AI3-15121 (BioDeep_00000017677)

Main id: BioDeep_00000001080

 

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


InChI=1/C8H8O2/c9-6-8(10)7-4-2-1-3-5-7/h1-5,9H,6H

化学式: C8H8O2 (136.0524268)
中文名称: 2-羟基苯乙酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)C(=O)CO
InChI: InChI=1S/C8H8O2/c9-6-8(10)7-4-2-1-3-5-7/h1-5,9H,6H2

描述信息

2-hydroxyacetophenone is a monohydroxyacetophenone that is acetophenone in which one of the methyl hydrogens has been replaced by a hydroxy group. It is a primary alcohol, a primary alpha-hydroxy ketone and a monohydroxyacetophenone.
2-Hydroxyacetophenone is a natural product found in Carissa spinarum, Scutellaria baicalensis, and Carissa edulis with data available.
2-Hydroxyacetophenone is a principal root volatile of the Carissa edulis[1]. 2-Hydroxyacetophenone shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC50 of 1.8 mM[2].
2-Hydroxyacetophenone is a principal root volatile of the Carissa edulis[1]. 2-Hydroxyacetophenone shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC50 of 1.8 mM[2].

同义名列表

34 个代谢物同义名

InChI=1/C8H8O2/c9-6-8(10)7-4-2-1-3-5-7/h1-5,9H,6H; Acetophenone, .alpha.-hydroxy-; 2-Hydroxy-1-phenylethan-1-one; Ethanone, 2-hydroxy-1-phenyl-; 2-Hydroxy-1-phenylethanone #; 2-hydroxy-1-phenyl-ethanone; 2-Hydroxyacetophenone, 98\\%; .alpha.-Hydroxyacetophenone; .omega.-Hydroxyacetophenone; Hydroxymethyl phenyl ketone; 2-Hydroxy-1-phenylethanone; alpha-hydroxy acetophenone; 1-phenyl-2-hydroxyethanone; alpha-Hydroxyacetophenone; omega-hydroxyacetophenone; Acetophenone, 2-hydroxy-; 2-hydroxy acetophenone; (Hydroxyacetyl)benzene; 2-hydroxyaceto-phenone; 2-hydroxy-acetophenone; 2-Phenyl-2-oxoethanol; a-hydroxyacetophenone; 2-Hydroxyacetophenone; ?-Hydroxyacetophenone; 2-hydroxyacetophenon; hydroxy-acetophenone; Methanol, benzoyl-; Phenacyl alcohol; benzoylmethanol; Benzoylcarbinol; UNII-DQ1N9R01IA; Glycolophenone; DQ1N9R01IA; AI3-15121



