Physalin D (BioDeep_00000017671)

 

Secondary id: BioDeep_00000618993, BioDeep_00001031775

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(1R,2S,8S,9R,14R,15R,17R,18S,21S,24R,26S,27S)-5,14,15-Trihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone

化学式: C28H32O11 (544.1944522)
中文名称:
谱图信息: 最多检出来源 Astragalus membranaceus(otcml) 24%

分子结构信息

SMILES: CC12CC3C4(C56C1C(=O)C(O5)(C7CC(C8(CC=CC(=O)C8(C7CCC6(C(=O)O4)O)C)O)O)OCC2C(=O)O3)C
InChI: InChI=1S/C28H32O11/c1-22-10-17-24(3)28-18(22)19(31)27(39-28,36-11-14(22)20(32)37-17)13-9-16(30)25(34)7-4-5-15(29)23(25,2)12(13)6-8-26(28,35)21(33)38-24/h4-5,12-14,16-18,30,34-35H,6-11H2,1-3H3

描述信息

Constituent of the famine food Physalis angulata (cutleaf ground cherry). Physalin D is found in herbs and spices and fruits.
Physalin D is a natural product found in Physalis angulata, Physalis peruviana, and other organisms with data available.
Physalin D is found in fruits. Physalin D is a constituent of the famine food Physalis angulata (cutleaf ground cherry)

同义名列表

7 个代谢物同义名

(1R,2S,8S,9R,14R,15R,17R,18S,21S,24R,26S,27S)-5,14,15-Trihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone; 16,14-secoergost-2-ene-18,26-dioic acid, 14,17:14,27-diepoxy-5,6,13,20,22-pentahydroxy-1,15-dioxo-, .gamma.-lactone .delta.-lactone, (5.alpha.,6.beta.,14.alpha.,16.beta.,22.alpha.,25S)-; (2S,5S,8S,9R,14R,15R,17R,21S,24R,27S)-5,14,15-Trihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone; 5,14,15-trihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.1¹⁸,²⁷.0¹,⁵.0²,²⁴.0⁸,¹⁷.0⁹,¹⁴.0²¹,²⁶]nonacos-11-ene-4,10,22,29-tetrone; 5,14,15-trihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone; 16,14-secoergost-2-ene-18,26-dioic acid, 14,17:14,27-diepoxy-5,6,13,20,22-pentahydroxy-1,15-dioxo-, .gamma.-lactone, .delta.-lactone; Physalin D



