Bepafant (BioDeep_00000176603)
human metabolite blood metabolite
代谢物信息卡片
9-(2-chlorophenyl)-3-methyl-13-(morpholine-4-carbonyl)-16-thia-2,4,5,8-tetraazatetracyclo[8.6.0.0^{2,6}.0^{11,15}]hexadeca-1(10),3,5,8,11(15)-pentaene
化学式: C23H22ClN5O2S (467.1183)
中文名称: 贝帕泛
谱图信息:
最多检出来源 Mus musculus(not specific) 5.41%
分子结构信息
SMILES: CC1=NN=C2CN=C(C3=C(SC4=C3CC(C4)C(=O)N3CCOCC3)N12)C1=CC=CC=C1Cl
InChI: InChI=1S/C23H22ClN5O2S/c1-13-26-27-19-12-25-21(15-4-2-3-5-17(15)24)20-16-10-14(11-18(16)32-23(20)29(13)19)22(30)28-6-8-31-9-7-28/h2-5,14H,6-12H2,1H3
描述信息
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
同义名列表
3 个代谢物同义名
9-(2-chlorophenyl)-3-methyl-13-(morpholine-4-carbonyl)-16-thia-2,4,5,8-tetraazatetracyclo[8.6.0.0^{2,6}.0^{11,15}]hexadeca-1(10),3,5,8,11(15)-pentaene; 6-(2-Chlorophenyl)-8,9-dihydro-1-methyl-8-(4-morpholinylcarbonyl)-4H,7H-cyclopenta(4,5)thieno(3,5-F)(1,2,4)triazolo(4,3-a)(1,4)diazepine; Bepafant
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 65923
- HMDB: HMDB0249083
- ChEMBL: CHEMBL325439
- chemspider: 59331
- CAS: 114776-28-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Matheus Correa-Costa, Vinicius Andrade-Oliveira, Tarcio T Braga, Angela Castoldi, Cristhiane F Aguiar, Clarice S T Origassa, Andrea C D Rodas, Meire I Hiyane, Denise M A C Malheiros, Francisco J O Rios, Sonia Jancar, Niels O S Câmara. Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis.
Laboratory investigation; a journal of technical methods and pathology.
2014 Apr; 94(4):455-66. doi:
10.1038/labinvest.2013.155. [PMID: 24492283] - Chong Chen, Shi-Hai Xia, Hong Chen, Xiao-Hong Li. Therapy for acute pancreatitis with platelet-activating factor receptor antagonists.
World journal of gastroenterology.
2008 Aug; 14(30):4735-8. doi:
10.3748/wjg.14.4735. [PMID: 18720532] - B O Ibe, M F Abdallah, A M Portugal, J U Raj. Platelet-activating factor stimulates ovine foetal pulmonary vascular smooth muscle cell proliferation: role of nuclear factor-kappa B and cyclin-dependent kinases.
Cell proliferation.
2008 Apr; 41(2):208-29. doi:
10.1111/j.1365-2184.2008.00517.x. [PMID: 18336468] - Cândida A L Kassuya, Aline Silvestre, Octávio Menezes-de-Lima, Denise Mollica Marotta, Vera Lúcia G Rehder, João B Calixto. Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor.
European journal of pharmacology.
2006 Sep; 546(1-3):182-8. doi:
10.1016/j.ejphar.2006.07.025. [PMID: 16925995] - Soraya Imon de Oliveira, Patricia Dias Fernandes, João Gustavo P Amarante Mendes, Sonia Jancar. Phagocytosis of apoptotic and necrotic thymocytes is inhibited by PAF-receptor antagonists and affects LPS-induced COX-2 expression in murine macrophages.
Prostaglandins & other lipid mediators.
2006 Jul; 80(1-2):62-73. doi:
10.1016/j.prostaglandins.2006.04.002. [PMID: 16846787] - J Jawień, M Lomnicka, R Korbut, S Chłopicki. The involvement of adhesion molecules and lipid mediators in the adhesion of human platelets to eosinophils.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2005 Dec; 56(4):637-48. doi:
". [PMID: 16391420] - Mary Ellen Hostettler, Pamela E Knapp, Sonia L Carlson. Platelet-activating factor induces cell death in cultured astrocytes and oligodendrocytes: involvement of caspase-3.
