Betamethasone phosphate (BioDeep_00000176650)
human metabolite blood metabolite
代谢物信息卡片
(2-{1-fluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl}-2-oxoethoxy)phosphonic acid
化学式: C22H30FO8P (472.1662242)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)COP(O)(O)=O
InChI: InChI=1S/C22H30FO8P/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30)
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
同义名列表
14 个代谢物同义名
(2-{1-fluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl}-2-oxoethoxy)phosphonic acid; 2-{1-fluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl}-2-oxoethoxyphosphonic acid; (2-{1-fluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0,.0,]heptadeca-3,6-dien-14-yl}-2-oxoethoxy)phosphonate; Betamethasone sodium phosphate, (11beta,16beta)-isomer; Betamethasone disodium phosphate, (11beta)-isomer; Betamethasone disodium phosphate; Betamethasone sodium phosphate; Betamethason sodium phosphate; Betamethasone phosphoric acid; Betamethasone 21-phosphate; Betamethasone phosphate; Celestone phosphate; Rinderone; Bentelan
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tsukasa Takahashi, Erin L Fee, Yuki Takahashi, Masatoshi Saito, Nobuo Yaegashi, Haruo Usuda, Lucy Furfaro, Sean Carter, Augusto F Schmidt, John P Newnham, Alan H Jobe, Matthew W Kemp. Betamethasone phosphate reduces the efficacy of antenatal steroid therapy and is associated with lower birthweights when administered to pregnant sheep in combination with betamethasone acetate.
American journal of obstetrics and gynecology.
2022 04; 226(4):564.e1-564.e14. doi:
10.1016/j.ajog.2021.10.001. [PMID: 34626553] - Tsukasa Takahashi, Masatoshi Saito, Augusto F Schmidt, Haruo Usuda, Yuki Takahashi, Shimpei Watanabe, Takushi Hanita, Shinichi Sato, Yusaku Kumagai, Shota Koshinami, Hideyuki Ikeda, Sean Carter, Michael Clarke, Erin L Fee, Nobuo Yaegashi, John P Newnham, Alan H Jobe, Matthew W Kemp. Variability in the efficacy of a standardized antenatal steroid treatment was independent of maternal or fetal plasma drug levels: evidence from a sheep model of pregnancy.
American journal of obstetrics and gynecology.
2020 12; 223(6):921.e1-921.e10. doi:
10.1016/j.ajog.2020.05.032. [PMID: 32445634] - Alan H Jobe, Mark A Milad, Thomas Peppard, William J Jusko. Pharmacokinetics and Pharmacodynamics of Intramuscular and Oral Betamethasone and Dexamethasone in Reproductive Age Women in India.
Clinical and translational science.
2020 03; 13(2):391-399. doi:
10.1111/cts.12724. [PMID: 31808984] - Matthew W Kemp, Masatoshi Saito, Augusto F Schmidt, Haruo Usuda, Shimpei Watanabe, Shinichi Sato, Takushi Hanita, Yusaku Kumagai, Tsukasa Takahashi, Gabrielle C Musk, Lucy Furfaro, Lisa Stinson, Erin L Fee, Peter J Eddershaw, Matthew S Payne, Kiara Smallwood, James Bridges, John P Newnham, Alan H Jobe. The duration of fetal antenatal steroid exposure determines the durability of preterm ovine lung maturation.
American journal of obstetrics and gynecology.
2020 02; 222(2):183.e1-183.e9. doi:
10.1016/j.ajog.2019.08.046. [PMID: 31494126] - Augusto F Schmidt, Matthew W Kemp, Mark Milad, Lisa A Miller, James P Bridges, Michael W Clarke, Paranthaman S Kannan, Alan H Jobe. Oral dosing for antenatal corticosteroids in the Rhesus macaque.
PloS one.
2019; 14(9):e0222817. doi:
10.1371/journal.pone.0222817. [PMID: 31536601] - Matthew W Kemp, Masatoshi Saito, Haruo Usuda, Shimpei Watanabe, Shinichi Sato, Takushi Hanita, Yusaku Kumagai, Timothy J Molloy, Michael Clarke, Peter J Eddershaw, Gabrielle C Musk, Augusto Schmidt, Demelza Ireland, Lucy Furfaro, Matthew S Payne, John P Newnham, Alan H Jobe. The efficacy of antenatal steroid therapy is dependent on the duration of low-concentration fetal exposure: evidence from a sheep model of pregnancy.
American journal of obstetrics and gynecology.
2018 09; 219(3):301.e1-301.e16. doi:
10.1016/j.ajog.2018.05.007. [PMID: 29758177] - Augusto F Schmidt, Matthew W Kemp, Judith Rittenschober-Böhm, Paranthaman S Kannan, Haruo Usuda, Masatoshi Saito, Lucy Furfaro, Shimpei Watanabe, Sarah Stock, Boris W Kramer, John P Newnham, Suhas G Kallapur, Alan H Jobe. Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep.
American journal of obstetrics and gynecology.
2018 01; 218(1):132.e1-132.e9. doi:
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2011 Feb; 27(1):29-34. doi:
10.1089/jop.2010.0106. [PMID: 21182429] - Chunhui He, Hongwei Fan, Jie Tan, Jianjun Zou, Yubing Zhu, Kun Yang, Qin Hu. Pharmacokinetics of betamethasone and betamethasone 17-monopropionate in Chinese healthy volunteers after intramuscular injection of betamethasone phosphate/betamethasone dipropionate.
Arzneimittel-Forschung.
2011; 61(7):417-20. doi:
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International journal of pharmaceutics.
2009 Jun; 375(1-2):148-54. doi:
10.1016/j.ijpharm.2009.04.001. [PMID: 19481700] - George Habib, Ahmed Safia. The effect of intra-articular injection of betamethasone acetate/betamethasone sodium phosphate on blood glucose levels in controlled diabetic patients with symptomatic osteoarthritis of the knee.
Clinical rheumatology.
2009 Jan; 28(1):85-7. doi:
10.1007/s10067-008-1023-9. [PMID: 18853221] - Matthias Schwab, Turhan Coksaygan, Mahesh N Samtani, William J Jusko, Peter W Nathanielsz. Kinetics of betamethasone and fetal cardiovascular adverse effects in pregnant sheep after different doses.
Obstetrics and gynecology.
2006 Sep; 108(3 Pt 1):617-25. doi:
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