beta-Lumicolchicine (BioDeep_00000176637)
human metabolite blood metabolite
代谢物信息卡片
化学式: C22H25NO6 (399.1682)
中文名称: β-Lumi (-)-秋水仙碱, gamma-光秋水仙碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=C1C4C3C=C(C4=O)OC)OC)OC)OC
InChI: InChI=1S/C22H25NO6/c1-10(24)23-13-7-6-11-8-15(27-3)21(28-4)22(29-5)16(11)17-12-9-14(26-2)20(25)18(12)19(13)17/h8-9,12-13,18H,6-7H2,1-5H3,(H,23,24)
描述信息
同义名列表
9 个代谢物同义名
N-{3,4,5,14-tetramethoxy-13-oxotetracyclo[9.5.0.0²,⁷.0¹²,¹⁶]hexadeca-1(11),2(7),3,5,14-pentaen-10-yl}acetamide; N-{3,4,5,14-tetramethoxy-13-oxotetracyclo[9.5.0.0,.0,]hexadeca-1(11),2,4,6,14-pentaen-10-yl}ethanimidate; gamma Lumicolchicine; gamma-Lumicolchicine; beta-Lumicolchicine; beta Lumicolchicine; Lumicolchicines; Lumicolchicine; gamma-Lumicolchicine
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 110937
- HMDB: HMDB0249140
- MeSH: Lumicolchicines
- CAS: 6901-14-0
- CAS: 6901-13-9
- CAS: 490-24-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 481258 - Colchicum robustum: 10.1007/BF00629836
- 13445 - Colchicum speciosum: 10.1135/CCCC19763146
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Tetsuji Morimoto, Wen Liu, Craig Woda, Marcelo D Carattino, Yuan Wei, Rebecca P Hughey, Gerard Apodaca, Lisa M Satlin, Thomas R Kleyman. Mechanism underlying flow stimulation of sodium absorption in the mammalian collecting duct.
American journal of physiology. Renal physiology.
2006 Sep; 291(3):F663-9. doi:
10.1152/ajprenal.00514.2005. [PMID: 16638910] - Chow H Lee. Differential regulation of P-glycoprotein genes in primary rat hepatocytes by collagen sandwich and drugs.
Journal of cellular biochemistry.
2002; 86(1):12-20. doi:
10.1002/jcb.10207. [PMID: 12112011] - F Saldías, E Lecuona, E Friedman, M L Barnard, K M Ridge, J I Sznajder. Modulation of lung liquid clearance by isoproterenol in rat lungs.
The American journal of physiology.
1998 05; 274(5):L694-701. doi:
10.1152/ajplung.1998.274.5.l694. [PMID: 9612284] - T Ikeda, N Sawada, M Satoh, M Mori. Induction of tyrosine aminotransferase of primary cultured rat hepatocytes depends on the organization of microtubules.
Journal of cellular physiology.
1998 Apr; 175(1):41-9. doi:
10.1002/(sici)1097-4652(199804)175:1<41::aid-jcp5>3.0.co;2-c. [PMID: 9491779] - F A Crocenzi, A Sisti, J M Pellegrino, M G Roma. Role of bile salts in colchicine-induced hepatotoxicity. Implications for hepatocellular integrity and function.
Toxicology.
1997 Aug; 121(2):127-42. doi:
10.1016/s0300-483x(97)00064-4. [PMID: 9230445] - J M Crawford, A R Crawford, D C Strahs. Microtubule-dependent transport of bile salts through hepatocytes: cholic vs. taurocholic acid.
Hepatology (Baltimore, Md.).
1993 Oct; 18(4):903-11. doi:
10.1002/hep.1840180423. [PMID: 8406366] - R Ravindra, R S Aronstam. Effect of colchicine and taxol on stimulation of G protein GTPase activity in anterior pituitary lobe of rats by gonadotrophin- and thyrotrophin-releasing hormones.
Journal of reproduction and fertility.
1993 Jan; 97(1):27-33. doi:
10.1530/jrf.0.0970027. [PMID: 8096547] - L Van Den Bosch, H De Smedt, R Borghgraef. Development of the Na(+)-dependent hexose carrier in LLC-PK1 cells is dependent on microtubules.
Biochimica et biophysica acta.
