Benoxaprofen (BioDeep_00000176510)

 

Secondary id: BioDeep_00000015073

human metabolite blood metabolite


代谢物信息卡片


2-(4-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid

化学式: C16H12ClNO3 (301.0506)
中文名称: 氧苯恶唑丙酸, 苯噁洛芬
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C(O)=O)C1=CC2=C(OC(=N2)C2=CC=C(Cl)C=C2)C=C1
InChI: InChI=1S/C16H12ClNO3/c1-9(16(19)20)11-4-7-14-13(8-11)18-15(21-14)10-2-5-12(17)6-3-10/h2-9H,1H3,(H,19,20)

描述信息

M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D004791 - Enzyme Inhibitors > D016859 - Lipoxygenase Inhibitors
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
D003879 - Dermatologic Agents

同义名列表

31 个代谢物同义名

2-(4-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid; 2-[2-(4-chlorophenyl)-1,3-benzoxazol-5-yl]propanoic acid; 2-(p-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid; 2-[2-(4-Chlorophenyl)-1,3-benzoxazol-5-yl]propanoate; 2-(p-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetate; 2-(p-Chlorophenyl)-α-methyl-5-benzoxazoleacetic acid; 2-(4-Chlorophenyl)-a-methyl-5-benzoxazoleacetic acid; 2-(p-Chlorophenyl)-a-methyl-5-benzoxazoleacetic acid; 2-(4-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetate; 2-(4-Chlorophenyl)-α-methyl-5-benzoxazoleacetic acid; (1)-2-(4-Chlorophenyl)benzoxazole-5-propionic acid; ()-2-(4-chlorophenyl)benzoxazole-5-propionic acid; 2-(4-Chlorophenyl)-a-methyl-5-benzoxazoleacetate; 2-(4-Chlorophenyl)-α-methyl-5-benzoxazoleacetate; 2-(p-Chlorophenyl)-a-methyl-5-benzoxazoleacetate; 2-(p-Chlorophenyl)-α-methyl-5-benzoxazoleacetate; (1)-2-(4-Chlorophenyl)benzoxazole-5-propionate; Benoxaprofen, monosodium salt; Benoxaprofen, ammonium salt; Benoxaprofen, (+-)-isomer; Benoxaprofen, (+)-isomer; Benoxaprofen, (-)-isomer; (+-)-Benoxaprofen; DL-Benoxaprofen; Benoxaprofenum; Benoxaprofeno; Benoxaprofene; Benoxaprofen; Lilly 90459; LRCL 3794; Oraflex



