Bis(2-propylheptyl) phthalate (BioDeep_00000176722)
human metabolite blood metabolite
代谢物信息卡片
化学式: C28H46O4 (446.3395916)
中文名称: 邻苯二甲酸二(2-丙基庚基)酯
谱图信息:
最多检出来源 Homo sapiens(blood) 93.75%
分子结构信息
SMILES: CCCCCC(CCC)COC(=O)C1=CC=CC=C1C(=O)OCC(CCC)CCCCC
InChI: InChI=1S/C28H46O4/c1-5-9-11-17-23(15-7-3)21-31-27(29)25-19-13-14-20-26(25)28(30)32-22-24(16-8-4)18-12-10-6-2/h13-14,19-20,23-24H,5-12,15-18,21-22H2,1-4H3
描述信息
同义名列表
8 个代谢物同义名
1,2-Bis(2-propylheptyl) benzene-1,2-dicarboxylic acid; 1,2-bis(2-propylheptyl) benzene-1,2-dicarboxylate; 1,2-bis(2-propylheptyl) phthalate; Bis(2-propylheptyl) phthalic acid; Bis(2-propylheptyl) phthalate; Di-(2-propylheptyl)phthalate; Bis(2-propylheptyl)phthalate; Di(2-propylheptyl)phthalate
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gerda Schwedler, André Conrad, Enrico Rucic, Holger M Koch, Gabriele Leng, Christine Schulz, Maria I H Schmied-Tobies, Marike Kolossa-Gehring. Hexamoll® DINCH and DPHP metabolites in urine of children and adolescents in Germany. Human biomonitoring results of the German Environmental Survey GerES V, 2014-2017.
International journal of hygiene and environmental health.
2020 08; 229(?):113397. doi:
10.1016/j.ijheh.2019.09.004. [PMID: 31585790] - Frederic Been, Govindan Malarvannan, Michiel Bastiaensen, Shanshan Yin, Alexander L N van Nuijs, Adrian Covaci. Development and validation of a bioanalytical assay based on liquid chromatography-tandem mass spectrometry for measuring biomarkers of exposure of alternative plasticizers in human urine and serum.
Talanta.
2019 Jun; 198(?):230-236. doi:
10.1016/j.talanta.2019.02.024. [PMID: 30876555] - Chia-Lung Shih, Hsin-Yi Wu, Pao-Mei Liao, Jen-Yi Hsu, Chia-Yun Tsao, Victor G Zgoda, Pao-Chi Liao. Profiling and comparison of toxicant metabolites in hair and urine using a mass spectrometry-based metabolomic data processing method.
Analytica chimica acta.
2019 Apr; 1052(?):84-95. doi:
10.1016/j.aca.2018.11.009. [PMID: 30685045] - Christoph Schmidtkunz, Wolfgang Gries, Till Weber, Gabriele Leng, Marike Kolossa-Gehring. Internal exposure of young German adults to di(2-propylheptyl) phthalate (DPHP): Trends in 24-h urine samples from the German Environmental Specimen Bank 1999-2017.
International journal of hygiene and environmental health.
2019 04; 222(3):419-424. doi:
10.1016/j.ijheh.2018.12.008. [PMID: 30772154] - Chia-Lung Shih, Jen-Yi Hsu, Chien-Ping Tien, Yi-Ning Chung, Victor G Zgoda, Pao-Chi Liao. Exposure marker discovery of di-2(propylheptyl) phthalate using ultra-performance liquid chromatography-mass spectrometry and a rat model.
Journal of food and drug analysis.
2019 04; 27(2):585-594. doi:
10.1016/j.jfda.2018.11.002. [PMID: 30987730] - D Klein, W Kessler, C Pütz, B Semder, W Kirchinger, A Langsch, W Gries, R Otter, A K E Gallien, X Wurzenberger, J G Filser. Single ingestion of di-(2-propylheptyl) phthalate (DPHP) by male volunteers: DPHP in blood and its metabolites in blood and urine.
Toxicology letters.
2018 Sep; 294(?):105-115. doi:
10.1016/j.toxlet.2018.05.010. [PMID: 29758360] - Chia-Lung Shih, Pao-Mei Liao, Jen-Yi Hsu, Yi-Ning Chung, Victor G Zgoda, Pao-Chi Liao. Identification of urinary biomarkers of exposure to di-(2-propylheptyl) phthalate using high-resolution mass spectrometry and two data-screening approaches.
Chemosphere.
2018 Feb; 193(?):170-177. doi:
10.1016/j.chemosphere.2017.10.162. [PMID: 29131975] - Gabriele Leng, Wolfgang Gries. New specific and sensitive biomonitoring methods for chemicals of emerging health relevance.
International journal of hygiene and environmental health.
2017 03; 220(2 Pt A):113-122. doi:
10.1016/j.ijheh.2016.09.014. [PMID: 27692573] - A Schütze, W Gries, M Kolossa-Gehring, P Apel, C Schröter-Kermani, U Fiddicke, G Leng, T Brüning, H M Koch. Bis-(2-propylheptyl)phthalate (DPHP) metabolites emerging in 24h urine samples from the German Environmental Specimen Bank (1999-2012).
International journal of hygiene and environmental health.
2015 Aug; 218(6):559-63. doi:
10.1016/j.ijheh.2015.05.007. [PMID: 26077891] - NULL. [Monograph on di-2-propylheptyl phthalate (DPHP) - human biomonitoring (HBM) values for the sum of metabolites oxo-mono-propylheptyl phthalate (oxo-MPHP) and hydroxy-mono-propylheptyl phthalate (OH MPHP) in adult and child urine. Opinion of the Commission 'Human Biomonitoring' of the Federal Environment Agency, Germany].
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz.
2015 Jul; 58(7):774-84. doi:
10.1007/s00103-015-2172-z. [PMID: 26092161] - Gabriele Leng, Holger M Koch, Wolfgang Gries, Andre Schütze, Angelika Langsch, Thomas Brüning, Rainer Otter. Urinary metabolite excretion after oral dosage of bis(2-propylheptyl) phthalate (DPHP) to five male volunteers--characterization of suitable biomarkers for human biomonitoring.
Toxicology letters.
2014 Dec; 231(2):282-8. doi:
10.1016/j.toxlet.2014.06.035. [PMID: 24973492] - Virunya S Bhat, Jennifer L Durham, J Caroline English. Derivation of an oral reference dose (RfD) for the plasticizer, di-(2-propylheptyl)phthalate (Palatinol® 10-P).
Regulatory toxicology and pharmacology : RTP.
2014 Oct; 70(1):65-74. doi:
10.1016/j.yrtph.2014.06.002. [PMID: 24925829] - Matthias Wittassek, Jürgen Angerer. Phthalates: metabolism and exposure.
International journal of andrology.
2008 Apr; 31(2):131-8. doi:
10.1111/j.1365-2605.2007.00837.x. [PMID: 18070048]