Bepafant (BioDeep_00000176603)
human metabolite blood metabolite
代谢物信息卡片
9-(2-chlorophenyl)-3-methyl-13-(morpholine-4-carbonyl)-16-thia-2,4,5,8-tetraazatetracyclo[8.6.0.0^{2,6}.0^{11,15}]hexadeca-1(10),3,5,8,11(15)-pentaene
化学式: C23H22ClN5O2S (467.11826620000005)
中文名称: 贝帕泛
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NN=C2CN=C(C3=C(SC4=C3CC(C4)C(=O)N3CCOCC3)N12)C1=CC=CC=C1Cl
InChI: InChI=1S/C23H22ClN5O2S/c1-13-26-27-19-12-25-21(15-4-2-3-5-17(15)24)20-16-10-14(11-18(16)32-23(20)29(13)19)22(30)28-6-8-31-9-7-28/h2-5,14H,6-12H2,1H3
描述信息
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
同义名列表
3 个代谢物同义名
9-(2-chlorophenyl)-3-methyl-13-(morpholine-4-carbonyl)-16-thia-2,4,5,8-tetraazatetracyclo[8.6.0.0^{2,6}.0^{11,15}]hexadeca-1(10),3,5,8,11(15)-pentaene; 6-(2-Chlorophenyl)-8,9-dihydro-1-methyl-8-(4-morpholinylcarbonyl)-4H,7H-cyclopenta(4,5)thieno(3,5-F)(1,2,4)triazolo(4,3-a)(1,4)diazepine; Bepafant
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 65923
- HMDB: HMDB0249083
- ChEMBL: CHEMBL325439
- chemspider: 59331
- CAS: 114776-28-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Matheus Correa-Costa, Vinicius Andrade-Oliveira, Tarcio T Braga, Angela Castoldi, Cristhiane F Aguiar, Clarice S T Origassa, Andrea C D Rodas, Meire I Hiyane, Denise M A C Malheiros, Francisco J O Rios, Sonia Jancar, Niels O S Câmara. Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis.
Laboratory investigation; a journal of technical methods and pathology.
2014 Apr; 94(4):455-66. doi:
10.1038/labinvest.2013.155. [PMID: 24492283] - Chong Chen, Shi-Hai Xia, Hong Chen, Xiao-Hong Li. Therapy for acute pancreatitis with platelet-activating factor receptor antagonists.
World journal of gastroenterology.
2008 Aug; 14(30):4735-8. doi:
10.3748/wjg.14.4735. [PMID: 18720532] - B O Ibe, M F Abdallah, A M Portugal, J U Raj. Platelet-activating factor stimulates ovine foetal pulmonary vascular smooth muscle cell proliferation: role of nuclear factor-kappa B and cyclin-dependent kinases.
Cell proliferation.
2008 Apr; 41(2):208-29. doi:
10.1111/j.1365-2184.2008.00517.x. [PMID: 18336468] - Cândida A L Kassuya, Aline Silvestre, Octávio Menezes-de-Lima, Denise Mollica Marotta, Vera Lúcia G Rehder, João B Calixto. Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor.
European journal of pharmacology.
2006 Sep; 546(1-3):182-8. doi:
10.1016/j.ejphar.2006.07.025. [PMID: 16925995] - Soraya Imon de Oliveira, Patricia Dias Fernandes, João Gustavo P Amarante Mendes, Sonia Jancar. Phagocytosis of apoptotic and necrotic thymocytes is inhibited by PAF-receptor antagonists and affects LPS-induced COX-2 expression in murine macrophages.
Prostaglandins & other lipid mediators.
2006 Jul; 80(1-2):62-73. doi:
10.1016/j.prostaglandins.2006.04.002. [PMID: 16846787] - J Jawień, M Lomnicka, R Korbut, S Chłopicki. The involvement of adhesion molecules and lipid mediators in the adhesion of human platelets to eosinophils.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2005 Dec; 56(4):637-48. doi:
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Glia.
2002 May; 38(3):228-39. doi:
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Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
2001 Jul; 5(4):364-70. doi:
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Pediatric research.
2000 Jul; 48(1):109-13. doi:
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The Journal of biological chemistry.
2000 Jun; 275(26):19891-6. doi:
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2000 Jun; 38(6):875-80. doi:
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Hepatology (Baltimore, Md.).