Glia.
2002 May; 38(3):228-39. doi:
10.1002/glia.10065. [PMID: 11968060] - L J de Souza, S N Sampietre, R S Assis, C H Knowles, K R Leite, S Jancar, J E Monteiro Cunha, M C Machado. Effect of platelet-activating factor antagonists (BN-52021, WEB-2170, and BB-882) on bacterial translocation in acute pancreatitis.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
2001 Jul; 5(4):364-70. doi:
10.1016/s1091-255x(01)80063-9. [PMID: 11985976] - W L Biffl, K E West, E E Moore, R J Gonzalez, R Carnaggio, P J Offner, C C Silliman. Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C.
Surgical infections.
2001; 2(4):289-93; discussion 294. doi:
10.1089/10962960152813322. [PMID: 12593704] - M Viswanath, C Palmer, R L Roberts. Reduction of hypoxic-ischemic brain swelling in the neonatal rat with PAF antagonist WEB 2170: lack of long-term protection.
Pediatric research.
2000 Jul; 48(1):109-13. doi:
10.1203/00006450-200007000-00019. [PMID: 10879808] - K M Howard, M S Olson. The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats.
The Journal of biological chemistry.
2000 Jun; 275(26):19891-6. doi:
10.1074/jbc.m001462200. [PMID: 10748027] - S L Rocha, V S Frutuoso, G B Domont, M A Martins, H Moussatché, J Perales. Inhibition of the hyperalgesic activity of Bothrops jararaca venom by an antibothropic fraction isolated from opossum (Didelphis marsupialis) serum.
Toxicon : official journal of the International Society on Toxinology.
2000 Jun; 38(6):875-80. doi:
10.1016/s0041-0101(99)00190-7. [PMID: 10695972] - S B Mustafa, B D Flickinger, M S Olson. Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat Kupffer cells.
Hepatology (Baltimore, Md.).
1999 Nov; 30(5):1206-14. doi:
10.1002/hep.510300530. [PMID: 10534342] - R Olszanecki, S Chłopicki. Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
1999 Sep; 50(3):443-54. doi:
. [PMID: 10574473] - A A Steil, W Tavares de Lima, S Jancar. Modulation by lipid mediators of immune complex-induced lung inflammation in mice.
European journal of pharmacology.
1998 Nov; 361(1):93-9. doi:
10.1016/s0014-2999(98)00680-3. [PMID: 9851546] - W Tavares de Lima, A A Steil, M Russo, N Starobinas, C F Teixeira, S Jancar. Lipid mediators, tumor necrosis factor and nitric oxide and their interactions in immune-complex-induced lung injury.
European journal of pharmacology.
1998 Sep; 358(1):69-75. doi:
10.1016/s0014-2999(98)00594-9. [PMID: 9809871] - C C Silliman, N F Voelkel, J D Allard, D J Elzi, R M Tuder, J L Johnson, D R Ambruso. Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model.
The Journal of clinical investigation.
1998 Apr; 101(7):1458-67. doi:
10.1172/jci1841. [PMID: 9525989] - T Jocks, J Freudenberg, G Zahner, R A Stahl. Platelet-activating factor mediates monocyte chemoattractant protein-1 expression in glomerular immune injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
1998 Jan; 13(1):37-43. doi:
10.1093/ndt/13.1.37. [PMID: 9481713] - A J Ammit, C O'Neill. Studies of the nature of the binding by albumin of platelet-activating factor released from cells.
The Journal of biological chemistry.
1997 Jul; 272(30):18772-8. doi:
10.1074/jbc.272.30.18772. [PMID: 9228051] - A C Savoy, D M Lupan, P B Manalo, J S Roberts, A M Schlageter, L C Weinhold, T R Kozel. Acute lethal toxicity following passive immunization for treatment of murine cryptococcosis.
