beta-GalCer (BioDeep_00000176630)
human metabolite blood metabolite
代谢物信息卡片
N-(3-Hydroxy-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}octadec-4-en-2-yl)tetracosanimidate
化学式: C48H93NO8 (811.6900818)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 83.33%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1OC(CO)C(O)C(O)C1O)C(O)C=CCCCCCCCCCCCCC
InChI: InChI=1S/C48H93NO8/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-44(52)49-41(40-56-48-47(55)46(54)45(53)43(39-50)57-48)42(51)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h35,37,41-43,45-48,50-51,53-55H,3-34,36,38-40H2,1-2H3,(H,49,52)
数据库引用编号
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
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PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gabriel Miltenberger-Miltenyi, Ana Rita Cruz-Machado, Jennifer Saville, Vasco A Conceição, Ângelo Calado, Inês Lopes, Maria Fuller, João Eurico Fonseca. Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patients.
Rheumatology (Oxford, England).
2020 08; 59(8):2085-2089. doi:
10.1093/rheumatology/kez545. [PMID: 31808525] - Wendy E Heywood, Ivan Doykov, Justyna Spiewak, Jenny Hallqvist, Kevin Mills, Albina Nowak. Global glycosphingolipid analysis in urine and plasma of female Fabry disease patients.
Biochimica et biophysica acta. Molecular basis of disease.
2019 10; 1865(10):2726-2735. doi:
10.1016/j.bbadis.2019.07.005. [PMID: 31319156] - Emilio J González-Ramírez, Félix M Goñi, Alicia Alonso. Mixing brain cerebrosides with brain ceramides, cholesterol and phospholipids.
Scientific reports.
2019 09; 9(1):13326. doi:
10.1038/s41598-019-50020-7. [PMID: 31527655] - Hongbin Xu, Frederic R Boucher, Thao T Nguyen, Graeme P Taylor, Julianna J Tomlinson, Roberto A Ortega, Brigitte Simons, Michael G Schlossmacher, Rachel Saunders-Pullman, Walt Shaw, Steffany A L Bennett. DMS as an orthogonal separation to LC/ESI/MS/MS for quantifying isomeric cerebrosides in plasma and cerebrospinal fluid.
Journal of lipid research.
2019 01; 60(1):200-211. doi:
10.1194/jlr.d089797. [PMID: 30413651] - Lingyu Zhang, Tiantian Zhang, Lin Ding, Jie Xu, Changhu Xue, Teruyoshi Yanagita, Yaoguang Chang, Yuming Wang. The Protective Activities of Dietary Sea Cucumber Cerebrosides against Atherosclerosis through Regulating Inflammation and Cholesterol Metabolism in Male Mice.
Molecular nutrition & food research.
2018 08; 62(16):e1800315. doi:
10.1002/mnfr.201800315. [PMID: 29883529] - Xiaofang Liu, Jie Xu, Yong Xue, Zhuang Gao, Zhaojie Li, Kailiang Leng, Jingfeng Wang, Changhu Xue, Yuming Wang. Sea cucumber cerebrosides and long-chain bases from Acaudina molpadioides protect against high fat diet-induced metabolic disorders in mice.
Food & function.
2015 Nov; 6(11):3428-36. doi:
10.1039/c5fo00602c. [PMID: 26399628] - Kazuhiro Sonomura, Shinobu Kudoh, Taka-Aki Sato, Fumihiko Matsuda. Plasma lipid analysis by hydrophilic interaction liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal of separation science.
2015 Jun; 38(12):2033-7. doi:
10.1002/jssc.201401440. [PMID: 25845351] - Seul Kee Byeon, Ju Yong Lee, Jin-Sung Lee, Myeong Hee Moon. Lipidomic profiling of plasma and urine from patients with Gaucher disease during enzyme replacement therapy by nanoflow liquid chromatography-tandem mass spectrometry.
Journal of chromatography. A.
2015 Feb; 1381(?):132-9. doi:
10.1016/j.chroma.2015.01.004. [PMID: 25597892] - Shrestha Priyadarsini, Akhee Sarker-Nag, Jeremy Allegood, Charles Chalfant, Dimitrios Karamichos. Description of the sphingolipid content and subspecies in the diabetic cornea.
Current eye research.
