Zheng. Sensitive and rapid LC-ESI-MS method for the determination of trimetazidine in human plasma. Journal of pharmaceutical and biomedical analysis. 2007 Jun; 44(2):526-31. doi: 10.1016/j.jpba.2007.01.041. [PMID: 17349764]
  • Philip M Lang, D Irnich. [Adenosine for treatment of ischemic pain in thromboangiitis obliterans. A case report]. Schmerz (Berlin, Germany). 2007 Jun; 21(3):234-7. doi: 10.1007/s00482-007-0528-5. [PMID: 17265013]
  • James David Adams, Rubin Wang, Jun Yang, Eric Jungchi Lien. Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions. Chinese medicine. 2006 Nov; 1(?):3. doi: 10.1186/1749-8546-1-3. [PMID: 17302964]
  • F K-h Sze, F F Yeung, E Wong, J Lau. Does Danshen improve disability after acute ischaemic stroke?. Acta neurologica Scandinavica. 2005 Feb; 111(2):118-25. doi: 10.1111/j.1600-0404.2004.00369.x. [PMID: 15644072]
  • Francesco S Briguglio, Maria Rita Mondello, Mariangela Galluzzo, Eugenio Raneri, Anna De Pasquale, Antonella Saija, Domenico Trombetta. Protective effect of buflomedil in a rat model of moderate cerebral ischemia. Arzneimittel-Forschung. 2005; 55(8):437-42. doi: 10.1055/s-0031-1296885. [PMID: 16149710]
  • Li Ding, Xin Wei, Shengqiang Zhang, Jianpin Sheng, Yindi Zhang. Rapid and sensitive liquid chromatography-electrospray ionization-mass spectrometry method for the determination of eperisone in human plasma: method and clinical applications. Journal of chromatographic science. 2004 May; 42(5):254-8. doi: 10.1093/chromsci/42.5.254. [PMID: 15189598]
  • Bernward Babel, Thomas Tatschner, Dieter Patzelt. [Suicidal buflomedil intoxication]. Archiv fur Kriminologie. 2004 Mar; 213(3-4):108-13. doi: NULL. [PMID: 15137632]
  • I Forfar-Bares, F Pehourcq, C Jarry. Rapid HPLC measurement of buflomedil in plasma in poisoning cases. Biomedical chromatography : BMC. 2002 Oct; 16(7):482-5. doi: 10.1002/bmc.189. [PMID: 12378562]
  • Ewa Nowak, Grazyna Wyrwicz, Zbigniew Dabrowski, Olgierd Smolenski, Krzysztof Spodaryk. Rheological and biochemical examination of red blood cells after treatment with different pharmacological and toxic substances. Clinical hemorheology and microcirculation. 2002; 26(2):91-7. doi: NULL. [PMID: 12082257]
  • I N Migdalis, N Varvarigos, J Charalabides, E Leontiades, B Gerolimou, F Mantzara, K Karmaniolas. Effects of buflomedil on early carotid atherosclerosis in Type 2 diabetic patients. International angiology : a journal of the International Union of Angiology. 2001 Jun; 20(2):126-30. doi: ". [PMID: 11533519]
  • H Blain, C Jeandel. [Myoclonic coma and severe cardiac insufficiency in a patient with arteritis]. La Revue de medecine interne. 2001 Jun; 22 Suppl 2(?):247s-249s. doi: 10.1016/s0248-8663(01)83662-6. [PMID: 11433584]
  • K Holzer, M Thiel, U Kreimeier, S Moritz, K Messmer. Buflomedil hydrochloride reduces systemic activation of polymorphonuclear leukocytes during hyperdynamic endotoxemia. Shock (Augusta, Ga.). 1998 Nov; 10(5):335-42. doi: 10.1097/00024382-199811000-00005. [PMID: 9840648]
  • P Redondo, J García-Foncillas, A España, F Cuevillas, E Quintanilla. Differential modulation of IL-8 and TNF-alpha expression in human keratinocytes by buflomedil chlorhydrate and pentoxifylline. Experimental dermatology. 1997 Aug; 6(4):186-94. doi: 10.1111/j.1600-0625.1997.tb00204.x. [PMID: 9293391]
  • P Papa, L Rocchi, C Mainardi, G Donzelli. Buflomedil interference with the monoclonal EMIT d.a.u. amphetamine/methamphetamine immunoassay. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. 1997 May; 35(5):369-70. doi: NULL. [PMID: 9189741]
  • F Laghi Pasini, P L Capecchi, A Acciavatti, S Petri, A de Lalla, G Cati, M Colafati, T Di Perri. Pharmacological preconditioning of ischaemia. Clinical hemorheology and microcirculation. 1997 Jan; 17(1):73-84. doi: NULL. [PMID: 9181761]