Infection and immunity.
1997 May; 65(5):1800-7. doi:
10.1128/iai.65.5.1800-1807.1997. [PMID: 9125564] - M G Ferreira, M C Fonteles. Different classes of PAF-antagonists block norepinephrine-induced vascular escape and tachyphylaxis in the isolated rabbit kidney.
Research communications in molecular pathology and pharmacology.
1996 Nov; 94(2):147-55. doi:
NULL. [PMID: 8987112] - P Yu, G Xiao, W Fu. [A study on changes and its mechanisms of intestinal mucosal permeability after severe burn].
Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns.
1996 Sep; 12(5):372-5. doi:
NULL. [PMID: 9387456] - C C Silliman, W O Dickey, A J Paterson, G W Thurman, K L Clay, C A Johnson, D R Ambruso. Analysis of the priming activity of lipids generated during routine storage of platelet concentrates.
Transfusion.
1996 Feb; 36(2):133-9. doi:
10.1046/j.1537-2995.1996.36296181925.x. [PMID: 8614963] - F Bussolino, M Arese, G Montrucchio, L Barra, L Primo, R Benelli, F Sanavio, M Aglietta, D Ghigo, M R Rola-Pleszczynski. Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis.
The Journal of clinical investigation.
1995 Aug; 96(2):940-52. doi:
10.1172/jci118142. [PMID: 7543496] - D A Lepore, K R Knight, A G Stewart, M Riccio, W A Morrison. Platelet-activating factor (PAF) receptor antagonism by WEB 2170 improves the survival of ischaemic skeletal muscle.
Annals of the Academy of Medicine, Singapore.
1995 Jul; 24(4 Suppl):63-7. doi:
". [PMID: 8572529] - S Jancar, E E Abdo, S N Sampietre, F H Kwasniewski, A M Coelho, A Bonizzia, M C Machado. Effect of PAF antagonists on cerulein-induced pancreatitis.
Journal of lipid mediators and cell signalling.
1995 Jan; 11(1):41-9. doi:
10.1016/0929-7855(94)00026-9. [PMID: 7537159] - F Thaiss, M J Mihatsch, G Oberle, U Haberstroh, H M Brecht, R A Stahl. Platelet-activating factor receptor antagonist improves renal function and glomerular lesions in renal ablation.
The Journal of laboratory and clinical medicine.
1994 Dec; 124(6):775-81. doi:
NULL. [PMID: 7798789] - C C Silliman, K L Clay, G W Thurman, C A Johnson, D R Ambruso. Partial characterization of lipids that develop during the routine storage of blood and prime the neutrophil NADPH oxidase.
The Journal of laboratory and clinical medicine.
1994 Nov; 124(5):684-94. doi:
NULL. [PMID: 7964126] - F Zhang, K Decker. Platelet-activating factor antagonists suppress the generation of tumor necrosis factor-alpha and superoxide induced by lipopolysaccharide or phorbol ester in rat liver macrophages.
European cytokine network.
1994 May; 5(3):311-7. doi:
NULL. [PMID: 7948767] - C F Teixeira, Y Cury, S Oga, S Jancar. Hyperalgesia induced by Bothrops jararaca venom in rats: role of eicosanoids and platelet activating factor (PAF).
Toxicon : official journal of the International Society on Toxinology.
1994 Apr; 32(4):419-26. doi:
10.1016/0041-0101(94)90293-3. [PMID: 8052996] - C J Watson, R Luddington, D G St John Collier, R Y Calne, S M Metcalfe. The platelet-activating factor antagonist WEB 2170. Its beneficial effect on dog renal allograft survival.
Transplantation.
1993 Oct; 56(4):1047-9. doi:
10.1097/00007890-199310000-00047. [PMID: 8212192] - D B Buxton, O Halvorsen, W Zhou, M S Olson. Glycogenolytic and haemodynamic responses to bovine serum albumin in isolated perfused livers from sensitized rats.
The Biochemical journal.
