Betamethasone 17,21-dipropionate (BioDeep_00000176649)

   

human metabolite blood metabolite


代谢物信息卡片


2-[1-fluoro-17-hydroxy-2,13,15-trimethyl-5-oxo-14-(propanoyloxy)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl]-2-oxoethyl propanoate

化学式: C28H37FO7 (504.2523184)
中文名称: 17,21-二丙酸倍他米松酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(=O)OCC(=O)C1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)OC(=O)CC
InChI: InChI=1S/C28H37FO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3

描述信息

D000893 - Anti-Inflammatory Agents

同义名列表

13 个代谢物同义名

2-[1-fluoro-17-hydroxy-2,13,15-trimethyl-5-oxo-14-(propanoyloxy)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl]-2-oxoethyl propanoate; 2-[1-Fluoro-17-hydroxy-2,13,15-trimethyl-5-oxo-14-(propanoyloxy)tetracyclo[8.7.0.0,.0,]heptadeca-3,6-dien-14-yl]-2-oxoethyl propanoic acid; Augmented betamethasone dipropionate; Betamethasone 17,21-dipropionic acid; Betamethasone 17,21-dipropionate; Betamethasone-17,21-dipropionate; BETAMETHASONE dipropionic acid; BETAMETHASONE DIPROPIONATE; Betamethasone propionate; Diprolene; Diprosone; Beloderm; Maxivate