2015; 40(12):1204-10. doi:
10.3109/02713683.2014.990984. [PMID: 25426847] - Yujiao Zhang, Li Zhou, Jun Zou, Mingyan Wang, Jianhua Qi, Zhi Qi. Palmitoylation of STREX domain confers cerebroside sensitivity to the BKCa channel.
Biochimica et biophysica acta.
2014 Oct; 1838(10):2451-9. doi:
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PloS one.
2013; 8(9):e73094. doi:
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Toxicology and applied pharmacology.
2012 Sep; 263(3):296-302. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 May; 19(7):639-47. doi:
10.1016/j.phymed.2012.02.012. [PMID: 22455995] - Bei Zhang, Changhu Xue, Xiaoqian Hu, Jie Xu, Zhaojie Li, Jingfeng Wang, Teruyoshi Yanagita, Yong Xue, Yuming Wang. Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats.
Lipids in health and disease.
2012 May; 11(?):48. doi:
10.1186/1476-511x-11-48. [PMID: 22569330] - Bei Zhang, Chang-Hu Xue, Ting-Yu Feng, Xiao-Qian Hu, Bing-Xing Ren, Jie Xu, Yu-Ming Wang. [Effect of sea cucumber cerebroside on lipid metabolism in fatty liver rats].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences.
2010 09; 39(5):493-8. doi:
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Glycobiology.
2010 Jun; 20(6):710-7. doi:
10.1093/glycob/cwq018. [PMID: 20157020] - Ken-Ichi Nagai, Keiko Tadano-Aritomi, Yukio Niimura, Ineo Ishizuka. Higher expression of renal sulfoglycolipids in marine mammals.
Glycoconjugate journal.
2008 Nov; 25(8):723-6. doi:
10.1007/s10719-008-9132-x. [PMID: 18470608] - Joan M Boggs, Wen Gao, Yukie Hirahara. Signal transduction pathways involved in interaction of galactosylceramide/sulfatide-containing liposomes with cultured oligodendrocytes and requirement for myelin basic protein and glycosphingolipids.
Journal of neuroscience research.
2008 May; 86(7):1448-58. doi:
10.1002/jnr.21603. [PMID: 18189317] - Prasoon Gupta, Dinesh Kumar Yadav, Kiran Babu Siripurapu, Guatam Palit, Rakesh Maurya. Constituents of Ocimum sanctum with antistress activity.
Journal of natural products.
2007 Sep; 70(9):1410-6. doi:
10.1021/np0700164. [PMID: 17850106] - Jinichiro Koga, Hidetoshi Kubota, Shuichi Gomi, Kenji Umemura, Masao Ohnishi, Toshiaki Kono. Cholic acid, a bile acid elicitor of hypersensitive cell death, pathogenesis-related protein synthesis, and phytoalexin accumulation in rice.
Plant physiology.
2006 Apr; 140(4):1475-83. doi:
10.1104/pp.105.070334. [PMID: 16461384] - Michael W Dennis, Colin Downey, Nicole Brufatto, Michael E Nesheim, Ken Stevenson, Cheng Hock Toh. Prothrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein.
Thrombosis and haemostasis.
2004 Mar; 91(3):522-30. doi:
10.1160/th03-08-0548. [PMID: 14983228] - O Rojas-Espinosa, R Arenas, P Arce-Parades, G Miranda-Contreras. Antibodies to diverse lipids in the serum of patients with clinically cured leprosy and tuberculosis.
Acta leprologica.
2003; 12(3):112-6. doi:
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Journal of experimental botany.
2002 Nov; 53(378):2159-66. doi:
10.1093/jxb/erf076. [PMID: 12379782] - Steven A Mechanic, Joan L Maurer, Mark J Igoe, Donna M Kavitsky, Sandra T Nance. Anti-Vel reactivity diminished by adsorption with rabbit RBC stroma.
Transfusion.
2002 Sep; 42(9):1180-3. doi:
10.1046/j.1537-2995.2002.00187.x. [PMID: 12430675] - Marion B Coulter-Mackie, Derek A Applegarth, Jennifer R Toone, Liane Gagnier, André R Anzarut, Glenda Hendson. Isolated peripheral neuropathy in atypical metachromatic leukodystrophy: a recurrent mutation.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques.
2002 May; 29(2):159-63. doi:
10.1017/s0317167100120931. [PMID: 12035837] - J M Boggs, H Wang. Effect of liposomes containing cerebroside and cerebroside sulfate on cytoskeleton of cultured oligodendrocytes.