1993 May; 292 ( Pt 1)(?):253-9. doi:
10.1042/bj2920253. [PMID: 8503854] - C C Silliman, C A Johnson, K L Clay, G W Thurman, D R Ambruso. Compounds biologically similar to platelet activating factor are present in stored blood components.
Lipids.
1993 May; 28(5):415-8. doi:
10.1007/bf02535939. [PMID: 8316049] - G Montrucchio, G Alloatti, F Mariano, E Lupia, P G Lucchina, E Musso, G Emanuelli, G Camussi. Role of platelet-activating factor in hypotension and platelet activation induced by infusion of thrombolytic agents in rabbits.
Circulation research.
1993 Mar; 72(3):658-70. doi:
10.1161/01.res.72.3.658. [PMID: 8381725] - A Räisänen, A Mennander, J Ustinov, T Paavonen, P Häyry. Effect of platelet-activating factor (PAF) receptor blockers on smooth muscle cell replication in vitro and allograft arteriosclerosis in vivo.
Transplant international : official journal of the European Society for Organ Transplantation.
1993; 6(5):251-7. doi:
10.1007/bf00336023. [PMID: 8216700] - W Zhou, W Chao, B A Levine, M S Olson. Role of platelet-activating factor in hepatic responses after bile duct ligation in rats.
The American journal of physiology.
1992 Nov; 263(5 Pt 1):G587-92. doi:
10.1152/ajpgi.1992.263.5.g587. [PMID: 1443133] - W Zhou, M O McCollum, B A Levine, M S Olson. Inflammation and platelet-activating factor production during hepatic ischemia/reperfusion.
Hepatology (Baltimore, Md.).
1992 Nov; 16(5):1236-40. doi:
10.1002/hep.1840160521. [PMID: 1427662] - S Ono, J Y Westcott, N F Voelkel. PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats.
Journal of applied physiology (Bethesda, Md. : 1985).
1992 Sep; 73(3):1084-92. doi:
10.1152/jappl.1992.73.3.1084. [PMID: 1400021] - G Kleber, A Braillon, C Gaudin, B Champigneulle, S Cailmail, D Lebrec. Hemodynamic effects of endotoxin and platelet activating factor in cirrhotic rats.
Gastroenterology.
1992 Jul; 103(1):282-8. doi:
10.1016/0016-5085(92)91124-m. [PMID: 1612334] - K Ikegami, C J Meade, H O Heuer, F Birke. Hetrazepine PAF antagonists.
Journal of lipid mediators.
1992 Jun; 5(2):177-82. doi:
". [PMID: 1326346] - W Zhou, M O McCollum, B A Levine, M S Olson. Role of platelet-activating factor in pancreatitis-associated acute lung injury in the rat.
The American journal of pathology.
1992 Apr; 140(4):971-9. doi:
. [PMID: 1562055] - X L Ma, A S Weyrich, S Krantz, A M Lefer. Mechanisms of the cardioprotective actions of WEB-2170, bepafant, a platelet activating factor antagonist, in myocardial ischemia and reperfusion.
The Journal of pharmacology and experimental therapeutics.
1992 Mar; 260(3):1229-36. doi:
NULL. [PMID: 1545390] - C C Silliman, G W Thurman, D R Ambruso. Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor.
Vox sanguinis.
1992; 63(2):133-6. doi:
10.1111/j.1423-0410.1992.tb02500.x. [PMID: 1332255] - C Z Amorim, M G Henriques, V B Weg, R S Cordeiro, B B Vargaftig. Effect of PAF-acether antagonists on active anaphylactic mouse paw edema.
Lipids.
1991 Dec; 26(12):1396-9. doi:
10.1007/bf02536574. [PMID: 1668123] - S Ono, N F Voelkel. PAF antagonists inhibit monocrotaline-induced lung injury and pulmonary hypertension.
Journal of applied physiology (Bethesda, Md. : 1985).
1991 Dec; 71(6):2483-92. doi:
10.1152/jappl.1991.71.6.2483. [PMID: 1838107] - G Lueddeckens, K Becker, R Rappold, W Förster. Influence of aminophylline and ketotifen in comparison to the lipoxygenase inhibitors NDGA and esculetin and the PAF antagonists WEB 2170 [correction of 2107] and BN 52021 on endothelin-1 induced vaso- and bronchoconstriction.