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mary Beth Gadarowski, Ritesh Agnihothri, Glynis Scott, Molly Plovanich. Pyoderma gangrenosum associated with levamisole-adulterated cocaine in a c-ANCA positive patient. Dermatology online journal. 2021 Jan; 27(1):. doi: . [PMID: 33560793]
  • Chunxia He, Hongzhong Jin, Xiguang Liu, Fengming Hu, Litao Zhang, Shifa Zhang, Yanling He, Xiumin Yang, Hao Chen, Xiaohua Wang, Chao Ji, Chengzhi Lv, Guoying Miao, Xiaojing Li, Qingchun Diao, Linfeng Li, Xuefei Li, Yuzhen Li, Rupeng Wang, Lijuan Zhang, Xiaoyong Zhou, Xiujuan Xia, Min Yan, Jiquan Song, Ruzhi Zhang, Long Geng, Min Zheng, Qianjin Lu, Tao Lu, Yuling Shi, Haixia Jing, Xiaojie Zhang, Jianqiang Shi, Jue Xia, Yu Gao, Yun Wang. Tazarotene/Betamethasone Dipropionate Cream in Patients with Plaque Psoriasis: Results of a Prospective, Multicenter, Observational Study. Dermatology (Basel, Switzerland). 2021; 237(4):603-610. doi: 10.1159/000511891. [PMID: 33352561]
  • Áurea Redondo-Sendino, Isabel Cristina González Sánchez, Beatriz de Victoria Fernández. [Skin manifestations associated with the new coronavirus SARS-CoV-2 disease]. Medicina clinica. 2020 11; 155(9):414-415. doi: 10.1016/j.medcli.2020.04.057. [PMID: 32873395]
  • Lunfei Liu, Chunlei Zhang, Jinyan Wang, Kun Chen, Yangfeng Ding, Guofu Yan, Qianjin Lu, Wei Li, Hong Fang, Hao Cheng, Jianzhong Zhang, Yanling He, Wei Zhu, Yan Lu, Jinhua Huang, Weili Pan, Ming Li, Shuanglin Cao, Shanshan Li, Xiuping Han, Li He, Yayuan Chen, Min Zheng. Comparison of safety and efficacy between calcipotriol plus betamethasone dipropionate gel and calcipotriol scalp solution as long-term treatment for scalp psoriasis in Chinese patients: a national, multicentre, prospective, randomized, active-controlled phase 4 trial. European journal of dermatology : EJD. 2020 Oct; 30(5):580-590. doi: 10.1684/ejd.2020.3876. [PMID: 33052103]
  • Nguyen-Thach Tung, Van-Duy Vu, Phuong-Lan Nguyen. DoE-based development, physicochemical characterization, and pharmacological evaluation of a topical hydrogel containing betamethasone dipropionate microemulsion. Colloids and surfaces. B, Biointerfaces. 2019 Sep; 181(?):480-488. doi: 10.1016/j.colsurfb.2019.06.002. [PMID: 31176120]
  • Pierre A Hanna, Mamdouh M Ghorab, Shadeed Gad. Development of Betamethasone Dipropionate-Loaded Nanostructured Lipid Carriers for Topical and Transdermal Delivery. Anti-inflammatory & anti-allergy agents in medicinal chemistry. 2019; 18(1):26-44. doi: 10.2174/1871523017666181115104159. [PMID: 30430947]
  • Akimichi Morita, Shinnosuke Muramatsu, Ryoji Kubo, Kyoko Ikumi, Yoko Sagawa, Chiyo Saito, Kan Torii, Emi Nishida. Low incidence of hypercalcemia following combined calcipotriol hydrate/betamethasone dipropionate ointment treatment in Japanese patients with severe psoriasis vulgaris. The Journal of dermatological treatment. 2018 Aug; 29(5):496-500. doi: 10.1080/09546634.2017.1398394. [PMID: 29076379]
  • Julia Weber, Nadine L Funk, Mariana H Motta, Alessandra M Guedes, Ana Paula C Visintainer, Solange B Tedesco, Cristiane de B Da Silva. Association of Borage Oil and Betamethasone Dipropionate in Lipid-Core Nanocapsules: Characterization, Photostability and In Vitro Irritation Test. Journal of nanoscience and nanotechnology. 2016 Feb; 16(2):1354-62. doi: 10.1166/jnn.2016.11674. [PMID: 27433586]
  • R A Moreno, P Moreno, N C Borges, J L Donato, S E Oliveira, N C Borges. Finasteride Quantification in Human Plasma by High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry. Application to a Comparative Pharmacokinetics Study. Drug research. 2015 Sep; 65(9):449-56. doi: 10.1055/s-0034-1376962. [PMID: 25919644]
  • M Gooderham, J-M Debarre, J Keddy-Grant, Z Xu, M Kurvits, M Goodfield. Safety and efficacy of calcipotriol plus betamethasone dipropionate gel in the treatment of scalp psoriasis in adolescents 12-17 years of age. The British journal of dermatology. 2014 Dec; 171(6):1470-7. doi: 10.1111/bjd.13235. [PMID: 24980277]
  • Shane Silver, Raj Tuppal, Aditya K Gupta, Fabrice Clonier, Martin Olesen, Randy Leeder, Victoria Taraska. Effect of calcipotriene plus betamethasone dipropionate topical suspension on the hypothalamic-pituitary-adrenal axis and calcium homeostasis in subjects with extensive psoriasis vulgaris: an open, non-controlled, 8-week trial. Journal of drugs in dermatology : JDD. 2013 Aug; 12(8):882-7. doi: NULL. [PMID: 23986161]
  • Naresh Punwani, Peggy Scherle, Robert Flores, Jack Shi, Jinjin Liang, Swamy Yeleswaram, Richard Levy, William Williams, Alice Gottlieb. Preliminary clinical activity of a topical JAK1/2 inhibitor in the treatment of psoriasis. Journal of the American Academy of Dermatology. 2012 Oct; 67(4):658-64. doi: 10.1016/j.jaad.2011.12.018. [PMID: 22281165]
