Benz(a)anthracene, 9,10-dimethyl- (BioDeep_00000176517)
human metabolite blood metabolite
代谢物信息卡片
Benz(a)anthracene, 9,10-dimethyl-
化学式: C20H16 (256.1252)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CC1=C(C)C=C2C=C3C(C=CC4=CC=CC=C34)=CC2=C1
InChI: InChI=1S/C20H16/c1-13-9-17-11-16-8-7-15-5-3-4-6-19(15)20(16)12-18(17)10-14(13)2/h3-12H,1-2H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Combinatorial chemistry & high throughput screening.
2012 Jun; 15(5):418-26. doi:
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2012 May; 33(3):440-5. doi:
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European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
2012 Mar; 21(2):182-92. doi:
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Chemistry & biodiversity.
2012 Feb; 9(2):428-40. doi:
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Pathology oncology research : POR.
2012 Jan; 18(1):69-77. doi:
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Nutrition and cancer.
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2011 Nov; 63(11):1470-82. doi:
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Journal of dental research.
2011 Oct; 90(10):1246-52. doi:
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Integrative cancer therapies.
2011 Sep; 10(3):289-97. doi:
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Molecular and cellular biochemistry.
2011 Sep; 355(1-2):117-26. doi:
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International journal of oncology.
2011 Sep; 39(3):747-54. doi:
10.3892/ijo.2011.1067. [PMID: 21667019] - Rami Abu Zeinab, Mohamad Mroueh, Mona Diab-Assaf, Abdo Jurjus, Brigitte Wex, Amer Sakr, Costantine F Daher. Chemopreventive effects of wild carrot oil against 7,12-dimethyl benz(a)anthracene-induced squamous cell carcinoma in mice.
Pharmaceutical biology.
2011 Sep; 49(9):955-61. doi:
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Environmental toxicology and pharmacology.
2011 Sep; 32(2):193-200. doi:
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Oncology reports.
2011 Sep; 26(3):731-6. doi:
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2011 Jul; 49(7):1511-20. doi:
10.1016/j.fct.2011.03.040. [PMID: 21443920] - Wei-Hsuan Hsu, Bao-Hong Lee, Tzu-Ming Pan. Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model.
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2011 Jun; 49(6):1292-7. doi:
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Journal of enzyme inhibition and medicinal chemistry.
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2011 Jun; 66(2):107-13. doi:
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European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
2011 May; 20(3):240-7. doi:
10.1097/cej.0b013e3283447410. [PMID: 21317654] - Ferenc Budán, István Szabó, Tímea Varjas, Ghodratollah Nowrasteh, Tamás Dávid, Péter Gergely, Zsuzsa Varga, Kornélia Molnár, Balázs Kádár, Zsuzsa Orsós, István Kiss, István Ember. Mixtures of Uncaria and Tabebuia extracts are potentially chemopreventive in CBA/Ca mice: a long-term experiment.
Phytotherapy research : PTR.
2011 Apr; 25(4):493-500. doi:
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Lipids in health and disease.
2011 Mar; 10(?):40. doi:
10.1186/1476-511x-10-40. [PMID: 21371291] - N Arora, A Koul, M P Bansal. Chemopreventive activity of Azadirachta indica on two-stage skin carcinogenesis in murine model.
Phytotherapy research : PTR.
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Phytotherapy research : PTR.
2011 Feb; 25(2):221-7. doi:
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Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2011 Feb; 32(1):167-77. doi:
10.1007/s13277-010-0110-0. [PMID: 20842472] - Veerasamy Vinothkumar, Shanmugam Manoharan. Chemopreventive efficacy of geraniol against 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.
Redox report : communications in free radical research.
2011; 16(3):91-100. doi:
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2011 01; 3(2):777-87. doi:
10.2741/s186. [PMID: 21196411] - Priyanka Sharma, Jyoti Parmar, Preeti Verma, Pradeep Kumar Goyal. Modulatory influence of Phyllanthus niruri on oxidative stress, antioxidant defense and chemically induced skin tumors.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.
2011; 30(1):43-53. doi:
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Asian Pacific journal of cancer prevention : APJCP.
2011; 12(2):531-5. doi:
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Nutrition and cancer.
2011; 63(3):410-20. doi:
10.1080/01635581.2011.535956. [PMID: 21391126] - Priyanka Arya, Madhu Kumar. Chemoprevention by Triticum Aestivum of mouse skin carcinogenesis induced by DMBA and croton oil - association with oxidative status.
Asian Pacific journal of cancer prevention : APJCP.
2011; 12(1):143-8. doi:
". [PMID: 21517247] - Thekkuttuparambil Ananthanarayanan Ajith, Kainoor Krishnankutty Janardhanan. Phellinus rimosus (Berk.) pilat attenuates 7,12-dimethylbenz[a] anthracene induced and croton oil promoted skin papilloma formation in mice.