Prostaglandins, leukotrienes, and essential fatty acids.
1991 Nov; 44(3):155-8. doi:
10.1016/0952-3278(91)90050-f. [PMID: 1808625] - A Ernst, H O Heuer. PAF receptor antagonists influence asphyxia-induced changes of the inner ear.
Journal of lipid mediators.
1991 Nov; 4(3):327-32. doi:
". [PMID: 1662548] - J M Pitman, G W Thurman, B O Anderson, L L Ketch, C E Hartford, A H Harken, D R Ambruso. WEB2170, a specific platelet-activating factor antagonist, attenuates neutrophil priming by human serum after clinical burn injury: the 1991 Moyer Award.
The Journal of burn care & rehabilitation.
1991 Sep; 12(5):411-9. doi:
10.1097/00004630-199109000-00004. [PMID: 1661287] - S M Metcalfe, C J Watson, D G Collier, M DaCosta, P J Friend, S G Pollard, R Luddington, R Y Calne. Survival of renal allografted dogs after limited therapy with cyclosporine and the PAF antagonist WEB 2170.
Transplantation proceedings.
1991 Aug; 23(4):2219-20. doi:
NULL. [PMID: 1871852] - R A Stahl, F Thaiss, G Oberle, H M Brecht, W Schoeppe, U Wenzel, U M Helmchen. The platelet activating factor receptor antagonist WEB 2170 improves glomerular hemodynamics and morphology in a proliferative model of mesangial cell injury.
Journal of the American Society of Nephrology : JASN.
1991 Jul; 2(1):37-44. doi:
10.1681/asn.v2137. [PMID: 1655092] - H O Heuer. WEB 2347: pharmacology of a new very potent and long acting hetrazepinoic PAF-antagonist and its action in repeatedly sensitized guinea-pigs.
Journal of lipid mediators.
1991 Jul; 4(1):39-44. doi:
". [PMID: 1893086] - E A Seeds, A J Coyle, C P Page. The effect of the selective PAF antagonist WEB 2170 on PAF and antigen induced airway hyperresponsiveness and eosinophil infiltration.
Journal of lipid mediators.
1991 Jul; 4(1):111-21. doi:
". [PMID: 1893085] - B O Anderson, R S Poggetti, P F Shanley, D D Bensard, J M Pitman, D W Nelson, G J Whitman, A Banerjee, A H Harken. Primed neutrophils injure rat lung through a platelet-activating factor-dependent mechanism.
The Journal of surgical research.
1991 May; 50(5):510-4. doi:
10.1016/0022-4804(91)90033-i. [PMID: 1710005] - J Yoo, D Schlondorff, J Neugarten. Protective effects of specific platelet-activating factor receptor antagonists in experimental glomerulonephritis.
The Journal of pharmacology and experimental therapeutics.
1991 Mar; 256(3):841-4. doi:
NULL. [PMID: 2005583] - W G Zhou, W Chao, B A Levine, M S Olson. Evidence for platelet-activating factor as a late-phase mediator of chronic pancreatitis in the rat.
The American journal of pathology.
1990 Dec; 137(6):1501-8. doi:
. [PMID: 1701964] - G Conyers, L Milks, M Conklyn, H Showell, E Cramer. A factor in serum lowers resistance and opens tight junctions of MDCK cells.
The American journal of physiology.
1990 Oct; 259(4 Pt 1):C577-85. doi:
10.1152/ajpcell.1990.259.4.c577. [PMID: 2221039] - S Fernández-Gallardo, M P Ortega, J G Priego, M F de Casa-Juana, C Sunkel, M Sánchez Crespo. Pharmacological actions of PCA 4248, a new platelet-activating factor receptor antagonist: in vivo studies.
The Journal of pharmacology and experimental therapeutics.
1990 Oct; 255(1):34-9. doi:
NULL. [PMID: 2170626]