Journal of neuroscience research.
2001 Oct; 66(2):242-53. doi:
10.1002/jnr.1217. [PMID: 11592120] - S Moffett, D A Brown, M E Linder. Lipid-dependent targeting of G proteins into rafts.
The Journal of biological chemistry.
2000 Jan; 275(3):2191-8. doi:
10.1074/jbc.275.3.2191. [PMID: 10636925] - D Bouhours, J Liaigre, C Richard, R Oriol, J F Bouhours. Forssman penta- and tetraglycosylceramide are xenoantigens of ostrich kidney and liver.
Glycobiology.
1999 Sep; 9(9):875-86. doi:
10.1093/glycob/9.9.875. [PMID: 10460829] - K A Mitropoulos. High affinity binding of factor XIIa to an electronegative surface controls the rates of factor XII and prekallikrein activation in vitro.
Thrombosis research.
1999 Apr; 94(2):117-29. doi:
10.1016/s0049-3848(98)00207-2. [PMID: 10230897] - T Tanimizu, H Ishihara, H Hattori, S Hamada, R Hirayama. The clinical significance of u-FCC, an antigen of anti-fucosylceramide antibody found in urine, in patients with gastric and colorectal carcinoma.
Cancer.
1998 Aug; 83(4):660-5. doi:
10.1002/(sici)1097-0142(19980815)83:4<660::aid-cncr5>3.0.co;2-o. [PMID: 9708928] - Q Fu, J F Goodrum, C Hayes, J D Hostettler, A D Toews, P Morell. Control of cholesterol biosynthesis in Schwann cells.
Journal of neurochemistry.
1998 Aug; 71(2):549-55. doi:
10.1046/j.1471-4159.1998.71020549.x. [PMID: 9681444] - P R Wheeler, J G Raynes, G M O'Sullivan, D Duggan, K P McAdam. Sulphatide-binding properties are shared by serum amyloid P component and a polyreactive germ-line IgM autoantibody, the TH3 idiotype.
Clinical and experimental immunology.
1998 May; 112(2):262-9. doi:
10.1046/j.1365-2249.1998.00593.x. [PMID: 9649189] - M S Webb, T C Irving, P L Steponkus. Cerebrosides alter the lyotropic and thermotropic phase transitions of DOPE:DOPC and DOPE:DOPC:sterol mixtures.
Biochimica et biophysica acta.
1997 Jun; 1326(2):225-35. doi:
10.1016/s0005-2736(97)00026-6. [PMID: 9218553] - H Hall, R Deutzmann, R Timpl, L Vaughan, B Schmitz, M Schachner. HNK-1 carbohydrate-mediated cell adhesion to laminin-1 is different from heparin-mediated and sulfatide-mediated cell adhesion.
European journal of biochemistry.
1997 May; 246(1):233-42. doi:
10.1111/j.1432-1033.1997.t01-1-00233.x. [PMID: 9210489] - P R Wheeler, J G Raynes, K P McAdam. Autoantibodies to cerebroside sulphate (sulphatide) in leprosy.
Clinical and experimental immunology.
1994 Oct; 98(1):145-50. doi:
10.1111/j.1365-2249.1994.tb06621.x. [PMID: 7923874] - S Soeda, M Hiraiwa, J S O'Brien, Y Kishimoto. Binding of cerebrosides and sulfatides to saposins A-D.
The Journal of biological chemistry.
1993 Sep; 268(25):18519-23. doi:
10.1016/s0021-9258(17)46658-0. [PMID: 8360153] - H Nakamura, H Yamada, H Kitagawa, A Masunaga, S Itoyama, I Sugawara. Immunoreactive fucosylceramide as a B-cell differentiation marker.
Immunology letters.
1993 Aug; 37(2-3):119-22. doi:
10.1016/0165-2478(93)90020-3. [PMID: 8258455] - H Yamada, H Ishihara, H Kitagawa, Y Kawabata, S Itoyama, I Sugawara. Preferential expression of immunoreactive fucosylceramide in adenocarcinoma of the lung.
Cancer research.
1992 Aug; 52(16):4408-12. doi:
NULL. [PMID: 1322788] - A L Fluharty, W E Meek, Z Katona, K K Tsay. The cerebroside sulfate activator from pig kidney: derivitization, cerebroside sulfate binding, and metabolic correction.
