BENPERIDOL (BioDeep_00000176513)

   

human metabolite blood metabolite


代谢物信息卡片


1-(4-fluorophenyl)-4-[4-(2-hydroxy-1H-1,3-benzodiazol-1-yl)piperidin-1-yl]butan-1-one

化学式: C22H24FN3O2 (381.1852456)
中文名称: 苯哌利多
谱图信息: 最多检出来源 Homo sapiens(blood) 91.67%

分子结构信息

SMILES: C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
InChI: InChI=1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28)

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AD - Butyrophenone derivatives
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist

同义名列表

14 个代谢物同义名

1-(4-fluorophenyl)-4-[4-(2-hydroxy-1H-1,3-benzodiazol-1-yl)piperidin-1-yl]butan-1-one; Neuraxpharm brand OF benperidol; Benperidol neuraxpharm brand; Janssen brand OF benperidol; Bayer brand OF benperidol; Benperidol janssen brand; Benperidol neuraxpharm; Benperidol bayer brand; Benperidol-neuraxpharm; Benperidolneuraxpharm; BENPERIDOL; Glianimon; Frenactil; Anquil



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Linda Hanssens, Gilbert L'Italien, Jean-Yves Loze, Ronald N Marcus, Miranda Pans, Wendy Kerselaers. The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913). BMC psychiatry. 2008 Dec; 8(?):95. doi: 10.1186/1471-244x-8-95. [PMID: 19102734]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Jo Ann V Antenor-Dorsey, Richard Laforest, Stephen M Moerlein, Tom O Videen, Joel S Perlmutter. Radiation dosimetry of N-([11C]methyl)benperidol as determined by whole-body PET imaging of primates. European journal of nuclear medicine and molecular imaging. 2008 Apr; 35(4):771-8. doi: 10.1007/s00259-007-0644-6. [PMID: 18071701]
  • J S Silvestre, J R Prous. Comparative evaluation of hERG potassium channel blockade by antipsychotics. Methods and findings in experimental and clinical pharmacology. 2007 Sep; 29(7):457-65. doi: 10.1358/mf.2007.29.7.1119172. [PMID: 17982510]
  • H Kirchherr, W N Kühn-Velten. Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Oct; 843(1):100-13. doi: 10.1016/j.jchromb.2006.05.031. [PMID: 16798119]
  • N Bergemann, A Frick, P Parzer, J Kopitz. Olanzapine plasma concentration, average daily dose, and interaction with co-medication in schizophrenic patients. Pharmacopsychiatry. 2004 Mar; 37(2):63-8. doi: 10.1055/s-2004-815527. [PMID: 15048613]
  • R Schlösser, S Schlegel, C Hiemke, O Nickel, A Bockisch, M L Rao, K Hahn. [123I]IBZM SPECT in patients treated with typical and atypical neuroleptics: relationship to drug plasma levels and extrapyramidal side effects. Psychiatry research. 1997 Sep; 75(2):103-14. doi: 10.1016/s0925-4927(97)00044-9. [PMID: 9351492]
  • S Schlegel, R Schlösser, C Hiemke, O Nickel, A Bockisch, K Hahn. Prolactin plasma levels and D2-dopamine receptor occupancy measured with IBZM-SPECT. Psychopharmacology. 1996 Apr; 124(3):285-7. doi: 10.1007/bf02246671. [PMID: 8740053]
  • S Dammers, T Zeit, M Leonhardt, V Schär, M W Agelink. [The neuroleptic malignant syndrome]. Deutsche medizinische Wochenschrift (1946). 1995 Dec; 120(50):1739-42. doi: 10.1055/s-2008-1055536. [PMID: 8542810]
  • W Seiler, H Wetzel, A Hillert, G Schöllnhammer, M Langer, U Barlage, C Hiemke. Pharmacokinetics and bioavailability of benperidol in schizophrenic patients after intravenous and two different kinds of oral application. Psychopharmacology. 1994 Dec; 116(4):457-63. doi: 10.1007/bf02247478. [PMID: 7701049]
