1-[1-(1-Benzothiophen-2-yl)cyclohexyl]piperidine (BioDeep_00000176851)

   

human metabolite blood metabolite


代谢物信息卡片


1-[1-(1-Benzothiophen-2-yl)cyclohexyl]piperidine

化学式: C19H25NS (299.170761)
中文名称: N-[1-(2-苯并[B]噻嗯-2-基)环己基)]哌啶马来酸
谱图信息: 最多检出来源 Homo sapiens(blood) 96.55%

分子结构信息

SMILES: C1CCC(CC1)(C2=CC3=CC=CC=C3S2)N4CCCCC4
InChI: InChI=1S/C19H25NS/c1-5-11-19(12-6-1,20-13-7-2-8-14-20)18-15-16-9-3-4-10-17(16)21-18/h3-4,9-10,15H,1-2,5-8,11-14H2

描述信息

D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists

同义名列表

9 个代谢物同义名

1-[1-(1-Benzothiophen-2-yl)cyclohexyl]piperidine; N-(1-(2-Benzo(b)thiophenyl)cyclohexyl)piperidine; 1-(1-(2-Benzo(b)thienyl)cyclohexyl)piperidine; 1-(1-Benzo(b)thien-2-ylcyclohexyl)piperidine; BTCP HCl; 1-BTCP; GK 13; GK-13; BTCP



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Luke R Odell, Mohammed K Abdel-Hamid, Timothy A Hill, Ngoc Chau, Kelly A Young, Fiona M Deane, Jennette A Sakoff, Sofia Andersson, James A Daniel, Phillip J Robinson, Adam McCluskey. Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain. Journal of medicinal chemistry. 2017 01; 60(1):349-361. doi: 10.1021/acs.jmedchem.6b01422. [PMID: 27997171]
  • Jérôme Ruel, Jing Wang, Danielle Demêmes, Serge Gobaille, Jean-Luc Puel, Guy Rebillard. Dopamine transporter is essential for the maintenance of spontaneous activity of auditory nerve neurones and their responsiveness to sound stimulation. Journal of neurochemistry. 2006 Apr; 97(1):190-200. doi: 10.1111/j.1471-4159.2006.03722.x. [PMID: 16524378]
  • Robert N Pechnick, Catherine J Bresee, Russell E Poland. The role of antagonism of NMDA receptor-mediated neurotransmission and inhibition of the dopamine reuptake in the neuroendocrine effects of phencyclidine. Life sciences. 2006 Mar; 78(17):2006-11. doi: 10.1016/j.lfs.2005.09.018. [PMID: 16288927]
  • B T Hoffman, T Kopajtic, J L Katz, A H Newman. 2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors. Journal of medicinal chemistry. 2000 Nov; 43(22):4151-9. doi: 10.1021/jm990472s. [PMID: 11063611]
  • C Deleuze-Masquefa, M Michaud-Dutreilh, J Vignon, J M Kamenka. 1-[1-(2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP) yields two active primary metabolites in vivo. Identification and quantification of BTCP primary metabolites in mice plasma, urine, and brain and their affinity for the neuronal dopamine transporter. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2000 Feb; 9(4):345-54. doi: 10.1016/s0928-0987(99)00077-9. [PMID: 10664474]
  • C Deleuze-Masquefa, M Michaud, J Vignon, J M Kamenka. 1-[1-2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP) yields two active primary metabolites in vitro: synthesis, identification from rat liver microsome extracts, and affinity for the neuronal dopamine transporter. Journal of medicinal chemistry. 1997 Dec; 40(25):4019-25. doi: 10.1021/jm970078z. [PMID: 9406593]
  • G Attali, A Weizman, I Gil-Ad, M Rehavi. Opposite modulatory effects of ovarian hormones on rat brain dopamine and serotonin transporters. Brain research. 1997 May; 756(1-2):153-9. doi: 10.1016/s0006-8993(97)00136-4. [PMID: 9187326]
  • A P Patel, C Cerruti, R A Vaughan, M J Kuhar. Developmentally regulated glycosylation of dopamine transporter. Brain research. Developmental brain research. 1994 Nov; 83(1):53-8. doi: 10.1016/0165-3806(94)90178-3. [PMID: 7697870]
  • G Billaud, J F Menard, N Marcellin, J M Kamenka, J Costentin, J J Bonnet. Thermodynamics of the binding of BTCP (GK 13) and related derivatives on the dopamine neuronal carrier. European journal of pharmacology. 1994 Aug; 268(3):357-63. doi: 10.1016/0922-4106(94)90060-4. [PMID: 7805759]
  • X He, L P Raymon, M V Mattson, M E Eldefrawi, B R de Costa. Further studies of the structure-activity relationships of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine. Synthesis and evaluation of 1-(2-benzo[b]thienyl)-N,N-dialkylcyclohexylamines at dopamine uptake and phencyclidine binding sites. Journal of medicinal chemistry. 1993 Dec; 36(25):4075-81. doi: 10.1021/jm00077a011. [PMID: 8258830]
  • X S He, L P Raymon, M V Mattson, M E Eldefrawi, B R de Costa. Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-binding sites. Journal of medicinal chemistry. 1993 Apr; 36(9):1188-93. doi: 10.1021/jm00061a009. [PMID: 8098066]
  • T Maurice, G Barbanel, J Vignon. Endogenous dopamine differently affects N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine and cocaine binding to the dopamine uptake complex. General pharmacology. 1993 Jan; 24(1):191-4. doi: 10.1016/0306-3623(93)90033-t. [PMID: 8482495]
  • R B Rothman, N Grieg, A Kim, B R De Costa, K C Rice, F I Carroll, A Pert. Cocaine and GBR12909 produce equivalent motoric responses at different occupancy of the dopamine transporter. Pharmacology, biochemistry, and behavior. 1992 Dec; 43(4):1135-42. doi: 10.1016/0091-3057(92)90493-y. [PMID: 1475296]
  • F I Carroll, A H Lewin, J W Boja, M J Kuhar. Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter. Journal of medicinal chemistry. 1992 Mar; 35(6):969-81. doi: 10.1021/jm00084a001. [PMID: 1552510]
  • T Maurice, G Barbanel, J M Kamenka, J Vignon. Modulation by dopamine of [3H]N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine ([3H]BTCP, a phencyclidine derivative) binding to the dopamine uptake complex. Neuropharmacology. 1991 Jun; 30(6):591-8. doi: 10.1016/0028-3908(91)90078-p. [PMID: 1681444]
  • T Maurice, J Vignon, J M Kamenka, R Chicheportiche. Differential interaction of phencyclidine-like drugs with the dopamine uptake complex in vivo. Journal of neurochemistry. 1991 Feb; 56(2):553-9. doi: 10.1111/j.1471-4159.1991.tb08185.x. [PMID: 1671086]
  • T Maurice, J Vignon, J M Kamenka, R Chicheportiche. In vivo labelling of the mouse dopamine uptake complex with the phencyclidine derivative [3H]BTCP. Neuroscience letters. 1989 Jun; 101(2):234-8. doi: 10.1016/0304-3940(89)90537-5. [PMID: 2771169]
  • F Filloux, M A Hunt, J K Wamsley. Localization of the dopamine uptake complex using [3H]N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine ([3H]BTCP) in rat brain. Neuroscience letters. 1989 May; 100(1-3):105-10. doi: 10.1016/0304-3940(89)90668-x. [PMID: 2527343]