Journal of experimental therapeutics & oncology.
2011; 9(3):207-15. doi:
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Asian Pacific journal of cancer prevention : APJCP.
2011; 12(3):665-9. doi:
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Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.
2011; 30(3):251-9. doi:
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Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.
2011; 30(4):283-300. doi:
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2011 Jan; 10(1):16-28. doi:
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African journal of traditional, complementary, and alternative medicines : AJTCAM.
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Chemico-biological interactions.
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Lipids in health and disease.
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Pharmacological reports : PR.
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Pharmacological reports : PR.
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Journal of agricultural and food chemistry.
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Human & experimental toxicology.
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Phytotherapy research : PTR.
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Current cancer drug targets.
2010 May; 10(3):279-86. doi:
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Nutricion hospitalaria.
2010 Mar; 25(2):304-10. doi:
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Cancer prevention research (Philadelphia, Pa.).
2010 Mar; 3(3):359-70. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2010 Mar; 17(3-4):269-73. doi:
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Molecular carcinogenesis.
2010 Mar; 49(3):290-301. doi:
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Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2010 Feb; 35(2):146-51. doi:
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Talanta.
2010 Jan; 80(3):1347-55. doi:
10.1016/j.talanta.2009.09.035. [PMID: 20006098] - Giovanni Nicolao Berta, Paolina Salamone, Andrea Elio Sprio, Federica Di Scipio, Lucy Marcela Marinos, Simona Sapino, Maria Eugenia Carlotti, Roberta Cavalli, Francesco Di Carlo. Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of resveratrol complexed with 2-hydroxypropyl-beta-cyclodextrin.
Oral oncology.
2010 Jan; 46(1):42-8. doi:
10.1016/j.oraloncology.2009.10.007. [PMID: 19932051] - Manish Kumar, Priyadarshi Meena, Shekhar Verma, Madhu Kumar, Ashok Kumar. Anti-tumour, anti-mutagenic and chemomodulatory potential of Chlorophytum borivilianum.
Asian Pacific journal of cancer prevention : APJCP.
2010; 11(2):327-34. doi:
". [PMID: 20843110] - Jyoti Parmar, Priyanka Sharma, Preeti Verma, P K Goyal. Chemopreventive action of Syzygium cumini on DMBA-induced skin papillomagenesis in mice.
Asian Pacific journal of cancer prevention : APJCP.
2010; 11(1):261-5. doi:
". [PMID: 20593968] - R C Agrawal, Tripti Beohar. Chemopreventive and anticarcinogenic effects of Momordica charantia extract.
Asian Pacific journal of cancer prevention : APJCP.
2010; 11(2):371-5. doi:
". [PMID: 20843118] - Jia-Ren Liu, Hong-Wei Dong, Xiang-Rong Sun, Qi Wang, Wen-Guang Sun, John W Parry, Qian Liu, Xiao-Hui Han, Chang-Hao Sun, Bing-Qing Chen, Bao-Feng Yang. Effects of beta-ionone on mammary carcinogenesis and antioxidant status in rats treated with DMBA.
Nutrition and cancer.
2010; 62(1):58-65. doi:
10.1080/01635580903191510. [PMID: 20043260] - Annapurna Agrawal, Preeti Verma, P K Goyal. Chemomodulatory effects of Aegle marmelos against DMBA-induced skin tumorigenesis in Swiss albino mice.
Asian Pacific journal of cancer prevention : APJCP.
2010; 11(5):1311-4. doi:
". [PMID: 21198283] - M Pandi, R Manikandan, J Muthumary. Anticancer activity of fungal taxol derived from Botryodiplodia theobromae Pat., an endophytic fungus, against 7, 12 dimethyl benz(a)anthracene (DMBA)-induced mammary gland carcinogenesis in Sprague Dawley rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2010 Jan; 64(1):48-53. doi:
10.1016/j.biopha.2009.03.001. [PMID: 19762199] - Kausar M Ansari, Mukul Das. Skin tumor promotion by argemone oil/alkaloid in mice: evidence for enhanced cell proliferation, ornithine decarboxylase, cyclooxygenase-2 and activation of MAPK/NF-kappaB pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2010 Jan; 48(1):132-8. doi:
10.1016/j.fct.2009.09.029. [PMID: 19796664] - M Saini, Pradeep Kumar Goyal, Geeta Chaudhary. Anti-tumor activity of Aloe vera against DMBA/croton oil-induced skin papillomagenesis in Swiss albino mice.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.
