Benziodarone (BioDeep_00000176538)
human metabolite blood metabolite
代谢物信息卡片
化学式: C17H12I2O3 (517.8875942)
中文名称: 本齐奥达隆
谱图信息:
最多检出来源 Homo sapiens(blood) 8.11%
分子结构信息
SMILES: CCC1=C(C(=O)C2=CC(I)=C(O)C(I)=C2)C2=CC=CC=C2O1
InChI: InChI=1S/C17H12I2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3
描述信息
C - Cardiovascular system > C01 - Cardiac therapy > C01D - Vasodilators used in cardiac diseases
D018501 - Antirheumatic Agents > D006074 - Gout Suppressants > D014528 - Uricosuric Agents
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:135814
- PubChem: 6237
- HMDB: HMDB0248996
- DrugBank: DB13277
- ChEMBL: CHEMBL232201
- Wikipedia: Benziodarone
- CAS: 68-90-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - S Barberi, P Menè. [Role of uric acid in hypertension and in the progression of chronic renal disease].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
2006 Jan; 23(1):4-11. doi:
NULL. [PMID: 16521070] - Michael Alderman, Kala J V Aiyer. Uric acid: role in cardiovascular disease and effects of losartan.
Current medical research and opinion.
2004 Mar; 20(3):369-79. doi:
10.1185/030079904125002982. [PMID: 15025846] - Carlos Lafuente Gormaz, Juan C Gallego Page, Francisco Llamas Fuentes. [Pharmacological interaction between flecainide and benziodarone].
Revista espanola de cardiologia.
2003 Jun; 56(6):631-2. doi:
10.1016/s0300-8932(03)76929-2. [PMID: 12783743] - Fernando Perez-Ruiz, Pablo Gomez-Ullate, Juan J Amenabar, Sofía Zarraga, Marcelo Calabozo, Ana M Herrero-Beites, Joan M Nolla. Long-term efficacy of hyperuricaemia treatment in renal transplant patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2003 Mar; 18(3):603-6. doi:
10.1093/ndt/18.3.603. [PMID: 12584286] - Takahiko Nakagawa, Marilda Mazzali, Duk-Hee Kang, John Kanellis, Susumu Watanabe, Laura G Sanchez-Lozada, Bernardo Rodriguez-Iturbe, Jaime Herrera-Acosta, Richard J Johnson. Hyperuricemia causes glomerular hypertrophy in the rat.
American journal of nephrology.
2003 Jan; 23(1):2-7. doi:
10.1159/000066303. [PMID: 12373074] - Duk-Hee Kang, Takahiko Nakagawa, Lili Feng, Susumu Watanabe, Lin Han, Marilda Mazzali, Luan Truong, Raymond Harris, Richard J Johnson. A role for uric acid in the progression of renal disease.
Journal of the American Society of Nephrology : JASN.
2002 Dec; 13(12):2888-97. doi:
10.1097/01.asn.0000034910.58454.fd. [PMID: 12444207] - Marilda Mazzali, John Kanellis, Lin Han, Lili Feng, Yi-Yang Xia, Qiang Chen, Duk-Hee Kang, Katherine L Gordon, Susumu Watanabe, Takahiko Nakagawa, Hui Y Lan, Richard J Johnson. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism.
American journal of physiology. Renal physiology.
2002 Jun; 282(6):F991-7. doi:
10.1152/ajprenal.00283.2001. [PMID: 11997315] - Antonio Franco, Luis Jimenez, Javier Torralba, Elisa Ortega, Miguel Trigueros, Jesus Olivares. Acute uric acid nephropathy by overdosage of benziodarone in a renal transplant recipient.
Nephron.
2002; 92(3):746-7. doi:
10.1159/000064077. [PMID: 12372973] - M Mazzali, J Hughes, Y G Kim, J A Jefferson, D H Kang, K L Gordon, H Y Lan, S Kivlighn, R J Johnson. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.
Hypertension (Dallas, Tex. : 1979).
2001 Nov; 38(5):1101-6. doi:
10.1161/hy1101.092839. [PMID: 11711505] - R Marcén, N Gallego, L Orofino, C Gámez, M R Estepa, J Sabater, J L Teruel, J Ortuño. Impairment of tubular secretion of urate in renal transplant patients on cyclosporine.
Nephron.
1995; 70(3):307-13. doi:
10.1159/000188609. [PMID: 7477618] - A Gumieniczek, L Przyborowski. Thin-layer chromatographic analysis of some benzofuran derivatives in human plasma.
Acta poloniae pharmaceutica.
1994; 51(6):429-32. doi:
. [PMID: 7762396] - R Marcen, N Gallego, C Gamez, L Orofino, J Ortuño. Hyperuricemia after kidney transplantation in patients treated with cyclosporine.
The American journal of medicine.
1992 Sep; 93(3):354-5. doi:
10.1016/0002-9343(92)90251-6. [PMID: 1482484] - M Lindusková, M Vykydal. [The importance of benziodarone in the treatment of gout and hyperuricemic syndrome].
Casopis lekaru ceskych.
1990 Nov; 129(48):1524-5. doi:
NULL. [PMID: 2257602] - S D Moulopoulos, D A Koutras, S Stamatelopoulos, A Souvatzoglou, G D Piperingos, G Philippou. Comparison of the effect of amiodarone and benziodarone on thyroxine metabolism and surface ECG.
Endocrinologia experimentalis.
1989 Dec; 23(4):269-78. doi:
NULL. [PMID: 2620658] - B Xanthopoulos, D A Koutras, M A Boukis, G D Piperingos, J Kitsopanides, A Souvatzoglou, S D Moulopoulos. The effect of benziodarone on the thyroid hormone levels and the pituitary-thyroid axis.
Journal of endocrinological investigation.
1986 Aug; 9(4):337-9. doi:
10.1007/bf03346938. [PMID: 3491129] - A M Brzozowska-Jurkowska. [Effect of benziodarone and benzbromarone on the uric acid level in the blood and urine and on the incidence of gout attacks].
Reumatologia.
1980; 18(3):287-92. doi:
NULL. [PMID: 6999575] - A VITOLO. [Influence of benziodarone on various enzyme activities in vitro].
Bollettino della Societa italiana di biologia sperimentale.
1963 Apr; 39(?):493-5. doi:
NULL. [PMID: 13997523]