  • W Seiler, H Wetzel, A Hillert, G Schöllnhammer, O Benkert, C Hiemke. Plasma levels of benperidol, prolactin, and homovanillic acid after intravenous versus two different kinds of oral application of the neuroleptic in schizophrenic patients. Experimental and clinical endocrinology. 1994; 102(4):326-33. doi: 10.1055/s-0029-1211299. [PMID: 7813605]
  • S Süss, W Seiler, C Hiemke, G Schöllnhammer, H Wetzel, A Hillert. Determination of benperidol and its reduced metabolite in human plasma by high-performance liquid chromatography and electrochemical detection. Journal of chromatography. 1991 Apr; 565(1-2):363-73. doi: 10.1016/0378-4347(91)80397-u. [PMID: 1874880]
  • M Furlanut, A Perosa, P Benetello, G Colombo. Electrochemical detection of benperidol in serum for drug monitoring in humans. Therapeutic drug monitoring. 1987 Sep; 9(3):343-6. doi: 10.1097/00007691-198709000-00015. [PMID: 3672579]
  • J Logan, A P Wolf, C Y Shiue, J S Fowler. Kinetic modeling of receptor-ligand binding applied to positron emission tomographic studies with neuroleptic tracers. Journal of neurochemistry. 1987 Jan; 48(1):73-83. doi: 10.1111/j.1471-4159.1987.tb13129.x. [PMID: 2432176]
  • C D Arnett, C Y Shiue, A P Wolf, J S Fowler, J Logan, M Watanabe. Comparison of three 18F-labeled butyrophenone neuroleptic drugs in the baboon using positron emission tomography. Journal of neurochemistry. 1985 Mar; 44(3):835-44. doi: 10.1111/j.1471-4159.1985.tb12891.x. [PMID: 2579198]
  • R Krüger, I Mengel, H J Kuss. Determination of benperidol in human plasma by high-performance liquid chromatography. Journal of chromatography. 1984 Nov; 311(1):109-16. doi: 10.1016/s0378-4347(00)84696-4. [PMID: 6520151]
  • M P Quaglio, A M Bellini, F Lambardi. Determination of benperidol, droperidol and pimozide in human plasma by GLC. Bollettino chimico farmaceutico. 1982 Jun; 121(6):276-84. doi: NULL. [PMID: 7171394]
  • M A Murray, J H Bancroft, D C Anderson, T G Tennent, P J Carr. Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers. The Journal of endocrinology. 1975 Nov; 67(2):179-88. doi: 10.1677/joe.0.0670179. [PMID: 1107462]
  • G Belvedere, A Frigerio, C Pantarotto. Gas chromatographic-mass fragmentographic determination of trazodone in rat plasma. Journal of chromatography. 1975 Oct; 112(?):631-6. doi: 10.1016/s0021-9673(00)99991-6. [PMID: 1184692]
  • T Tammisto, S Takki, P Nikki, A Jäättelä. Effect of operative stress on plasma catecholamine levels during neuroleptanalgesia. Der Anaesthesist. 1973 Apr; 22(4):158-61. doi: NULL. [PMID: 4705926]
  • W A Cressman, J Plostnieks, P C Johnson. Absorption, metabolism and excretion of droperidol by human subjects following intramuscular and intravenous administration. Anesthesiology. 1973 Apr; 38(4):363-9. doi: 10.1097/00000542-197304000-00010. [PMID: 4707581]
  • W Chachaj, A Cieślińska, K Kuczyńska-Sekieta, M Wrzeszcz. [Effect of dihydrobenzperidol on urinary excretion of 17-hydroxycorticosteroids, 3-methyl-4-hydroxymandelic acid 5-hydroxy-indoleacetic acid and uropepsin in patients with chronic gastric and duodenal ulcer]. Polski tygodnik lekarski (Warsaw, Poland : 1960). 1972 Oct; 27(41):1596-8. doi: NULL. [PMID: 4484874]
  • A D Clarke, M A Tobias, P D Challen. The use of neuroleptanalgesia during surgery for phaeochromocytoma. Reports of two cases. British journal of anaesthesia. 1972 Oct; 44(10):1093-6. doi: 10.1093/bja/44.10.1093. [PMID: 4639830]