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Guillermo Rodríguez-Gutiérrez, Garry G Duthie, Sharon Wood, Phil Morrice, Fergus Nicol, Martin Reid, Louise L Cantlay, Thomas Kelder, Graham W Horgan, Juan Fernández-Bolaños Guzmán, Baukje de Roos. Alperujo extract, hydroxytyrosol, and 3,4-dihydroxyphenylglycol are bioavailable and have antioxidant properties in vitamin E-deficient rats--a proteomics and network analysis approach. Molecular nutrition & food research. 2012 Jul; 56(7):1137-47. doi: 10.1002/mnfr.201100808. [PMID: 22648667]
  • Maiko Machida, Shigeru Takechi, Tetsuya Fujimoto, Shigeo Kakinoki, Akikazu Nomura. Carvedilol improves uptake-1 in patients with systolic congestive heart failure. Journal of cardiovascular pharmacology. 2012 Feb; 59(2):175-81. doi: 10.1097/fjc.0b013e31823a94a2. [PMID: 21997260]
  • Maura Castelli, Mauro Federici, Silvia Rossi, Valentina De Chiara, Francesco Napolitano, Valeria Studer, Caterina Motta, Lucia Sacchetti, Rosaria Romano, Alessandra Musella, Giorgio Bernardi, Alberto Siracusano, Howard H Gu, Nicola B Mercuri, Alessandro Usiello, Diego Centonze. Loss of striatal cannabinoid CB1 receptor function in attention-deficit / hyperactivity disorder mice with point-mutation of the dopamine transporter. The European journal of neuroscience. 2011 Nov; 34(9):1369-77. doi: 10.1111/j.1460-9568.2011.07876.x. [PMID: 22034972]
  • Palanisamy Sathyadevi, Paramasivam Krishnamoorthy, Rachel R Butorac, Alan H Cowley, Nattamai S P Bhuvanesh, Nallasamy Dharmaraj. Effect of substitution and planarity of the ligand on DNA/BSA interaction, free radical scavenging and cytotoxicity of diamagnetic Ni(II) complexes: a systematic investigation. Dalton transactions (Cambridge, England : 2003). 2011 Oct; 40(38):9690-702. doi: 10.1039/c1dt10767d. [PMID: 21858314]
  • Baukje de Roos, Xuguang Zhang, Guillermo Rodriguez Gutierrez, Sharon Wood, Garry J Rucklidge, Martin D Reid, Gary J Duncan, Louise L Cantlay, Garry G Duthie, Niamh O'Kennedy. Anti-platelet effects of olive oil extract: in vitro functional and proteomic studies. European journal of nutrition. 2011 Oct; 50(7):553-62. doi: 10.1007/s00394-010-0162-3. [PMID: 21197537]
  • Yamin Bibi, Sobia Nisa, Fayyaz M Chaudhary, Muhammad Zia. Antibacterial activity of some selected medicinal plants of Pakistan. BMC complementary and alternative medicine. 2011 Jun; 11(?):52. doi: 10.1186/1472-6882-11-52. [PMID: 21718504]
  • Alexander A Zoerner, Karsten Heusser, Frank M Gutzki, Anja Mitschke, Jens Tank, Dirk O Stichtenoth, Jens Jordan, Dimitrios Tsikas. Unique pentafluorobenzylation and collision-induced dissociation for specific and accurate GC-MS/MS quantification of the catecholamine metabolite 3,4-dihydroxyphenylglycol (DHPG) in human urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 May; 879(17-18):1444-56. doi: 10.1016/j.jchromb.2010.06.022. [PMID: 20638915]
  • Alonso Montoya, Rodrigo Escobar, María J García-Polavieja, D Richard Lachno, José Ángel Alda, Josep Artigas, Esther Cardo, Marta García, Xavier Gastaminza, Inmaculada Gilaberte. Changes of urine dihydroxyphenylglycol to norepinephrine ratio in children with attention-deficit hyperactivity disorder (ADHD) treated with atomoxetine. Journal of child neurology. 2011 Jan; 26(1):31-6. doi: 10.1177/0883073810371981. [PMID: 20525942]
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  • Leonardo Crema, Michele Schlabitz, Bárbara Tagliari, Aline Cunha, Fabrício Simão, Rachel Krolow, Letícia Pettenuzzo, Christianne Salbego, Deusa Vendite, Angela T S Wyse, Carla Dalmaz. Na+, K+ ATPase activity is reduced in amygdala of rats with chronic stress-induced anxiety-like behavior. Neurochemical research. 2010 Nov; 35(11):1787-95. doi: 10.1007/s11064-010-0245-9. [PMID: 20717721]