Biochemical medicine and metabolic biology.
1992 Feb; 47(1):86-96. doi:
10.1016/0885-4505(92)90010-v. [PMID: 1348622] - S Eskelinen, J W Kok, R Sormunen, D Hoekstra. Coated endosomal vesicles: sorting and recycling compartment for transferrin in BHK cells.
European journal of cell biology.
1991 Dec; 56(2):210-22. doi:
NULL. [PMID: 1802708] - J Holgersson, P A Jovall, B E Samuelsson, M E Breimer. Blood group type glycosphingolipids of human kidneys. Structural characterization of extended globo-series compounds.
Glycoconjugate journal.
1991 Oct; 8(5):424-33. doi:
10.1007/bf00731294. [PMID: 1841684] - R T Huang, E Dietsch. Cellular incorporation and localization of fluorescent derivatives of gangliosides, cerebroside and sphingomyelin.
FEBS letters.
1991 Apr; 281(1-2):39-42. doi:
10.1016/0014-5793(91)80353-5. [PMID: 2015906] - H Holtschmidt, K Sandhoff, W Fürst, H Y Kwon, D Schnabel, K Suzuki. The organization of the gene for the human cerebroside sulfate activator protein.
FEBS letters.
1991 Mar; 280(2):267-70. doi:
10.1016/0014-5793(91)80308-p. [PMID: 2013321] - J L Avila, M Rojas. Elevated cerebroside antibody levels in human visceral and cutaneous leishmaniasis, Trypanosoma rangeli infection, and chronic Chagas' disease.
The American journal of tropical medicine and hygiene.
1990 Jul; 43(1):52-60. doi:
10.4269/ajtmh.1990.43.52. [PMID: 2116736] - A L Pelonero, A K Pandurangi, V P Calabrese. Autoantibodies to brain lipids in schizophrenia.
The American journal of psychiatry.
1990 May; 147(5):661-2. doi:
10.1176/ajp.147.5.661. [PMID: 2327498] - J D Jones, P F Almeida, T E Thompson. Spontaneous interbilayer transfer of hexosylceramides between phospholipid bilayers.
Biochemistry.
1990 Apr; 29(16):3892-7. doi:
10.1021/bi00468a015. [PMID: 2354161] - G C Owens, R P Bunge. Schwann cells depleted of galactocerebroside express myelin-associated glycoprotein and initiate but do not continue the process of myelination.
Glia.
1990; 3(2):118-24. doi:
10.1002/glia.440030205. [PMID: 1692007] - J W Kok, S Eskelinen, K Hoekstra, D Hoekstra. Salvage of glucosylceramide by recycling after internalization along the pathway of receptor-mediated endocytosis.
Proceedings of the National Academy of Sciences of the United States of America.
1989 Dec; 86(24):9896-900. doi:
10.1073/pnas.86.24.9896. [PMID: 2690077] - C Lubetzki, Y Thuillier, A Galli, O Lyon-Caen, F Lhermitte, B Zalc. Galactosylceramide: a reliable serum index of demyelination in multiple sclerosis.
Annals of neurology.
1989 Sep; 26(3):407-9. doi:
10.1002/ana.410260319. [PMID: 2802541] - L J Krzalić, D R Nedeljković, D H Cvetković, M K Skender. Serum lipids and demyelination in experimental allergic encephalomyelitis induced by the increased encephalitogenicity of myelin basic protein given with galactocerebrospide.
Journal of neuroimmunology.
1989 May; 22(3):193-9. doi:
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Journal of biochemistry.
1989 May; 105(5):829-33. doi:
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Acta neuropathologica.
1989; 77(6):621-8. doi:
10.1007/bf00687890. [PMID: 2750480] - N P Taranova, O S Luchakova, A V Buriakova. [Antibodies to galactocerebrosides of the brain in the blood serum of children with neuroinfections].
Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952).
1989; 89(7):27-31. doi:
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Clinical and experimental neurology.
1989; 26(?):33-44. doi:
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Journal of Korean medical science.
1988 Sep; 3(3):89-98. doi:
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Journal of neurochemistry.
1988 Aug; 51(2):380-4. doi:
10.1111/j.1471-4159.1988.tb01049.x. [PMID: 3392533] - M Katayama. [The origin of renal galactosylceramide in the twitcher mouse, an animal model of human globoid cell leukodystrophy].