  • T Oyama, M Takiguchi, Y Nakai, H Imura. Plasma levels of ACTH and cortisol in man during droperidol-pentazocine anesthesia and surgery. Anesthesia and analgesia. 1972 Sep; 51(5):726-30. doi: NULL. [PMID: 4341717]
  • T Oyama, A Aoki, T Kudo. Effects of droperidol-pentazocine-N 2 O anaesthesia and surgery on human plasma testosterone levels. Der Anaesthesist. 1972 Aug; 21(8):364-5. doi: NULL. [PMID: 5075178]
  • P Rudolph, H Haug, K H Weis. [The influence of halothane anaesthesia and neuroleptanalgesia on various chemical and corpuscular constituents of the blood]. Der Anaesthesist. 1972 Apr; 21(4):177-82. doi: NULL. [PMID: 5031543]
  • R J Trudnowski, J W Mostert, G H Hobika, R Rico. Neuroleptanalgesia for patients with kidney malfunction. Anesthesia and analgesia. 1971 Jul; 50(4):679-84. doi: NULL. [PMID: 4397673]
  • H Hirasawa. [Effects of several anesthetics on blood flow of the renal cortex and medulla--by means of thermoelectrical method]. Masui. The Japanese journal of anesthesiology. 1971 Jun; 20(6):539-48. doi: NULL. [PMID: 4935008]
  • A Hillebrand, C van der Meer, A T Ariëns, M Wijnans. The effect of anesthetics on the occurrence of kidney lesions caused by hypotension. European journal of pharmacology. 1971 May; 14(3):217-37. doi: 10.1016/0014-2999(71)90132-4. [PMID: 5156143]
  • H B Aronson, F Magora, M London. The influence of droperidol on blood viscosity in man. British journal of anaesthesia. 1970 Dec; 42(12):1089-92. doi: 10.1093/bja/42.12.1089. [PMID: 5504450]
  • T Oyama, M Takiguchi. Effects of neuroleptanaesthesia on plasma levels of growth hormone and insulin. British journal of anaesthesia. 1970 Dec; 42(12):1105-12. doi: 10.1093/bja/42.12.1105. [PMID: 5504453]
  • Z Zagrobelny. [Effect of neuroleptoanalgesia, type II (NLA II) on the course of experimental and clinical hyperthyroidism. II. Effects of NLA II on the oxygen metabolism of the brain stem, heart, liver and kidney in experimental hyperthyroidism]. Endokrynologia Polska. 1970 Sep; 21(5):457-68. doi: NULL. [PMID: 5476826]
  • J W Mostert, J L Evers, G H Hobika, R H Moore, G P Murphy. Circulatory effects of analgesic and neuroleptic drugs in patients with chronic renal failure undergoing maintenance dialysis. British journal of anaesthesia. 1970 Jun; 42(6):501-13. doi: 10.1093/bja/42.6.501. [PMID: 5423839]
  • A Gedeon. Droperidol in the management of acute circulatory failure. Arzneimittel-Forschung. 1970 May; 20(5):674-6. doi: NULL. [PMID: 5468055]
  • K Bihler. [Anesthesia induced renal changes and electrolyte excretion]. Der Anaesthesist. 1969 Dec; 18(12):396-400. doi: NULL. [PMID: 5374288]
  • I Pichlmayr. [Liver circulation, cardiac output and other circulatory measurements under the effect of various anesthetics in dogs]. Zeitschrift fur Kreislaufforschung. 1969 Jul; 58(7):759-73. doi: NULL. [PMID: 5811157]
  • H L Zauder, R J Nichols. Intravenous anesthesia. Clinical anesthesia. 1969; 3(?):317-57. doi: NULL. [PMID: 5001180]
  • A De Blasi, L Appiani, A Brienza, A Gasparetto, C Manni, M Maritano, B Mazzarella, V Morpurgo. [Neuroleptoanalgesia]. Minerva anestesiologica. 1968 Aug; 34(8):933-90. doi: NULL. [PMID: 5736580]
  • A Gasparetto, G Barusco, E Tajoli, P Scalella, G C Agostinis. [Metabolic actions induced with noradrenaline in the dog pretreated with narcotataraxic and neuroleptic drugs in current use in anesthesiology]. Acta anaesthesiologica. 1968; 19(?):Suppl 7:13-29. doi: ". [PMID: 5757445]