1990 Dec; 1030(2):223-30. doi:
10.1016/0005-2736(90)90298-3. [PMID: 1979753] - T Veel, T Buanes, T Grotmol, E Engeland, M G Raeder. Colchicine blocks the effects of secretin on bile duct cell tubulovesicles and plasma membrane geometry and impairs ductular HCO3- secretion in the pig.
Acta physiologica Scandinavica.
1990 Aug; 139(4):603-7. doi:
10.1111/j.1748-1716.1990.tb08965.x. [PMID: 2248039] - A Benedetti, L Marucci, G Ferretti, G Curatola, A M Jézéquel, F Orlandi. Evidence that plasma membrane fluidity of isolated hepatocytes is modified by exposure to microtubule-depolymerizing drugs.
Journal of hepatology.
1990 Mar; 10(2):144-8. doi:
10.1016/0168-8278(90)90043-q. [PMID: 2332583] - T D McKinney, K K Davidson. Effects of respiratory acidosis on HCO3- transport by rabbit collecting tubules.
The American journal of physiology.
1988 Oct; 255(4 Pt 2):F656-65. doi:
10.1152/ajprenal.1988.255.4.f656. [PMID: 2845808] - M Hirafuji, Y Ogura. The effects of colchicine on prostaglandin I2 and thromboxane A2 biosynthesis in the rat dental pulp.
Archives of oral biology.
1988; 33(5):311-5. doi:
10.1016/0003-9969(88)90063-5. [PMID: 3056350] - J Reibman, K A Haines, A M Rich, P Cristello, K N Giedd, G Weissmann. Colchicine inhibits ionophore-induced formation of leukotriene B4 by human neutrophils: the role of microtubules.
Journal of immunology (Baltimore, Md. : 1950).
1986 Feb; 136(3):1027-32. doi:
NULL. [PMID: 3001184] - V P Rajan, K M Menon. Involvement of microtubules in lipoprotein degradation and utilization for steroidogenesis in cultured rat luteal cells.
Endocrinology.
1985 Dec; 117(6):2408-16. doi:
10.1210/endo-117-6-2408. [PMID: 2866086] - L M Garcia-Segura. Trans-synaptic modulation of Purkinje cell plasma membrane organization by climbing fiber axonal flow.
Experimental brain research.
1985; 61(1):186-93. doi:
10.1007/bf00235634. [PMID: 4085596] - A Seidel. Influence of the antimicrotubular agents, colchicine and vinblastin, on the uptake of americium by rat liver, kidneys, and skeleton.
Toxicology and applied pharmacology.
1984 Oct; 76(1):113-7. doi:
10.1016/0041-008x(84)90034-6. [PMID: 6148793] - J A Antonow, N Bhat, J J Volpe. Cytoskeletal structures and oligodendroglial differentiation in C-6 glial cells.
Journal of neurochemistry.
1984 Apr; 42(4):1030-9. doi:
10.1111/j.1471-4159.1984.tb12707.x. [PMID: 6321655] - V S Donoso, M D Bailie. Effect of colchicine on drug-induced changes in plasma renin concentration in rats.
Hypertension (Dallas, Tex. : 1979).
1982 Sep; 4(5):676-80. doi:
10.1161/01.hyp.4.5.676. [PMID: 7049920] - S Leoni, S Spagnuolo, M T Mangiantini, A Trentalance. Effect of colchicine on rat liver plasma membrane biochemical composition.
Cellular and molecular biology.
1982; 28(1):125-9. doi:
NULL. [PMID: 7083273] - R Tauber, W Reutter. A colchicine-sensitive uptake system in Morris hepatomas.
Proceedings of the National Academy of Sciences of the United States of America.
1980 Sep; 77(9):5282-6. doi:
10.1073/pnas.77.9.5282. [PMID: 6933560] - S Leoni, S Spagnuolo, L Conti Devirgiliis, P Baldini, S Incerpi, P Luly. Effect of colchicine on rat liver plasma membrane.
Biochimica et biophysica acta.
1980 Mar; 596(3):451-5. doi:
10.1016/0005-2736(80)90133-9. [PMID: 6102480] - G Matsumoto, H Sakai. Microtubules inside the plasma membrane of squid giant axons and their possible physiological function.
The Journal of membrane biology.
1979 Oct; 50(1):1-14. doi:
10.1007/bf01868784. [PMID: 501731]