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Frida Gustafsson, Alison J Foster, Sunil Sarda, Matthew H Bridgland-Taylor, J Gerry Kenna. A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jan; 137(1):189-211. doi: 10.1093/toxsci/kft223. [PMID: 24085192]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jan; 40(1):130-8. doi: 10.1124/dmd.111.040758. [PMID: 21965623]
  • Hamish T Southwood, Yvette C DeGraaf, Peter I Mackenzie, John O Miners, Philip C Burcham, Benedetta C Sallustio. Carboxylic acid drug-induced DNA nicking in HEK293 cells expressing human UDP-glucuronosyltransferases: role of acyl glucuronide metabolites and glycation pathways. Chemical research in toxicology. 2007 Oct; 20(10):1520-7. doi: 10.1021/tx700188x. [PMID: 17880178]
  • Jennifer Q Dong, Jianhua Liu, Philip C Smith. Role of benoxaprofen and flunoxaprofen acyl glucuronides in covalent binding to rat plasma and liver proteins in vivo. Biochemical pharmacology. 2005 Sep; 70(6):937-48. doi: 10.1016/j.bcp.2005.05.026. [PMID: 16046212]
  • Kiminori Mohri, Kenji Okada, Leslie Z Benet. Stereoselective taurine conjugation of (R)-benoxaprofen enantiomer in rats: in vivo and in vitro studies using rat hepatic mitochondria and microsomes. Pharmaceutical research. 2005 Jan; 22(1):79-85. doi: 10.1007/s11095-004-9012-4. [PMID: 15771233]
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  • K J Lavelle. Effect of indomethacin and benoxaprofen on immune complex interaction with cultured glomerular cells. Immunological investigations. 1985 Jun; 14(3):211-22. doi: 10.3109/08820138509076145. [PMID: 2931361]
  • J A Salmon, L C Tilling, S Moncada. Evaluation of inhibitors of eicosanoid synthesis in leukocytes: possible pitfall of using the calcium ionophore A23187 to stimulate 5' lipoxygenase. Prostaglandins. 1985 Mar; 29(3):377-85. doi: 10.1016/0090-6980(85)90097-8. [PMID: 2988019]
  • O F James. Drugs and the ageing liver. Journal of hepatology. 1985; 1(4):431-5. doi: 10.1016/s0168-8278(85)80780-7. [PMID: 3902953]
  • F Rossi, W Filippelli, V Guarino, S Russo, R Magliulo, E Marmo. Organ tolerance of non-steroidal anti-inflammatory drugs: effect on liver cells. Drugs under experimental and clinical research. 1985; 11(8):511-6. doi: NULL. [PMID: 3836872]
  • W H Inman, N S Rawson. Side-effects of benoxaprofen. Lancet (London, England). 1984 Dec; 2(8415):1336. doi: 10.1016/s0140-6736(84)90840-7. [PMID: 6150341]
  • G J Fancourt, H Adams, J Walls, J W Ward. Fatal self-poisoning with benoxaprofen. Human toxicology. 1984 Dec; 3(6):517-9. doi: 10.1177/096032718400300608. [PMID: 6526401]
  • R R Ghose, H R Jivan. Acute multisystem toxicity associated with the use of nonsteroidal anti-inflammatory drugs. Archives of internal medicine. 1984 Nov; 144(11):2282-3. doi: NULL. [PMID: 6497536]
  • G Mallarkey, G M Smith. The effect of arachidonic acid metabolism on intravascular platelet aggregation in rats. Thrombosis research. 1984 Oct; 36(2):91-102. doi: 10.1016/0049-3848(84)90331-1. [PMID: 6438829]
  • R S Stern, M Bigby. An expanded profile of cutaneous reactions to nonsteroidal anti-inflammatory drugs. Reports to a specialty-based system for spontaneous reporting of adverse reactions to drugs. JAMA. 1984 Sep; 252(11):1433-7. doi: NULL. [PMID: 6236306]
  • J B Silkworth, L Antrim, L S Kaminsky. Correlations between polychlorinated biphenyl immunotoxicity, the aromatic hydrocarbon locus, and liver microsomal enzyme induction in C57BL/6 and DBA/2 mice. Toxicology and applied pharmacology. 1984 Aug; 75(1):156-65. doi: 10.1016/0041-008x(84)90086-3. [PMID: 6431639]
  • A J Lewis, R P Carlson, J Chang, F DeLustro. Effect of gold salts, D-penicillamine and benoxaprofen on type II collagen-induced arthritis in rats. Agents and actions. 1984 Jun; 14(5-6):707-14. doi: 10.1007/bf01978912. [PMID: 6433677]
  • E A Kitchen, W Dawson. Comparative effects of inhibitors of the lipoxygenase enzyme system on leucocyte chemotaxis. The Journal of pharmacy and pharmacology. 1984 May; 36(5):300-4. doi: 10.1111/j.2042-7158.1984.tb04378.x. [PMID: 6145764]
  • I E Kochevar, K W Hoover, M Gawienowski. Benoxaprofen photosensitization of cell membrane disruption. The Journal of investigative dermatology. 1984 Mar; 82(3):214-8. doi: 10.1111/1523-1747.ep12260034. [PMID: 6699424]
  • R Anderson, P T Lukey, S P Naudé, G Jooné. Benoxaprofen: a pro-oxidant anti-inflammatory drug?. Agents and actions. 1984 Feb; 14(2):238-46. doi: 10.1007/bf01966648. [PMID: 6324560]
  • J M Danion, M Schmidt, J L Imbs, L Singer, J Schwartz. Benoxaprofen has no influence on the urinary elimination of lithium. Contributions to nephrology. 1984; 42(?):248-52. doi: 10.1159/000409984. [PMID: 6532653]
  • I F Anderson, S P Naudé, H A Eftychis, R Anderson, E de Klerk. The antirheumatic effect of benoxaprofen. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 1983 Jun; 63(24):923-5. doi: NULL. [PMID: 6857416]
  • S P Naude, R Anderson, E Eftychis, A Theron, H van Wyk, G K Jooné. The effects of benoxaprofen on mononuclear and polymorphonuclear leucocyte motility. An in vitro and in vivo study. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 1983 Jun; 63(24):926-30. doi: NULL. [PMID: 6304922]
  • M J Palmoski, K D Brandt. Benoxaprofen stimulates proteoglycan synthesis in normal canine knee cartilage in vitro. Arthritis and rheumatism. 1983 Jun; 26(6):771-4. doi: 10.1002/art.1780260611. [PMID: 6860379]
  • C J Hawkey, D S Rampton. Benoxaprofen in the treatment of active ulcerative colitis. Prostaglandins, leukotrienes, and medicine. 1983 Apr; 10(4):405-9. doi: 10.1016/0262-1746(83)90052-5. [PMID: 6407032]
  • J K Onwubalili. Oliguric renal failure associated with benoxaprofen. Nephron. 1983; 35(4):279-80. doi: 10.1159/000183102. [PMID: 6646306]
  • M Furlanut, G Montanari, V Colonna, A Perosa. Tolerability and serum levels of benoxaprofen in healthy volunteers. International journal of clinical pharmacology research. 1983; 3(3):163-6. doi: NULL. [PMID: 6679519]
  • J Okamoto, K Fujimoto, H Fujitomo, E Hirai. [Analysis of benoxaprofen glucuronide in human plasma and urine by gas chromatography]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1983 Jan; 103(1):54-61. doi: 10.1248/yakushi1947.103.1_54. [PMID: 6602873]
  • L Erwin, J M Boulton Jones. Benoxaprofen and papillary necrosis. British medical journal (Clinical research ed.). 1982 Sep; 285(6343):694. doi: 10.1136/bmj.285.6343.694. [PMID: 6809194]
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  • J M Brogard, F Comte, M Madon, M O Spach. Pharmacokinetic profile of benoxaprofen in subjects with normal and impaired renal function, prediction of multiple-dose kinetics. European journal of rheumatology and inflammation. 1982; 5(2):113-23. doi: NULL. [PMID: 7084275]
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