  • A B Dobkin, A H Giesecke. Urinary epinephrine and norepinephrine during Innovar-nitrous oxide anesthesia. Anesthesiology. 1968 Jan; 29(1):167-9. doi: 10.1097/00000542-196801000-00048. [PMID: 5634562]
  • M Violani, I Piacentini, U Bonomi, G Franchi. [Blood and cerebrospinal fluid concentration and urinary elimination of thiamine used together with the drugs of NLA II]. Acta anaesthesiologica. 1968; 19(?):Suppl 1:125-9. doi: NULL. [PMID: 5761558]
  • L Semino, G Virdis. [Behavior of the hepatic and renal parenchyma and of isolated liver and kidney mitochondria in neuroleptoanalgesia. Experimental research]. Minerva anestesiologica. 1967 Dec; 33(12):864-71. doi: NULL. [PMID: 5610005]
  • G M Wyant. The anaesthetist looks at tissue transplantation: three years' experience with kidney transplants. Canadian Anaesthetists' Society journal. 1967 Jul; 14(4):255-75. doi: 10.1007/bf03003696. [PMID: 5340458]
  • S Fossa, A Bertolini, G Becchi. [Neuroleptoanalgesia and renal function. Experimental study]. Chirurgia e patologia sperimentale. 1967 Jul; 15(3):339-44. doi: NULL. [PMID: 5617667]
  • J Császár, E Wölfer, K Mihalecz. [Our experiences with the neurolept-II-analgesia with special reference to kidney function changes]. Der Anaesthesist. 1967 Apr; 16(4):107-9. doi: NULL. [PMID: 5591167]
  • J W McIntyre, D J Campbell. Serum cholinesterase in anaesthesia with reference to neostigmine, fentanyl, and dihydrobenzpiridol. Canadian Anaesthetists' Society journal. 1966 Nov; 13(6):557-61. doi: 10.1007/bf03002225. [PMID: 5957441]
  • E Salehi, H Müssiggang, S Lymberopoulos. [Experiences with neuroleptoanalgesia in urological surgery and its effect on the kidney function]. Der Urologe. 1966 May; 5(3):141-4. doi: NULL. [PMID: 5997419]
  • R Fritsch, A L van Zuylen. [Neuroleptanalgesia, type II, in dogs and its influence on kidney function and blood composition]. Berliner und Munchener tierarztliche Wochenschrift. 1966 Apr; 79(8):150-7. doi: NULL. [PMID: 5971432]
  • R M Konrad, J Haase, S Eunike, W Staib. [Does neuroleptic anesthesia influence the catecholamine production in patients following the breaking open of mitral stenosis?]. Zentralblatt fur Chirurgie. 1966 Apr; 91(15):568-77. doi: NULL. [PMID: 5985219]
  • H M Gorman, N W Craythorne. The effects of a new neuroleptanalgesic agent (Innovar) on renal function in man. Acta anaesthesiologica Scandinavica. Supplementum. 1966; 24(?):111-8. doi: 10.1111/j.1399-6576.1966.tb01110.x. [PMID: 6003586]
  • A B Dobkin, P H Byles. Comparison of anaesthesia with innovar, halothane and methoxyflurane-nitrous oxide. Acta anaesthesiologica Scandinavica. Supplementum. 1966; 18(?):1-43. doi: 10.1111/j.1399-6576.1966.tb00326.x. [PMID: 4287535]
  • L Havers, E Kreppel. [On the effect of neuroleptanalgesia on sympathetic activity]. Acta anaesthesiologica Scandinavica. Supplementum. 1966; 23(?):12-7. doi: NULL. [PMID: 6003627]
  • A B Dobkin, P H Byles, M H Cho. Neuroleptanalgesics. 3. Effect of innovar-nitrous oxide anaesthesia on blood levels of histamine, serotonin, epinephrine, and norepinephrine, and on urine excretion. Canadian Anaesthetists' Society journal. 1965 Jul; 12(4):349-60. doi: 10.1007/bf03007826. [PMID: 5837814]
  • R Zatelli, U Maggi. [The kidney in neuroleptoanalgesia: histological and histochemical aspects]. Acta anaesthesiologica. 1965; 16(?):Suppl 5:1-11. doi: NULL. [PMID: 5899654]