  • Susana Coimbra, Hugo Oliveira, Flávio Reis, Luís Belo, Susana Rocha, Alexandre Quintanilha, Américo Figueiredo, Frederico Teixeira, Elisabeth Castro, Petronila Rocha-Pereira, Alice Santos-Silva. Erythroid disturbances before and after treatment of Portuguese psoriasis vulgaris patients: a cross-sectional and longitudinal study. American journal of clinical dermatology. 2012 Feb; 13(1):37-47. doi: 10.2165/11592110-000000000-00000. [PMID: 21888450]
  • Chunhui He, Hongwei Fan, Jie Tan, Jianjun Zou, Yubing Zhu, Kun Yang, Qin Hu. Pharmacokinetics of betamethasone and betamethasone 17-monopropionate in Chinese healthy volunteers after intramuscular injection of betamethasone phosphate/betamethasone dipropionate. Arzneimittel-Forschung. 2011; 61(7):417-20. doi: 10.1055/s-0031-1296220. [PMID: 21899210]
  • Ana González-Paredes, Maria Manconi, Carla Caddeo, Alberto Ramos-Cormenzana, Mercedes Monteoliva-Sánchez, Anna Maria Fadda. Archaeosomes as carriers for topical delivery of betamethasone dipropionate: in vitro skin permeation study. Journal of liposome research. 2010 Dec; 20(4):269-76. doi: 10.3109/08982100903402962. [PMID: 19954402]
  • B Lebrun-Vignes, V Legrain, J Amoric, A Taïeb. [Comparative study of efficacy and effect on plasma cortisol levels of micronised desonide cream 0.1 p. 100 versus betamethasone dipropionate cream 0.05 p. 100 In the treatment of childhood atopic dermatitis]. Annales de dermatologie et de venereologie. 2000 Jun; 127(6-7):590-5. doi: NULL. [PMID: 10930856]
  • H M Sheu, J Y Lee, K W Kuo, J C Tsai. Permeability barrier abnormality of hairless mouse epidermis after topical corticosteroid: characterization of stratum corneum lipids by ruthenium tetroxide staining and high-performance thin-layer chromatography. The Journal of dermatology. 1998 May; 25(5):281-9. doi: 10.1111/j.1346-8138.1998.tb02399.x. [PMID: 9640880]
  • H Granlund, P Erkko, E Eriksson, S Reitamo. Comparison of cyclosporine and topical betamethasone-17,21-dipropionate in the treatment of severe chronic hand eczema. Acta dermato-venereologica. 1996 Sep; 76(5):371-6. doi: 10.2340/0001555576371376. [PMID: 8891011]
  • J Delescluse, J D van der Endt. A comparison of the safety, tolerability, and efficacy of fluticasone propionate ointment, 0.005\%, and betamethasone-17,21-dipropionate ointment, 0.05\%, in the treatment of eczema. Cutis. 1996 Feb; 57(2 Suppl):32-8. doi: NULL. [PMID: 8646867]
  • D T Roberts. Comparison of fluticasone propionate ointment, 0.005\%, and betamethasone-17,21-dipropionate ointment, 0.05\%, in the treatment of psoriasis. Cutis. 1996 Feb; 57(2 Suppl):27-31. doi: NULL. [PMID: 8646866]
  • P Walsh, J L Aeling, L Huff, W L Weston. Hypothalamus-pituitary-adrenal axis suppression by superpotent topical steroids. Journal of the American Academy of Dermatology. 1993 Sep; 29(3):501-3. doi: 10.1016/s0190-9622(08)82011-7. [PMID: 8349876]
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  • L Hillström, L Pettersson, L Svensson. Comparison of betamethasone dipropionate lotion with salicylic acid (Diprosalic) and clobetasol propionate lotion (Dermovate) in the treatment of psoriasis of the scalp. The Journal of international medical research. 1982; 10(6):419-22. doi: 10.1177/030006058201000606. [PMID: 7152080]
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  • M Nakano, A Takashima, M Nishiuchi, M Takeuchi, M Doteuchi, H Yamada. [Placental transfer and distribution of betamethasone 17,21-dipropionate in various regions of the brain of pregnant rats and mice (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1981 Feb; 77(2):165-76. doi: NULL. [PMID: 7239360]
  • Y Hasegawa, T Yoshida, Y Fukiishi, Y Mizushima. A change in the adrenocortical response in perinatal rat offspring given betamethasone 17,21-dipropionate. Acta endocrinologica. 1981 Feb; 96(2):243-51. doi: 10.1530/acta.0.0960243. [PMID: 6258371]
  • M Scott, L A Malmsten, I Thelin. Effect on plasma cortisol level and urinary cortisol excretion, in healthy volunteers, after application of three different topical steroid ointments under occlusion. Acta dermato-venereologica. 1981; 61(6):543-6. doi: NULL. [PMID: 6177167]
  • M Nakano, M Takeuchi, K Sugeno. [Effects of betamethasone 17-propionate and betamethasone on hypothalamo-pituitary-adrenal cortex axis in rats (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1980 Nov; 76(8):729-35. doi: 10.1254/fpj.76.729. [PMID: 7274840]