2010; 29(2):127-35. doi:
10.1615/jenvironpatholtoxicoloncol.v29.i2.60. [PMID: 20932247] - N Krishnakumar, S Manoharan, Pl Rm Palaniappan, P Venkatachalam, M G Arun Manohar. Chemopreventive efficacy of piperine in 7,12-dimethyl benz [a] anthracene (DMBA)-induced hamster buccal pouch carcinogenesis: an FT-IR study.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2009 Nov; 47(11):2813-20. doi:
10.1016/j.fct.2009.08.017. [PMID: 19733613] - T Varjas, G Nowrasteh, F Budán, E Nadasi, G Horváth, S Makai, T Gracza, J Cseh, I Ember. Chemopreventive effect of Panax ginseng.
Phytotherapy research : PTR.
2009 Oct; 23(10):1399-403. doi:
10.1002/ptr.2786. [PMID: 19274701] - Kuppusamy Panjamurthy, Shanmugam Manoharan, Madhavan Ramados Nirmal, Lakshmanan Vellaichamy. Protective role of Withaferin-A on immunoexpression of p53 and bcl-2 in 7,12-dimethylbenz(a)anthracene-induced experimental oral carcinogenesis.
Investigational new drugs.
2009 Oct; 27(5):447-52. doi:
10.1007/s10637-008-9199-z. [PMID: 19009234] - Swafiya Jahan, Ranu Chaudhary, Pradeep Kumar Goyal. Anticancer activity of an Indian medicinal plant, Alstonia scholaris, on skin carcinogenesis in mice.
Integrative cancer therapies.
2009 Sep; 8(3):273-9. doi:
10.1177/1534735409343590. [PMID: 19815597] - G Vinothini, P Manikandan, R Anandan, S Nagini. Chemoprevention of rat mammary carcinogenesis by Azadirachta indica leaf fractions: modulation of hormone status, xenobiotic-metabolizing enzymes, oxidative stress, cell proliferation and apoptosis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2009 Aug; 47(8):1852-63. doi:
10.1016/j.fct.2009.04.045. [PMID: 19427891] - Nabiha Yusuf, Tahseen H Nasti, Sreelatha Meleth, Craig A Elmets. Resveratrol enhances cell-mediated immune response to DMBA through TLR4 and prevents DMBA induced cutaneous carcinogenesis.
Molecular carcinogenesis.
2009 Aug; 48(8):713-23. doi:
10.1002/mc.20517. [PMID: 19142898] - Shanmugam Manoharan, Kuppusamy Panjamurthy, Subramanian Balakrishnan, Kalaiarasan Vasudevan, Lakshmanan Vellaichamy. Circadian time-dependent chemopreventive potential of withaferin-A in 7,12-dimethylbenz[a]anthracene-induced oral carcinogenesis.
Pharmacological reports : PR.
2009 Jul; 61(4):719-26. doi:
10.1016/s1734-1140(09)70125-2. [PMID: 19815955] - R C Agrawal, Rachana Jain, Wasim Raja, M Ovais. Anticarcinogenic effects of Solanum lycopersicum fruit extract on Swiss albino and C57 Bl mice.
Asian Pacific journal of cancer prevention : APJCP.
2009 Jul; 10(3):379-82. doi:
". [PMID: 19640177] - Soumya S Bhattacharyya, Saili Paul, Sushil K Mandal, Antara Banerjee, Naoual Boujedaini, Anisur R Khuda-Bukhsh. A synthetic coumarin (4-methyl-7 hydroxy coumarin) has anti-cancer potentials against DMBA-induced skin cancer in mice.
European journal of pharmacology.
2009 Jul; 614(1-3):128-36. doi:
10.1016/j.ejphar.2009.04.015. [PMID: 19393233] - Prachi Mishra, Anand Kar, Raosaheb K Kale. Prevention of chemically induced mammary tumorigenesis by daidzein in pre-pubertal rats: the role of peroxidative damage and antioxidative enzymes.
Molecular and cellular biochemistry.
2009 May; 325(1-2):149-57. doi:
10.1007/s11010-009-0029-1. [PMID: 19214712] - Zeliha Selamoglu Talas, Ismet Yilmaz, Ilknur Ozdemir, Burhan Ates, Yetkin Gok, Bekir Cetinkaya. Role of synthesized organoselenium compounds on protection of rat erythrocytes from DMBA-induced oxidative stress.
Biological trace element research.
2009 May; 128(2):167-75. doi:
10.1007/s12011-008-8262-0. [PMID: 18974938] - Eun Jeong Choi, Gun-Hee Kim. Hepatoprotective effects of daidzein against 7,12-dimetylbenz[a]anthracene-induced oxidative stress in mice.
International journal of molecular medicine.
