BETA-AMANITIN (BioDeep_00000176613)

   

human metabolite blood metabolite


代谢物信息卡片


2-[34-(butan-2-yl)-13-(3,4-dihydroxybutan-2-yl)-8,22-dihydroxy-2,5,11,14,27,30,33,36,39-nonaoxo-27λ⁴-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11.0⁶,¹⁰.0¹⁸,²⁶.0¹⁹,²⁴]nonatriaconta-18(26),19,21,23-tetraen-4-yl]acetic acid

化学式: C39H53N9O15S (919.3381668)
中文名称: β-鹅膏菌素
谱图信息: 最多检出来源 Homo sapiens(blood) 43.48%

分子结构信息

SMILES: CCC(C)C1C(=O)NCC(=O)NC2CS(=O)C3=C(CC(C(=O)NCC(=O)N1)NC(=O)C(NC(=O)C4CC(CN4C(=O)C(NC2=O)CC(=O)O)O)C(C)C(CO)O)C5=C(N3)C=C(C=C5)O
InChI: InChI=1S/C39H53N9O15S/c1-4-16(2)31-36(60)41-11-28(53)42-25-15-64(63)38-21(20-6-5-18(50)7-22(20)45-38)9-23(33(57)40-12-29(54)46-31)43-37(61)32(17(3)27(52)14-49)47-35(59)26-8-19(51)13-48(26)39(62)24(10-30(55)56)44-34(25)58/h5-7,16-17,19,23-27,31-32,45,49-52H,4,8-15H2,1-3H3,(H,40,57)(H,41,60)(H,42,53)(H,43,61)(H,44,58)(H,46,54)(H,47,59)(H,55,56)

描述信息

D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
D009676 - Noxae > D011042 - Poisons > D000546 - Amanitins