1999 Nov; 30(5):1206-14. doi:
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Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
1999 Sep; 50(3):443-54. doi:
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European journal of pharmacology.
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1998 Sep; 358(1):69-75. doi:
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The Journal of clinical investigation.
1998 Apr; 101(7):1458-67. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
1998 Jan; 13(1):37-43. doi:
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The Journal of biological chemistry.
1997 Jul; 272(30):18772-8. doi:
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Infection and immunity.
1997 May; 65(5):1800-7. doi:
10.1128/iai.65.5.1800-1807.1997. [PMID: 9125564] - M G Ferreira, M C Fonteles. Different classes of PAF-antagonists block norepinephrine-induced vascular escape and tachyphylaxis in the isolated rabbit kidney.
Research communications in molecular pathology and pharmacology.
1996 Nov; 94(2):147-55. doi:
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1996 Sep; 12(5):372-5. doi:
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Transfusion.
1996 Feb; 36(2):133-9. doi:
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The Journal of clinical investigation.
1995 Aug; 96(2):940-52. doi:
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Annals of the Academy of Medicine, Singapore.
1995 Jul; 24(4 Suppl):63-7. doi:
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Journal of lipid mediators and cell signalling.
1995 Jan; 11(1):41-9. doi:
10.1016/0929-7855(94)00026-9. [PMID: 7537159] - F Thaiss, M J Mihatsch, G Oberle, U Haberstroh, H M Brecht, R A Stahl. Platelet-activating factor receptor antagonist improves renal function and glomerular lesions in renal ablation.
The Journal of laboratory and clinical medicine.
1994 Dec; 124(6):775-81. doi:
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The Journal of laboratory and clinical medicine.
1994 Nov; 124(5):684-94. doi:
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European cytokine network.
1994 May; 5(3):311-7. doi:
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Toxicon : official journal of the International Society on Toxinology.
1994 Apr; 32(4):419-26. doi:
10.1016/0041-0101(94)90293-3. [PMID: 8052996] - C J Watson, R Luddington, D G St John Collier, R Y Calne, S M Metcalfe. The platelet-activating factor antagonist WEB 2170. Its beneficial effect on dog renal allograft survival.
Transplantation.
1993 Oct; 56(4):1047-9. doi:
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The Biochemical journal.
1993 May; 292 ( Pt 1)(?):253-9. doi:
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Lipids.
1993 May; 28(5):415-8. doi:
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Circulation research.
1993 Mar; 72(3):658-70. doi:
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Transplant international : official journal of the European Society for Organ Transplantation.
1993; 6(5):251-7. doi:
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The American journal of physiology.
1992 Nov; 263(5 Pt 1):G587-92. doi:
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Hepatology (Baltimore, Md.).
1992 Nov; 16(5):1236-40. doi:
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1992 Sep; 73(3):1084-92. doi:
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Gastroenterology.
1992 Jul; 103(1):282-8. doi:
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Journal of lipid mediators.
1992 Jun; 5(2):177-82. doi:
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The American journal of pathology.
1992 Apr; 140(4):971-9. doi:
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The Journal of pharmacology and experimental therapeutics.
1992 Mar; 260(3):1229-36. doi:
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Vox sanguinis.
1992; 63(2):133-6. doi:
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Lipids.
1991 Dec; 26(12):1396-9. doi:
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1991 Dec; 71(6):2483-92. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
1991 Nov; 44(3):155-8. doi:
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Journal of lipid mediators.
1991 Nov; 4(3):327-32. doi:
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The Journal of burn care & rehabilitation.
1991 Sep; 12(5):411-9. doi:
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Transplantation proceedings.
1991 Aug; 23(4):2219-20. doi:
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Journal of the American Society of Nephrology : JASN.
1991 Jul; 2(1):37-44. doi:
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Journal of lipid mediators.
1991 Jul; 4(1):39-44. doi:
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The Journal of surgical research.
1991 May; 50(5):510-4. doi:
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The Journal of pharmacology and experimental therapeutics.
1991 Mar; 256(3):841-4. doi:
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The American journal of pathology.
1990 Dec; 137(6):1501-8. doi:
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1990 Oct; 255(1):34-9. doi:
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