2009 May; 23(5):659-64. doi:
10.3892/ijmm_00000177. [PMID: 19360325] - Linsa Mary Alias, Shanmugam Manoharan, Lakshmanan Vellaichamy, Subramanian Balakrishnan, Cinnamanoor Rajamani Ramachandran. Protective effect of ferulic acid on 7,12-dimethylbenz[a]anthracene-induced skin carcinogenesis in Swiss albino mice.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2009 May; 61(3):205-14. doi:
10.1016/j.etp.2008.09.001. [PMID: 18845425] - Wen Fu, Tom McCormick, Xiaoping Qi, Liping Luo, Lingyin Zhou, Xin Li, Bing-Cheng Wang, Heidi E Gibbons, Fadi W Abdul-Karim, George I Gorodeski. Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice.
BMC cancer.
2009 Apr; 9(?):114. doi:
10.1186/1471-2407-9-114. [PMID: 19379509] - Kulbhushan Tikoo, Parveen Kumar, Jeena Gupta. Rosiglitazone synergizes anticancer activity of cisplatin and reduces its nephrotoxicity in 7, 12-dimethyl benz{a}anthracene (DMBA) induced breast cancer rats.
BMC cancer.
2009 Apr; 9(?):107. doi:
10.1186/1471-2407-9-107. [PMID: 19356226] - Ken Yasukawa, Susumu Kitanaka, Kenji Kawata, Kumiko Goto. Anti-tumor promoters phenolics and triterpenoid from Hippophae rhamnoides.
Fitoterapia.
2009 Apr; 80(3):164-7. doi:
10.1016/j.fitote.2009.01.006. [PMID: 19535023] - Ila Das, Tapas Saha. Effect of garlic on lipid peroxidation and antioxidation enzymes in DMBA-induced skin carcinoma.
Nutrition (Burbank, Los Angeles County, Calif.).
2009 Apr; 25(4):459-71. doi:
10.1016/j.nut.2008.10.014. [PMID: 19084378] - Toshio Imai, Shigeaki Takami, Young-Man Cho, Masao Hirose, Akiyoshi Nishikawa. Modifying effects of prepubertal exposure to potassium perchlorate and tetrabromobisphenol A on susceptibility to N-bis(2-hydroxypropyl)nitrosamine- and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in rats.
Toxicology letters.
2009 Mar; 185(3):160-7. doi:
10.1016/j.toxlet.2008.12.013. [PMID: 19152830] - Zeliha Selamoglu Talas, Ilknur Ozdemir, Ismet Yilmaz, Yetkin Gok. Antioxidative effects of novel synthetic organoselenium compound in rat lung and kidney.
Ecotoxicology and environmental safety.
2009 Mar; 72(3):916-21. doi:
10.1016/j.ecoenv.2007.11.012. [PMID: 18222543] - Syed M Meeran, Mudit Vaid, Thejass Punathil, Santosh K Katiyar. Dietary grape seed proanthocyanidins inhibit 12-O-tetradecanoyl phorbol-13-acetate-caused skin tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated mouse skin, which is associated with the inhibition of inflammatory responses.
Carcinogenesis.
2009 Mar; 30(3):520-8. doi:
10.1093/carcin/bgp019. [PMID: 19158151] - S Manoharan, S Balakrishnan, V P Menon, L M Alias, A R Reena. Chemopreventive efficacy of curcumin and piperine during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.
Singapore medical journal.
2009 Feb; 50(2):139-46. doi:
". [PMID: 19296028] - Jia-Ren Liu, Hong-Wei Dong, Bing-Qing Chen, Peng Zhao, Rui Hai Liu. Fresh apples suppress mammary carcinogenesis and proliferative activity and induce apoptosis in mammary tumors of the Sprague-Dawley rat.
Journal of agricultural and food chemistry.
2009 Jan; 57(1):297-304. doi:
10.1021/jf801826w. [PMID: 19072049] - R C Agrawal, Sonam Pandey. Evaluation of anticarcinogenic and antimutagenic potential of Bauhinia variegata extract in Swiss albino mice.
Asian Pacific journal of cancer prevention : APJCP.
2009; 10(5):913-6. doi:
". [PMID: 20104989] - S Manoharan, K Panjamurthy, Venugopal P Menon, S Balakrishnan, Linsa Mary Alias. Protective effect of Withaferin-A on tumour formation in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis in hamsters.
Indian journal of experimental biology.
2009 Jan; 47(1):16-23. doi:
". [PMID: 19317347] - Neil Sidell, Lijuan Hao, Marzia Pasquali, J David McDonald. Carcinogenic effects in a phenylketonuria mouse model.
PloS one.
2009; 4(1):e4292. doi:
10.1371/journal.pone.0004292. [PMID: 19172175]
