Bis(2-ethylhexyl) terephthalate (BioDeep_00000176718)

   

human metabolite blood metabolite Industrial Pollutants


代谢物信息卡片


1,4-Bis(2-ethylhexyl) benzene-1,4-dicarboxylic acid

化学式: C24H38O4 (390.277)
中文名称: 对苯二甲酸二辛酯 (DOTP), 对苯二甲酸二(2-乙基己基)酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCC(CC)COC(=O)C1=CC=C(C=C1)C(=O)OCC(CC)CCCC
InChI: InChI=1S/C24H38O4/c1-5-9-11-19(7-3)17-27-23(25)21-13-15-22(16-14-21)24(26)28-18-20(8-4)12-10-6-2/h13-16,19-20H,5-12,17-18H2,1-4H3

描述信息

同义名列表

8 个代谢物同义名

1,4-Bis(2-ethylhexyl) benzene-1,4-dicarboxylic acid; 1,4-bis(2-ethylhexyl) benzene-1,4-dicarboxylate; Bis(2-ethylhexyl) terephthalate; Di-(2-ethylhexyl) terephthalate; dioctyl terephthalate; UNII:4VS908W98L; 1,4-DEHT; DEHT



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Linda Larsson, Per Sandgren, Sara Ohlsson, Julia Derving, Tove Friis-Christensen, Felicia Daggert, Naïma Frizi, Stefan Reichenberg, Sonia Chatellier, Beatrice Diedrich, Jovan Antovic, Stella Larsson, Michael Uhlin. Non-phthalate plasticizer DEHT preserves adequate blood component quality during storage in PVC blood bags. Vox sanguinis. 2021 Jan; 116(1):60-70. doi: 10.1111/vox.12982. [PMID: 32918773]
  • Gerda Schwedler, Enrico Rucic, Holger M Koch, Frederik Lessmann, Thomas Brüning, André Conrad, Maria I H Schmied-Tobies, Marike Kolossa-Gehring. Metabolites of the substitute plasticiser Di-(2-ethylhexyl) terephthalate (DEHTP) in urine of children and adolescents investigated in the German Environmental Survey GerES V, 2014-2017. International journal of hygiene and environmental health. 2020 09; 230(?):113589. doi: 10.1016/j.ijheh.2020.113589. [PMID: 32836070]
  • Manori J Silva, Lee-Yang Wong, Ella Samandar, James L Preau, Lily T Jia, Antonia M Calafat. Exposure to di-2-ethylhexyl terephthalate in the U.S. general population from the 2015-2016 National Health and Nutrition Examination Survey. Environment international. 2019 02; 123(?):141-147. doi: 10.1016/j.envint.2018.11.041. [PMID: 30529838]
  • Stefanie Baldofski, Carsten Jörg Canitz, Leif-Alexander Garbe, Rudolf J Schneider. Studies on the development of antibodies for the highly hydrophobic plasticizers DINCH and DEHT. Analytical biochemistry. 2018 02; 543(?):90-96. doi: 10.1016/j.ab.2017.12.006. [PMID: 29233681]
  • Manori J Silva, Lee-Yang Wong, Ella Samandar, James L Preau, Antonia M Calafat, Xiaoyun Ye. Exposure to di-2-ethylhexyl terephthalate in a convenience sample of U.S. adults from 2000 to 2016. Archives of toxicology. 2017 Oct; 91(10):3287-3291. doi: 10.1007/s00204-017-1956-3. [PMID: 28314884]
  • Frederik Lessmann, André Schütze, Tobias Weiss, Thomas Brüning, Holger M Koch. Determination of metabolites of di(2-ethylhexyl) terephthalate (DEHTP) in human urine by HPLC-MS/MS with on-line clean-up. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Feb; 1011(?):196-203. doi: 10.1016/j.jchromb.2015.12.042. [PMID: 26773884]
  • Gwendolyn L Ball, Clifton J McLellan, Virunya S Bhat. Toxicological review and oral risk assessment of terephthalic acid (TPA) and its esters: A category approach. Critical reviews in toxicology. 2012 Jan; 42(1):28-67. doi: 10.3109/10408444.2011.623149. [PMID: 22050403]
  • U Wirnitzer, U Rickenbacher, A Katerkamp, A Schachtrupp. Systemic toxicity of di-2-ethylhexyl terephthalate (DEHT) in rodents following four weeks of intravenous exposure. Toxicology letters. 2011 Aug; 205(1):8-14. doi: 10.1016/j.toxlet.2011.04.020. [PMID: 21616130]
  • James A Deyo. Carcinogenicity and chronic toxicity of di-2-ethylhexyl terephthalate (DEHT) following a 2-year dietary exposure in Fischer 344 rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2008 Mar; 46(3):990-1005. doi: 10.1016/j.fct.2007.10.037. [PMID: 18077073]
  • S Barnabé, I Beauchesne, D G Cooper, J A Nicell. Plasticizers and their degradation products in the process streams of a large urban physicochemical sewage treatment plant. Water research. 2008 Jan; 42(1-2):153-62. doi: 10.1016/j.watres.2007.07.043. [PMID: 17706266]
  • E D Barber, D C Topping. Subchronic 90-day oral toxicology of di(2-ethylhexyl) terephthalate in the rat. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1995 Nov; 33(11):971-8. doi: 10.1016/0278-6915(95)00060-f. [PMID: 7590545]
  • E D Barber, J A Fox, C J Giordano. Hydrolysis, absorption and metabolism of di(2-ethylhexyl) terephthalate in the rat. Xenobiotica; the fate of foreign compounds in biological systems. 1994 May; 24(5):441-50. doi: 10.3109/00498259409043247. [PMID: 8079503]
  • E D Barber. Genetic toxicology testing of di(2-ethylhexyl) terephthalate. Environmental and molecular mutagenesis. 1994; 23(3):228-33. doi: 10.1002/em.2850230311. [PMID: 8162897]
  • D C Topping, G P Ford, J G Evans, B G Lake, J L O'Donoghue, H B Lockhart. Peroxisome induction studies on di(2-ethylhexyl)terephthalate. Toxicology and industrial health. 1987 Jun; 3(2):63-78. doi: 10.1177/074823378700300206. [PMID: 3617070]