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  • Julie Marchaland, Corrado Calì, Susan M Voglmaier, Haiyan Li, Romano Regazzi, Robert H Edwards, Paola Bezzi. Fast subplasma membrane Ca2+ transients control exo-endocytosis of synaptic-like microvesicles in astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Sep; 28(37):9122-32. doi: 10.1523/jneurosci.0040-08.2008. [PMID: 18784293]
  • David S Goldstein, Courtney Holmes, Felicia B Axelrod. Plasma catechols in familial dysautonomia: a long-term follow-up study. Neurochemical research. 2008 Sep; 33(9):1889-93. doi: 10.1007/s11064-008-9662-4. [PMID: 18357519]
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  • Erik B Malarkey, Yingchun Ni, Vladimir Parpura. Ca2+ entry through TRPC1 channels contributes to intracellular Ca2+ dynamics and consequent glutamate release from rat astrocytes. Glia. 2008 Jun; 56(8):821-35. doi: 10.1002/glia.20656. [PMID: 18338793]
  • Tsung-Ming Lee, Chien-Chang Chen, Mei-Shu Lin, Nen-Chung Chang. Effect of endothelin receptor antagonists on ventricular susceptibility in postinfarcted rats. American journal of physiology. Heart and circulatory physiology. 2008 Apr; 294(4):H1871-9. doi: 10.1152/ajpheart.01129.2007. [PMID: 18281380]
  • Stephen G Kaler, Courtney S Holmes, David S Goldstein, Jingrong Tang, Sarah C Godwin, Anthony Donsante, Clarissa J Liew, Susumu Sato, Nicholas Patronas. Neonatal diagnosis and treatment of Menkes disease. The New England journal of medicine. 2008 Feb; 358(6):605-14. doi: 10.1056/nejmoa070613. [PMID: 18256395]
  • Murray Esler, Elisabeth Lambert, Marlies Alvarenga, Florentia Socratous, Jeff Richards, David Barton, Ciaran Pier, Celia Brenchley, Tye Dawood, Jacqueline Hastings, Ling Guo, Deepak Haikerwal, David Kaye, Garry Jennings, Victor Kalff, Michael Kelly, Glen Wiesner, Gavin Lambert. Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor. Stress (Amsterdam, Netherlands). 2007 Aug; 10(3):295-304. doi: 10.1080/10253890701300904. [PMID: 17613943]
  • David S Goldstein, Graeme Eisenhofer, Irwin J Kopin. Clinical catecholamine neurochemistry: a legacy of Julius Axelrod. Cellular and molecular neurobiology. 2006 Jul; 26(4-6):695-702. doi: 10.1007/s10571-006-9041-0. [PMID: 16871444]
  • Mikko J Järvisalo, Laura Jartti, Jukka Marniemi, Tapani Rönnemaa, Jorma S A Viikari, Terho Lehtimäki, Olli T Raitakari. Determinants of short-term variation in arterial flow-mediated dilatation in healthy young men. Clinical science (London, England : 1979). 2006 Apr; 110(4):475-82. doi: 10.1042/cs20050333. [PMID: 16396629]
  • Jainuch Kanchanapoo, Mrinalini C Rao, Samaisukh Sophasan, Apichart Suksamrarn, Pawinee Piyachaturawat. Inhibitory effects of choleretic hydroxyacetophenones on ileal bile acid transport in rats. Life sciences. 2006 Feb; 78(14):1630-6. doi: 10.1016/j.lfs.2005.07.032. [PMID: 16253286]
  • Alfredo Gamboa, Jorge L Gamboa, Courtney Holmes, Yehonatan Sharabi, Fabiola Leon-Velarde, Gary J Fischman, Otto Appenzeller, David S Goldstein. Plasma catecholamines and blood volume in native Andeans during hypoxia and normoxia. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2006 Feb; 16(1):40-5. doi: 10.1007/s10286-006-0305-z. [PMID: 16477494]
  • Maiko Machida, Ayumi Sakaguchi, Satoshi Kamada, Tetsuya Fujimoto, Shigeru Takechi, Shigeo Kakinoki, Akikazu Nomura. Simultaneous analysis of human plasma catecholamines by high-performance liquid chromatography with a reversed-phase triacontylsilyl silica column. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Jan; 830(2):249-54. doi: 10.1016/j.jchromb.2005.10.047. [PMID: 16301006]