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • J C C Arruda, N C Rocha, E G Santos, L G B Ferreira, M L Bello, C Penido, T E M M Costa, J A A Santos, I M Ribeiro, T C B Tomassini, R X Faria. Physalin pool from Physalis angulata L. leaves and physalin D inhibit P2X7 receptor function in vitro and acute lung injury in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):112006. doi: 10.1016/j.biopha.2021.112006. [PMID: 34392085]
  • Yunliang Zheng, Meihua Lin, Xingjiang Hu, You Zhai, Qiao Zhang, Yan Lou, Jianzhong ShenTu, Lihua Wu. Simultaneous pharmacokinetics and stability studies of physalins in rat plasma and intestinal bacteria culture media using liquid chromatography with mass spectrometry. Journal of separation science. 2018 Apr; 41(8):1781-1790. doi: 10.1002/jssc.201701089. [PMID: 29331063]
  • Eszter Laczkó-Zöld, Péter Forgó, István Zupkó, Eşianu Sigrid, Judit Hohmann. Isolation and quantitative analysis of physalin D in the fruit and calyx of Physalis alkekengi L. Acta biologica Hungarica. 2017 Sep; 68(3):300-309. doi: 10.1556/018.68.2017.3.7. [PMID: 28901802]
  • Yunliang Zheng, Cong Cao, Meihua Lin, You Zhai, Zhiwei Ge, Jianzhong ShenTu, Lihua Wu, Xingjiang Hu. Identification and quantitative analysis of physalin D and its metabolites in rat urine and feces by liquid chromatography with triple quadrupole time-of-flight mass spectrometry. Journal of separation science. 2017 Jun; 40(11):2355-2365. doi: 10.1002/jssc.201700038. [PMID: 28388002]
  • Xinli Li, Cuili Zhang, Weiling Li, Dachang Wu, Jianjun Liu, Li Tang, Yi Xin. In vivo effects on the intestinal microflora of Physalis alkekengi var. francheti extracts. Fitoterapia. 2013 Jun; 87(?):43-8. doi: 10.1016/j.fitote.2013.03.018. [PMID: 23562629]
  • Yunliang Zheng, Yong Chen, Yiping Ren, Lianjun Luan, Yongjiang Wu. Quantitative and transformation product analysis of major active physalins from Physalis alkekengi var. franchetii (Chinese lantern) using ultraperformance liquid chromatography with electrospray ionisation tandem mass spectrometry and time-of-flight mass spectrometry. Phytochemical analysis : PCA. 2012 Jul; 23(4):337-44. doi: 10.1002/pca.1363. [PMID: 21997776]
  • Yunliang Zheng, Yong Chen, Yiping Ren, Lianjun Luan, Yongjiang Wu. An ultra-pressure liquid chromatography-tandem mass spectrometry method for the simultaneous determination of three physalins in rat plasma and its application to pharmacokinetic study of Physalis alkekengi var. franchetii (Chinese lantern) in rats. Journal of pharmaceutical and biomedical analysis. 2012 Jan; 58(?):94-101. doi: 10.1016/j.jpba.2011.09.012. [PMID: 21996065]
  • Yongjiang Wu, Yunliang Zheng, Na Chen, Lianjun Luan, Xuesong Liu. Plasma pharmacokinetics and tissue distribution study of physalin D in rats by ultra-pressure liquid chromatography with tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Feb; 879(5-6):443-8. doi: 10.1016/j.jchromb.2010.12.032. [PMID: 21269892]
  • S Helvaci, G Kökdil, M Kawai, N Duran, G Duran, A Güvenç. Antimicrobial activity of the extracts and physalin D from Physalis alkekengi and evaluation of antioxidant potential of physalin D. Pharmaceutical biology. 2010 Feb; 48(2):142-50. doi: 10.3109/13880200903062606. [PMID: 20645830]
  • Nadia J Jacobo-Herrera, Paul Bremner, Nieves Marquez, Mahabir P Gupta, Simon Gibbons, Eduardo Muñoz, Michael Heinrich. Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade. Journal of natural products. 2006 Mar; 69(3):328-31. doi: 10.1021/np050225t. [PMID: 16562828]
  • Hemerson Iury Ferreira Magalhães, Maria Leopoldina Veras, Márcia Rocha Torres, Ana Paula Negreiros Nunes Alves, Otília Deusdênia Loiola Pessoa, Edilberto Rocha Silveira, Letícia Veras Costa-Lotufo, Manoel Odorico de Moraes, Cláudia Pessoa. In-vitro and in-vivo antitumour activity of physalins B and D from Physalis angulata. The Journal of pharmacy and pharmacology. 2006 Feb; 58(2):235-41. doi: 10.1211/jpp.58.2.0011. [PMID: 16451752]
  • Milena B P Soares, Moema C Bellintani, Ivone M Ribeiro, Therezinha C B Tomassini, Ricardo Ribeiro dos Santos. Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids purified from Physalis angulata L. European journal of pharmacology. 2003 Jan; 459(1):107-12. doi: 10.1016/s0014-2999(02)02829-7. [PMID: 12505539]
  • A H Januário, E Rodrigues Filho, R C L R Pietro, S Kashima, D N Sato, S C França. Antimycobacterial physalins from Physalis angulata L. (Solanaceae). Phytotherapy research : PTR. 2002 Aug; 16(5):445-8. doi: 10.1002/ptr.939. [PMID: 12203265]
  • M Kawai, T Yamamoto, B Makino, H Yamamura, S Araki, Y Butsugan, K Saito. The structure of physalin T from Physalis alkekengi var. franchetti. Journal of Asian natural products research. 2001; 3(3):199-205. doi: 10.1080/10286020108041391. [PMID: 11491395]