Fukuoka igaku zasshi = Hukuoka acta medica.
1988 Jul; 79(7):529-36. doi:
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Biochimica et biophysica acta.
1988 Apr; 939(3):577-86. doi:
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Journal of chromatography.
1988 Apr; 426(1):188-93. doi:
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Journal of neurochemistry.
1988 Feb; 50(2):630-8. doi:
10.1111/j.1471-4159.1988.tb02957.x. [PMID: 3335862] - K Inui, M Furukawa, S Okada, H Yabuuchi. Metabolism of cerebroside sulfate and subcellular distribution of its metabolites in cultured skin fibroblasts from controls, metachromatic leukodystrophy, and globoid cell leukodystrophy.
The Journal of clinical investigation.
1988 Feb; 81(2):310-7. doi:
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Journal of neuroscience research.
1988; 20(2):182-8. doi:
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Biulleten' eksperimental'noi biologii i meditsiny.
1987 Dec; 104(12):755-7. doi:
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Molecular immunology.
1987 Nov; 24(11):1135-43. doi:
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Molecular and biochemical parasitology.
1987 Nov; 26(1-2):99-111. doi:
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Annals of neurology.
1987 Sep; 22(3):381-3. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
1987 Jun; 84(12):4259-63. doi:
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Archives of biochemistry and biophysics.
1987 Jun; 255(2):385-91. doi:
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FEBS letters.
1987 Apr; 214(1):41-4. doi:
10.1016/0014-5793(87)80009-1. [PMID: 3569516] - J A Benjamins, R E Callahan, I N Montgomery, D M Studzinski, C A Dyer. Production and characterization of high titer antibodies to galactocerebroside.
Journal of neuroimmunology.
1987 Apr; 14(3):325-38. doi:
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The New England journal of medicine.
1987 Feb; 316(7):369-74. doi:
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Biochemical and biophysical research communications.
1987 Jan; 142(1):194-9. doi:
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Brain & development.
1987; 9(1):26-32. doi:
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1986 Jul; 877(3):387-98. doi:
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Laboratory investigation; a journal of technical methods and pathology.
1986 Jul; 55(1):86-90. doi:
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Biochemistry and cell biology = Biochimie et biologie cellulaire.
1986 Jul; 64(7):631-7. doi:
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Archives of biochemistry and biophysics.
1986 Jun; 247(2):446-9. doi:
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Journal of immunology (Baltimore, Md. : 1950).
1986 Apr; 136(7):2562-7. doi:
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The Japanese journal of experimental medicine.
1986 Apr; 56(2):43-9. doi:
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Journal of neurology, neurosurgery, and psychiatry.
1986 Mar; 49(3):258-64. doi:
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Journal of neurochemistry.
1986 Jan; 46(1):300-2. doi:
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Biochimica et biophysica acta.
1985 Oct; 837(1):27-34. doi:
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The Biochemical journal.
1985 Oct; 231(2):393-400. doi:
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Journal of neurochemistry.
1985 Jul; 45(1):191-8. doi:
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Brain research.
1985 Mar; 330(2):378-81. doi:
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Biochemical and biophysical research communications.
1985 Mar; 127(2):663-7. doi:
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The Journal of biological chemistry.
1985 Feb; 260(4):2295-300. doi:
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Journal of the neurological sciences.
1985 Feb; 67(2):201-12. doi:
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The Journal of cell biology.
1985 Jan; 100(1):27-34. doi:
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1985; 14(4):433-47. doi:
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Journal of neuroimmunology.
1985 Jan; 7(4):207-14. doi:
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International journal of cancer.
1984 Nov; 34(5):689-97. doi:
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Laboratory investigation; a journal of technical methods and pathology.
1984 Oct; 51(4):416-24. doi:
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The Journal of experimental medicine.
1984 Aug; 160(2):506-20. doi:
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Journal of neurochemistry.
1984 Jul; 43(1):139-45. doi:
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Annals of neurology.
1984 Jun; 15(6):581-9. doi:
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Journal of neuroscience methods.
1984 Jun; 11(2):137-41. doi:
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Journal of the neurological sciences.
1984 Jun; 64(3):297-303. doi:
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Analytical biochemistry.
1984 May; 138(2):380-5. doi:
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