Benzolamide (BioDeep_00000176559)
human metabolite blood metabolite
代谢物信息卡片
5-[(Phenylsulphonyl)amino]-1,3,4-thiadiazole-2-sulphonamide
化学式: C8H8N4O4S3 (319.9707688)
中文名称: 苯唑拉胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)S(=O)(=O)NC2=NN=C(S2)S(=O)(=O)N
InChI: InChI=1S/C8H8N4O4S3/c9-18(13,14)8-11-10-7(17-8)12-19(15,16)6-4-2-1-3-5-6/h1-5H,(H,10,12)(H2,9,13,14)
描述信息
D004791 - Enzyme Inhibitors > D002257 - Carbonic Anhydrase Inhibitors
C471 - Enzyme Inhibitor > C29577 - Carbonic Anhydrase Inhibitor
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 18794
- HMDB: HMDB0249023
- DrugBank: DB07050
- ChEMBL: CHEMBL73962
- MeSH: Benzolamide
- CAS: 3368-13-6
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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The Journal of neuroscience : the official journal of the Society for Neuroscience.
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Journal of medicinal chemistry.
2009 Feb; 52(3):646-54. doi:
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American journal of physiology. Lung cellular and molecular physiology.
2007 Jan; 292(1):L178-84. doi:
10.1152/ajplung.00205.2006. [PMID: 16936246] - Cynthia M Miracle, Timo Rieg, Roland C Blantz, Volker Vallon, Scott C Thomson. Combined effects of carbonic anhydrase inhibitor and adenosine A1 receptor antagonist on hemodynamic and tubular function in the kidney.
Kidney & blood pressure research.
2007; 30(6):388-99. doi:
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Kidney international.
2004 Dec; 66(6):2348-53. doi:
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Pflugers Archiv : European journal of physiology.
2004 Sep; 448(6):621-8. doi:
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Physiological and biochemical zoology : PBZ.
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2000 Nov; 20(22):8247-53. doi:
10.1523/jneurosci.20-22-08247.2000. [PMID: 11069930] - A Scozzafava, F Briganti, M A Ilies, C T Supuran. Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.
Journal of medicinal chemistry.
2000 Jan; 43(2):292-300. doi:
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The Journal of clinical investigation.
1999 Oct; 104(8):1149-58. doi:
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1998 01; 274(1):F139-47. doi:
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The American journal of physiology.
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The American journal of physiology.
1996 Jun; 270(6 Pt 2):F1004-14. doi:
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The Journal of clinical investigation.
1993 Aug; 92(2):702-9. doi:
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Journal of applied physiology (Bethesda, Md. : 1985).
1993 Feb; 74(2):838-48. doi:
10.1152/jappl.1993.74.2.838. [PMID: 8458804] - G Planelles, F Discala, T Anagnostopoulos. Luminal pH in the amphibian distal tubule: effects of carbonic anhydrase and carbonic anhydrase inhibitors.
The American journal of physiology.
1992 Dec; 263(6 Pt 2):R1254-9. doi:
10.1152/ajpregu.1992.263.6.r1254. [PMID: 1481935] - T H Maren, A Fine, E R Swenson, D Rothman. Renal acid-base physiology in marine teleost, the long-horned sculpin (Myoxocephalus octodecimspinosus).
The American journal of physiology.
1992 Jul; 263(1 Pt 2):F49-55. doi:
10.1152/ajprenal.1992.263.1.f49. [PMID: 1322056] - E R Swenson, K L Leatham, R C Roach, R B Schoene, W J Mills, P H Hackett. Renal carbonic anhydrase inhibition reduces high altitude sleep periodic breathing.
Respiration physiology.
1991 Dec; 86(3):333-43. doi:
10.1016/0034-5687(91)90104-q. [PMID: 1788493] - R P Henry, N J Smatresk, J N Cameron. The distribution of branchial carbonic anhydrase and the effects of gill and erythrocyte carbonic anhydrase inhibition in the channel catfish Ictalurus punctatus.
The Journal of experimental biology.
1988 Jan; 134(?):201-18. doi:
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The American journal of physiology.
1987 Sep; 253(3 Pt 2):R450-8. doi:
10.1152/ajpregu.1987.253.3.r450. [PMID: 3115121] - I Ichikawa, V Kon. Role of peritubular capillary forces in the renal action of carbonic anhydrase inhibitor.
Kidney international.
1986 Dec; 30(6):828-35. doi:
10.1038/ki.1986.262. [PMID: 3820935] - J B Tarloff, P H Brand. Active tetraethylammonium uptake across the basolateral membrane of rabbit proximal tubule.
The American journal of physiology.
1986 Jul; 251(1 Pt 2):F141-9. doi:
10.1152/ajprenal.1986.251.1.f141. [PMID: 3728682] - B J Tucker, C A Mundy, R C Blantz. Can causality be determined from proximal tubular reabsorption and peritubular physical factors?.
The American journal of physiology.
1986 Jan; 250(1 Pt 2):F169-75. doi:
10.1152/ajprenal.1986.250.1.f169. [PMID: 3942222] - A D Kenny. Role of carbonic anhydrase in bone: plasma acetazolamide concentrations associated with inhibition of bone loss.
Pharmacology.
1985; 31(2):97-107. doi:
10.1159/000138104. [PMID: 3927329] - C E Johanson. Differential effects of acetazolamide, benzolamide and systemic acidosis on hydrogen and bicarbonate gradients across the apical and basolateral membranes of the choroid plexus.
The Journal of pharmacology and experimental therapeutics.
1984 Dec; 231(3):502-11. doi:
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The American journal of physiology.
1984 Jul; 247(1 Pt 2):F151-7. doi:
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Kidney international.
1984 May; 25(5):739-46. doi:
10.1038/ki.1984.84. [PMID: 6381854] - J L Gamble, A M Skoff. Bicarbonate concentrations in the renal cortex.
Renal physiology.
1982; 5(4):157-64. doi:
10.1159/000172852. [PMID: 6812181] - M A Hanson, P C Nye, R W Torrance. Studies on the localization of pulmonary carbonic anhydrase in the cat.
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1981; 319(?):93-109. doi:
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Federation proceedings.
1981 Jan; 40(1):104-8. doi:
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1980 Dec; 388(3):211-6. doi:
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1980 Dec; 215(3):673-80. doi:
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1980 Aug; 387(1):69-72. doi:
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1980 Aug; 386(3):239-44. doi:
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1980 May; 213(2):321-31. doi:
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1980 May; 238(5):F372-9. doi:
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1979 Dec; 237(6):F473-8. doi:
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1979 Jun; 15(6):624-9. doi:
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1979 May; 236(5):F494-500. doi:
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1979 Mar; 15(3):227-37. doi:
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1978 Jun; 375(1):39-43. doi:
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1977 Oct; 43(4):582-90. doi:
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