  • E Rey, A Moynot, P d'Athis, J Y Pello, A Maurel, M O Frydman, C Buisson, G Olive. Dialysis clearance of buflomedil in hemodialysed patients. Arzneimittel-Forschung. 1996 May; 46(5):492-5. doi: NULL. [PMID: 8737633]
  • A Tracqui, M Deveaux, P Kintz, P Mangin, D Gosset. A fatal case of buflomedil self-poisoning: toxicological data and literature review. Forensic science international. 1995 Jan; 71(1):43-9. doi: 10.1016/0379-0738(94)01632-f. [PMID: 7875617]
  • P L Capecchi, F Laghi Pasini, N Sodi, M Chiavetta, S Sensi, A De Lalla, L Volpi, T Di Perri. Increase in plasma levels of adenosine and adenine nucleotides after intravenous infusion of buflomedil in humans. Journal of cardiovascular pharmacology. 1995 Jan; 25(1):35-9. doi: 10.1097/00005344-199501000-00007. [PMID: 7723351]
  • M Molinaro, M B Regazzi, S Raffaghello, I Buggia, I Iacona, P Graziani, G Specchia, G Melzi D'eril. Evaluation of two buflomedil tablet formulations in patients with atherosclerotic disease. Journal of clinical pharmacy and therapeutics. 1994 Apr; 19(2):111-5. doi: 10.1111/j.1365-2710.1994.tb01121.x. [PMID: 8071390]
  • A Alberti, S Valenti, F Gallo, M Petolillo, D Del Monte. Acute buflomedil intoxication: a life-threatening condition. Intensive care medicine. 1994; 20(3):219-21. doi: 10.1007/bf01704705. [PMID: 8014291]
  • H Partsch, W Jochmann, A Mostbeck, M Hirschl. [Nuclear medicine studies of tissue concentration and hemodynamic effects of retrograde intravenous pressure infusions]. Wiener medizinische Wochenschrift (1946). 1993; 143(7-8):172-6. doi: NULL. [PMID: 8397459]
  • F L Fort, S A Ruckman, R L Gregson, D R Patterson. Buflomedil: one-year oral safety evaluation in rats. Drug and chemical toxicology. 1993; 16(2):195-205. doi: 10.3109/01480549309031996. [PMID: 8486099]
  • M de Bernardi di Valserra, R Germogli, F Feletti, D Covini, E Borgonovo. Pharmacokinetics of a sustained release formulation of pyridoxal phosphate of buflomedil after single or repeated oral doses in healthy volunteers. Arzneimittel-Forschung. 1992 May; 42(5):632-6. doi: NULL. [PMID: 1530676]
  • C H Tseng, T Y Tai, H P Wu, L M Chuang, B J Lin. The effect of oral buflomedil on microalbuminuria in non-insulin-dependent diabetic patients. Diabetes research and clinical practice. 1992 May; 16(2):117-22. doi: 10.1016/0168-8227(92)90082-3. [PMID: 1600849]
  • P Pola, R Flore, P Tondi, G Nolfe. Rheological activity of propionyl L-carnitine. Drugs under experimental and clinical research. 1991; 17(3):191-6. doi: NULL. [PMID: 1914846]
  • M Mares, F Sogaro, M A Scomparin, G Boeri, G Cella. Effect of buflomedil, dipyridamole and indobufene on hemorrheologic and blood coagulation parameters in patients who underwent vascular surgery for severe atherosclerosis. Journal of medicine. 1991; 22(3):163-9. doi: NULL. [PMID: 1770324]
  • R J Eastwood, R K Bhamra, D W Holt. High-performance liquid chromatographic method for the measurement of buflomedil in plasma and serum. Journal of chromatography. 1990 Oct; 532(1):187-92. doi: 10.1016/s0378-4347(00)83768-8. [PMID: 2079534]
  • P P Rop, M Bresson, J Antoine, J Spinazzola, M Fornaris, A Viala. Quantitation and ultraviolet spectrum identification of buflomedil in whole blood and plasma by HPLC. Journal of analytical toxicology. 1990 Jan; 14(1):18-21. doi: 10.1093/jat/14.1.18. [PMID: 2314057]
  • G Ciuffetti, M Mercuri, R Lombardini, D Palazzetti, M T Rizzo, L Parnetti. [Whole blood filterability in chronic cerebrovascular disorders: effects of the use of buflomedil hydrochloride]. Minerva medica. 1989 Nov; 80(11):1237-40. doi: NULL. [PMID: 2689916]