  • M Krsek, M Rosická, J Nedvídková, H Kvasnicková, V Hána, J Marek, M Haluzík, E W Lai, K Pacák. Increased lipolysis of subcutaneous abdominal adipose tissue and altered noradrenergic activity in patients with Cushing's syndrome: an in-vivo microdialysis study. Physiological research. 2006; 55(4):421-428. doi: 10.33549/physiolres.930832. [PMID: 16238457]
  • Nicola Berretta, Peter S Freestone, Ezia Guatteo, Denis de Castro, Raffaella Geracitano, Giorgio Bernardi, Nicola B Mercuri, Janusz Lipski. Acute effects of 6-hydroxydopamine on dopaminergic neurons of the rat substantia nigra pars compacta in vitro. Neurotoxicology. 2005 Oct; 26(5):869-81. doi: 10.1016/j.neuro.2005.01.014. [PMID: 15890406]
  • E Sastre, A Nicolay, B Bruguerolle, H Portugal. Effect of lithium on norepinephrine metabolic pathways. Life sciences. 2005 Jul; 77(7):758-67. doi: 10.1016/j.lfs.2004.12.033. [PMID: 15936350]
  • Chantal Csajka, Bruno P Imbimbo, Annalisa Piccinno, Philippe Dostert, Davide Verotta. Mechanistic pharmacokinetic and pharmacodynamic modeling of CHF3381 (2-[(2,3-dihydro-1H-inden-2-yl)amino]acetamide monohydrochloride), a novel N-methyl-D-aspartate antagonist and monoamine oxidase-A inhibitor in healthy subjects. The Journal of pharmacology and experimental therapeutics. 2005 May; 313(2):647-57. doi: 10.1124/jpet.104.080457. [PMID: 15671203]
  • Simon N Jacob, Chi-Un Choe, Per Uhlen, Brenda DeGray, Mark F Yeckel, Barbara E Ehrlich. Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Mar; 25(11):2853-64. doi: 10.1523/jneurosci.4313-04.2005. [PMID: 15772345]
  • Elena Meli, Roberto Baronti, Marilena Pangallo, Roberta Picca, Flavio Moroni, Domenico E Pellegrini-Giampietro. Group I metabotropic glutamate receptors stimulate the activity of poly(ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures. Neuropharmacology. 2005; 49 Suppl 1(?):80-8. doi: 10.1016/j.neuropharm.2005.05.017. [PMID: 16023154]
  • David S Goldstein, Courtney Holmes, Horacio Kaufmann, Roy Freeman. Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2004 Dec; 14(6):363-8. doi: 10.1007/s10286-004-0221-z. [PMID: 15666063]
  • Christoph Schroeder, Jens Tank, David S Goldstein, Michael Stoeter, Sebastian Haertter, Friedrich C Luft, Jens Jordan. Influence of St John's wort on catecholamine turnover and cardiovascular regulation in humans. Clinical pharmacology and therapeutics. 2004 Nov; 76(5):480-9. doi: 10.1016/j.clpt.2004.08.005. [PMID: 15536462]
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  • Nancy R Keller, André Diedrich, Martin Appalsamy, Sunti Tuntrakool, Suzanna Lonce, Charlene Finney, Marc G Caron, David Robertson. Norepinephrine transporter-deficient mice exhibit excessive tachycardia and elevated blood pressure with wakefulness and activity. Circulation. 2004 Sep; 110(10):1191-6. doi: 10.1161/01.cir.0000141804.90845.e6. [PMID: 15337696]
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  • Elisabeth Sastre, Alain Nicolay, Bernard Bruguerolle, Henri Portugal. Method for simultaneous measurement of norepinephrine, 3-methoxy-4-hydroxyphenylglycol and 3,4-dihydroxyphenylglycol by liquid chromatography with electrochemical detection: application in rat cerebral cortex and plasma after lithium chloride treatment. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Mar; 801(2):205-11. doi: 10.1016/j.jchromb.2003.11.012. [PMID: 14751788]
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