Benzylpenicilloyl G (BioDeep_00000176602)

   

human metabolite blood metabolite


代谢物信息卡片


2-{[(5-carboxypentyl)-C-hydroxycarbonimidoyl][(1-hydroxy-2-phenylethylidene)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylate

化学式: C22H31N3O6S (465.19334660000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C(NC(S1)C(C(=O)NCCCCCC(=O)O)NC(=O)CC2=CC=CC=C2)C(=O)O)C
InChI: InChI=1S/C22H31N3O6S/c1-22(2)18(21(30)31)25-20(32-22)17(19(29)23-12-8-4-7-11-16(27)28)24-15(26)13-14-9-5-3-6-10-14/h3,5-6,9-10,17-18,20,25H,4,7-8,11-13H2,1-2H3,(H,23,29)(H,24,26)(H,27,28)(H,30,31)

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams

同义名列表

4 个代谢物同义名

2-{[(5-carboxypentyl)-C-hydroxycarbonimidoyl][(1-hydroxy-2-phenylethylidene)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylate; 2-{[(5-carboxypentyl)carbamoyl](2-phenylacetamido)methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid; Benzylpenicilloyl G; pre-pen



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Donald MacGlashan. Two regions of down-regulation in the IgE-mediated signaling pathway in human basophils. Journal of immunology (Baltimore, Md. : 1950). 2003 May; 170(10):4914-25. doi: 10.4049/jimmunol.170.10.4914. [PMID: 12734334]
  • D L Auci, G I Kleiner, S M Chice, T J Athanassiades, P Dukor, H G Durkin. Control of IgE responses. V. Oral administration of a synthetic derivative of the inner bacterial cell wall (SDZ 280.636) to sensitized mice induces isotype specific suppression of peak hapten specific IgE antibody forming cell responses, serum IgE levels and immediate hypersensitivity responses. Immunological investigations. 1998 Jan; 27(1-2):105-20. doi: 10.3109/08820139809070894. [PMID: 9561922]
  • S Kimura, M Nagata, M Takeuchi, K Takano, M Harada. Anti-granulocyte antibody suppression of active and passive anaphylactic shock in WBB6F1-W/Wv mice. Cellular and molecular life sciences : CMLS. 1997 Aug; 53(8):663-6. doi: 10.1007/s000180050085. [PMID: 9351469]
  • C Brander, D Mauri-Hellweg, F Bettens, H Rolli, M Goldman, W J Pichler. Heterogeneous T cell responses to beta-lactam-modified self-structures are observed in penicillin-allergic individuals. Journal of immunology (Baltimore, Md. : 1950). 1995 Sep; 155(5):2670-8. doi: . [PMID: 7650395]
  • J Rocha, J Bohner, J Kömpf. Transient bisalbuminemia: separation by isoelectric focusing of human albumin fractions linked to different numbers of benzylpenicilloyl groups. Electrophoresis. 1995 Jun; 16(6):1031-3. doi: 10.1002/elps.11501601174. [PMID: 7498126]
  • D L Auci, H Miller, S M Chice, H G Durkin. IL-6 mediated isotype specific suppression of hapten specific IgE in serum of BPO-KLH sensitized mice: role of IFN alpha in maintainance of hapten specific IgE responses. Immunological investigations. 1994 Apr; 23(3):213-21. doi: 10.3109/08820139409087801. [PMID: 8070849]
  • Z M Wen, S T Ye. Skin testing in patients with high risk of anaphylactic reactions to penicillin. Asian Pacific journal of allergy and immunology. 1993 Jun; 11(1):13-8. doi: NULL. [PMID: 8216554]
  • D W MacGlashan. Releasability of human basophils: cellular sensitivity and maximal histamine release are independent variables. The Journal of allergy and clinical immunology. 1993 Feb; 91(2):605-15. doi: 10.1016/0091-6749(93)90266-i. [PMID: 7679683]
  • D L Auci, J A Carucci, S M Chice, M C Smith, P Dukor, H G Durkin. Control of IgE responses. 4. Isotype-specific suppression of peak BPO-specific IgE antibody-forming cell responses and of BPO-specific IgE in serum by muramyldipeptide or murabutide after administration to mice by gavage. International archives of allergy and immunology. 1993; 101(2):167-76. doi: 10.1159/000236515. [PMID: 8508053]
  • M Yvon, J M Wal. Tandem immunoaffinity and reversed-phase high-performance liquid chromatography for the identification of the specific binding sites of a hapten on a proteic carrier. Journal of chromatography. 1991 Feb; 539(2):363-71. doi: 10.1016/s0021-9673(01)83945-5. [PMID: 2045448]
  • M Yvon, P Anglade, J M Wal. Identification of the binding sites of benzyl penicilloyl, the allergenic metabolite of penicillin, on the serum albumin molecule. FEBS letters. 1990 Apr; 263(2):237-40. doi: 10.1016/0014-5793(90)81382-x. [PMID: 2335227]
  • M Yvon, P Anglade, J M Wal. Binding of benzyl penicilloyl to human serum albumin. Evidence for a highly reactive region at the junction of domains 1 and 2 of the albumin molecule. FEBS letters. 1989 Apr; 247(2):273-8. doi: 10.1016/0014-5793(89)81351-1. [PMID: 2497032]
  • M Harada, M Nagata, M Takeuchi. Production of passive cutaneous anaphylaxis (PCA) and reversed PCA by rat IgE antibody in the mouse. Experientia. 1988 May; 44(5):459-62. doi: 10.1007/bf01940548. [PMID: 3131155]
  • I F Lüscher, A De Weck, C Gitler. A 3 beta-cholestanyl-containing mono-benzylpenicilloyl oligoamide and peptide suppress anti-benzylpenicilloyl antibody formation in mice. European journal of immunology. 1985 Mar; 15(3):243-50. doi: 10.1002/eji.1830150307. [PMID: 3979422]
  • P A Greenberger, J P Phair. Treatment of venereal disease in the penicillin-allergic patient: administration of penicillin following testing with major and minor determinants. New England and regional allergy proceedings. 1985; 6(2):166-9. doi: 10.2500/108854185779045242. [PMID: 3870499]
  • D MacGlashan, L M Lichtenstein. Studies of antigen binding on human basophils. I. Antigen binding and functional consequences. Journal of immunology (Baltimore, Md. : 1950). 1983 May; 130(5):2330-6. doi: NULL. [PMID: 6187850]
  • P C Fox, L K Basciano, R P Siraganian. Mouse mast cell activation and desensitization for immune aggregate-induced histamine release. Journal of immunology (Baltimore, Md. : 1950). 1982 Jul; 129(1):314-9. doi: NULL. [PMID: 6177754]
  • A H Sehon. Suppression of IgE antibody responses with tolerogenic conjugates of allergens and haptens. Progress in allergy. 1982; 32(?):161-202. doi: ". [PMID: 6181520]
  • D W MacGlashan, L M Lichtenstein. The transition from specific to nonspecific desensitization in human basophils. Journal of immunology (Baltimore, Md. : 1950). 1981 Dec; 127(6):2410-4. doi: NULL. [PMID: 6170702]
  • D Kraft, A Berglund, H Rumpold, A Roth, H Ebner. Radioallergosorbent test with conjugates specific for 'minor' haptenic determinants in the diagnosis of IgE-mediated penicillin allergy in man. Clinical allergy. 1981 Nov; 11(6):579-87. doi: 10.1111/j.1365-2222.1981.tb02178.x. [PMID: 6174254]