同义名列表

5 个代谢物同义名

2-[34-(butan-2-yl)-13-(3,4-dihydroxybutan-2-yl)-8,22-dihydroxy-2,5,11,14,27,30,33,36,39-nonaoxo-27λ⁴-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11.0⁶,¹⁰.0¹⁸,²⁶.0¹⁹,²⁴]nonatriaconta-18(26),19,21,23-tetraen-4-yl]acetic acid; 1-Asp-alpha-amanitin; BETA-AMANITIN; b-Amanitin; Β-amanitin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiao-Min Xu, Zhen Meng, Jing-Shun Zhang, Qing Chen, Jian-Long Han. Analytical method development for α-amanitin and β-amanitin in plasma at ultra-trace level by online solid phase extraction-high performance liquid chromatography-triple quadrupole mass spectrometry and its application in poisoning events. Journal of pharmaceutical and biomedical analysis. 2020 Oct; 190(?):113523. doi: 10.1016/j.jpba.2020.113523. [PMID: 32814259]
  • Thomas P Bambauer, Lea Wagmann, Armin A Weber, Markus R Meyer. Analysis of α- and β-amanitin in Human Plasma at Subnanogram per Milliliter Levels by Reversed Phase Ultra-High Performance Liquid Chromatography Coupled to Orbitrap Mass Spectrometry. Toxins. 2020 10; 12(11):. doi: 10.3390/toxins12110671. [PMID: 33113909]
  • Chunlei Li, Hongyan Qian, Tao Bao, Guangde Yang, Sicen Wang, Xinshe Liu. Simultaneous identification and characterization of amanita toxins using liquid chromatography-photodiode array detection-ion trap and time-of-flight mass spectrometry and its applications. Toxicology letters. 2018 Oct; 296(?):95-104. doi: 10.1016/j.toxlet.2018.08.005. [PMID: 30107194]
  • Lei Tan, Rong He, Yongxian Li, Yong Liang, He Li, Youwen Tang. Fabrication of a biomimetic adsorbent imprinted with a common specificity determinant for the removal of α- and β-amanitin from plasma. Journal of chromatography. A. 2016 Aug; 1459(?):1-8. doi: 10.1016/j.chroma.2016.06.072. [PMID: 27394089]
  • Ismail Yilmaz, Fatih Ermis, Ilgaz Akata, Ertugrul Kaya. A Case Study: What Doses of Amanita phalloides and Amatoxins Are Lethal to Humans?. Wilderness & environmental medicine. 2015 Dec; 26(4):491-6. doi: 10.1016/j.wem.2015.08.002. [PMID: 26453489]
  • Andreas G Helfer, Markus R Meyer, Julian A Michely, Hans H Maurer. Direct analysis of the mushroom poisons α- and β-amanitin in human urine using a novel on-line turbulent flow chromatography mode coupled to liquid chromatography-high resolution-mass spectrometry/mass spectrometry. Journal of chromatography. A. 2014 Jan; 1325(?):92-8. doi: 10.1016/j.chroma.2013.11.054. [PMID: 24342531]
  • Marta Leite, Andreia Freitas, Anabela Marisa Azul, Jorge Barbosa, Saul Costa, Fernando Ramos. Development, optimization and application of an analytical methodology by ultra performance liquid chromatography-tandem mass spectrometry for determination of amanitins in urine and liver samples. Analytica chimica acta. 2013 Oct; 799(?):77-87. doi: 10.1016/j.aca.2013.08.044. [PMID: 24091377]
  • V A Robinson-Fuentes, J L Jaime-Sánchez, L García-Aguilar, M Gómez-Peralta, M S Vázquez-Garcidueñas, G Vázquez-Marrufo. Determination of alpha- and beta-amanitin in clinical urine samples by Capillary Zone Electrophoresis. Journal of pharmaceutical and biomedical analysis. 2008 Aug; 47(4-5):913-7. doi: 10.1016/j.jpba.2008.03.032. [PMID: 18502601]
  • Ramadan A Abuknesha, Alexandra Maragkou. A highly sensitive and specific enzyme immunoassay for detection of beta-amanitin in biological fluids. Analytical and bioanalytical chemistry. 2004 Jul; 379(5-6):853-60. doi: 10.1007/s00216-004-2663-5. [PMID: 15221190]
  • Chiemi Nishizawa, Yoshio Yamaura. [Determination of amanitatoxins by HPLC]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. 2003 Oct; 16(4):441-5. doi: NULL. [PMID: 14740566]
  • H H Maurer, C J Schmitt, A A Weber, T Kraemer. Validated electrospray liquid chromatographic-mass spectrometric assay for the determination of the mushroom toxins alpha- and beta-amanitin in urine after immunoaffinity extraction. Journal of chromatography. B, Biomedical sciences and applications. 2000 Oct; 748(1):125-35. doi: 10.1016/s0378-4347(00)00270-x. [PMID: 11092592]
  • H H Maurer, T Kraemer, O Ledvinka, C J Schmitt, A A Weber. Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) in toxicological analysis. Studies on the detection of clobenzorex and its metabolites within a systematic toxicological analysis procedure by GC-MS and by immunoassay and studies on the detection of alpha- and beta-amanitin in urine by atmospheric pressure ionization electrospray LC-MS. Journal of chromatography. B, Biomedical sciences and applications. 1997 Feb; 689(1):81-9. doi: 10.1016/s0378-4347(96)00348-9. [PMID: 9061484]
  • V Raghavan. Gene activity during germination of spores of the fern, Onoclea sensibilis. Cell-free translation analysis of mRNA of spores and the effect of alpha-amanitin on spore germination. Journal of plant physiology. 1992; 140(4):434-40. doi: 10.1016/s0176-1617(11)80821-7. [PMID: 11538173]
  • H Faulstich, K Kirchner, M Derenzini. Strongly enhanced toxicity of the mushroom toxin alpha-amanitin by an amatoxin-specific Fab or monoclonal antibody. Toxicon : official journal of the International Society on Toxinology. 1988; 26(5):491-9. doi: 10.1016/0041-0101(88)90188-2. [PMID: 3188055]
  • F Jehl, C Gallion, P Birckel, A Jaeger, F Flesch, R Minck. Determination of alpha-amanitin and beta-amanitin in human biological fluids by high-performance liquid chromatography. Analytical biochemistry. 1985 Aug; 149(1):35-42. doi: 10.1016/0003-2697(85)90474-9. [PMID: 4073484]
  • O O Barriga. Depression of cell-mediated immunity following inoculation of Trichinella spiralis extract in the mouse. Immunology. 1978 Jan; 34(1):167-73. doi: NULL. [PMID: 23994]