  • L Zecca, P Ferrario, R Pirola, L Reina, F Zambotti, N Zonta, A M Lepore, F Scaglione, F Fraschini. Pharmacokinetics of buflomedil after various dosage forms. Arzneimittel-Forschung. 1989 Apr; 39(4):518-9. doi: NULL. [PMID: 2751740]
  • K Van Acker, E Rillaerts, I De Leeuw. The influence of buflomedil on blood viscosity parameters in insulin-dependent diabetic patients: a preliminary study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 1989; 43(3):219-22. doi: 10.1016/0753-3322(89)90218-7. [PMID: 2775859]
  • A Craveri, G Tornaghi, L Paganardi, R Ranieri, M Di Bella. [Decrease of blood viscosity induced by buflomedil in healthy volunteers]. Minerva cardioangiologica. 1988 Jul; 36(7-8):357-60. doi: NULL. [PMID: 3211334]
  • L J Wurzinger, H Schmid-Schönbein. Effect of buflomedil on epinephrine-enhanced platelet aggregation in vitro and ex vivo. Arzneimittel-Forschung. 1987 Oct; 37(10):1113-5. doi: NULL. [PMID: 3435582]
  • G Karoutas, I Milonas, N Artemis, D Karacostas, J Pitas, J Logothetis. The pharmacological effects of buflomedil in patients with multi-cerebral infarcts dementia: an open, preliminary assessment. Current medical research and opinion. 1987; 10(6):380-9. doi: 10.1185/03007998709111107. [PMID: 3568750]
  • M Leschke, W Motz, B E Strauer. [Hemorheologic therapy applications in coronary heart disease]. Wiener medizinische Wochenschrift (1946). 1986; 136 Spec No(?):17-24. doi: NULL. [PMID: 3825169]
  • H Sinzinger, C Wirthumer-Hoche. [Platelet function after the single administration of buflomedil]. Wiener klinische Wochenschrift. 1985 Sep; 97(18):720-2. doi: NULL. [PMID: 4072227]
  • B Dorigo, D Raspanti, M Trapani, B Albanese, A M Cameli, V Digiesi. [Flowmetric, thermometric and rheologic studies in obliterating arterial diseases of the lower extremities treated with buflomedil]. Minerva medica. 1985 Feb; 76(7):269-75. doi: NULL. [PMID: 3974940]
  • E Mozzi, D Chiurazzi, A Spinola, F Annoni, R Germiniani. Effects of buflomedil in a group of patients with chronic peripheral arterial diseases. Clinical and hemorheological evaluation. The Journal of international medical research. 1985; 13(6):317-21. doi: 10.1177/030006058501300603. [PMID: 4076530]
  • E Rey, P d'Athis, M O Richard, J P Fillastre, G Olive. Pharmacokinetics of buflomedil after intravenous administration in patients with chronic renal failure. International journal of clinical pharmacology, therapy, and toxicology. 1984 Dec; 22(12):648-52. doi: NULL. [PMID: 6526539]
  • S Athanaselis, C Maravelias, M Michalodimitrakis, A Koutselinis. Buflomedil concentrations in blood and viscera in a case of fatal intoxication. Clinical chemistry. 1984 Jan; 30(1):157. doi: 10.1093/clinchem/30.1.157. [PMID: 6690131]
  • G Olive, J P Fillastre, E Rey, P d'Athis. [Buflomedil in the patient with renal insufficiency]. Presse medicale (Paris, France : 1983). 1983 Feb; 12(9):579. doi: NULL. [PMID: 6219380]
  • E W Thomas. Analysis of buflomedil in mouse, rat and rabbit plasma by reversed-phase ion-pair high-performance liquid chromatography. Journal of chromatography. 1982 Mar; 228(?):387-91. doi: 10.1016/s0378-4347(00)80460-0. [PMID: 7076767]
  • F L Fort, S Tekeli, J P Lewkowski, I A Heyman, P K Cusick, J W Kesterson. Buflomedil: three month intravenous safety evaluation in rats. Drug and chemical toxicology. 1982; 5(4):401-14. doi: 10.3109/01480548208993192. [PMID: 7169013]
  • A Dubourg, R F Scamuffa. An experimental overview of a new vasoactive drug: buflomedil HCl. Angiology. 1981 Oct; 32(10):663-75. doi: 10.1177/000331978103201001. [PMID: 7034590]
  • A Pacheco e Silva, A M Landi de Almedia. Double blind comparative study of cinnarizine and buflomedil in patients suffering from cerebrovascular insufficiency. Angiology. 1981 Oct; 32(10):728-32. doi: 10.1177/000331978103201010. [PMID: 7325407]